Signaling adenomatous polyposis coli protein. Medical search. Frequent questions

Therefore, genetic mutation of the APC gene is also strongly linked to cancers, and in particular colorectal cancer resulting from familial adenomatous polyposis (FAP). (wikipedia.org)
Intestinal polyposis syndromes can be divided, based on histology, into the broad categories of familial adenomatous polyposis (FAP) , hamartomatous polyposis syndromes, and other rare polyposis syndromes, such as hereditary-mixed polyposis syndrome (HMPS) and serrated polyposis syndrome (SPS). (medscape.com)
Although APC -related desmoid tumors are commonly associated with a form of colon cancer called familial adenomatous polyposis (described below), APC gene mutations can cause tumors in individuals without this inherited disease. (medlineplus.gov)
More than 700 mutations in the APC gene have been identified in families with the classic and attenuated types of familial adenomatous polyposis (FAP). (medlineplus.gov)
Mutations in the APC gene are also responsible for a disorder called Turcot syndrome, which is closely related to familial adenomatous polyposis. (medlineplus.gov)
Defects in this gene cause familial adenomatous polyposis (FAP), an autosomal dominant pre-malignant disease that usually progresses to malignancy. (nih.gov)
The initial case for the participation of WNT signaling in individual cancers was produced when the hereditary cancers symptoms termed familial adenomatous polyposis (FAP) gene item, adenomatous polyposis coli (APC) 13, 14, was discovered to connect to -catenin 15, 16, and was afterwards shown to enjoy a critical function in managing -catenin proteins stability. (icsv20.org)

Wnt and Rho GTPase signaling Rabbit polyclonal to NGFR and their discussion In the canonical Wnt signaling pathway, most -catenin in the cytoplasm can be sequestered in a oligomeric complicated of casein kinase, axin, the adenomatous polyposis coli tumor suppressor proteins (APC) and glycogen synthase kinase 3 (GSK3) [16]. (exposed-skin-care.net)
In canonical Wnt signaling, most -catenin in the cytoplasm can be sequestered within an oligomeric complicated of glycogen synthase kinase 3 (GSK3), casein kinase (CK), axin and adenomatous polyposis coli tumor suppressor proteins (APC). (exposed-skin-care.net)
The degradation of β-catenin is regulated by interaction with a number of proteins including Axin , glycogen synthase kinase 3 (GSK3) and the adenomatous polyposis coli protein (APC). (biomedcentral.com)
these in turn inhibit the destruction complex responsible for degrading β-catenin, which includes GSK-3 , adenomatous polyposis coli (APC) and axin. (tocris.com)
Mutations in β-catenin, axin and APC have been discovered in numerous cancers, and other members of the canonical pathway may also contribute to misregulation of Wnt signaling. (tocris.com)
In the lack of Wnt signaling, cytoplasmic -catenin is definitely destined by damage complicated healthy proteins, including AXIN, adenomatous polyposis coli (APC), and glycogen synthase kinase 3 beta (GSK3M). (insulin-receptor.info)
The level of free β-catenin is low in normal cells, since the protein is sequestered in a complex, which includes the adenomatous polyposis coli (APC) protein, a serine threonine glycogen kinase (GSK-3β) and conductin or Axin, leading to degradation of β-catenin by proteasome. (biomedcentral.com)
Therefore in the nucleus of AML stem/BPCs the β-catenin-TCF4/LEF1 complex increases manifestation of the pro-growth and pro-survival genes including cyclin D1 c-MYC and survivin while reducing Axin 2 levels1 3 15 In AML stem/BPCs Citalopram Hydrobromide multiple mechanisms are known to deregulate WNT signaling. (researchassistantresume.com)

Generally speaking, signal transduction pathways in the initiation and progression of cancer are essential. (hindawi.com)
The Wnt pathway is one of the most critical signaling pathways activated by mutation in many cancers [ 7 - 9 ]. (hindawi.com)
Cancer-preventing strategies of these beneficial bacteria such as binding to carcinogens and degrading them, stimulating anti-cancer enzymes, and preventing the conversion of procarcinogens to carcinogens, production of beneficial compounds that act as signaling molecules affecting the immune system, cell death, and proliferation, and interference with cell signaling pathways are reported [ 16 - 19 ]. (hindawi.com)
The developmental biology of EO can be of crucial importance in understanding the procedure of OA, and there is a lot scientific proof indicating that signaling pathways modulating joint formation and homeostasis are of central importance in the pathogenesis of OA. (exposed-skin-care.net)
Wnt signaling pathways control a wide range of processes during embryonic development and tissue homeostasis. (nature.com)
Frizzled2 signaling regulates growth of high-risk neuroblastomas by interfering with β-catenin-dependent and β-catenin-independent signaling pathways. (cams.cn)
Many signal transduction pathways are composed of modules that are remarkably conserved across species, such that lessons from different experimental model organisms have contributed to the understanding of molecular hierarchies that control signal communication in many cellular contexts. (biomedcentral.com)
The first step in the Wnt signal occurs when extracellular Wnt ligand binds Frizzled receptors on the cell surface, leading to the activation of several distinct transduction pathways (see Figure 1 ). (biomedcentral.com)
The intracellular protein Dishevelled is common to both canonical and non-canonical signaling pathways, raising the question of how this mysterious protein acts at the signal crossroads. (biomedcentral.com)
Wnt signals via canonical and non-canonical pathways. (biomedcentral.com)
The roles of the other proteins in the two pathways, and of the Dsh motifs, are discussed in the text. (biomedcentral.com)
HGUE-C-1 represents a novel and peculiar colon carcinoma model to study chemoresistance to chemotherapeutic agents and to novel anti-neoplasic drugs that interrupt signalling pathways such as the APC/βcatenin, Ras/Raf/Mek/Erk, PI3K/mTOR/p70S6K pathways as well as histone regulation mechanisms. (biomedcentral.com)
Furthermore, the Wnt/β-catenin can crosstalk with other signaling pathways including Notch, FGF, Hedgehog, and TGF-β/BMP signaling cascades to form a signaling network to regulate the survival and progression of cancer cells ( 14 - 16 ). (frontiersin.org)
Understanding the functional biology of CSCs - especially the signaling pathways that are involved in their self-renewal mechanisms - is crucial for discovering new forms of treatment. (docksci.com)
Glioblastoma stem cells play an important role in tumor formation by activation of several signaling pathways. (biomedcentral.com)
One of pathways gaining attention in GBM is the Wnt signaling. (biomedcentral.com)
Traditionally, WNT signaling is usually classified into two large groups: the canonical WNT (or -catenin-dependent) and non-canonical WNT (or -catenin-independent) pathways. (icsv20.org)

Catenin beta-1, also known as β-catenin (beta-catenin), is a protein that in humans is encoded by the CTNNB1 gene. (wikipedia.org)
β-Catenin is regulated and destroyed by the beta-catenin destruction complex, and in particular by the adenomatous polyposis coli (APC) protein, encoded by the tumour-suppressing APC gene. (wikipedia.org)
It is now clear that Armadillo and beta-catenin bind directly to members of the T-cell factor/lymphoid enhancer factor subfamily of HMG box DNA-binding proteins, forming bipartite transcription factors that regulate Wingless/Wnt responsive genes in both Drosophila and vertebrates. (embl.de)
Beta-catenin is essential for cadherin-based cell adhesion and Wnt/Wingless growth factor signaling. (embl.de)
Signal transduction of beta-catenin. (embl.de)
Beta-catenin participates in signal transduction and developmental patterning in Xenopus and Drosophila embryos as a component of the Wnt signaling pathway. (embl.de)
The adenomatous polyposis coli tumor suppressor protein is also implicated in beta-catenin signaling. (embl.de)
2003. Promotion versus suppression of rat colon carcinogenesis by chlorophyllin and chlorophyll: modulation of apoptosis, cell proliferation, and beta-catenin/Tcf signaling. . (oregonstate.edu)
2003. Suppression of tumorigenesis in the Apc(min) mouse: down-regulation of beta-catenin signaling by a combination of tea plus sulindac. . (oregonstate.edu)
Feng C, Liang S, Harold V. Wnt signals across the plasma membrane to activate the beta-catenin pathway by forming oligomers containing its receptors, Frizzled and LRP. (cams.cn)
One protein with which APC associates is beta-catenin. (medlineplus.gov)
Association of APC with beta-catenin signals for beta-catenin to be broken down when it is no longer needed. (medlineplus.gov)
The shortened protein is unable to interact with the beta-catenin protein, which prevents the breakdown of beta-catenin when it is no longer needed. (medlineplus.gov)
ChemDiv's Inhibitors of beta-Catenin Signaling Library contains 8,000 compounds. (chemdiv.com)
2004. Activator protein 2alpha associates with adenomatous polyposis coli/beta-catenin and Inhibits beta-catenin/T-cell factor transcriptional activity in colorectal cancer cells. . (oregonstate.edu)

β-Catenin is a dual function protein, involved in regulation and coordination of cell-cell adhesion and gene transcription. (wikipedia.org)
In humans, the CTNNB1 protein is encoded by the CTNNB1 gene. (wikipedia.org)
The armadillo (Arm) repeat is an approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila melanogaster segment polarity gene armadillo involved in signal transduction through wingless. (embl.de)
In these roles, it binds to cadherins, Tcf-family transcription factors, and the tumor suppressor gene product Adenomatous Polyposis Coli (APC). (embl.de)
These phenotypes range from a mild phenotype in attenuated polyposis syndrome to specific clinical syndromes recognized many decades prior to the discovery of the adenomatous polyposis ( APC ) gene. (medscape.com)
First described in 2002, MYH-associated polyposis, or MutYH - associated polyposis (MAP), occurs in a small number of patients with FAP and results from a mutation in the human MutY homolog gene instead of the APC gene. (medscape.com)
Here, we aimed at identifying a β-catenin-independent Wnt target gene signature in order to understand the functional significance of non-canonical signaling in colon cancer cells. (nature.com)
Gene expression profiling was performed after silencing of key components of Wnt signaling pathway and an iterative signature algorithm was applied to predict pathway-dependent gene signatures. (nature.com)
Membrane-spanning proteins often function as receptors involved in recognition and cell adhesion, whereas nuclear proteins frequently play a role in regulating gene expression and transcription. (biomedcentral.com)
such studies have defined the molecules that ensure signals initiated at the cell surface are efficiently transmitted to the cell nucleus, where they often result in the induction of a specific gene-expression program. (biomedcentral.com)
The first genetic alteration, found in 85% of adenomas, are mutations in the adenomatous polyposis coli (MC) gene. (um.es)
The APC gene provides instructions for making the APC protein, which plays a critical role in several cellular processes. (medlineplus.gov)
Most APC gene mutations that cause sporadic desmoid tumors lead to an abnormally short APC protein. (medlineplus.gov)
Adenomatous polyposis coli protein is a protein in humans that is encoded by APC gene. (cusabio.com)
The roles of b-catenin are 'classically' defined: as an adhesion protein and as a signaling protein, transducing extracellular signals to the nucleus to modify gene expression. (chemdiv.com)
The APC gene encodes a tumor suppressor protein that acts as an antagonist of the Wnt signaling pathway. (nih.gov)
There are several proposed mechanisms for resistance, including increased androgen receptor (AR) signaling caused by increased AR expression, gene amplification, gene transcription, and tumor growth. (oncologynurseadvisor.com)
Non-canonical WNT signaling can also activate calcium flux and kinase cascades, including protein kinase C (PKC), calcium/calmodulin-dependent protein kinase II (CaMKII) and JUN N-terminal kinase (JNK), leading to the activation of AP1- and NFAT-regulated gene expression 25-27. (icsv20.org)
We observe that each gene and its products have a unique set of DNA, RNA or protein motifs that encode a regulatory program to define the logical circuitry that guides the life cycle of these biomolecules, from transcription to degradation. (biomedcentral.com)

In the absence of Wnt signals, the cytoplasmic catenin beta-1 ( β-catenin ) is associated with a complex including auxin, glycogen synthase kinase 3 ( GSK-3 ), and adenomatous polyposis coli ( APC ) (the APC protein acts as the primary regulator of β-catenin function). (hindawi.com)

Open up in another window Shape 1 Schematic representation from the 41294-56-8 manufacture canonical Wnt signaling pathway. (exposed-skin-care.net)
β-catenin protein is an integral part of the canonical Wnt signaling pathway. (tocris.com)
Canonical Wnt signaling pathway is essential for embryonic development [ 10 ] and non-canonical Wnt pathway regulates cell movement and tissue polarity [ 11 ]. (biomedcentral.com)

Recent large scale sequencing analyses also have highlighted the predominance of large number of CRC patients carrying sequence variants in proteins involved in Wnt signaling pathway. (coloncanceratlas.org)
β-catenin is involved in Wnt signaling pathway that regulates cellular differentiation and proliferation. (biomedcentral.com)

Nevertheless, when Wnt ligands bind to cell membrane receptors, signaling through the frizzled receptors inhibits this degradation procedure, thereby raising the degrees of free of charge cytoplasmic -catenin. (exposed-skin-care.net)
When Wnt ligands bind with their cognate cell membrane receptors, indicators are released to inhibit this degradation procedure, leading to -catenin build up and nuclear translocation controlled by Rac1, DKK1 and FRZB, which are antagonists of canonical Wnt signaling. (exposed-skin-care.net)
TMEM9-v-ATPase hyperactivates Wnt/β-catenin signalling via lysosomal degradation of adenomatous polyposis coli (APC). (nature.com)
Our results reveal the unexpected roles of TMEM9-controlled vesicular acidification in hyperactivating Wnt/β-catenin signalling through APC degradation, and propose the blockade of TMEM9-v-ATPase as a viable option for colorectal cancer treatment. (nature.com)
Promotes rapid degradation of CTNNB1 and participates in Wnt signaling as a negative regulator. (cusabio.com)

The Wnt signaling pathway can be well established to be always a crucial regulator in EO [13,14], an activity through which bone tissue and articular cartilage are shaped. (exposed-skin-care.net)
We identified transmembrane protein 9 (TMEM9) as a vesicular acidification regulator. (nature.com)
Moreover, TMEM9 transactivated by β-catenin functions as a positive feedback regulator of Wnt signalling in colorectal cancer. (nature.com)

In the presence of Wnt signals, the Wnt proteins bind to (frizzled) frizzled receptors ( FZDs ) and low-density lipoprotein receptor-related protein ( LRP ) receptors, leading to the stabilization of β-catenin , its transfer to the nucleus, and the activation of target genes. (hindawi.com)
A fuller picture of the WNT signaling pathway surfaced when T-cell aspect/lymphocyte enhancer aspect (TCF/LEF) transcription elements had been defined as WNT nuclear effectors 9, 10 and Frizzleds (FZDs) had been defined as WNT obligate receptors 11, working as well as co-receptors, such as for example low-density lipoprotein-receptor-related proteins (LRPs)/Arrow 12. (icsv20.org)
Non-canonical WNT signaling can be initiated by WNT conversation with Frizzled receptors, or RYK and ROR receptor tyrosine kinases, and regulates small GTPases (such as RhoA, Rac and Cdc42) in DVL-dependent manner. (icsv20.org)

Altogether, the results of our studies have revealed that berberine inhibits the development of CACRC by interfering with inflammatory response-driven EGFR signaling in tumor cell growth. (nih.gov)
Activation of protein phosphatase 2A by palmitate inhibits AMP-activated protein. (abdur.ca)
Since BCL2, a protein that indirectly inhibits cell apoptosis, is required for certain chemotherapies to work, the absence of BCL2 obscures their uses in prostate cancer. (oncologynurseadvisor.com)

β-catenin is a subunit of the cadherin protein complex and acts as an intracellular signal transducer in the Wnt signaling pathway. (wikipedia.org)
In mammals, the family of Wnt ligands consists of 19 members, which trigger multiple intracellular signaling cascades and orchestrate complex, context-dependent responses. (nature.com)
The canonical Wnt pathway involves stabilization of the intracellular protein β-catenin . (biomedcentral.com)

β-Catenin was initially discovered in the early 1990s as a component of a mammalian cell adhesion complex: a protein responsible for cytoplasmatic anchoring of cadherins. (wikipedia.org)
But very soon, it was realized that the Drosophila protein armadillo - implicated in mediating the morphogenic effects of Wingless/Wnt - is homologous to the mammalian β-catenin, not just in structure but also in function. (wikipedia.org)
Telomerase maintains telomeres canonically, but latest reviews possess suggested that the primary proteins mammalian telomerase change transcriptase (TERT) element, together with the chromatin remodeling element BRG1 and -catenin, might also situation to and promote appearance of Wnt focus on genetics. (insulin-receptor.info)
Generally in most mammalian genomes, the WNT family members is normally made up of 19 associates that are seen as a an extremely conserved cysteine-rich secreted glycoproteins, which present the specialized challenges in effective creation, biochemical characterization and structural evaluation of WNT proteins 28, however the structure from the Xenopus WNT8 proteins as destined to Frizzled (FZD) was lately resolved 29. (icsv20.org)

Wnt signaling regulates cell proliferation, cell polarity and cell-fate determination. (biomedcentral.com)

Furthermore, in vivo administration of IL-6 to DSS-treated Apc Min/+ mice effectively weakened the inhibitory effects of berberine on tumorigenesis and EGFR-ERK signaling in colon tissues. (nih.gov)
Non-canonical, β-catenin-independent Wnt signaling is proposed to have a multifunctional role in tumorigenesis, being either tumor supportive or suppressive depending on tumorstage and tumortype 9 . (nature.com)
2009. Activator protein 2alpha suppresses intestinal tumorigenesis in the Apc(min) mouse. . (oregonstate.edu)
Recent evidence suggests that plakoglobin may suppress tumorigenesis and metastasis by multiple mechanisms, including the suppression of oncogenic signaling, interactions with various proteins involved in tumorigenesis and metastasis, and the regulation of the expression of genes involved in these processes. (oncotarget.com)

It is believed that mutations in the deoxyribonucleic acid (DNA) signal the cells related to the esophagus to multiply abnormally [ 4 , 5 ]. (hindawi.com)
Most of these mutations lead to the production of an abnormally short, nonfunctional version of the APC protein. (medlineplus.gov)
Disease-associated mutations tend to be clustered in a small region designated the mutation cluster region (MCR) and result in a truncated protein product. (nih.gov)

The HGUE-C-1 cell line was sensitive to erlotinib, gefitinib, NVP-BEZ235, rapamycin and trichostatin, among other drugs, but partially resistant to heat shock protein inhibitors and highly resistant to AZD-6244 and oxaliplatin, even though the patient from which this cell line was derived had not been exposed to these drugs. (biomedcentral.com)
Inhibitors of apoptosis proteins (IAPs), mainly survivin and X-linked inhibitor of apoptosis (XIAP) prevent the processing of procaspase 3 to caspase 3, thereby inhibiting apoptosis. (oncologynurseadvisor.com)

Thus, targeting signal molecules can be helpful for cancer therapy [ 6 ]. (hindawi.com)
Wnt/β-catenin signaling is a delicate and complex signal transduction pathway mediated by multiple signaling molecules, which plays a significant role in regulating human physiology and pathology. (frontiersin.org)
The current review focuses on the importance of Wnt signaling pathway in glioblastoma stem cell progression and explores targeting of Wnt signaling molecules as a potential therapy for glioblastoma. (biomedcentral.com)
71 Clusterin is a small heat shock glycoprotein overexpressed in most of the solid tumors, which promotes apoptosis by binding to various molecules such as BAX (BCL2-associated X protein) 72 and signal transducer and activator of transcription (STAT)−1. (oncologynurseadvisor.com)

During growth, development and disease, extracellular signals are communicated, or transduced, into the cell and in such a way as to elicit a particular cellular response. (biomedcentral.com)

MKPs (mitogen-activated protein kinase phosphatases). (abdur.ca)

It is a member of the catenin protein family and homologous to γ-catenin, also known as plakoglobin. (wikipedia.org)
Plakoglobin (also known as γ-catenin) is a member of the Armadillo family of proteins and a paralog of β-catenin. (oncotarget.com)
Similar to β-catenin, plakoglobin is capable of participating in cell signaling in addition to its role in cell-cell adhesion. (oncotarget.com)
How plakoglobin acts as a growth/metastasis inhibitory protein has remained, until recently, unclear. (oncotarget.com)
At the adherens junction in epithelia, the C-terminal domain of E-cadherin interacts, in a mutually exclusive manner, with β-catenin or γ-catenin (plakoglobin), which then interacts with α-catenin, an actin-binding protein. (oncotarget.com)

Wnt/β-catenin signaling is a branch of a functional network that is involved in a broad range of biological systems including stem cells, embryonic development and adult organs. (chemdiv.com)
Wnt signaling pathway is mediated by Wnt family of 19 secreted glycoproteins (bearing22 or 24 cysteine residues) which are essential for cell proliferation, embryonic development, cell polarity, and tissue homeostasis [ 9 ]. (biomedcentral.com)

The real-time PCR method was used to analyse the L. rhamnosus supernatant effect on the expression of Wnt signaling pathway genes. (hindawi.com)
The supernatant of this bacterium significantly reduced the expression of Wnt signaling pathway genes. (hindawi.com)
This study is the first report that assessed the potential impact of L. rhamnosus , especially its supernatant on esophageal cancer and Wnt signaling pathway genes. (hindawi.com)
β-catenin forms a complex with T-cell factor ( TCF ) /lymphoid enhancer factor ( LEF ) transcription factors and cofactors such as histone acetyltransferase p300 (p300), CBP, BCL9, and pygopus, to transcribe Wnt signaling target genes such as Cyclin D1 , C-Myc , and survivin [ 9 , 12 - 15 ]. (hindawi.com)
Aberrant TCF-β-catenin signaling is also evident in many cancers, and results in altered expression of genes controlling cell proliferation, differentiation, migration and apoptosis. (tocris.com)
Aberrations of AR, erythroblast transformation-specific ( ETS ) genes, Tumor protein 53 (TP53), and Phosphatase and tensin homolog (PTEN) occurred in 40%-60% of 150 mCRPC cases in a recent study. (oncologynurseadvisor.com)
A substantial portion of the regulatory interactions in the higher eukaryotic cell are mediated by simple sequence motifs in the regulatory segments of genes and (pre-)mRNAs, and in the intrinsically disordered regions of proteins. (biomedcentral.com)

EGFR-ERK signaling act downstream of berberine/pro-inflammatory cytokines axis to regulate CACRC cell proliferation. (nih.gov)
Our experiments indicate that colon cancer cells are dependent on both β-catenin-dependent and -independent Wnt signaling routes for growth and proliferation. (nature.com)
This suggests the possibility that strictly regulated self-renewal mediated by Wnt signaling in cancer cells may be disturbed by the SUMOylation pathway to allow more malignant proliferation. (frontiersin.org)
Biologically, the canonical WNT/-catenin signaling pathway usually plays crucial functions in regulating cell fate, proliferation and survival, while the non-canonical WNT signaling is usually more associated with differentiation, cell polarity and migration 25-27. (icsv20.org)

However, predicting the signaling outcome of different Wnt ligands has remained difficult. (nature.com)

Deregulation of components involved in Wnt/β-catenin signaling has been implicated in a wide spectrum of diseases including a number of cancers and degenerative diseases. (chemdiv.com)
Proteins associated with the Wnt/β-catenin pathway have been identified as SUMOylated substrates, and evidences suggested that the initiation and progression of cancers depended on the function of the SUMOylation ( 23 ). (frontiersin.org)

When secreted Wnt protein situation to Frizzled and low-density lipoprotein receptor-related protein (LRPs) at the plasma membrane layer, a sign is definitely transduced to destabilize the -catenin damage complicated. (insulin-receptor.info)

Involved in transducing the Wingless/Wnt signal. (embl.de)
Within the past year, Armadillo and beta-catenin's role in transducing the Wingless/Wnt signal has been substantially clarified. (embl.de)
AAV-NRP-1 and LV-NRP-1 treatments increased the wingless integration (Wnt)-associated signals and β-catenin nuclear localization. (biomedcentral.com)

WNT5a is required for normal ovarian follicle development and antagonizes gonadotropin responsiveness in granulosa cells by suppressing canonical WNT signaling. (cams.cn)
The APC protein acts as a tumor suppressor, which means that it keeps cells from growing and dividing too fast or in an uncontrolled way. (medlineplus.gov)
mouse embryonic fibroblasts (MEFs) and human being fibroblast (BJ) cells and that, in SW-13 and HeLa tumor cells, TERT overexpression hyperactivated a Wnt signaling media reporter in a BRG1-reliant way (13). (insulin-receptor.info)
Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. (cusabio.com)
Cadherins are single-pass transmembrane glycoproteins that form homotypic interactions with cadherin proteins on neighboring cells and interact intracellularly with proteins of the catenin family [ 4 , 5 ]. (oncotarget.com)
However, these cells showed loss of heterozygosity affecting Adenomatous Polyposis Coli and nuclear staining of β-catenin protein. (biomedcentral.com)
Abnormally activated Wnt/β-catenin signaling pathway plays a crucial role in promoting malignant tumor occurrence, development, recurrence, and metastasis, particularly in cancer stem cells. (frontiersin.org)
β-catenin is also required for the HOXA9 and MEIS1-mediated transformation of the hematopoietic stem cells MLL-AF9-mediated transformation of the committed myeloid progenitor cells as well as necessary for the development and growth of MLL fusion protein-transformed leukemia stem cells2-5. (researchassistantresume.com)
In this review, we discuss about the significance of glioblastoma stem cells in cancer progression through Wnt signaling pathway and highlight the clinical targets being potentially considered for therapy in glioblastoma. (biomedcentral.com)
Using TCF/LEF luciferase promotor assay (Top/Flash) we show that resistant A2780cis cells possess a threefold higher Wnt signaling activity compared to A2780 cells. (oncotarget.com)
Consequently, Wnt signaling pathway appears as primary target of LMWH in sensitizing A2780cis cells for cisplatin toxicity. (oncotarget.com)
The rising evidence signifies that WNT signaling performs an essential function in regulating many natural procedures, including embryonic advancement, tissues maintenance and homoeostasis of stem cells. (icsv20.org)

Structure-function analysis of the Dishevelled (Dsh) protein in frog embryos has defined sequences that regulate Dsh nuclear localization, which proves critical for Wnt signaling. (biomedcentral.com)
Post-translational modifications (PTMs) of proteins, including phosphorylation, acetylation, ubiquitination, and SUMOylation, can regulate the function of proteins, determine the active state and subcellular location of proteins, and dynamically interact with other proteins related to carcinogenesis and progression ( 17 - 20 ). (frontiersin.org)

Docetaxel, in addition to stabilizing microtubules, also induces apoptosis by downregulating antiapoptotic proteins. (oncologynurseadvisor.com)
70 Mcl1 (myeloid cell leukemia differentiation protein 1) and other members of the BCL family, such as BCL-xl (B-cell lymphoma-extra-large), are also involved in resistance to Interleukin (IL)-6, stromal cell derived factor-1, and cytokine-induced apoptosis. (oncologynurseadvisor.com)

This mutation changes the sequence of the building blocks of proteins (amino acids) in the resulting APC protein. (medlineplus.gov)
This mutation replaces the amino acid isoleucine with the amino acid lysine at position 1307 in the APC protein (written as Ile1307Lys or I1307K). (medlineplus.gov)
The uvr8-2 genotype carries a mutation in the C-terminus of the UVR8 protein that impairs signaling in response to UV-B (Cloix et al. (abdur.ca)

Wnt signaling pathway is one such important pathway which helps cellular differentiation to promote tumor formation in the brain. (biomedcentral.com)

In Drosophila, the homologous protein is called armadillo. (wikipedia.org)
Termed armadillo repeats, all these elements fold together into a single, rigid protein domain with an elongated shape - called armadillo (ARM) domain. (wikipedia.org)

[ 16 ] In one study, arecoline was found to elevate the mRNA and protein expression of cystatin C, a nonglycosylated basic protein consistently up-regulated in a variety of fibrotic diseases, in a dose-dependent manner in persons with oral submucous fibrosis. (medscape.com)

Its signaling activity is distinct from its role in cadherin-mediated cell adhesion, and it probably acts either in the cytosol or in the nucleus. (embl.de)

The compendium encompasses sequence variants and proteins identified in more than 179 colorectal cancer cell lines and 13,711 tissue samples. (coloncanceratlas.org)
Role of rare variants in undetermined multiple adenomatous polyposis and early-onset colorectal cancer. (ox.ac.uk)

It has been suggested that APC could function through its regulation of Bcatenin, an ubiquitous cytoskeletal protein with multiple binding specificities resulting in diverse functions including cell growth, adhesion, and migration. (um.es)

Studies of the Wnt pathway provide a wonderful example of how researchers from different fields have contributed to a detailed understanding of a key signal transduction pathway [ 2 ]. (biomedcentral.com)

Some 15-20% of multiple adenomatous polyposis have no genetic explanation and 20-30% of colorectal cancer (CRC) cases are thought to be due to inherited multifactorial causes. (ox.ac.uk)

Studies have shown that the Wnt/β-catenin signaling pathway controls cell fate and function through the transcriptional and post-translational regulation of omics networks. (frontiersin.org)
Therefore, precise regulation of Wnt/β-catenin signaling as a cancer-targeting strategy may contribute to the treatment of some malignancies. (frontiersin.org)
Here, we review the complex regulation of Wnt/β-catenin signaling by SUMOylation and discuss the potential targets of SUMOylation therapy. (frontiersin.org)
The ease of motif acquisition simplifies access to basal housekeeping functions, facilitates the co-regulation of multiple biomolecules allowing them to respond in a coordinated manner to changes in the cell state, and supports the integration of multiple signals for combinatorial decision-making. (biomedcentral.com)
Finally, we contrast the regulatory properties of protein motifs and the regulatory elements of DNA and (pre-)mRNAs, advocating that co-regulation, co-operativity, and motif-driven regulatory programs are common mechanisms that emerge from the use of simple, evolutionarily plastic regulatory modules. (biomedcentral.com)

Furthermore, WNT5A methyl modification influence on Wnt5a expression level and Wnt5a acts on different signal pathway. (cams.cn)
Wnt5a/planar cell polarity signaling pathway in urothelial carcinoma, a potential prognostic biomarker. (cams.cn)

Molecular characterization of this cell line revealed low expression levels and activity of Retinoblastoma protein and elevated basal levels of Erk1/2 activity and p70S6K expression and activity, which may be related to chemoresistance mechanisms. (biomedcentral.com)

β-catenin is a component of the complex cadherin complex whose stabilization is required to activate Wnt/β-catenin signaling. (chemdiv.com)

Wnt and Rho GTPase signaling play critical tasks in governing several areas of cell physiology, and also have been proven to be engaged in endochondral ossification and osteoarthritis (OA) advancement. (exposed-skin-care.net)

Anatomy2

Organisms1

Diseases14

Chemicals and Drugs10

Analytical, Diagnostic and Therapeutic Techniques and Equipment1

Phenomena and Processes4

Familial adenomato7

Axin8

Pathways17

Beta-catenin15

Gene19

Glycogen1

Canonical Wnt signali3

Involved in Wnt signali2

Degradation5

Regulator3

Receptors3

Inhibits3

Intracellular3

Mammalian4

Regulates1

Tumorigenesis4

Mutations3

Inhibitors2

Molecules4

Extracellular signals1

Kinase1

Plakoglobin5

Embryonic development2

Genes7

Proliferation4

Ligands1

Cancers2

Lipoprotein receptor-related protein1

Wingless3

Cells12

Regulate2

Apoptosis2

Mutation3

Cellular differentiation1

Armadillo2

MRNA1

Cytosol1

Variants2

Cytoskeletal1

Transduction pathway1

Genetic1

Regulation5

Wnt5a2

Mechanisms1

Activate1

GTPase1