Regulatory proteins and peptides that are signaling molecules involved in the process of PARACRINE COMMUNICATION. (curehunter.com)
Extracellular matrix2
It is a member of the CCN family (CCN intercellular signaling protein) of secreted, extracellular matrix (ECM)-associated signaling matricellular proteins. (wikipedia.org)
CHD8 is an independent prognostic indicator that regulates Wnt/ß-catenin signaling and the cell cycle in gastric cancer. (ouhsc.edu)
Distinct2
CCN proteins characteristically contain an N-terminal secretory signal peptide followed by four structurally distinct domains with homologies to insulin-like growth factor binding protein (IGFBP), von Willebrand type C repeats (vWC), thrombospondin type 1 repeat (TSR), and a cysteine knot motif within the C-terminal (CT) domain. (wikipedia.org)
Distinct pathways of cell migration and antiapoptotic response to epithelial injury: structure-function analysis of human intestinal trefoil factor. (embl.de)
Regulation3
Interaction of PPARa With the Canonic Wnt Pathway in the Regulation of Renal Fibrosis. (ouhsc.edu)
They are found in many cell types and are involved in the maintenance and regulation of cell shape and behavior, including PLATELET ACTIVATION and aggregation, through many different signaling pathways and differences in their affinities for collagen isoforms. (lookformedical.com)
Cytosine monophosphate kinase 2 (Cmpk2) was identified as a direct target gene of GATA6 and EC-GATA6 deletion decreased monocyte adherence, migration and pro-inflammatory macrophage foam cell formation through regulation of the CMPK2-Nlrp3 pathway. (bvsalud.org)
Glycoproteins1
Wnt proteins are a large family of secreted glycoproteins that play essential roles in EMBRYONIC AND FETAL DEVELOPMENT, and tissue maintenance. (ouhsc.edu)
Interaction1
Atherosclerotic lesion formation, endothelial inflammatory signaling, and endothelial-macrophage interaction were examined in vivo and in vitro by using cellular and molecular biological approaches. (bvsalud.org)
Activation2
Wnt-pathway activation in two molecular classes of hepatocellular carcinoma and experimental modulation by sorafenib. (ouhsc.edu)
Endothelial target delivery of Cmpk2-shRNA by intercellular adhesion molecule 2 (Icam-2) promoter-driven AAV9 carrying the shRNA reversed the Gata6 upregulation mediated elevated Cmpk2 expression and further Nlrp3 activation and thus attenuated atherosclerosis. (bvsalud.org)
No tumor-specific expression levels of protein kinase C isoenzymes and of c-fos in human breast cancer cell cultures. (shengsci.com)
Zinc protoporphyrin suppresses cancer cell viability through a heme oxygenase-1-independent mechanism: the involvement of the Wnt/ß-catenin signaling pathway. (ouhsc.edu)
Large1
Moderate to large variations of protein levels of three protein kinase C (PKC) isoenzymes (alpha, delta and epsil. (shengsci.com)
Alpha1
The predominant form of the protein is comprised of two alpha1(IV) subunits and one alpha2(IV) subunit, however, at least six different alpha subunits can be incorporated into the heterotrimer. (lookformedical.com)
Cells1
The proteins are lost or reduced when these cells undergo viral or chemical transformation. (musc.edu)
Development1
Complementary Wnt Sources Regulate Lymphatic Vascular Development via PROX1-Dependent Wnt/ß-Catenin Signaling. (ouhsc.edu)
Total2
This graph shows the total number of publications written about "Wnt Proteins" by people in this website by year, and whether "Wnt Proteins" was a major or minor topic of these publications. (ouhsc.edu)
A polypeptide substance comprising about one third of the total protein in mammalian organisms. (lookformedical.com)
CCN42
These proteins, together with WISP1 (CCN4), and WISP2 (CCN5) comprise the six-member CCN family in vertebrates. (wikipedia.org)
20. Clinical significance of Wnt-induced secreted protein-1 (WISP-1/CCN4) in esophageal squamous cell carcinoma. (nih.gov)
Metabolism2
HN - 2009 BX - alpha-Globin MH - AMP-Activated Protein Kinases UI - D055372 MN - D8.811.913.696.620.682.700.85 MN - D12.644.360.62 MN - D12.776.476.62 MS - Intracellular signaling protein kinases that play a signaling role in the regulation of cellular energy metabolism. (nih.gov)
AMP-activated protein kinases modify enzymes involved in LIPID METABOLISM, which in turn provide substrates needed to convert AMP into ATP. (nih.gov)
Gene3
WNT1-inducible-signaling pathway protein 3 (WISP3, also named CCN6) is a matricellular protein that in humans is encoded by the WISP3 gene. (wikipedia.org)
16. Effect of genetic variation in microRNA binding site in WNT1-inducible signaling pathway protein 1 gene on oral squamous cell carcinoma susceptibility. (nih.gov)
The regenerating gene (Reg) family proteins have recently been implicated in the repair and regeneration of inflamed pancreatic tissue, though the exact mechanisms of their involvement in the pathogenesis of CP are not yet fully understood. (bvsalud.org)
Proliferation2
The results confirmed that WISP1 is a stroma-specific secreting protein, enhancing the cell migration and contraction of prostate fibroblasts, as well as the proliferation, invasion, and tumor growth of prostate carcinoma cells. (nih.gov)
Exosomal tRF-19-PNR8YPJZ from PSCs targeted AXIN2 in PC cells and decreased its expression, thus activating the Wnt pathway and promoting proliferation and metastasis. (bvsalud.org)
WISP11
The WNT1 inducible signaling pathway protein 1 (WISP1), a member of the connective tissue growth factor family, plays a crucial role in several important cellular functions in a highly tissue-specific manner. (nih.gov)
Genes4
however, there are very few investigations addressing the effects of polymorphisms in the Wnt pathway genes on MI susceptibility. (nih.gov)
We investigated the possible correlation between genetic variations in Wnt pathway genes and MI risk. (nih.gov)
To investigate the role of Reg family proteins in CP, we generated global knockout mice (Reg-/-) for Reg1-3 (Reg1,2,3a,3b,3d,3g) genes using the CRISPR/Cas9 system. (bvsalud.org)
We then investigated the effect of Reg family protein deficiency in a genetic model of CP (X-SPINK1) mice by knocking out Reg1-3 genes. (bvsalud.org)
Prostate1
8. Osteoblast-derived WNT-induced secreted protein 1 increases VCAM-1 expression and enhances prostate cancer metastasis by down-regulating miR-126. (nih.gov)
Human3
1. Apoptosis signal-regulating kinase 1 is involved in WISP-1-promoted cell motility in human oral squamous cell carcinoma cells. (nih.gov)
9. WISP-2 in human gastric cancer and its potential metastatic suppressor role in gastric cancer cells mediated by JNK and PLC-γ pathways. (nih.gov)
12. Cyr61 increases migration and MMP-13 expression via alphavbeta3 integrin, FAK, ERK and AP-1-dependent pathway in human chondrosarcoma cells. (nih.gov)
Family4
It is a member of the CCN family (CCN intercellular signaling protein) of secreted, extracellular matrix (ECM)-associated signaling matricellular proteins. (wikipedia.org)
The CCN acronym is derived from the first three members of the family identified, namely CYR61 (cysteine-rich angiogenic inducer 61, or CCN1), CTGF (connective tissue growth factor, or CCN2), and NOV (nephroblastoma overexpressed, or CCN3). (wikipedia.org)
4. WISP-1 a novel angiogenic regulator of the CCN family promotes oral squamous cell carcinoma angiogenesis through VEGF-A expression. (nih.gov)
Wnt proteins are a large family of secreted glycoproteins that play essential roles in EMBRYONIC AND FETAL DEVELOPMENT , and tissue maintenance. (nih.gov)
Major2
10/20/2008) TOTAL 2009 NEW DESCRIPTORS = 446 MH - 2S Albumins, Plant UI - D055516 MN - D12.776.765.725.249 MS - A major class of water-soluble seed storage proteins. (nih.gov)
Many proteins from this class are major PLANT ALLERGENS. (nih.gov)