DNA DamageMutagensTumor Suppressor Protein p53Ataxia Telangiectasia Mutated ProteinsMutagenicity TestsCell Cycle ProteinsMethyl MethanesulfonateDNA RepairUltraviolet RaysRadiation, IonizingApoptosisTumor Suppressor ProteinsComet AssayGamma RaysCell CycleProtein-Serine-Threonine KinasesDNA-Binding ProteinsCell Line, TumorNuclear ProteinsCRADD Signaling Adaptor ProteinGenomic InstabilityPhosphorylationProto-Oncogene Proteins c-mdm2Checkpoint Kinase 2DoxorubicinG2 PhaseCell LineDNA Breaks, Double-StrandedStress, PhysiologicalProto-Oncogene Proteins c-ablMicronuclei, Chromosome-DefectiveHCT116 CellsSignal TransductionCyclin-Dependent Kinase Inhibitor p21Cell SurvivalMutationFibroblastsS PhaseEtoposideHydroxyureaMitomycinHistonesProtein BindingGenes, p53Poly Adenosine Diphosphate RiboseCarcinogensPoly(ADP-ribose) PolymerasesDNA ReplicationrhoB GTP-Binding Proteinzeta-CrystallinsCell NucleusProtein KinasesHeLa Cellscdc25 PhosphatasesUbiquitinationCell AgingCaspase 2Cell Cycle CheckpointsGene Expression RegulationRNA, Small InterferingDNA AdductsMethylnitronitrosoguanidineUbiquitinCells, CulturedTranscriptional ActivationSister Chromatid ExchangeDNA Repair EnzymesMitosisCisplatinTranscription FactorsSumoylationAlkylating AgentsDNAAntimutagenic AgentsActive Transport, Cell NucleusAtaxia TelangiectasiaOxidative StressTranscription, GeneticIntracellular Signaling Peptides and ProteinsHEK293 CellsDeath Domain Receptor Signaling Adaptor ProteinsMolecular Sequence DataChromosome AberrationsTransfectionRNA InterferenceRadiation ToleranceEnzyme ActivationNeoplasmsAntibiotics, AntineoplasticMice, KnockoutTumor Cells, CulturedReplication Protein AAntineoplastic AgentsCyclinsModels, BiologicalDown-RegulationPromoter Regions, GeneticG1 PhaseSirtuin 1Gene Expression Regulation, Neoplastic