Signaling schizophrenia adrenergic alpha 1 receptor antagonists. Medical search. Frequent questions

The premise of β 2 -agonist-mediated receptor activation (applying also to 'non-selective' β-receptor agonists) is based on both smooth muscle relaxation and reduced airway resistance. (pharmacology2000.com)
is a commonly used selective β 2 -adrenergic receptor agonist that may be administered either orally or by inhalation. (pharmacology2000.com)
When comparing the non-selective adrenergic agonist isoproterenol to albuterol, at doses that produce comparable bronchodilation, albuterol will exhibit substantially less cardiac stimulation. (pharmacology2000.com)
In C57BL/6 J mice, LH-targeted microinfusion of an α1-adrenergic receptor (AR) agonist blunted binge-like ethanol intake across both sexes, while LH infusion of a ß-AR agonist blunted binge-like ethanol intake in females exclusively. (bvsalud.org)
Finally, in mice with high baseline ethanol intake both an α1- AR agonist and an α-2 AR antagonist blunted binge-like ethanol intake. (bvsalud.org)
It has recently been demonstrated that prenatal exposure to the cannabinoid receptor 1 agonist (R)-(+)-[2,3-dihydro-5-methyl-3-(4-morpholinyl-methyl)pyrrolo[1,2,3-de]-1,4-benzoxazin-6-yl]-1-naphthalenylmethanone (WIN 55,212-2) produces memory deficit in adulthood, an effect associated with a reduced functionality of the glutamatergic system. (researchgate.net)
Olodaterol is a novel, long-acting β2-adrenergic agonist (EC50s: 97.7 nM for the human β2-adrenoceptor) that exerts its pharmacological effect by binding and act. (targetmol.com)
SynephrineHCl (Oxedrine, p-Synephrine) is an agonist that acts on sympathomimetic α-adrenergic receptor (AR). (targetmol.com)
ST-91 is an agonist of α2-adrenoceptor with a mixed α-adrenergic receptor type/subtype selection profile. (targetmol.com)
Rotigotine Hydrochloride, a dopamine receptor agonist prefering for D3 receptors over D1 and D2, has effective activity of anti-Parkinsonian. (targetmol.com)
Taken together this suggests that an estrogen receptor agonist might be an effective autism therapy in this sub-group. (epiphanyasd.com)
If not you would either need an estrogen receptor agonist that is cleverly developed to be brain specific, or take the much easier route of delivering an existing agonist direct to the brain, which may also be possible. (epiphanyasd.com)
S)-Glutamic acid acts as an excitatory transmitter and an agonist at all subtypes of glutamate receptors (metabotropic, kainate, NMDA, and AMPA). (adooq.com)
PSB-1114 tetrasodium is a potent, enzymatically stable, and subtype-selective P2Y2 receptor agonist with an EC50 of 134 nM. (dcchemicals.com)
Denufosol tetrasodium (INS37217) is a long-acting P2Y2 receptor agonist, which exhibits an EC50 of ~10 μM for P2Y2 receptor activation. (dcchemicals.com)
MRS2768 tetrasodium salt is a moderately potent and selective P2Y2 receptor agonist. (dcchemicals.com)

It acts as both a selective α2 adrenergic receptor antagonist, and an antagonist for the imidazoline receptor. (wikipedia.org)
Previously, descriptions of pharmacological effects associated with 'non-selective' β-adrenergic receptor agonists used to manage pulmonary diseases such as asthma or COPD necessarily include unwanted side effects often due to β 1 adrenergic receptor activation. (pharmacology2000.com)
Other medications, which are relatively selective for β 2 -adrenergic receptors, retain the benefits in management of asthma and COPD, while limiting adverse effects mediated by β 1 -adrenergic receptor activation. (pharmacology2000.com)
At higher doses β 2 -selective adrenergic agonists are still able to activate β 1 -receptors, again emphasizing the role of drug concentration in drug specificity. (pharmacology2000.com)
Rezatomidine is a selective antagonist of α2-adrenergic receptor and can be used in studies about chronic pain, including neuropathic pain. (targetmol.com)
Blonanserin is a relatively selective serotonin (5-HT)2A and dopamine D2 antagonist, used the treatment of schizophrenia. (absource.de)
Azasetron HCl is a selective 5-HT3 receptor antagonist with IC50 of 0.33 nM used in the management of nausea and vomiting induced by cancer chemotherapy. (absource.de)
Levosulpiride is a selective antagonist for D2 dopamine receptors used as an antipsychotic and prokinetic agent. (absource.de)
Bexarotene is a retinoid specifically selective for retinoid X receptors, used as an oral antineoplastic agent in the treatment of cutaneous T-cell lymphoma. (absource.de)
LY404187 is a selective, potent and centrally active positive allosteric modulator of AMPA receptors. (adooq.com)
NBQX is a potent, selective and competitive AMPA receptor antagonist. (adooq.com)
CP 465022 is a selective, non-competitive AMPA antagonist with IC50 of 25 nM in rat cortical neurons that displays potent anticonvulsant activity. (adooq.com)
YM90K hydrochloride is a selective AMPA receptor antagonist that delays neuronal death in a global ischemia model and cerebral infarction in a focal ischemia model following postischemic administration. (adooq.com)
LY3130481 is an AMPA receptor antagonist that is dependent upon transmembrane AMPA receptor regulatory protein (TARP) γ-8, selective inhibits AMPA/TARP γ-8 with an IC50 of 65 nM. (adooq.com)
Zonampanel (YM 872) is a selective antagonist of the glutamate receptor subtype, α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA) receptor. (adooq.com)
ACT-246475 (ACT246475) is a potent, selective, reversible P2Y12 receptor antagonist with binding IC50 of 1.0 nM. (dcchemicals.com)
NF157 is a highly selective nanomolar P2Y11 antagonist with a pKi of 7.35. (dcchemicals.com)
Adenosine 2',5'-diphosphate sodium exhibits non-selective antagonism at recombinant and human platelet P2X1 receptors. (dcchemicals.com)
MRS2279 is a selective and high affinity P2Y1 receptor antagonist, with a Ki of 2.5 nM and an IC50 of 51.6 nM. (dcchemicals.com)
2-Methylthio-AMP (2-MeSAMP) diTEA is a selective and direct P2Y12 antagonist. (dcchemicals.com)
NF340 is a potent and selective P2Y11 receptor antagonist. (dcchemicals.com)

It has been widely established that dopamine and its agonists play an important role in cardiovascular, renal, hormonal, and central nervous system regulation through stimulation of alpha and beta adrenergic and dopaminergic receptors. (biopsychiatry.com)
From a therapeutic point of view, the above-mentioned agonists are used for treating Parkinson's disease, acting over DA 2 dopaminergic receptors of the nigrostriatal system. (biopsychiatry.com)
Bromocriptine and the other dopaminergic agonists mentioned act over DA 2 receptors of the tuberoinfundibular system, inhibiting prolactin release and decreasing hyperprolactinemia and tumor size. (biopsychiatry.com)
Additional therapeutic benefits associated with β-adrenergic receptor agonists likely include reduced pulmonary mast cell leukotriene and histamine release, reduced microvascular permeability, phospholipase A 2 inhibition and increased mucociliary activity. (pharmacology2000.com)
Combination of long-acting β-adrenergic receptor agonists with anti-inflammatory agents represents a strongly endorsed therapeutic approach. (pharmacology2000.com)
Short-acting β 2 -adrenergic agonists administered by inhalation represent drugs of choice for management of acute asthma presentations and for prevention of exercise-induced bronchospastic reactions. (pharmacology2000.com)
The adrenergic receptors or adrenoceptors are a class of G protein-coupled receptors that are targets of many catecholamines like norepinephrine (noradrenaline) and epinephrine (adrenaline) produced by the body, but also many medications like beta blockers, β2 agonists and α2 agonists, which are used to treat high blood pressure and asthma, for example. (targetmol.com)
These 4 graphics show the potencies of 3 agonists (adrenaline, noradrenaline, isoprenaline) for the different adrenergic receptors. (trc-p.nl)
For the β2 receptor, noradrenaline is the least potent of all 3 agonists and adrenaline has intermediate potency. (trc-p.nl)

Therefore, downstream signaling pathways that are responsible for NPAS3-VGF induced proliferation via glutamate receptors were explored. (frontiersin.org)
This effect was associated with decreased activation of pathways linked to neurotrophin and glutamate receptor signaling. (researchgate.net)
As we all known, RIPK1 is a critical driver of inflammation, involving in various pathways downstream of the death receptors, such as TNFR1, FasL, TRAIL, and toll-like receptors. (immune-system-research.com)

It also enables downstream signaling following activation of the pattern recognition receptors NOD1 and NOD2 leading to the production of inflammatory cytokines. (immune-system-research.com)

5-HT1A modulator 1 displays very high affinities for the 5-HT1A, α1-adrenergic receptor, and D2 receptor (IC50s = 2 nM, 10 nM, and 40 nM). (targetmol.com)
CNQX is a competitive, non-NMDA glutamate receptor antagonist (IC50s = 0.3 and 1.5 uM for AMPA and kainate receptors, respectively, versus IC50 = 25 uM for NMDA receptors). (adooq.com)

Neurons that receive neurotransmitter signals are called postsynaptic neurons. (msdmanuals.com)
Sometimes signals between neurons occur in the reverse direction (called retrograde neurotransmission). (msdmanuals.com)
In such cases, the dendrites (a neuron's receiving branches) on the postsynaptic neurons release neurotransmitters that affect receptors on the presynaptic neurons. (msdmanuals.com)
The serotonin-1A (5-HT1A) receptor is among the most abundant and widely distributed 5-HT receptors in the brain, but is also expressed on serotonin neurons as an autoreceptor where it plays a critical role in regulating the activity of the entire serotonin system. (biomedcentral.com)
this is flanked by a series of upstream repressor elements for REST, Freud-1/CC2D1A and Freud-2/CC2D1B factors that not only restrict its expression to neurons, but may also regulate the level of expression of 5-HT1A receptors in various subsets of neurons, including serotonergic neurons. (biomedcentral.com)
Elevated 5-HT1A autoreceptor expression would tend to reduce the activity of 5-HT neurons, while reduced post-synaptic 5-HT1A receptors would result in a blunted behavioral response to 5-HT. (biomedcentral.com)
The AVP-producing (arginine-vasopressin, related to angiotensin and vasopressin peptides) neurons respond to signals relating to thirst and water regulation. (pharmaceuticalintelligence.com)
If body fluids have a high osmolality, this signal causes the neurons to release AVP into the bloodstream. (pharmaceuticalintelligence.com)

Due to its alpha-2 receptor antagonism it is capable of enhancing therapeutic effects of antipsychotics, possibly by enhancing dopamine neurotransmission in the prefrontal cortex of the brain, a brain area thought to be involved in the pathogenesis of schizophrenia. (wikipedia.org)
A lower level of KYNA is observed in patients with neurodegenerative diseases such as Alzheimer's and Parkinson's diseases or psychiatric disorders such as depression and autism spectrum disorders, whereas a higher level of KYNA is associated with the pathogenesis of schizophrenia. (mdpi.com)

The present findings indicate that oxLDL disrupts the PI3K/Akt signaling pathway at the level of p85 in EPCs. (braf-signal.com)
Furthermore, ectopically expressed NPAS3 in PC12 cells produced parallel responses for nuclear factor kappa-light-chain-enhancer of activated B cells [NF-κB (P65)] expression, which specifies that NPAS3 regulates VGF through the NF-κB signaling pathway. (frontiersin.org)

Turnock-Jones JJ, Jennings CA, Robbins MJ, Cluderay JE, Cilia J, Reid JL, Taylor A , Jones DN, Emson PC , Southam E. Increased expression of the NR2A NMDA receptor subunit in the prefrontal cortex of rats reared in isolation. (neurotree.org)
DNQX is a non-N-methyl-D-aspartate (non-NMDA) receptor complex antagonist. (adooq.com)

Tezampanel is an antagonist at the AMPA and kainate families of ionotropic glutamate receptors, with selectivity for the GluR5 subtype of the kainate receptor. (adooq.com)

Pharmacological activity is mediated by the R-form, which exhibits about 100 times more affinity for the β-receptor compared to the S-form. (pharmacology2000.com)
This section focuses on disease management using pharmacological interventions, namely -receptor antagonists. (pharmacology2000.com)
IBMX (3-isobutyl-1-methylxanthine), used as investigative tool in pharmacological research. (biomedjournal.com)

Piperoxan hydrochloride is an α2 adrenoceptor antagonist. (targetmol.com)
Alfuzosin hydrochloride is an α1 adrenergic receptor antagonist. (targetmol.com)
GYKI53655 Hydrochloride is a non-competitive AMPA and kainate receptor antagonist. (adooq.com)

it apparently blocks alpha-adrenergic, histamine H1, and some types of serotonin r. (targetmol.com)
Mizolastine is a histamine H1-receptor antagonist with IC50 of 47 nM used in the treatment of hay fever (seasonal allergic rhinitis), hives and other allergic reactions. (absource.de)
It also has manage to high af?nity for a-1-adrenergic, D3, D4, and H1-histamine receptors. (fosite.ru)

These agents stimulate alpha-adrenergic receptors and cause a sympathomimetic response at toxic doses. (medscape.com)

Mice treated with idazoxan, which blocks the α2A receptor which regulates norepinephrine, behaved similarly to control animals despite still having amyloid-beta plaques in the brain, as a proof-of-concept experiment that dramatically reduced Alzheimer's pathology and symptoms in two mouse models, potentially offering an immediate treatment for this devastating disease. (wikipedia.org)
Female and male transgenic mice with varying capacities to translate β-E were subjected to either the forced swim (FST, Experiment 1) or the tail suspension test (TST, Experiment 2). (blogspot.com)
In Experiment 3, mice were divided into three groups based on hormonal status (male, female-estrous, and female-nonestrous) and injected with either 1 g/kg EtOH or equivolume saline 14 minutes prior to behavioral assessment on the TST. (blogspot.com)

Prasugrel is an orally active and potent P2Y12 receptor antagonist, and inhibits ADP-induced platelet aggregation. (dcchemicals.com)

[12] The human brain has more cannabinoid receptors than any other G protein-coupled receptor (GPCR) type. (cloudfront.net)

[1] [2] The most notable cannabinoid is the phytocannabinoid tetrahydrocannabinol (THC) (delta-9-THC), the primary psychoactive compound in cannabis . (cloudfront.net)
The discovery of the first cannabinoid receptors in the 1980s helped to resolve this debate. (cloudfront.net)
Two known cannabinoid receptors are termed CB 1 and CB 2 , [11] with mounting evidence of more. (cloudfront.net)
[20] CB 2 receptors appear to be responsible for immunomodulatory [19] and possibly other therapeutic effects of cannabinoid as seen in vitro and in animal models. (cloudfront.net)
These cannabinoids produce the effects associated with cannabis by binding to the CB 1 cannabinoid receptors in the brain. (cloudfront.net)

GSK583 potently and dose-dependently inhibits MDP-stimulated tumor necrosis factor-alpha (TNFα) production with an IC 50 of 8 nM. (immune-system-research.com)
In vivo, GSK583 (0.1, 1, and 10 mg/kg, p.o.) inhibits serum KC levels in rats in a dose-dependent manner. (immune-system-research.com)
Ticagrelor is the first reversibly binding oral P2Y12 receptor antagonist, also inhibits CYP2C9 and 4-hydroxylation with IC50 of 10.5 μM and 8.2 μM respectively. (dcchemicals.com)

glutamate receptor, ionotropic, NMDA1. (wikigenes.org)

Org-26576 is a AMPA receptor positive allosteric modulator. (adooq.com)
PF-4778574 is a potent AMPA receptor positive allosteric modulator (PAM) that has been shown to enhance cognition in animal models. (adooq.com)
BPTU is an Allosteric antagonist of P2Y1 (EC50 = 0.06-0.3 μM). (dcchemicals.com)

However, the complexity of the current incurable pathologies has clearly demonstrated that such single-target drugs are inadequate to achieve a therapeutic effect [ 1 , 2 ]. (springeropen.com)
Some drugs increase the expression of GLT-1 and so reduce the amount of glutamate. (epiphanyasd.com)

The signal may stimulate or inhibit the receiving cell, depending on the neurotransmitter and receptor involved. (msdmanuals.com)

SYM 2206 is a novel, potent, non-competitive AMPA receptor antagonist. (adooq.com)
Isoprenaline is less potent for both receptors. (trc-p.nl)
For the β1 receptor adrenaline and noradrenaline are both less potent than isoprenaline, but with about the same ED50. (trc-p.nl)
MRS2578 is a potent P2Y6 receptor antagonist with IC50 of 37 nM, exhibits insignificant activity at P2Y1, P2Y2, P2Y4,and P2Y11 receptors. (dcchemicals.com)
PSB-0739 is a high-affinity potent, competitive, nonselective platelet P2Y12 receptor antagonist with a Ki values of 24.9 nM. (dcchemicals.com)
MRS2395, an dipivaloyl derivative, is a potent P2Y12 receptor antagonist. (dcchemicals.com)

Depending on the receptor, the response may be excitatory or inhibitory. (msdmanuals.com)

LY450108 is an alpha-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid (AMPA) receptor potentiator. (adooq.com)
Cyclothiazide is a benzothiadiazide that acts as a potentiator of AMPA receptors, positively modulating its response to glutamic acid (EC50 = 3.8 M). (adooq.com)
Farampator has been investigated for its effect on AMPA receptors and researched for potential use in the treatment of schizophrenia and Alzheimer's Disease. (adooq.com)
IEM 1754 Dihydrobromide is a voltage-dependent open-channel blocker of AMPA receptors. (adooq.com)
Talampanel is a non-competitive antagonist of AMPA-receptor. (adooq.com)
CNQX disodium salt, water-soluble form of AMPA/kainate antagonist CNQX (GLXC-11053). (adooq.com)
gamma-DGG is a competitive AMPA receptor blocker. (adooq.com)
Becampanel (AMP397) is the first competitive AMPA antagonist and an antiepileptic agent. (adooq.com)

Delta -9- tetrahydrocannabinol (Δ 9 -THC, THC) and delta-8-tetrahydrocannabinol (Δ 8 -THC), through intracellular CB 1 activation, induce anandamide and 2-arachidonoylglycerol synthesis produced naturally in the body and brain [ citation needed ] [ dubious - discuss ] . (cloudfront.net)

In vitro, GSK583 (1 μM) exhibits excellent selectivity in a panel of 300 kinases, including p38α and VEGFR2. (immune-system-research.com)

The effectiveness of adrenergic antagonists in this setting is likely due to reduced outflow tract pressure gradients. (pharmacology2000.com)

Activation of these receptors decreases peripheral resistance, inducing lowering of arterial blood pressure and increases in heart rate, sympathetic tone, and activity of the renin aldosterone system. (biopsychiatry.com)
Figure 1 shows the theory - principally derived from inflammatory translational models - that inflammatory triggers cause IRS activation and induce the production of PICs, which in turn may provoke sickness behavior and depression, thus explaining the phenomenological overlap between these conditions. (biomedcentral.com)

Aniracetam (1-(4-methoxybenzoyl)-2-pyrrolidinone) is an N-side chain derivative of piracetam . (nootropicsexpert.com)

Clopidogrel is an irreversible inhibitor of the P2Y12 receptor, which is responsible for initiating signal transduction via a GPCR. (dcchemicals.com)

This could mean that penicillin is a competitive GABA specific antagonist, which would further explain its epileptogenic properties. (epiphanyasd.com)

PSB-1114 tetrasodium displays >50-fold selectivity versus the P2Y4 (EC50 of 9.3 μM) and P2Y6 (EC50 of 7.0 μM) receptors. (dcchemicals.com)

Alterations in 5-HT1A receptor levels are commonly observed in depressed individuals. (biomedcentral.com)
This review examines the evidence that alterations in transcriptional regulation of the 5-HT1A receptor could underlie its dys-regulation in mental illness. (biomedcentral.com)

In parallel, we have learned that molecules hitting more than one target may possess in principle a safer profile compared to single-targeted ones [ 1 , 2 ]. (springeropen.com)
For this purpose, WIN 55,212-2 was injected in pregnant wistar rats from gestation day 5 to 20 and a detailed analysis of the levels of the neurotrophin brain-derived neurotrophic factor (BDNF) as well as of the signaling molecules extracellular signal-regulated kinase (ERK)1/2 and alpha-calcium/calmodulin-dependent protein kinase II (alpha-CaMKII) was carried out in adult offspring. (researchgate.net)

Perphenazine is a phenothiazine derivative and a dopamine antagonist with antiemetic and antipsychotic properties. (targetmol.com)
Zotepine is a second-generation antipsychotic with a primary use as a treatment for schizophrenia, although clinical trials have been conducted into its efficacy. (targetmol.com)

Glutamate is the major excitatory neurotransmitter, and is inactivated by uptake via GLT-1 (EAAT2) and GLAST (EAAT1) transporters. (epiphanyasd.com)

1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) causes nigrostriatal dopaminergic neurotoxicity and behavioral impairment in rodents. (researchgate.net)

A neuron generates and propagates an action potential along its axon, then transmits this signal across a synapse by releasing neurotransmitters, which trigger a reaction in another neuron or an effector cell (eg, muscle cells, most exocrine and endocrine cells). (msdmanuals.com)
Neurotransmitters that are released bind to receptors on another neuron. (msdmanuals.com)
Neurotransmitters diffuse across the synaptic cleft and bind briefly to specific receptors on the adjoining neuron or effector cell. (msdmanuals.com)

The present results suggest that the CNS innate immune system can respond to an acute stressor as if it were cellular damage, thereby releasing the danger signal HMGB-1 in the brain to prime microglia by acting on the NLRP3 inflammasome, in preparation for a later immune challenge. (jneurosci.org)
The concept has developed that innate immune receptors discriminate between danger and non-danger rather than self and non-self ( Matzinger, 2002 ). (jneurosci.org)

More recently, it is under investigation as an adjunctive treatment in schizophrenia. (wikipedia.org)
Intracerebral disulfide HMGB-1 mimicked the effect of the stressor, because microglia isolated from HMGB-1-treated rats expressed exaggerated NLRP3 and proinflammatory cytokine expression after LPS treatment, whereas fully reduced HMGB-1 had no effect. (jneurosci.org)
Wilmington, DE) Patent Number: 6,451,807 group identified: April 26, 2000 Gas: The translational reduction concludes to normally congestive reduction( enough) cancer symptoms and to their fraction in remedies of including chronic agent in minutes imposing from a proper treatment, plasminogen 1 septal PW credit, or prosthetic tendency. (siriuspixels.com)
Elinogrel is a reversible P2Y12 receptor antagonist for the treatment of acute coronary syndrome and prevention of secondary thrombotic events. (dcchemicals.com)

Naltrexone HCl is an opioid receptor antagonist used primarily in the management of alcohol dependence and opioid dependence. (absource.de)
Cannabinoids ( / k ə ˈ n æ b ə n ɔɪ d z ˌ ˈ k æ n ə b ə n ɔɪ d z / ) are several structural classes of compounds found in the cannabis plant primarily and most animal organisms (although insects lack such receptors) or as synthetic compounds. (cloudfront.net)
CB 1 receptors are found primarily in the brain , more specifically in the basal ganglia and in the limbic system , including the hippocampus [11] and the striatum . (cloudfront.net)

A growing body of literature implicates noradrenergic (NE) signaling in the modulation of ethanol consumption. (bvsalud.org)

adrenergic receptor antagonists i.e. typically propranolol (Inderal) are used in management of hypertrophic obstructive cardiomyopathy. (pharmacology2000.com)

adrenergic receptor antagonists have also shown helpful in management of acute dissecting aortic aneurysm due to -blocker-mediated reduction in myocardial contractility and reduced rate of force development . (pharmacology2000.com)
The models were defined as acute (4 h after carrageenan injection), subacute (24 h after carrageenan injection), and late (1 week after carrageenan injection) phase. (bvsalud.org)

For example, administration of drug by aerosol targets β 2 pulmonary receptors, while limiting systemic drug. (pharmacology2000.com)
The significance of PDEs as regulators of signaling is evident from their development as drug targets in diseases such as asthma and obstructive pulmonary disease, cardiovascular diseases such as heart failure and atherosclerotic peripheral disease, neurological disorders, erectile dysfunction. (biomedjournal.com)

Bucindolol Formatel is a blocker of β1-adrenergic receptor. (targetmol.com)

Approaches to targeting β 2 -pulmonary adrenergic receptors involves not only drug design but also drug delivery. (pharmacology2000.com)
The book Компоненты further backs to water-soluble proteins avoiding cardiac patients and approaches for using Adrenergic congestive changes. (augenta.net)

electric stimulation with high intensity at 6 Hz frequency and 1-ms pulse duration served as a contrast in the other group. (maxwellmagneticmeds.co.za)

This observation illustrates the relatively weaker albuterol β 1 -receptor activating property compared to its effect at β 2 receptor sites. (pharmacology2000.com)
A main effect of genotype in Experiment 3 replicated findings in Experiments 1 and 2. (blogspot.com)
But beta-lactams have other effects, so it is not certain that GLT-1 accounts for the beneficial effect sometimes found in autism. (epiphanyasd.com)
The signal cascade initiates platelet aggregation and thus clopidogrel has the effect of "thinning" the blood. (dcchemicals.com)

Anatomy8

Organisms5

Diseases4

Chemicals and Drugs122

Analytical, Diagnostic and Therapeutic Techniques and Equipment12

Psychiatry and Psychology25

Phenomena and Processes15

Information Science2

Health Care2

Agonist16

Selective21

Agonists9

Pathways3

Pattern recogniti1

IC50s2

Neurons8

Pathogenesis of schizophrenia2

Pathway2

NMDA2

Glutamate receptors1

Pharmacological3

Hydrochloride3

Histamine3

Sympathomimetic1

Mice3

Orally1

Protein-coupled1

Cannabinoid5

Inhibits3

Ionotropic1

Allosteric3

Drugs2

Stimulate1

Potent6

Inhibitory1

AMPA8

Synthesis1

Exhibits1

Tract1

Activation2

Aniracetam1

GPCR1

GABA1

Selectivity1

Alterations2

Molecules2

Antipsychotic2

Excitatory1

Nigrostriatal1

Neurotransmitters3

Innate2

Treatment4

Primarily3

Modulation1

Typically1

Acute2

Targets2

Blocker1

Approaches2

Stimulation1

Effect4