• Recently, we have demonstrated that PLA 2 and 5-LOX are involved in lipopolysaccharide (LPS)-induced iNOS gene expression via dependent and independent NF-κB pathways in glial cells [ 11 ]. (biomedcentral.com)
  • Induction of growth factors [interleukin 6 (IL-6), insulin-like growth factor-1, and vascular endothelial growth factor/platelet-derived growth factor) may indirectly activate the AR and/or its downstream signaling pathways (5, 6, 7) . (aacrjournals.org)
  • [email protected] tion of the important signalling pathways [3]. (sagepub.com)
  • Furthermore, activated miR-146a inhibited cancer migration, invasion, and metastasis by downregulating vascular endothelial growth factor through dual pathways in HCC. (biomedcentral.com)
  • Our studies demonstrate that RvD1 promotes IL-4-induced alternative activation via STAT6 and PPARγ signaling pathways in microglia. (biomedcentral.com)
  • It is a signal transducing adaptor protein that undergoes tyrosine PHOSPHORYLATION in signaling pathways that regulate CELL MIGRATION and CELL PROLIFERATION. (ucdenver.edu)
  • Weyant MJ, Carothers AM, Bertagnolli ME, Bertagnolli MM. Colon cancer chemopreventive drugs modulate integrin-mediated signaling pathways. (ucdenver.edu)
  • GSE-related anti-cancer activity mostly relies on the induced increase in reactive oxygen species, followed by the orchestrated down- and up-regulation of several key-molecular pathways, including MAPK kinases, PI3K/Akt, NF-kB, cytoskeleton proteins and metalloproteinases. (oatext.com)
  • 3,8-9 In fact, there is a great interest in the understanding of its structure and its mechanism of action, particularly of the molecular pathways involved in its recognition and cellular signaling, 10-15 as well as the forms of its inactivation 3,16 . (bvsalud.org)
  • Arachidonate 5-lipoxygenase-activating protein also known as 5-lipoxygenase activating protein, or FLAP, is a protein that in humans is encoded by the ALOX5AP gene. (wikipedia.org)
  • FLAP is necessary for the activation of 5-lipoxygenase and therefore for the production of leukotrienes, 5-hydroxyeicosatetraenoic acid, 5-oxo-eicosatetraenoic acid, and specialized pro-resolving mediators of the lipoxin and resolvin classes. (wikipedia.org)
  • Leukotrienes, which require the FLAP protein to be synthesized, have an established pathological role in allergic and respiratory diseases. (wikipedia.org)
  • Leukotrienes derived from 5-lipoxygenase (5-LOX) cause inflammation and are thus involved in the pathobiology of stroke injury. (biomedcentral.com)
  • The arachidonic acid, released by phospholipase A2, is an important substrate for the production of a group of lipid mediators known as leukotrienes, which induce proinflammatory signaling through the activation of specific BLT and CysLT receptors. (hindawi.com)
  • Cysteinyl leukotrienes (Cys-LTs) are potent inflammatory lipid mediators derived from the 5-lypoxygenase (5-LO) pathway of arachidonic acid (AA) metabolism [ 1 ], initially identified to have important effects on pathogenetic aspects of allergic rhinitis and bronchial asthma and approved in the late 1990s for the relief of perennial and seasonal allergic rhinitis symptoms, and the treatment of mild persistent bronchial asthma [ 2 - 5 ]. (hindawi.com)
  • Leukotrienes (LTs) are lipid mediators derived from the 5-lipoxygenase pathway of arachidonic acid metabolism. (springer.com)
  • The metabolic pathway of arachidonic acid (AA) has two main branches: 1) AA is converted by COX-1 and COX-2 into prostaglandins (PG) and thromboxane (TX), and 2) the actions of 5-lipoxygenase (5-LO) and 5-Lipoxygenase Activating Protein (FLAP) create leukotrienes (LT) in the other arm of the pathway [ 16 ]. (biomedcentral.com)
  • Kim E, Cho KO, Rothschild A, Sheng M. Heteromultimerization and NMDA receptor-clustering activity of Chapsyn-110, a member of the PSD-95 family of proteins. (umassmed.edu)
  • Cholinergic muscarinic receptors are members of the G-protein coupled receptor super-family and are further divided into 5 subtypes, M 1 to M 5 . (justia.com)
  • Moreover, we investigated the effects of RvD1 on IL-4-induced activation of signal transducer and activators of transcription 6 (STAT6) and peroxisome proliferator-activated receptor gamma (PPARγ). (biomedcentral.com)
  • Binding insulin to the insulin receptor recruits PI3K to the plasma membrane which then activates the central mediator of insulin's effects, Akt-1 also called protein kinase B. Protein kinase B inhibits apoptosis, stimulates myocyte hypertrophy/fibrosis, and nitric oxide (NO) production. (thepmc.org)
  • Receptor-facilitated antigen presentation requires the recruitment of B cell linker protein to Igalpha. (uchicago.edu)
  • CD45 (LCA, leukocyte common antigen) is a receptor-type protein tyrosine phosphatase (PTP) ubiquitously expressed in all nucleated hematopoietic cells, comprising approximately 10% of all surface proteins in lymphocytes. (thermofisher.com)
  • CD45 has been shown to be an essential regulator of T- and B-cell antigen receptor signaling and suppresses JAK kinases to regulate cytokine receptor signaling. (thermofisher.com)
  • It translocates to the nuclear membrane upon stimulation, where it co-localizes with 5-LOX activating protein (FLAP) and cytosolic phospholipase A 2 (cPLA 2 ) [ 5 ]. (biomedcentral.com)
  • Coupled with influx of extracellular calcium, Rut produced the endothelium-dependent vasorelaxant effect by activation of endothelium NOS and release of NO without pertussis toxin-sensitive Gi protein and other G proteins or phospholipase C activation being involved [ 8 ]. (biomedcentral.com)
  • FLAP functions as a membrane anchor for 5-lipooxygenase and as an amine acid-bind protein. (wikipedia.org)
  • How FLAP activates 5-lipooxygenase is not completely understood, but there is a physical interaction between the two. (wikipedia.org)
  • Emerging data implicate both 5-LOX and FLAP in the disease process of cerebral ischemia [ 6 ]. (biomedcentral.com)
  • Abnormal expression of 5-Lipoxygenase Activating Protein (FLAP) has been detected in many tumor cells. (biomedcentral.com)
  • We demonstrated that miR-146a expression is overexpressed, while FLAP protein and mRNA are suppressed in hepatocellular carcinoma tissues and HepG2 cells compared to para-carcinoma tissues and HL-7702 cells. (biomedcentral.com)
  • To test the neuroprotective efficacy of 5-LOX inhibition in a rat model of focal cerebral IR, ischemic animals were either pre- or post-treated with a potent selective 5-LOX inhibitor, (N- [3-[3-(-fluorophenoxy) phenyl]-1-methyl-2-propenyl]- N -hydroxyurea (BW-B 70C). (biomedcentral.com)
  • The study demonstrates the neuroprotective potential of 5-LOX inhibition through down-regulation of NF-κB in a rat model of experimental stroke. (biomedcentral.com)
  • It interacts directly with MTOR to enhance its kinase activity and stabilizes the MTOR-RPTOR PROTEIN interaction in nutrient-poor conditions, favoring RPTOR inhibition of MTOR activity. (bvsalud.org)
  • Resistance to Src inhibition alters the BRAF-mutant tumor secretome to promote an invasive phenotype and therapeutic escape through a FAK>p130Cas>c-Jun signaling axis. (ucdenver.edu)
  • CD45 is also important in promoting cell survival by modulating integrin-mediated signal transduction pathway, DNA fragmentation during apoptosis and inhibition or upregulation of various immunological functions. (thermofisher.com)
  • inhibition of 5-lipoxygenase (5-LO), which is expected to be involved in DHEA- and NALA-degradation pathway, also partially blocked the ability of DHEA and NALA to inhibit cell proliferation and phosphorylated Akt. (biomedcentral.com)
  • Interestingly, ROS production as a result of DHEA and NALA treatment was decreased by inhibition of 5-LO. (biomedcentral.com)
  • Many studies regarding myocardial ischemia and reperfusion show that leukotriene signaling may be involved in the development of ischemic injury. (hindawi.com)
  • Fisetin has anti-inflammatory traits that inhibit the 5-lipoxygenase protein enzyme (5LO), which is key to treating AD. (redolaughlin.com)
  • It undergoes tyrosine phosphorylation by C-SRC PROTEIN PP60 and plays a regulatory role in CAVEOLAE formation. (nih.gov)
  • STAT transcription factors are recruited to the cytoplasmic region of CELL SURFACE RECEPTORS and are activated via PHOSPHORYLATION . (nih.gov)
  • Hyaluronan-mediated CD44 interaction with RhoGEF and Rho kinase promotes Grb2-associated binder-1 phosphorylation and phosphatidylinositol 3-kinase signaling leading to cytokine (macrophage-colony stimulating factor) production and breast tumor progression. (uchicago.edu)
  • In the present study, we used a 5-LOX inhibitor, N- [3-[3-(-fluorophenoxy) phenyl]-1-methyl-2-propenyl]- N -hydroxyurea (BW-B 70C), in a rat model of focal cerebral IR. (biomedcentral.com)
  • Repurposing mechanistic insight of PDE-5 inhibitor in cancer chemoprevention through. (sagepub.com)
  • Kaithwas, Gaurav 2019-10-24 00:00:00 Background: This study evaluates the anti-cancer effects of Tadalafil (potent PDE-5 inhibitor) in female albino wistar rats against n-methyl n-nitrosourea induced mammary gland carcinogenesis. (sagepub.com)
  • Tadalafil is a known phosphodiesterase-5 Distinct metastasis and resistance development by self- (PDE-5) inhibitor, which have anti-cancer effects in vari- renewing nascent cancer cells in response with the ous types of cancer [2]. (sagepub.com)
  • The mainstay of treatment for advanced hepatocellular carcinoma (HCC) was the tyrosine kinase inhibitor (TKI) sorafenib [ 5 ]. (biomedcentral.com)
  • Unlike the short pentraxin C reactive protein (CRP), whose expression is mostly confined to the liver, PTX3 is made by several immune and non-immune cells at sites of infection and inflammation, where it intercepts fundamental aspects of infection immunity, inflammation, and tissue remodeling. (bvsalud.org)
  • Synaptic proteins were maintained at functional levels, and markers of inflammation were reduced. (redolaughlin.com)
  • 5LO (5-lipoxygenase) modulates oxidation and inflammation. (redolaughlin.com)
  • This compound has been shown to impact a wide range of genes in the body, inhibiting the activity and synthesis of cyclooxygenase-2 and 5-lipoxygenase and a number of other enzymes responsible for inflammation. (thealternativedaily.com)
  • Nod Signaling Adaptor Proteins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (uchicago.edu)
  • Cytosolic signaling adaptor proteins that were initially discovered by their role in the innate immunity (IMMUNITY, INNATE) response of organisms that lack an adaptive immune system. (uchicago.edu)
  • This graph shows the total number of publications written about "Nod Signaling Adaptor Proteins" by people in this website by year, and whether "Nod Signaling Adaptor Proteins" was a major or minor topic of these publications. (uchicago.edu)
  • Below are the most recent publications written about "Nod Signaling Adaptor Proteins" by people in Profiles. (uchicago.edu)
  • Two other structurally different 5-LOX inhibitors were also administered post IR: caffeic acid and 2, 3, 5-trimethyl-6- [12-hydroxy-5, 10-dodecadiynyl]-1, 4-benzoquinone (AA-861). (biomedcentral.com)
  • In unstimulated cells, p50:p65 is sequestered in the cytoplasm by inhibitory proteins known as NF-κB inhibitors (IκBs). (biomedcentral.com)
  • This article reviews the anti-inflammatory relative and anti-infectious effects of Evodia rutaecarpa and its major bioactive components and the involvement of the nitric oxide synthases, cyclooxygenase, NADPH oxidase, nuclear factor kappa B, hypoxia-inducible factor 1 alpha, reactive oxygen species, prostaglandins, tumor necrosis factor, LIGHT, amyloid protein and orexigenic neuropeptides. (biomedcentral.com)
  • Soluble pattern recognition molecules (PRMs) are a heterogenous group of proteins that recognize pathogen- and danger-associated molecular patterns (PAMPs and DAMPs, respectively), and cooperate with cell-borne receptors in the orchestration of innate and adaptive immune responses to pathogenic insults and tissue damage. (bvsalud.org)
  • It has an essential role in animal development and recruits ion channels, receptors, and signaling molecules to discrete plasma membrane regions of polarized cells in the HEART ATRIA MYOCARDIUM. (umassmed.edu)
  • Plant oxylipins are a class of lipid-derived signaling molecules being involved in the regulation of various biotic and abiotic stress responses. (frontiersin.org)
  • Signal transducer and activators of transcription 6 (STAT6) is activated by IL-4 and IL-13 and plays an important role in alternative activation. (biomedcentral.com)
  • Furthermore, di-GA inhibited the generation of lymphendothelial gaps by cancer cell spheroid-secreted lipoxygenase metabolites. (nature.com)
  • Loss of the tuberous sclerosis complex tumor suppressors triggers the unfolded protein response to regulate insulin signaling and apoptosis. (nih.gov)
  • Members of this family of proteins are often found associated with histone-modifying enzymes and protein complexes that regulate gene expression. (bvsalud.org)
  • In summary, our results indicate that the SCA-resistant line is better adapted to activate early defense signaling mechanisms in response to SCA infestation because of the rapid activation of the defense mechanisms by regulating genes involved in monolignol biosynthesis pathway, oxidoreductase activity, biosynthesis of phytohormones, and cell wall composition. (biomedcentral.com)
  • Cardinal signs of resolution are: (1) limitation/cessation of PMN infiltration, (2) sequestration and counter-regulation of pro-inflammatory chemical mediators, (3) apoptosis of PMN and removal (e.g., by efferocytosis), (4) clearance of pathogens, inflammatory stimuli, and cell debris, and (5) tissue repair. (frontiersin.org)
  • Protein activation and expression were analysed by western blotting, deoxyribonucleoside triphosphate levels by HPLC, ribonucleotide reductase activity by 14 C-cytidine incorporation into nascent DNA and cell-cycle distribution by FACS. (nature.com)
  • group ation of their intracellular downstream signaling mech- II (toxic control, MNU 47 mg/kg, i.v. (sagepub.com)
  • A signal transducing adaptor protein that links extracellular signals to the MAP KINASE SIGNALING SYSTEM. (uchicago.edu)
  • MNU was dissolved im- (cAMP) and cyclic guanosine monophosphate (cGMP) mediately before use in glacial acetic acid and water (pH into their intermediate inactive 50 derivatives and 5- 4.5-5). (sagepub.com)
  • These include biological agents targeting pro-inflammatory cytokines such as interleukin-5 and interleukin-13, inhaled ultra long-acting β 2 -agonists and once daily inhaled corticosteroids. (biomedcentral.com)
  • Taxol-induced TRPV4-mediated hyperalgesia and the enhanced osmotransduction in cultured nociceptors were dependent on integrin/Src tyrosine kinase signaling. (jneurosci.org)
  • We also demonstrate that Taxol-induced TRPV4-mediated hyperalgesia is essentially dependent on integrin/Src tyrosine kinase signaling. (jneurosci.org)
  • An adaptor protein, consisting of seven WD REPEATS along its length, that functions as a component of the MECHANISTIC TARGET OF RAPAMYCIN COMPLEX 1 and MTORC2 COMPLEX. (bvsalud.org)
  • Lipoxins, resolvins, protectins, and maresins are SPM derived from polyunsaturated fatty acids that limit excessive leukocyte infiltration and pro-inflammatory signals, stimulate innate microbial killing, and enhance resolution. (frontiersin.org)
  • It is an integral protein within the nuclear membrane. (wikipedia.org)
  • The AA, a normal component of cell membrane phospholipids, serve as substrate for prostaglandin endoperoxide (PGH) syntases-1 and -2, also known as cycloxygenase (COX)-1 and -2, lipoxygenase (5-, 12-, or 15) (LO), or cytochrome p450 enzymes [ 18 ]. (hindawi.com)
  • brain abundant membrane attached signal. (gsea-msigdb.org)
  • From these findings, we suggest that ROS production induced by the 5-LO pathway mediates the anti-cancer effects of DHEA and NALA on HNSCC cells. (biomedcentral.com)
  • Hyaluronan promotes CD44v3-Vav2 interaction with Grb2-p185(HER2) and induces Rac1 and Ras signaling during ovarian tumor cell migration and growth. (uchicago.edu)
  • MNU 47 mg/kg, i.v.) and group IV (Tada- activate protein kinase G and map kinase pathway of lafil 4 mg/kg, p.o. (sagepub.com)
  • An extracellular-signal-regulated kinase (ERK) is one pathway the brain uses for signaling and memory. (redolaughlin.com)
  • PMNs also release their granule contents, DNA, and chromatin proteins to form extracellular fibers that immobilize and kill bacteria. (frontiersin.org)
  • CD45 protein exists as multiple isoforms as a result of alternative splicing, differ in their extracellular domains but share identical transmembrane and cytoplasmic domains. (thermofisher.com)
  • CD45 glycoprotein is crucial in lymphocyte development and antigen signaling, serving as an important regulator of Src-family kinases. (thermofisher.com)
  • BMC Cancer (2019) 19:996 Page 2 of 15 PDE-5, PDE-6, PDE-9 are the predominant active iso- Sciences, Naini Allahabad, India. (sagepub.com)
  • This class of proteins contains three domains, a C-terminal ligand recognition domain, an N-terminal effector-binding domain, and a centrally located nuclear-binding oligomerization domain. (uchicago.edu)
  • In HL-60 leukaemia cells, di-GA activated caspase 3 and dose-dependently induced apoptosis. (nature.com)
  • Genes have been cloned for all 5 sub-types and of these, M 1 , M 2 and M 3 receptors have been extensively pharmacologically characterized in animal and human tissue. (justia.com)
  • There were 187 genes that were highly expressed during the early time of aphid infestation in the SCA-resistant line, including genes encoding leucine-rich repeat (LRR) proteins, ethylene response factors, cell wall-related, pathogenesis-related proteins, and disease resistance-responsive dirigent-like proteins. (biomedcentral.com)
  • The effects of DNA methylation and the histone code are due, at least in part, to modification-specific recruitment of factors, such as heterochromatin-associated proteins (HP1) and methyl-binding domain proteins, which establish and maintain higher order of chromatin structure. (aacrjournals.org)