Signals focal adhesions. Medical search. Frequent questions

Focal adhesion kinase (FAK) is a key integrator of integrin-mediated signals from the extracellular matrix to the cytoskeleton and downstream signaling molecules. (techscience.com)
Here, we show that the integrin effector protein Focal Adhesion Kinase (FAK) is dispensable for normal intestinal homeostasis and DNA damage signaling, but is essential for intestinal regeneration following DNA damage. (cardiff.ac.uk)
Tenascin-C modulates matrix contraction via focal adhesion kinase- and Rho-mediated signaling pathways. (ox.ac.uk)
Using a synthetic model of the provisional matrix, we have found that tenascin-C regulates cell responses to a fibrin-FN matrix through modulation of focal adhesion kinase (FAK) and RhoA activation. (ox.ac.uk)
Proteins Secreted by Lung Cancer Cells Induce the Onset of Proteinuria via Focal Adhesion Kinase Signaling in Mice. (bvsalud.org)
Integrin - focal adhesion kinase (FAK) signaling and inflammatory responses were evaluated in podocytes either exposed to soluble LCSePs or seeded onto substrates with immobilized LCSePs. (bvsalud.org)
The rac1 target p21-activated kinase translocated from a cytosolic to a cytoskeletal distribution, suggesting that rac1 activation was inducing focal adhesion reorganization. (jci.org)
KEGG pathways enrichment and PPI network indicate four major pathways, including extracellular matrix -receptor interaction, focal adhesion, phosphatidylinositol 3-kinase (PI3K)-Protein kinase B (Akt), and Ras signaling pathways were involved in the degeneration of cartilage. (nature.com)
Focal adhesion kinase (FAK) is a nonreceptor tyrosine kinase that regulates cell signaling, proliferation, migration, and development. (rcsb.org)
Focal adhesion kinase splice variants maintain primitive acute myeloid leukemia cells through altered Wnt signaling. (nih.gov)
I suggest that in the context of semaphorin 3A signaling, RhoA-kinase serves as a switch to change the function of the F-actin cytoskeleton from promoting protrusive activity to generating contractile forces. (biologists.com)
Little is known about how the kinase activity-deficient RYKs transduce Wnt signals. (biologists.com)
Biliverdin reductase bridges focal adhesion kinase to Src to modulate synaptic signaling. (harvard.edu)
Integrin-linked kinase (ILK) is a major structural adaptor protein governing signaling complex formation and cytoskeletal dynamics. (jneurosci.org)
Here, we show that vinculin null (vin −/− ) cells and cells expressing a vinculin Y822F mutant have increased survival due to up-regulated activity of extracellular signal-regulated kinase (ERK). (rupress.org)
Both vinY822F and vin −/− cells exhibit increased interaction between paxillin and focal adhesion kinase (FAK) and increased paxillin and FAK phosphorylation. (rupress.org)
Focal Adhesion Kinase (FAK) is a cytoplasmic tyrosine kinase that colocalizes with integrins in focal adhesions. (fishersci.com)
In addition, phosphorylation of other Tyr residues (Tyr-925, and Tyr-861) creates binding sites for SH2 domains of intracellular signaling molecules such as Src, PI3 kinase, and Grb2. (fishersci.com)
Podosomes are structurally divided into a core, which mainly contains proteins involved in actin polymerization (such as WASP, the Arp2/3 complex and cortactin ), and a surrounding ring populated by integrin receptors and adhesion proteins (for example, paxillin and focal adhesion kinase (FAK/Pyk2) ) [15] . (cellmigration.org)
Binding of viral proteins to their ligands activates signaling pathways-focal adhesion kinase for human herpesvirus 8, JAK1, tyk2 and STAT1/2 for West Nile virus (WNV), I κ B-kinase, and nuclear transcription factor κ B (NF-κB) for influenza virus-resulting in virus entry, DNA delivery to nucleus, and modulation of protein expression that stimulate or inhibit virus replication. (cdc.gov)
Moreover, Wnt-5a is known to inhibit migration of breast epithelial cells in culture and expression of Wnt-5a potentiates activation of the receptor tyrosine kinase DDR1, a collagen receptor implicated in cell adhesion and migration. (lu.se)
Finally, we found that phospho-DARPP-32 inhibited the activity of the focal adhesion kinase (FAK) in MCF-7 breast cancer cells, and that MCF-7 cells expressing phospho-DARPP-32 displayed less filopodia formation. (lu.se)

This discovering signifies that PCP signaling is among the many numerous pathways employed all through early lung branching to orchestrate the place and path of lung branches. (myspaceastronomy.com)
This study, the first examination of rac1-mediated cardiac effects in vivo, demonstrates that dilation and hypertrophy can share a common molecular origin and presents evidence that both timing and concurrent signaling from multiple pathways can influence cardiac remodeling. (jci.org)
These results suggest that MAAs accelerate wound repair by activating the FAK-MAPK signaling pathways. (elsevierpure.com)
This study was designed to identify signaling pathways and crucial proteins involved in the pathological mechanism of KBD compared with osteoarthritis (OA). (nature.com)
In conclusion, our results demonstrated that compared with OA, the differential abundance proteins and signaling pathways may contribute to the occurrence and development of joint damage in KBD. (nature.com)
The GFRα and GFRα-mediated signaling pathways. (medsci.org)
Guidance cues activate signaling transduction pathways that, in turn, regulate the dynamics and organization of the neuronal cytoskeleton. (biologists.com)
Defects in the signaling pathways associated with cell adhesion provide the basis for cell transformation and cancer cell metastasis, various developmental defects and cardiovascular disease. (upstate.edu)
We previously showed that Musashi-2 (MSI2) RNA-binding protein is associated with NSCLC progression by regulating several signaling pathways relevant to NSCLC. (researchgate.net)
The process is highly regulated by multiple signaling pathways and orchestrated by more than 30 autophagy-related (Atgs) proteins organized in several functional units ( 2 ). (frontiersin.org)
These studies have served to highlight the role of AND-34/BCAR3 and p130Cas in cell adhesion and migration signaling pathways. (molvis.org)
We study genes, proteins and signaling pathways that might be essential for RGC and optic nerve development, function, survival, and regeneration. (nih.gov)
We demonstrated that myocilin is involved in myelination of the optic and sciatic nerves acting through different signaling pathways. (nih.gov)
Pathways involved in PI3K-Akt signaling may play a role in the altered focal adhesion and extracellular matrix (ECM)‒receptor interactions noted in Hailey-Hailey disease. (medscape.com)
Aside from binding to membranes, the activated FERM domain of ERM proteins can also bind the guanine nucleotide dissociation inhibitor of Rho GTPase (RhoDGI), which suggests that in addition to functioning as a cross-linker, ERM proteins may influence Rho signalling pathways. (embl.de)
Several examples of the role of viral glycoproteins, their ligands, and cellular proteins of the signaling pathways have been described. (cdc.gov)
We selected most pathways MAPK4 participated on our site, such as B Cell Receptor Signaling Pathway, Focal Adhesion, Insulin Signaling, which may be useful for your reference. (creativebiomart.net)
A SH2 DOMAIN-containing protein that mediates SIGNAL TRANSDUCTION pathways from multiple CELL SURFACE RECEPTORS, including the EPHB1 RECEPTOR. (bvsalud.org)

FAK is activated by phosphorylation at specific tyrosine residues, which then stimulate downstream signaling including the ERK1/2 pathway, leading to a variety of cellular responses. (techscience.com)
Our results demonstrate that FAK signaling emanating from Y397, Y925, and to a lesser extent Y576/7, but not from Y861, controls osteogenic differentiation through an ERK1/2 pathway, as measured by expression levels of key osteogenesis marker genes and subsequent matrix mineralization. (techscience.com)
Transgenic rac1 protein was expressed at levels comparable to endogenous rac levels, with activation of the rac1 signaling pathway resulting in two distinct cardiomyopathic phenotypes: a lethal dilated phenotype associated with neonatal activation of the transgene and a transient cardiac hypertrophy seen among juvenile mice that resolved with age. (jci.org)
The signaling model is based on a biochemical pathway where IP 3 molecules are generated when focal adhesions grow. (wustl.edu)
The signaling model is based on a biochemical pathway where IP3 molecules are generated when focal adhesions grow. (wustl.edu)
Importantly, increasing numbers of novel reports suggest that the GFRα-mediated signaling pathway acts as an oncogenic promoter related to tumor proliferation, invasion, and metastasis as well as treatment resistance. (medsci.org)
On the biochemistry function, POGLUT2 can catalyze to transfer the glucose from UDP-glucose to a serine residue and specifically target extracellular epidermal growth factor (EGF) repeats of proteins such as Notch signaling members (NOTCH1 and NOTCH3) ( 9 , 10 ), thereby affecting Notch signaling pathway ( 11 ). (frontiersin.org)
Involvement of C/EBPβ-related signaling pathway in methamphetamine-induced neuronal autophagy and apoptosis. (cancerindex.org)
DEGs were also enriched in human papillomavirus infections, the focal adhesion pathway, PI3K-Akt signaling pathway, and among others. (hindawi.com)
KEGG pathway analysis showed that the differential genes of LUAD were significantly enriched in viral carcinogenesis and adhesion spots. (hindawi.com)
Then, GO and KEGG signal pathway enrichment analyses were used to conduct functional annotation and signal pathway analysis for DEGs. (hindawi.com)
Some family members, such as latrophilins and gliomedin, are membrane-bound proteins containing the olfactomedin domain in the extracellular N-terminal region, while the intracellular C-terminal domain of these proteins is essential for the transduction of extracellular signals to the intracellular signaling pathway. (nih.gov)
Genes in the 'Focal adhesion', 'Wnt signaling pathway' and 'MAPK signaling' pathway. (biomedcentral.com)
Downregulation of Herg1 suppresses osteosarcoma proliferation and invasion by targeting Hippo signaling pathway]. (cancerindex.org)
Our results demonstrate an association between cognitive impairment and a defect in a signalling pathway that depends on a Ras-like GTPase. (embl-heidelberg.de)

Integrins link the actin cytoskeleton with the extracellular matrix and they transmit signals bidirectionally between the extracellular matrix and cytoplasmic domains. (wikipedia.org)
Focal adhesions connect extracellular matrix (ECM) and F-actin cytoskeleton through transmembrane protein integrins [3]-[6]. (technologybooksindustrialprojectreports.com)
Feedback interactions from mechanical and biochemical signals within focal adhesion and the F-actin cytoskeleton coordinate the behavior of the protrusive and contractile lamella by promoting and sustaining the proper spatial and temporal control in the cell [3]. (technologybooksindustrialprojectreports.com)
ILK forms an obligate heterotrimeric complex with particularly interesting Cys-His-rich protein (PINCH) and parvin, which together lend stability to the actin cytoskeleton at focal adhesions ( Brakebusch and Fässler, 2003 ). (jneurosci.org)
Members of the Rho family of small G proteins transduce signals from plasma-membrane receptors and control cell adhesion, motility and shape by actin cytoskeleton formation. (embl-heidelberg.de)

Cells communicate with their external environment via focal adhesions and generate activation signals that in turn trigger the activity of the intracellular contractile machinery. (wustl.edu)
GO analysis shows that the differential abundant proteins are associated with cell junction and signal transducer activity from extracellular to intracellular. (nature.com)
We hypothesize that it is through these various interactions that the cell coordinates intracellular signaling and cytoskeletal reorganization to regulate cell adhesion, migration and tumor invasion. (upstate.edu)
These multiprotein complexes are capable of capturing and integrating many signals from the extracellular as well as intracellular environments ( Rosales and Juliano, 1995 ). (rupress.org)

Integrin family members are membrane receptors involved in cell adhesion and recognition in a variety of processes including embryogenesis, hemostasis, tissue repair, immune response and metastatic diffusion of tumor cells. (wikipedia.org)
Beta-integrins are primarily responsible for targeting integrin dimers to the appropriate subcellular locations, which in adhesive cells is mainly focal adhesions. (wikipedia.org)
Integrin beta-1 mutants lose the ability to target to sites of focal adhesions. (wikipedia.org)
The integrin beta-1B isoform appears to act as a dominant negative in that it inhibits cell adhesion. (wikipedia.org)
The formation of focal adhesions on 2D surfaces begins with integrin clustering upon conversation with the ECM. (technologybooksindustrialprojectreports.com)
Small transient integrin-associated nascent adhesions form first followed by the formation of larger more stable fibrillar adhesion with actin stress fibers which facilitate cell distributing and migration [7]. (technologybooksindustrialprojectreports.com)
In light of these findings, precisely how β1 integrin transduces ECM cues via signaling intermediates, and the mechanism by which this translates to cellular responses, need to be addressed. (jneurosci.org)

My lab uses a multi-faceted approach combining biochemistry, cell and molecular biology and various high-end microscopy techniques along with mouse knockout and tumor models to determine the molecular organization of the proteins that are involved in cell adhesion and thereby understand how they each contribute to cell behavior in vivo. (upstate.edu)

However, abnormal expression or aberrant activation of these molecules may convert normal growth signals to undesirable signals inducing overgrowth, becoming an important contributor to a variety of human cancers. (medsci.org)
Cell surface recognition and cytosolic sensing of these molecules result in signaling cascades that promote rapid and localized autophagy machinery recruitment. (frontiersin.org)
Adhesion complexes (i.e., focal adhesions and focal complexes) and cell-cell contacts are specialized structures that harbor a large number of cytoskeletal proteins and one of the highest concentrations of signaling molecules in cells ( Ruoslahti and Obrink, 1996 ). (rupress.org)
Gene expression may be affected in benign familial pemphigus, as may phosphorylation of adhesion molecules. (medscape.com)

Given Wnt/c-Myc signaling is activated following intestinal regeneration, we investigated the functional importance of FAK following deletion of the Apc tumor suppressor protein within the intestinal epithelium. (cardiff.ac.uk)
Introduction The study of focal adhesions in the two-dimensional (2D) environment has led to an in depth understanding of their protein composition [1] structure [2] and their role in cell migration as well as mechanical sensing. (technologybooksindustrialprojectreports.com)
Signaling evaluations indicated a decrease in VEGFR2 and phAKT protein levels with MSI2 KD (Figure 3A,B), while phERK protein levels were not changed (Supplementary Figure S4B). (researchgate.net)
Dr. Marchese has had a long-standing interest in understanding the molecular mechanisms governing G protein-coupled receptor signaling. (mcw.edu)
Research in the Marchese lab is directed towards understanding the molecular mechanisms governing G protein-coupled receptor (GPCR) signaling. (mcw.edu)
AND-34/BCAR3 (Breast Cancer Anti-Estrogen Resistance 3) associates with the focal adhesion adaptor protein, p130CAS/BCAR1. (molvis.org)
An overall defect in keratinocyte adhesion appears to be secondary to a primary defect in a calcium pump protein, ATP2C1. (medscape.com)
Focal-adhesion kinases (FAKs), cytoplasmic protein tyrosine kinases involved in signalling through integrins. (embl.de)
The chemokine signal is transduced by chemokine receptors (G-protein coupled receptors) expressed on the immune cells. (genome.jp)
Subsequent proteomic mass spectrometry revealed that MWCNT treatment significantly altered serum exosome protein cargo, with particular increases in focal adhesion proteins and decreases in protease inhibitors, changes consistent with altered endocytosis and signaling. (cdc.gov)

We found that SH, M-Gly, and P334 have significant effects on the wound healing process in human keratinocytes and these effects were mediated by activation of focal adhesion kinases (FAK), extracellular signal-regulated kinases (ERK), and c-Jun N-terminal kinases (JNK). (elsevierpure.com)
Here, we show that the non-receptor Src family tyrosine kinases, SRC64B and SRC42A, are involved in WNT5-mediated signaling through Derailed in the Drosophila embryonic central nervous system. (biologists.com)
We have found that these multi-domain proteins bind numerous structural and signaling proteins including kinases, phosphatases and Rho family GTPase regulators and effectors. (upstate.edu)
Focal adhesion targeting (FAT) domains target the non-receptor tyrosine kinases FAK and Pyk2 to cellular focal adhesion areas, where the signaling molecule paxillin is also located. (rcsb.org)

The discrepancy of cellular migratory behavior when focal adhesion-related components in 2D and 3D are altered could indicate that focal adhesions in 3D if they exist may carry out different functions [12]-[14]. (technologybooksindustrialprojectreports.com)
However, the molecular and cellular events downstream of epithelial and mesenchymal Wnt5a signaling are unclear. (myspaceastronomy.com)
and mediates signaling between the ECM and the cellular interior. (jneurosci.org)
These junctions consist of calcium-binding transmembrane glycoproteins, which contribute to cellular adhesion. (medscape.com)
This cellular localization is directed by a 125 amino acid sequence at the C-terminus called the "Focal Adhesion Targeting" sequence (FAT). (fishersci.com)

Nascent adhesions are the first observable adhesive structures, emerging within the lamellipodium. (cellmigration.org)
Nascent adhesions are small and highly transient - either maturing or disassembling ('turning over') - and are therefore not easily observed in every cell type [6] , [7] . (cellmigration.org)
They are larger than nascent adhesions, depend on myosin II for their formation and maintenance, and reside at the boundary of the lamellum and lamellipodium [10] , [11] . (cellmigration.org)
Like nascent adhesions, they also tend to either disassemble (turnover) or grow and elongate into focal adhesions. (cellmigration.org)
Although focal adhesions are similar, in terms of molecular composition, to nascent adhesions and focal complexes, several adhesion proteins appear to change as focal adhesions evolve in response to tension, e.g., zyxin and vinculin . (cellmigration.org)

For example, cell adhesion to a fibronectin substratum involves concurrent activation of Src and phosphorylation of the FAK activation loop. (fishersci.com)
Thus, FAK activity is regulated by a complex set of phosphorylation sites, and thisphospho-regulation could be important for cell motility, cell growth, cytoskeletal organization, and adhesion-dependent cell survival. (fishersci.com)

FAK's ability to bind numerous structural and signaling proteins via a variety of interactions is important for FAK activation level, and for FAK interaction with a variety of substrates localized to sites of cell adhesion. (fishersci.com)

Regulation of cell migration by focal adhesion adapter proteins and their role in cancer cell metastasis. (upstate.edu)
Next, we established cell lines with VEGFR2 OE to evaluate the effects of MSI2 on AKT signaling via VEGFR2 regulation. (researchgate.net)
[ 8 ] Other classification systems categorize the ectodermal dysplasias based on defects in cell-cell communication and signaling, adhesion, transcription regulation, or development. (medscape.com)

We discovered that cytoskeletal reorganization induced by PCP signaling ends in modifications in focal adhesions required for branching. (myspaceastronomy.com)

It is anticipated that the Wnt5a signal is acquired by a particular subset of receptors/coreceptors and participates in a definite signaling neighborhood in a given tissue or natural course of. (myspaceastronomy.com)

When GFLs bind with GFRα, they form complexes and associate with the RET receptor, subsequently activating downstream signaling. (medsci.org)
The mammalian orthologs of Derailed and SRC64B also form complexes, suggesting that Src roles in RYK signaling are conserved. (biologists.com)
other signaling adaptors are also recruited to these complexes, including FAK and paxillin. (cellmigration.org)
Focal complexes are adhesions in the early stages of maturation. (cellmigration.org)

Second high cytoplasmic fluorescence background may give low signal-to-background ratio that hinders the detection of focal adhesions [10]-[12]. (technologybooksindustrialprojectreports.com)

In addition when cells are in the 3D environment there is a continuum of migration modes that are determined by both matrix substrate and intrinsic contractility of the cell [7] and focal adhesions may not be needed for migration. (technologybooksindustrialprojectreports.com)
The dynamic adhesion of cells to their surrounding extracellular matrix provides many of the environmental cues necessary for controlling cell migration and cell shape, survival, proliferation and differentiation. (upstate.edu)
Cell adhesion (the physical interaction of a cell with another cell or with the extracellular matrix (ECM)) is essential for cell migration and tissue integrity. (cellmigration.org)
Cell-cell adhesion maintains epithelial tissues, supports functional contacts between specialized cells, and can facilitate directed migration (for example, radial glia can guide neuronal progenitor cells to specific layers of the brain). (cellmigration.org)
Cell-matrix adhesion is the best-studied form of adhesion that mediates cell migration, and is the focus of this outline. (cellmigration.org)
Endoglin controls cell migration and composition of focal adhesions: function of the cytosolic domain. (medlineplus.gov)

These adhesions generate signals that activate Rac, promoting actin polymerization and preventing myosin II engagement in the lamellipodium. (cellmigration.org)
Rho activation is thought to generate focal adhesions and actin bundling due to increased myosin II activity. (cellmigration.org)

These results demonstrate the loss of AND-34 dysregulates focal adhesion complex signaling in lens epithelial cells and suggest that AND-34-mediated signaling is required for maintenance of the structural integrity of the adult ocular lens. (molvis.org)

When podocytes were stimulated by immobilized LCSePs, FAK accumulated at focal adhesions , synaptopodin dissociated from F-actin , and disrupting the interactions between synaptopodin and α- actinin was observed. (bvsalud.org)

These signals can be triggered by mechanical loading that gives rise to a cooperative feedback loop among signaling, focal adhesion formation, and cytoskeletal contractility, which in turn equilibrates with the applied mechanical loads. (wustl.edu)
We devise a signaling model that couples stress fiber contractility and mechano-sensitive focal adhesion models to complete this above mentioned feedback loop. (wustl.edu)
Whereas the formation of focal adhesions requires actomyosin-mediated contractile force mediated by RhoA , podosome formation is stimulated by a local loss of contractility and the recruitment of negative regulators of RhoA, such as p190RhoGAP [16] . (cellmigration.org)

A simple numerical example is presented where a one-dimensional cell adhered to a rigid substrate is pulled at one end, and the evolution of the stress fiber activation signal, stress fiber concentrations, and focal adhesion distributions are investigated. (wustl.edu)
These adhesions are usually physically linked to large, readily visualized actomyosin bundles [13] , and their appearance correlates inversely with motility, such that they are conspicuously absent in cells migrating within a three-dimensional (3D) substrate. (cellmigration.org)

Our findings demonstrate that by multiplexing these techniques we have the ability to spatially and temporally quantify focal adhesion assembly and disassembly in 3D space and allow the understanding tumor cell invasion in a more complex relevant environment. (technologybooksindustrialprojectreports.com)
Increased levels of POGLUT2 could result in the dysregulated immune cell infiltration and tumor microenvironment and showed a significant regulatory effect on the progression of breast cancer through Notch-related signaling. (frontiersin.org)
Goreczny, G.J., Forsythe, I. and Turner, C.E. (2018) Hic-5 Regulates Fibrillar Adhesion Formation to Control Tumor Stromal Matrix Remodeling through Interaction with Tensin 1. (upstate.edu)
Cell adhesion molecule-1 (CADM1) is a member of the immunoglobulin superfamily that functions as a tumor suppressor of lung tumors. (cancerindex.org)

Cells on fibrin-FN+tenascin-C redistribute their actin to the cell cortex, downregulate focal adhesion formation, and do not assemble a FN matrix. (ox.ac.uk)
Business and dynamics of focal adhesion proteins have been well characterized in cells grown on two-dimensional (2D) cell culture surfaces. (technologybooksindustrialprojectreports.com)
Obtaining focal adhesion sites in live cells embedded in 3D matrices has been challenging. (technologybooksindustrialprojectreports.com)
Recent literature has discussed several other issues regarding focal adhesion studies of live cells in 3D. (technologybooksindustrialprojectreports.com)
First the focal adhesions detected may be from your cells that experience the stiff glass surface due to the proximity to the imaging dish ('edge effect') which is not a true 3D environment. (technologybooksindustrialprojectreports.com)
This suggests that ad hoc signaling models may not be able to capture the mechanical response of cells to a wide range of mechanical loading events. (wustl.edu)
Fibrillar adhesions represent an extreme in the maturation of adhesions and are not generally seen in migrating cells. (cellmigration.org)
Podosomes are ring-shaped adhesions often found in fast-moving cells, such as macrophages. (cellmigration.org)

We demonstrate that while it is sufficient to approximate the activation signal as spatially uniform due to the rapid diffusion of the IP 3 through the cytosol, the level of the activation signal is sensitive to the rate of application of the mechanical loads. (wustl.edu)
Prior data link AND-34 expression to the activation of Akt signaling. (molvis.org)

and microtubule targeting, which may contribute to adhesion disassembly. (cellmigration.org)

The anti-migratory effects of Wnt-5a and DARPP-32 were reduced by dominant negative-CREB, which suggests that CREB plays a functional role in this signalling mechanism. (lu.se)

In addition the N&B analysis shows paxillin aggregated predominantly at these focal contacts which are next to collagen fibers. (technologybooksindustrialprojectreports.com)

The complete integumentary organ system (IOS) regeneration and scarless wound healing mechanism, which occurs in specific species, body sites and developmental stages, clearly shows that mechanical stress signals and immune responses play important roles in determining the wound healing mode. (mdpi.com)

5 μm (fibrillar adhesion) with slower turnover rates [3] [8]. (technologybooksindustrialprojectreports.com)

In 2003, Lamartine reclassified the ectodermal dysplasias into the following 4 functional groups based on the underlying pathophysiologic defect: (1) cell-to-cell communication and signaling, (2) adhesion, (3) development, and (4) other. (medscape.com)

The results of GO analysis showed that the downregulated genes were significantly enriched in matrix adhesion and angiogenesis and upregulated differential genes were significantly enriched in cell adhesion and vascular development. (hindawi.com)
Hereditary hemorrhagic telangiectasia: an update on transforming growth factor beta signaling in vasculogenesis and angiogenesis. (medlineplus.gov)

PSPN not only binds GFRα4 but also signals in neurons mediated by GFRα1 [ 5 ]. (medsci.org)

Anatomy39

Organisms7

Diseases8

Chemicals and Drugs126

Analytical, Diagnostic and Therapeutic Techniques and Equipment23

Phenomena and Processes50

Disciplines and Occupations2

Technology, Industry, Agriculture1

Information Science5

Kinase22

Pathways18

Pathway15

Cytoskeleton5

Intracellular4

Integrin7

Involved in cell adhesion1

Molecules4

PROTEIN10

Kinases4

Cellular5

Nascent adhesions5

Phosphorylation2

Bind numerous structural and signalin1

Regulation3

Cytoskeletal reorganization1

Receptors1

Complexes4

Fluorescence1

Migration6

Myosin2

Epithelial cells1

Interactions1

Contractility3

Substrate2

Tumor4

Cells8

Activation2

Disassembly1

Migratory1

Fibers1

Mechanism1

Fibrillar1

Defect1

Angiogenesis2

Binds1