Signaling pathways focal adhesions. Medical search. Frequent questions

Genes in the 'Focal adhesion', 'Wnt signaling pathway' and 'MAPK signaling' pathway. (biomedcentral.com)
These events are influenced by and activate other molecular pathways, including phosphatidylinositol 3-kinase (PI3K), mammalian target of rapamycin (mTOR), and mitogen-activated protein kinase (MAPK),[2] and therapies are now available that target these pathocellular processes. (cancernetwork.com)
Cripto-1 overexpression in U87 glioblastoma cells activates MAPK, focal adhesion and ErbB pathways. (eurekaselect.com)
FAK suppressed RTKs signalling in Drosophila melanogaster epithelia by impairing MAPK pathway. (gla.ac.uk)
Conversely, increasing the membrane pool of the receptor increased MAPK pathway signalling. (gla.ac.uk)
Therefore, the FAK-mediated negative regulation of RTK/MAPK signalling described here may have potential implications in the designing of therapy strategies for RTK-driven tumours. (gla.ac.uk)
These results suggest that MAAs accelerate wound repair by activating the FAK-MAPK signaling pathways. (elsevierpure.com)

Some family members, such as latrophilins and gliomedin, are membrane-bound proteins containing the olfactomedin domain in the extracellular N-terminal region, while the intracellular C-terminal domain of these proteins is essential for the transduction of extracellular signals to the intracellular signaling pathway. (nih.gov)
Signal transduction in cancer. (eurekaselect.com)
The leucine-rich repeat is a recently characterized structural motif used in molecular recognition processes as diverse as signal transduction, cell adhesion, cell development, DNA repair and RNA processing. (embl.de)
A SH2 DOMAIN-containing protein that mediates SIGNAL TRANSDUCTION pathways from multiple CELL SURFACE RECEPTORS, including the EPHB1 RECEPTOR. (bvsalud.org)

We demonstrated that myocilin is involved in myelination of the optic and sciatic nerves acting through different signaling pathways. (nih.gov)
In this review article, different signaling pathways and how their dysregulation contributes to the development of tumors have been discussed. (eurekaselect.com)

DEGs were also enriched in human papillomavirus infections, the focal adhesion pathway, PI3K-Akt signaling pathway, and among others. (hindawi.com)

After receptor activation, the alpha- and beta-gamma-subunits of G protein dissociate to activate diverse downstream pathways resulting in cellular polarization and actin reorganization. (genome.jp)
Focal adhesion kinase (FAK) is a key integrator of integrin-mediated signals from the extracellular matrix to the cytoskeleton and downstream signaling molecules. (techscience.com)
FAK is activated by phosphorylation at specific tyrosine residues, which then stimulate downstream signaling including the ERK1/2 pathway, leading to a variety of cellular responses. (techscience.com)
In addition, the development of RAS inhibitors, either direct or indirect, that target the downstream components in RAS pathway is summarized as well. (researchgate.net)
FAK interacts with several RTKs but little is known about how FAK regulates their downstream signalling. (gla.ac.uk)
Click on one of the biological effects of VEGF-VEGF R2 signaling shown in the Explore Pathways box below to see the specific molecules involved in promoting each effect and the phosphorylation sites on VEGF R2 that are necessary for recruitment of key downstream adaptor proteins or kinases. (rndsystems.com)
Targeting activated Gα subunits to specific cells in vivo permits identification of downstream effector pathways independent of receptor activation, and thus permits insight into disease mechanisms otherwise impossible to study in vivo . (medscape.com)

Cell surface recognition and cytosolic sensing of these molecules result in signaling cascades that promote rapid and localized autophagy machinery recruitment. (frontiersin.org)
Gene expression may be affected in benign familial pemphigus, as may phosphorylation of adhesion molecules. (medscape.com)
Adhesion complexes (i.e., focal adhesions and focal complexes) and cell-cell contacts are specialized structures that harbor a large number of cytoskeletal proteins and one of the highest concentrations of signaling molecules in cells ( Ruoslahti and Obrink, 1996 ). (rupress.org)
Although previous studies have identified different chemotropic and adhesion molecules that influence axonal development, the molecular mechanism by which these signals control the cytoskeleton remains poorly understood. (biologists.com)
However, despite all these recent advances, it remained to be established how exactly NDRG1 was able to affect such a wide array of signalling pathways and molecules. (edu.au)

FAK signaling facilitated TNF-α-induced, mitogen-activated protein kinase activation, and, surprisingly, FAK inhibition resulted in the loss of the GATA4 transcription factor required for TNF-α-induced VCAM-1 production. (escholarship.org)

Using a synthetic model of the provisional matrix, we have found that tenascin-C regulates cell responses to a fibrin-FN matrix through modulation of focal adhesion kinase (FAK) and RhoA activation. (ox.ac.uk)
Here we investigated how FAK regulates signalling resulting from the overexpression of the RTKs RET and EGFR. (gla.ac.uk)
One such input is mechanical force, which activates signalling and regulates cell behaviour in the process of mechanotransduction. (ibecbarcelona.eu)

KEGG pathways enrichment and PPI network indicate four major pathways, including extracellular matrix -receptor interaction, focal adhesion, phosphatidylinositol 3-kinase (PI3K)-Protein kinase B (Akt), and Ras signaling pathways were involved in the degeneration of cartilage. (nature.com)
Both vinY822F and vin −/− cells exhibit increased interaction between paxillin and focal adhesion kinase (FAK) and increased paxillin and FAK phosphorylation. (rupress.org)
We identified 580 differentially expressed genes (DEGs) in LACCk, which were mainly invovled in Human papillomavirus infection, focal adhesion, and ECM-receptor interaction signaling pathways. (researchsquare.com)
Human papillomavirus infection, focal adhesion, and ECM-receptor interaction signaling pathway are related to the failure of CCRT for LACC, which warrants further research to improve CCRT sensitivity in LACC targeting on these candidate genes or pathways. (researchsquare.com)
In the present study, we explored the interaction network of DEGs between responders and non-responders along with interrelated signaling pathways in LACC by analyzing the expression profile of gene expression microarray data (GSE56303-GPL10191, GSE56303-GPL16025, and GSE56363) using bioinformatics tools. (researchsquare.com)
In particular, the study highlighted the differential expression of genes associated with crucial pathways such as phagosome, focal adhesion, cytokine-cytokine receptor interaction, and toll-like receptor signaling. (aquahoy.com)

Here, we show that vinculin null (vin −/− ) cells and cells expressing a vinculin Y822F mutant have increased survival due to up-regulated activity of extracellular signal-regulated kinase (ERK). (rupress.org)

Gene Ontology (GO) analysis and Kyoto Encyclopedia of Gene and Genome (KEGG) pathway analysis were performed using the Database for Annotation, Visualization, and Integrated Discovery (DAVID). (hindawi.com)

Cells on fibrin-FN+tenascin-C redistribute their actin to the cell cortex, downregulate focal adhesion formation, and do not assemble a FN matrix. (ox.ac.uk)
Tensin is a focal adhesion molecule that binds to actin filaments and participates in signaling pathways. (wikipedia.org)
This applies a tensile signal to the actin-binding domain (ABD) of α-catenin, which provides a clutch to promote lateral adhesion growth and inhibit the lamellipodial activity necessary for migration. (ibecbarcelona.eu)
In addition, we also demonstrated that NDRG1 reduced cell locomotion by inhibiting the formation of F-actin stress fibers and focal adhesions, via its ability to suppress the Src and ROCK/pMLC2 pathways. (edu.au)

Next, we established cell lines with VEGFR2 OE to evaluate the effects of MSI2 on AKT signaling via VEGFR2 regulation. (researchgate.net)
However, transcriptional dynamic regulation of adipose differentiation driven by complex signal cascades remains largely unexplored in this model. (biomedcentral.com)
[ 8 ] Other classification systems categorize the ectodermal dysplasias based on defects in cell-cell communication and signaling, adhesion, transcription regulation, or development. (medscape.com)

This study was designed to identify signaling pathways and crucial proteins involved in the pathological mechanism of KBD compared with osteoarthritis (OA). (nature.com)

Binding of viral proteins to their ligands activates signaling pathways-focal adhesion kinase for human herpesvirus 8, JAK1, tyk2 and STAT1/2 for West Nile virus (WNV), I κ B-kinase, and nuclear transcription factor κ B (NF-κB) for influenza virus-resulting in virus entry, DNA delivery to nucleus, and modulation of protein expression that stimulate or inhibit virus replication. (cdc.gov)

GO analysis shows that the differential abundant proteins are associated with cell junction and signal transducer activity from extracellular to intracellular. (nature.com)
Signaling pathways are an important means of communication from the exterior of cell to intracellular mediators, as well as intracellular interactions that govern diverse cellular processes. (eurekaselect.com)
These multiprotein complexes are capable of capturing and integrating many signals from the extracellular as well as intracellular environments ( Rosales and Juliano, 1995 ). (rupress.org)
Its activity is directed by intracellular signals mediated by various types of receptors such as G protein-coupled receptors. (embl-heidelberg.de)

These junctions consist of calcium-binding transmembrane glycoproteins, which contribute to cellular adhesion. (medscape.com)
Cervical and ovarian carcinogenesis employ different pathways to achieve cellular immortalization, and this has a significant bearing on the evidence supporting the use of anti-angiogenic agents in the two malignancies. (cancernetwork.com)
Several examples of the role of viral glycoproteins, their ligands, and cellular proteins of the signaling pathways have been described. (cdc.gov)
Cancer cell biology takes advantage of identifying diverse cellular signaling pathways that are disrupted in cancer. (eurekaselect.com)
At the proliferation stage, proliferation related pathways and basic cellular and metabolic processes were inhibited, while regulatory factors that initiate differentiation enter the ready-to-activate state, which provides a precondition for initiating adipose differentiation. (biomedcentral.com)

Tumor necrosis factor-α (TNF-α) and focal adhesion kinase (FAK) are key regulators of inflammatory and integrin-matrix signaling, respectively. (escholarship.org)
Integrin costimulatory signals modulate inflammatory gene expression, but the important control points between these pathways remain unresolved. (escholarship.org)

Pathways involved in PI3K-Akt signaling may play a role in the altered focal adhesion and extracellular matrix (ECM)‒receptor interactions noted in Hailey-Hailey disease. (medscape.com)
Further, using selective pharmacological inhibition assays, focused on the PI3K/mTOR/AKT signaling axis, we validate whether there is a causal relationship to electrotaxis and these mechanisms of action. (nature.com)
We find that U87 mg electrotaxis is abolished under pharmacological inhibition of PI3Kγ, mTOR, AKT and ErbB2 signaling, whereas DAOY cell electrotaxis was not attenuated by these or other pathways evaluated. (nature.com)
Other oncogenic pathways found to be suppressed by NDRG1 in cancer cells include TGF-β, PI3K, NF-κB, Ras and WNT/β-catenin signalling. (edu.au)

In the last 8 decades, theories regarding carcinogenesis have progressed to include numerous pathways by which cells achieve immortality. (cancernetwork.com)

Briefly, the user provides a KEGG formatted species id for either human, mouse or rat, and the package will download and store species specific ENTREZ gene IDs and map them to their respective KEGG pathways by accessing the KEGG REST API. (univ-lyon1.fr)
Next, the user will identify significantly enriched pathways in two different gene sets, and finally, the user will identify pathways that are differentially enriched between the two gene sets. (univ-lyon1.fr)
One key component of a statistically rigorous functional enrichment analysis is the definition of a background data set that can be used to estimate the number of candidate genes that are 'expected' to be associated with the pathway by chance, e.g., if 5% of genes in the background data set are associated with a pathway then 5% of candidate gene are expected to be associated with the pathway by chance. (univ-lyon1.fr)
What pathways are this gene/protein implicaed in? (cancerindex.org)
Studies of the similar gene in mouse suggested that this protein may interact with and regulate the activity of numerous protein kinases of the JNK signaling pathway, and thus function as a scaffold protein in neuronal cells. (wikipedia.org)
The C. elegans counterpart of this gene is found to regulate synaptic vesicle transport, possibly by integrating JNK signaling and kinesin-1 transport. (wikipedia.org)
The gene ATP2C1 encodes the human secretory pathway Ca ++ -ATPase hSPCA1, which is dysfunctional and causes abnormal calcium release from the Golgi apparatus and endoplasmic reticulum. (medscape.com)
Gene Ontology and Kyoto Encyclopedia of Genes and Genomes pathway enrichment analyses were performed on differentially expressed genes (DEGs). (spandidos-publications.com)
According to weighted gene co-expression network analysis, pathways positively related to adipogenic differentiation are significantly activated at the differentiation stage, while WNT, FOXO and other pathways that inhibit preadipocyte differentiation are negatively regulated. (biomedcentral.com)
These medicines have been looked at in terms of their detailed chemical structures, their proteomic properties, the molecular biological pathways through which they work, their gene activation and epigenetic properties, their pharmacological properties, etc, This work has generally been of high quality and has resulted in thousands or tens of thousands of research reports, many of them published in highly respected Western journals. (anti-agingfirewalls.com)

The gasotransmitter hydrogen sulfide (H 2 S), recognized as the third gaseous signalling molecule along with nitric oxide (NO) and carbon monoxide (CO), is produced enzymatically in mammals under physiological conditions [ 1 ]. (hindawi.com)
The vascular adhesion molecule, E-selectin (E-sel) is responsible for the tethering and rolling of leukocytes on perivascular endothelial BM niche cells (EC). (confex.com)
Vascular cell adhesion molecule-1 (VCAM-1) plays important roles in development and inflammation. (escholarship.org)

Receptor Tyrosine Kinases (RTKs) and Focal Adhesion Kinase (FAK) regulate multiple signalling pathways, including mitogen-activated protein (MAP) kinase pathway. (gla.ac.uk)

Phosphorylation-dependent scaffolding role of JSAP1/JIP3 in the ASK1-JNK signaling pathway. (wikipedia.org)
eNOS phosphorylation was subsequently decreased in EC, suggesting that inhibition of E-sel may protect BM vasculature by blocking the production of NO. In addition, targeting E-sel showed signaling alterations in AML MSC. (confex.com)

Further, only one study has reported that miR-637 can inhibit tumorigenesis through disruption of signal transducers and activation of transcription 3 signalings in hepatocellular carcinoma [9]. (scirp.org)
Considering that EGFR is a master regulator of numerous signalling pathways, including those previously found to be regulated by NDRG1, this novel finding suggested that the ability of NDRG1 to inhibit EGFR signalling was key to its many down-stream effects in cancer cells. (edu.au)
Moreover, Wnt-5a is known to inhibit migration of breast epithelial cells in culture and expression of Wnt-5a potentiates activation of the receptor tyrosine kinase DDR1, a collagen receptor implicated in cell adhesion and migration. (lu.se)

We found that SH, M-Gly, and P334 have significant effects on the wound healing process in human keratinocytes and these effects were mediated by activation of focal adhesion kinases (FAK), extracellular signal-regulated kinases (ERK), and c-Jun N-terminal kinases (JNK). (elsevierpure.com)

An overall defect in keratinocyte adhesion appears to be secondary to a primary defect in a calcium pump protein, ATP2C1. (medscape.com)
The chemokine signal is transduced by chemokine receptors (G-protein coupled receptors) expressed on the immune cells. (genome.jp)
Transgenic rac1 protein was expressed at levels comparable to endogenous rac levels, with activation of the rac1 signaling pathway resulting in two distinct cardiomyopathic phenotypes: a lethal dilated phenotype associated with neonatal activation of the transgene and a transient cardiac hypertrophy seen among juvenile mice that resolved with age. (jci.org)
Signaling evaluations indicated a decrease in VEGFR2 and phAKT protein levels with MSI2 KD (Figure 3A,B), while phERK protein levels were not changed (Supplementary Figure S4B). (researchgate.net)
We previously showed that Musashi-2 (MSI2) RNA-binding protein is associated with NSCLC progression by regulating several signaling pathways relevant to NSCLC. (researchgate.net)

To further understand electrotactic migration of tumor cells, we performed RNA-sequencing for pathway discovery to identify signaling that is differentially affected by the exposure of direct-current electrical fields. (nature.com)
Oncogenic mutations or abnormal expression of signaling components disrupt the regulatory networks that govern cell function, thus enabling tumor cells to undergo dysregulated mitogenesis, to resist apoptosis, and to promote invasion to neighboring tissues. (eurekaselect.com)
Unraveling of dysregulated signaling pathways may advance the understanding of tumor pathophysiology and lead to the improvement of targeted tumor therapy. (eurekaselect.com)
Increased levels of POGLUT2 could result in the dysregulated immune cell infiltration and tumor microenvironment and showed a significant regulatory effect on the progression of breast cancer through Notch-related signaling. (frontiersin.org)

To mimic activation of Gα12 pathways, constitutively active Gα12 (QL) was conditionally expressed in podocytes using Nphs2-Cre and LacZ/floxed QLα12 transgenic mice. (medscape.com)

Involvement of C/EBPβ-related signaling pathway in methamphetamine-induced neuronal autophagy and apoptosis. (cancerindex.org)

Defactinib is a selective inhibitor of focal adhesion kinase (FAK), which reduces stromal density in preclinical pancreatic cancer models and in liver metastases from pancreatic cancer patients. (pancan.org)

Whereas the mechanisms activating mechanotransduction are well studied, the reversibility of this process, whereby cells disassemble and reverse force-activated signalling pathways upon cessation of mechanical stimulation is far less understood. (ibecbarcelona.eu)

The rac1 target p21-activated kinase translocated from a cytosolic to a cytoskeletal distribution, suggesting that rac1 activation was inducing focal adhesion reorganization. (jci.org)
Pharmacological activation of this pathway may constitute a novel way of limiting breast cancer metastasis. (lu.se)
The mechanisms of chronic kidney disease progression are not well defined, but may include activation of numerous vasoactive and inflammatory pathways. (medscape.com)

Induction of nitric oxide and production of reactive oxygen species are as well regulated by chemokine signal via calcium mobilization and diacylglycerol production. (genome.jp)

Candidate target genes were identified through Kyoto Encyclopedia of Genes and Genomes pathway enrichment analysis. (scirp.org)
Functional enrichment analysis discovered a plethora of metabolic and immune system-related pathways activated in all three tilapia lines. (aquahoy.com)

To this end, our recent study identified a crucial new link between NDRG1 and multiple signalling pathways, which involved its ability to affect the epidermal growth factor receptor (EGFR) in cancer cells. (edu.au)

Thus, the key pathways and genes associated with CCRT in LACC should be identified urgently. (researchsquare.com)

As an example, enrichment of a particular pathway among a list of genes that are differentially expressed after an experimental manipulation may indicate that the pathway has been altered by that manipulation. (univ-lyon1.fr)

The process is highly regulated by multiple signaling pathways and orchestrated by more than 30 autophagy-related (Atgs) proteins organized in several functional units ( 2 ). (frontiersin.org)
This study, the first examination of rac1-mediated cardiac effects in vivo, demonstrates that dilation and hypertrophy can share a common molecular origin and presents evidence that both timing and concurrent signaling from multiple pathways can influence cardiac remodeling. (jci.org)
Please note that proteins can be included in multiple pathways, ie. (embl.de)
The Part 2 post in this series is concerned with mainline anti-cancer drug interventions that simultaneously address multiple growth pathways, ones that are entering clinical practice. (anti-agingfirewalls.com)

We hypothesized that podocytes are susceptible to filtered plasma components, including hormones and growth factors that stimulate signaling pathways leading to glomerulosclerosis. (medscape.com)

Consequently, we aimed to assess miR-637 expression in gliomas to determine the effects of miR-637 on glioma cell migration and invasion, as well as to explore the possible signaling pathways involved. (scirp.org)
Deregulation of cell signaling in cancer. (eurekaselect.com)
Cell signaling and cancer. (eurekaselect.com)
Adhesion to the bone marrow (BM) niche is critical for AML initiation, progression and leukemic stem cell (LSC) survival after induction therapy. (confex.com)
In 2003, Lamartine reclassified the ectodermal dysplasias into the following 4 functional groups based on the underlying pathophysiologic defect: (1) cell-to-cell communication and signaling, (2) adhesion, (3) development, and (4) other. (medscape.com)

The Part 1 post in this series is concerned principally with anti-cancer interventions that address the mTOR pathway, a growth pathway also of great interest from the viewpoint of longevity. (anti-agingfirewalls.com)

a Simplified representations of transgenes and the RAS-ERK and Wnt/β-catenin pathways, indicating relative positions of the KRAS and BRAF proto-oncogenes. (researchgate.net)
FAK gets activated alongside KRAS and can compensate for the absence of KRAS signaling via RAF/MEK inhibitor. (pancan.org)

As an example of application, a new drug, SC75741, which blocks the NF-κB pathway without affecting the interferon (IFN)-γ pathway, may suppress the cytokine storm observed during influenza A virus (H5N1) infection. (cdc.gov)

And the above pathways were enriched primarily in the metabolism of xenobiotics by cytochrome P450, drug metabolism-cytochrome P450, and retinol metabolism. (hindawi.com)

A molecular regulatory network consisting of three circRNAs, seven miRNAs and seven mRNAs was constructed, resulting in identification of two signaling axes, hsa_circ_0035431/hsa‑miR‑940/fucosyltransferase 6 (FUT6) and hsa_circ_0035431/hsa‑miR‑940/cingulin‑like 1 (CGNL1). (spandidos-publications.com)
His group studies the physical and molecular mechanisms by which cells detect and respond to mechanical signals. (ibecbarcelona.eu)

Our results demonstrate that FAK signaling emanating from Y397, Y925, and to a lesser extent Y576/7, but not from Y861, controls osteogenic differentiation through an ERK1/2 pathway, as measured by expression levels of key osteogenesis marker genes and subsequent matrix mineralization. (techscience.com)

[ 1 ] Although risk factors such as hypertension and diabetes are linked to CKD, little is known about the signaling mechanisms that lead to progression with aging. (medscape.com)

Depending on PAMP/DAMP nature and localization, autophagy can selectively capture bacteria, such event is called xenophagy, damaged organelles, and other signaling platforms activated during the infection ( 4 , 5 ). (frontiersin.org)

We study genes, proteins and signaling pathways that might be essential for RGC and optic nerve development, function, survival, and regeneration. (nih.gov)

Numerous conditions predispose patients to GS, including diabetes, hypertension, IgA nephropathy, FSGS (focal segmental GS) and immune-mediated injury. (medscape.com)

Anatomy37

Organisms5

Diseases8

Chemicals and Drugs132

Analytical, Diagnostic and Therapeutic Techniques and Equipment22

Phenomena and Processes48

Disciplines and Occupations2

Technology, Industry, Agriculture1

Information Science4

MAPK7

Transduction4

Different signalin2

Enriched in human papillomavirus1

Downstream7

Molecules5

Mitogen-activa1

Regulates3

Interaction6

Extracellular signal1

KEGG PATHWAY1

Actin4

Regulation3

Identify signalin1

Activates1

Intracellular4

Cellular5

Integrin2

PI3K4

Numerous pathways1

Gene10

Molecule3

Receptor tyrosin1

Phosphorylation2

Inhibit3

Kinases1

Protein5

Tumor4

Constitutively active1

Neuronal1

Pancreatic1

Mechanotransduction1

Activation3

Calcium1

Enrichment analysis2

EGFR1

Genes associated1

Differentially expressed1

Multiple4

Stimulate1

Cell5

MTOR1

KRAS2

Suppress1

Metabolism1

Molecular2

Differentiation1

Progression1

Infection1

Survival1

Segmental1