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  • immune
  • The surprising find that bacteria pump out a totally new and highly immunogenic molecule suggests that it may be possible to improve vaccines that use live or disabled bacteria to activate the immune system. (berkeley.edu)
  • ii) The shorter tRNA-derived fragments (tRFs) are 18-22 nt long, and are produced from both mature and pre-tRNAs by Dicer or RNase Z. Here, I will consider only the tRNA halves and argue their potential as immune signaling molecules. (frontiersin.org)
  • London, June 29 (ANI): Scientists at Imperial College London say that blocking a signal molecule made by the human body, which triggers the immune system into action, may make it possible to develop more effective treatments for rheumatoid arthritis. (thefreedictionary.com)
  • pathways
  • Osteoblastic differentiation is controlled by complex interplay of several signaling pathways and associated key transcription factors, as well as by microRNAs (miRNAs). (nih.gov)
  • tumors
  • Tumors can leverage glucose and other nutrients to resist targeted therapies directed at specific cellular molecules, according to researchers at University of California, San Diego School of Medicine and Ludwig Cancer Research. (ucsd.edu)
  • In the study, published this week in Proceedings of the National Academy of Sciences , the team used human tissue and mouse models to demonstrate that nutrients can strongly affect the signaling molecules that drive tumors in glioblastoma, a deadly brain cancer. (ucsd.edu)
  • activate
  • The researchers delved further, showing how acetate and glucose activate mTORC2 through a molecule formed from these metabolites, acetyl-coA, which is critical for activating a key component of mTORC2. (ucsd.edu)
  • Agrobacterium perceives plant-derived signals to activate its virulence genes, which are responsible for transferring and integrating its Transferred DNA (T-DNA) from its Tumor-inducing (Ti) plasmid into the plant nucleus. (frontiersin.org)
  • Agrobacterium utilizes opines as nutrient sources as well as signals in order to activate its quorum sensing (QS) to further promote virulence and opine metabolism. (frontiersin.org)
  • Intriguingly, Agrobacterium also recognizes plant-derived signals including γ-amino butyric acid and salicylic acid (SA) to activate quorum quenching that reduces the level of QS signals, thereby avoiding the elicitation of plant defense and preserving energy. (frontiersin.org)
  • Superior because it has the other side of the equation - the RS molecules necessary to activate antioxidants that will neutralize the oxidation the chlorine compounds will cause. (energeticforum.com)
  • In the present review, we will describe the mechanisms by which various eukaryotic signal molecules produced by host may activate Gram-negative bacteria virulence. (mdpi.com)
  • Notch
  • The current work provides the rationale for determining whether manipulating Notch signaling will be useful in combating such diseases as parasitic infections, asthma, and inflammatory bowel disease. (bio-medicine.org)
  • hydrogen
  • Very recently, a third endogenously produced gaseous signaling molecule, hydrogen sulfide (H 2 S), has emerged as a potentially important mediator of CV homeo stasis and cytoprotection ( 3 ). (pnas.org)
  • Sodium Choride and Distilled Water is composed of molecules that come from 4 different atoms: sodium, chlorine, hydrogen and oxygen. (energeticforum.com)
  • When they are rearranged, they can create ozone (o3), hydrogen peroxide (h2o2), various chlorine derivatives that are superior to a popular chlorine product known by a three letter acronym and other molecules that are highly reactive. (energeticforum.com)
  • activation
  • Willert cautioned that "it would be a stretch to say that activation of WNT signaling will allow us to regenerate limbs," but said WNT activation is likely valuable in assisting tissue repair. (ucsd.edu)
  • Mischel and other researchers have previously shown that this shift can occur through the activation of a central cellular signal, mTORC2. (ucsd.edu)
  • Because these molecules are critical for the potency of activation of acute virulence functions, here we investigated whether they are also produced during human P. aeruginosa acute wound infection and whether their ratio is similar to that observed in P. aeruginosa -infected mice. (hindawi.com)
  • recognition
  • Agrobacterium pathogenicity is largely attributed to its evolved capabilities of precise recognition and response to plant-derived chemical signals. (frontiersin.org)
  • inflammation
  • By studying mouse models of skin, lung and breast cancer development, the Coussens lab is identifying important molecules involved in regulating tumor-associated inflammation, angiogenesis, and cancer development. (healthcanal.com)
  • relies
  • Pseudomonas aeruginosa has developed a complex cell-to-cell communication system that relies on low-molecular weight excreted molecules to control the production of its virulence factors. (hindawi.com)
  • gene expression
  • QS is a cell-density-dependent phenomenon based on the release of low-molecular weight molecules that coordinate gene expression in a cell population [ 11 , 13 , 14 ]. (hindawi.com)
  • wound
  • A variety of efforts are already underway exploring how to leverage WNT signaling to promote wound healing, such as speeding bone fracture repairs, and even hair growth. (ucsd.edu)
  • These molecules could be isolated from wound tissue as well as from drainage liquid. (hindawi.com)
  • important
  • The second edition of this encyclopedia presents about 1000 chapters and includes thousands of biologically important signaling molecules and the content is built on the core concepts of their functions along with early findings written by some of the world's foremost experts. (springer.com)
  • biological
  • Since the recent discovery that H 2 S is a powerful gaseous signaling molecule, studies have begun to characterize the biological profile of this promiscuous gas. (pnas.org)
  • function
  • Krengel U, Schlichting L, Scherer A, Schumann R, Frech M, John J, Kabsch W, Pai EF, Wittinghofer A (1990) Three-dimensional structures of H-ras p21 mutants: molecular basis for their inability to function as signal switch molecules. (springer.com)
  • single
  • What is unique and profound about the latest and most significant is that the ROS and RS molecules are able to co-exist in a single stabilized solution so that they do NOT neutralize themselves. (energeticforum.com)
  • different
  • That bonus chapter is NOT about the same topic of the call but does deal with electrolysis, which is used in a unique way to electrically rearrange a sodium chloride solution into 16 different molecules. (energeticforum.com)
  • body
  • Message Body (Your Name) thought you would like to see this page from the Science Signaling web site. (sciencemag.org)
  • That means they can be ingested so that the ROS and RS molecules can be absorbed into the body and can do their respective jobs. (energeticforum.com)
  • negative
  • Until now, this was claimed to be impossible by the medical, physics, biology and other scientific fields because it is counter intuitive - how can you put both the positive and negative molecules together without them neutralizing themselves? (energeticforum.com)