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  • inhibitor
  • Disrupting endogenous Fak/Src signaling either by expression of a dominant-negative Fak mutant with phenylalanine substituted for Tyr-397 or by treatment with a c-Src pharmacological inhibitor (PP-2) markedly attenuated stretch-induced Fak activation and clustering at myofilaments and inhibited stretch-induced ANF gene activation. (ahajournals.org)
  • cells
  • While it is well-recognized that stimuli for osteogenesis of mesenchymal stem cells (MSCs) drive FA maturation, actin organization, and stress-fiber polarization, the extent to which FA-mediated signals regulated by the FA protein composition specifies MSC commitment remains largely unknown. (biologists.org)
  • As implied above, the structure of organisms and their tissues depends on the adhesion and inter- action of cells to each other as well as of cells to basement membranes and the ECM. (damasgate.com)
  • 8,9 In addition, Fak, a primary integrin effector that is known to play a key role in the responses of cells to mechanical stimuli through focal adhesion sites, 10-12 is rapidly activated by mechanical stimuli in cultured neonatal rat ventricular myocytes (NRVMs) 13,14 and in overloaded myocardium of adult animals. (ahajournals.org)
  • Consistent with the proposal that FAK modulates adhesion turnover, the number of adhesions that turned over in protrusive regions of FAK -/- cells was markedly less than in wild-type cells. (hindawi.com)