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  • subunit
  • This study demonstrates that loss of the laminin γ subunit (LanB2) in the peripheral glia of Drosophila melanogaster results in the disruption of glial morphology due to disruption of laminin secretion. (sdbonline.org)
  • Gene
  • Smo activation leads to signaling through several well-characterized effectors to activate Hh target gene expression. (sdbonline.org)
  • Mutations in the human laminin α 2 ( LAMA2 ) gene result in the most common form of congenital muscular dystrophy (MDC1A). (pnas.org)
  • Here we show that the degenerative muscle phenotype in the zebrafish dystrophic mutant, candyfloss ( caf ) results from mutations in the laminin α 2 ( lama2 ) gene. (pnas.org)
  • Moreover, estrogen receptor-dependent reporter gene expression, as well as estrogen receptor α levels, were increased threefold in a functionally normal mammary epithelial cell line when reconstituted basement membrane was added to the medium. (biologists.org)
  • Our data provides support for a primary role of laminin-511 promoting hair follicle epithelial downgrowth without affecting dermal primary cilia and Shh target gene induction. (biomedcentral.com)
  • Laminin mediates tissue-specific gene expression in mammary epithelia. (semanticscholar.org)
  • The laminin 521 cell culture substrates have a positive effect on stabilizing and homogenizing pluripotent gene expression profiles between hES cell lines, providing a more controllable and robust culture system compared to feeder and many other feeder-free culture systems. (biolamina.se)
  • We provide evidence that these two UNC-5 homologues, as well as the rcm gene product, are netrin-binding proteins, supporting the hypothesis that UNC-5 and its relatives are netrin receptors. (embl.de)
  • LM511
  • Laminin-511 (LM511) and laminin-332 (LM332) are the most abundant laminins in developing and adult skin. (biomedcentral.com)
  • In addition, LM511-YAP signaling increased the expression of transcription factors critical for mDA identity, such as LMX1A and PITX3, and prevented the loss of mDA neurons in response to oxidative stress, a finding that warrants further investigation to assess therapeutic potential for PD patients. (sciencemag.org)
  • We propose that by enhancing LM511-YAP signaling, it may be possible to prevent mDA neuron degeneration in PD or enhance the survival of mDA neurons in cell replacement therapies. (sciencemag.org)
  • LAMA2
  • Early muscle formation and myoblast fusion are normal, indicating that any deficiency in early Lama2 signaling does not lead to muscle pathology. (pnas.org)
  • The incidence of CMDs has been estimated to be approximately one in 21,500 ( 2 ), with laminin α2- (LAMA2) deficient CMD (MDC1A) accounting for ≈40-50% of the CMD cases in European countries ( 3 ). (pnas.org)
  • actin
  • Publications] Ozawa K.: 'Translocation of cortactin (p80/85) to the actin-based cytokeleton during thrombin receptor-mediated platelet activation. (nii.ac.jp)
  • fibroblasts
  • Estrogen receptor α expression in primary mammary fibroblasts was not altered by these culture conditions, indicating that its regulation is cell type specific. (biologists.org)
  • whereas
  • Matrix metalloproteinase (MMP)-9 activity was increased at 5 days of warfarin treatment, whereas TGF-β signaling was increased at 7 days. (ahajournals.org)
  • interaction
  • These findings suggest that s-LOTUS inhibits NgR1-mediated signaling, possibly by interfering with the interaction between NgR1 and p75 NTR . (jneurosci.org)
  • glial
  • Accumulation of laminin monomers in Drosophila glia leads to glial endoplasmic reticulum stress and disrupted larval locomotion. (sdbonline.org)
  • functionally
  • Acetylcholine, the neurotransmitter of skeletal neuromuscular junctions (NMJs), activates two structurally and functionally distinct types of receptors: nicotinic (nAChR) and muscarinic (mAChR). (jneurosci.org)
  • Role
  • Hedgehog (Hh) signaling plays a key role in the development and maintenance of animal tissues. (sdbonline.org)
  • Here we use a human BCC model system and mouse mutants to re-evaluate the role of laminin-511 in epithelial invagination in the skin. (biomedcentral.com)
  • We investigated whether gustatory afferents express functional 5-HT 3 receptors and, if so, whether these receptors play a role in transmission of taste information from taste buds to nerves. (jneurosci.org)
  • In the present study, we demonstrate that a subset of gustatory sensory neurons express functional 5-HT 3 receptors that play a significant role in the neurotransmission of taste information from taste buds to nerves. (jneurosci.org)
  • Herein, we test whether 5-HT released by taste cells plays a role in the transmission of taste information by activation of 5-HT 3 receptors on afferent nerve fibers. (jneurosci.org)
  • basal
  • Laminins are major structural components of basal laminae and exist as heterotrimeric complexes of one α, one β, and one γ chain. (pnas.org)
  • pharmacological
  • Pharmacological blockade of 5-HT 3 receptors in vivo or genetic deletion of the 5-HT 3 receptors reduces taste nerve responses to acids and other taste stimuli compared with controls, but only when urethane was used as the anesthetic. (jneurosci.org)
  • functional
  • The expression level and functional activity of estrogen receptor α is an important determinant of breast physiology and breast cancer treatment. (biologists.org)
  • The functional crosstalk between Wnt/β-catenin and BRAF signaling may yield more effective therapies for treating melanoma. (sciencemag.org)
  • therefore
  • Biolaminin 521 LN (LN521) is the natural laminin for pluripotent stem cells and therefore reliably facilitates self-renewal of human ES and iPS cells in a chemically defined, feeder-free and animal component-free stem cell culture system. (biolamina.se)
  • expression
  • In this dataset, we include the expression data obtained from laminin binding O-glycan high or low androgen-independent PC cells. (datamed.org)
  • neural
  • Our results suggest that 5-HT released from type III cells activates gustatory nerve fibers via 5-HT 3 receptors, accounting for a significant proportion of the neural taste response. (jneurosci.org)
  • nerve
  • Myelin is a multi-lamellar sheath that invests large axons and permits rapid conduction of nerve signals. (buffalo.edu)
  • In addition, we show that the anesthetic pentobarbital, widely used in taste nerve recordings, blocks 5-HT 3 signaling. (jneurosci.org)
  • common
  • Laminins are common to tissues of most multicellular metazoans and they are highly conserved across evolution. (sdbonline.org)
  • After birth, α5-laminins represent the most common laminins in the body and LN521 supports many diverse tissue cell types, such as cells from pancreas, vascular, nervous and muscular systems. (biolamina.se)
  • Function
  • RNA interference loss-of-function Studien prüften molekulare Wirkstoffziele um den 67 kDa laminin Rezeptor und den TLR4-Signalweg. (tum.de)