In conclusion, our results demonstrated that compared with OA, the differential abundance proteins and signaling pathways may contribute to the occurrence and development of joint damage in KBD. (nature.com)
We study genes, proteins and signaling pathways that might be essential for RGC and optic nerve development, function, survival, and regeneration. (nih.gov)
Phosphatidylinositol 3-kina2
KEGG pathways enrichment and PPI network indicate four major pathways, including extracellular matrix -receptor interaction, focal adhesion, phosphatidylinositol 3-kinase (PI3K)-Protein kinase B (Akt), and Ras signaling pathways were involved in the degeneration of cartilage. (nature.com)
These events are influenced by and activate other molecular pathways, including phosphatidylinositol 3-kinase (PI3K), mammalian target of rapamycin (mTOR), and mitogen-activated protein kinase (MAPK),[2] and therapies are now available that target these pathocellular processes. (cancernetwork.com)
Different signalin1
We demonstrated that myocilin is involved in myelination of the optic and sciatic nerves acting through different signaling pathways. (nih.gov)
Intracellular4
GO analysis shows that the differential abundant proteins are associated with cell junction and signal transducer activity from extracellular to intracellular. (nature.com)
Some family members, such as latrophilins and gliomedin, are membrane-bound proteins containing the olfactomedin domain in the extracellular N-terminal region, while the intracellular C-terminal domain of these proteins is essential for the transduction of extracellular signals to the intracellular signaling pathway. (nih.gov)
These multiprotein complexes are capable of capturing and integrating many signals from the extracellular as well as intracellular environments ( Rosales and Juliano, 1995 ). (rupress.org)
Its activity is directed by intracellular signals mediated by various types of receptors such as G protein-coupled receptors. (embl-heidelberg.de)
Extracellular matrix2
His early research focused on signaling by protein kinases, with a subsequent focus on the proteins that regulate the turnover of cell contacts with the extracellular matrix. (wikipedia.org)
One such input is mechanical force, which activates signalling and regulates cell behaviour in the process of mechanotransduction. (ibecbarcelona.eu)
Molecules3
Cell surface recognition and cytosolic sensing of these molecules result in signaling cascades that promote rapid and localized autophagy machinery recruitment. (frontiersin.org)
Adhesion complexes (i.e., focal adhesions and focal complexes) and cell-cell contacts are specialized structures that harbor a large number of cytoskeletal proteins and one of the highest concentrations of signaling molecules in cells ( Ruoslahti and Obrink, 1996 ). (rupress.org)
Although previous studies have identified different chemotropic and adhesion molecules that influence axonal development, the molecular mechanism by which these signals control the cytoskeleton remains poorly understood. (biologists.com)
PI3K2
Further, using selective pharmacological inhibition assays, focused on the PI3K/mTOR/AKT signaling axis, we validate whether there is a causal relationship to electrotaxis and these mechanisms of action. (nature.com)
We find that U87 mg electrotaxis is abolished under pharmacological inhibition of PI3Kγ, mTOR, AKT and ErbB2 signaling, whereas DAOY cell electrotaxis was not attenuated by these or other pathways evaluated. (nature.com)
Interaction4
Both vinY822F and vin −/− cells exhibit increased interaction between paxillin and focal adhesion kinase (FAK) and increased paxillin and FAK phosphorylation. (rupress.org)
We identified 580 differentially expressed genes (DEGs) in LACCk, which were mainly invovled in Human papillomavirus infection, focal adhesion, and ECM-receptor interaction signaling pathways. (researchsquare.com)
Human papillomavirus infection, focal adhesion, and ECM-receptor interaction signaling pathway are related to the failure of CCRT for LACC, which warrants further research to improve CCRT sensitivity in LACC targeting on these candidate genes or pathways. (researchsquare.com)
In the present study, we explored the interaction network of DEGs between responders and non-responders along with interrelated signaling pathways in LACC by analyzing the expression profile of gene expression microarray data (GSE56303-GPL10191, GSE56303-GPL16025, and GSE56363) using bioinformatics tools. (researchsquare.com)
Mechanotransduction1
Whereas the mechanisms activating mechanotransduction are well studied, the reversibility of this process, whereby cells disassemble and reverse force-activated signalling pathways upon cessation of mechanical stimulation is far less understood. (ibecbarcelona.eu)
Cellular4
After receptor activation, the alpha- and beta-gamma-subunits of G protein dissociate to activate diverse downstream pathways resulting in cellular polarization and actin reorganization. (genome.jp)
Cervical and ovarian carcinogenesis employ different pathways to achieve cellular immortalization, and this has a significant bearing on the evidence supporting the use of anti-angiogenic agents in the two malignancies. (cancernetwork.com)
FAK is activated by phosphorylation at specific tyrosine residues, which then stimulate downstream signaling including the ERK1/2 pathway, leading to a variety of cellular responses. (techscience.com)
At the proliferation stage, proliferation related pathways and basic cellular and metabolic processes were inhibited, while regulatory factors that initiate differentiation enter the ready-to-activate state, which provides a precondition for initiating adipose differentiation. (biomedcentral.com)
Genes3
Our results demonstrate that FAK signaling emanating from Y397, Y925, and to a lesser extent Y576/7, but not from Y861, controls osteogenic differentiation through an ERK1/2 pathway, as measured by expression levels of key osteogenesis marker genes and subsequent matrix mineralization. (techscience.com)
Thus, the key pathways and genes associated with CCRT in LACC should be identified urgently. (researchsquare.com)
Therefore, we need to look for genes and signaling pathways associated with the treatment of LACC. (researchsquare.com)
Integrin2
Tumor necrosis factor-α (TNF-α) and focal adhesion kinase (FAK) are key regulators of inflammatory and integrin-matrix signaling, respectively. (escholarship.org)
Integrin costimulatory signals modulate inflammatory gene expression, but the important control points between these pathways remain unresolved. (escholarship.org)
Actin1
This applies a tensile signal to the actin-binding domain (ABD) of α-catenin, which provides a clutch to promote lateral adhesion growth and inhibit the lamellipodial activity necessary for migration. (ibecbarcelona.eu)
Neuronal1
Involvement of C/EBPβ-related signaling pathway in methamphetamine-induced neuronal autophagy and apoptosis. (cancerindex.org)
Differentiation2
However, transcriptional dynamic regulation of adipose differentiation driven by complex signal cascades remains largely unexplored in this model. (biomedcentral.com)
According to weighted gene co-expression network analysis, pathways positively related to adipogenic differentiation are significantly activated at the differentiation stage, while WNT, FOXO and other pathways that inhibit preadipocyte differentiation are negatively regulated. (biomedcentral.com)
Tumor1
To further understand electrotactic migration of tumor cells, we performed RNA-sequencing for pathway discovery to identify signaling that is differentially affected by the exposure of direct-current electrical fields. (nature.com)
Autophagy3
Autophagy is a well-conserved lysosomal degradation pathway that plays key roles in bacterial infections. (frontiersin.org)
The process is highly regulated by multiple signaling pathways and orchestrated by more than 30 autophagy-related (Atgs) proteins organized in several functional units ( 2 ). (frontiersin.org)
Depending on PAMP/DAMP nature and localization, autophagy can selectively capture bacteria, such event is called xenophagy, damaged organelles, and other signaling platforms activated during the infection ( 4 , 5 ). (frontiersin.org)
Activation1
FAK signaling facilitated TNF-α-induced, mitogen-activated protein kinase activation, and, surprisingly, FAK inhibition resulted in the loss of the GATA4 transcription factor required for TNF-α-induced VCAM-1 production. (escholarship.org)
Protein2
What pathways are this gene/protein implicaed in? (cancerindex.org)
The chemokine signal is transduced by chemokine receptors (G-protein coupled receptors) expressed on the immune cells. (genome.jp)
Roles2
The complete integumentary organ system (IOS) regeneration and scarless wound healing mechanism, which occurs in specific species, body sites and developmental stages, clearly shows that mechanical stress signals and immune responses play important roles in determining the wound healing mode. (mdpi.com)
Vascular cell adhesion molecule-1 (VCAM-1) plays important roles in development and inflammation. (escholarship.org)
Molecular1
His group studies the physical and molecular mechanisms by which cells detect and respond to mechanical signals. (ibecbarcelona.eu)
Mechanism1
This study was designed to identify signaling pathways and crucial proteins involved in the pathological mechanism of KBD compared with osteoarthritis (OA). (nature.com)
Activity1
Here, we show that vinculin null (vin −/− ) cells and cells expressing a vinculin Y822F mutant have increased survival due to up-regulated activity of extracellular signal-regulated kinase (ERK). (rupress.org)
Cells1
In the last 8 decades, theories regarding carcinogenesis have progressed to include numerous pathways by which cells achieve immortality. (cancernetwork.com)
Data1
Data is normalized to a mean signal of 1.0 and standard deviation of 0.5. (cancer.gov)
Studies1
In particular, Schlaepfer is well known for his studies on focal adhesion kinase (FAK). (wikipedia.org)