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Cytokine Receptor gp130Signal TransductionReceptors, Interleukin-6Protein Sorting SignalsTransduction, GeneticReceptors, Oncostatin MReceptors, OSM-LIFMolecular Sequence DataReceptors, CytokineLeukemia Inhibitory Factor Receptor alpha SubunitAmino Acid SequenceReceptors, InterleukinAdaptor Proteins, Signal TransducingLeukemia Inhibitory FactorAntigens, CDInterleukin-6Base SequenceCell LineLysogenyTyrosineMembrane GlycoproteinsEndosomal Sorting Complexes Required for TransportGrowth InhibitorsProtein-Tyrosine KinasesSTAT3 Transcription FactorJanus Kinase 1PhosphorylationOncostatin MTransfectionRecombinant Fusion ProteinsCells, CulturedEnzyme ActivationProtein BindingDNA-Binding ProteinsMembrane ProteinsProto-Oncogene ProteinsRecombinant ProteinsPhosphoproteinsColiphagesCloning, MolecularRNA, MessengerProteinsCell MembraneGTP-Binding ProteinsKineticsTumor Cells, CulturedReceptors, Cell SurfaceSequence Homology, Amino AcidCell DivisionBinding SitesEscherichia coliProtein Structure, TertiaryGene ExpressionTrans-ActivatorsBacteriophagesLymphokinesMutagenesis, Site-DirectedBacteriophage lambdaGene Expression RegulationMutationDNABlotting, WesternSalmonella PhagesT-LymphocytesGenetic VectorsModels, MolecularGenesSignal Processing, Computer-AssistedChromosomes, BacterialPlasmidsChromosome MappingModels, BiologicalNuclear Localization SignalsRecombination, GeneticBacterial ProteinsTranscription, GeneticDNA, ViralOperonStaphylococcus PhagesGenes, BacterialDNA, BacterialTranscription FactorsGreen Fluorescent ProteinsLentivirusCell DifferentiationTime FactorsCalciumPseudomonas PhagesCarrier ProteinsMice, Inbred C57BLGene Transfer TechniquesDependovirusProtein-Serine-Threonine KinasesCOS CellsProtein TransportCell NucleusNeuronsDNA VirusesDensovirusUltraviolet Rays
ProteinsPathwayPathwaysTransductionMoleculesAdaptorReceptorsExtracellularKinaseCanonicalPrimary ciliaDownstreamPhosphorylationRegulateMTORCuesRegulatesNeuronsUnderlieSonic HedgehogCiliaHippoMechanismsRolesInhibitorGeneRegulatorAmino acidsCell proliferationCellsDefectsCellularHarborInvolvementResponseFunction
Proteins11
  • TcMYC2a was also found to bind with TcJAZ3 in yeast, which was a homolog of Arabidopsis JASMONATE ZIM-domain JAZ proteins, indicating that TcMYC2a had a similar function to AtMYC2 of JA signal transduction. (frontiersin.org)
  • The pH-responsive one-component signaling system CadC in Escherichia coli belongs to the family of ToxR-like proteins, whose members share a conserved modular structure, with an N-terminal cytoplasmic winged helix-turn-helix DNA-binding domain being followed by a single transmembrane helix and a C-terminal periplasmic pH-sensing domain. (cipsm.de)
  • Adaptor Proteins, Signal Transducing" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (childrensmercy.org)
  • A broad category of carrier proteins that play a role in SIGNAL TRANSDUCTION. (childrensmercy.org)
  • This graph shows the total number of publications written about "Adaptor Proteins, Signal Transducing" by people in this website by year, and whether "Adaptor Proteins, Signal Transducing" was a major or minor topic of these publications. (childrensmercy.org)
  • Below are the most recent publications written about "Adaptor Proteins, Signal Transducing" by people in Profiles. (childrensmercy.org)
  • Cytoskeletal proteins appear to be involved in the control of intracellular signaling. (jneurosci.org)
  • This study involves precisely defining by molecular techniques the individual signaling proteins expressed in the acinar cell and then subsequently assessing if individual agonists utilize discrete and different elements of the PI-signaling pathway. (rochester.edu)
  • In addition to ligand-regulated degradation of β-catenin, Wnt signaling is antagonized by extracellular factors that inhibit the ability of Wnt ligands to bind to Fzd and initiate signaling, such as the secreted frizzled-related proteins (SFRP1, WNT inhibitory factor (WIF) and dickkopf (DKK) [3] . (plos.org)
  • According to the current view, prokaryotic signal transduction is conducted mostly by two-component regulatory systems that function as a result of phosphotransfer between two key proteins: a sensor histidine kinase and a response regulator [1-6]. (handlebar-online.com)
  • What are the two key proteins that are present in two-component signal transduction systems? (handlebar-online.com)
Pathway15
  • Among all JA downstream transcription factors, MYC2 is considered as the fatal point of the entire JA signaling pathway ( Kazan and Manners, 2013 ). (frontiersin.org)
  • Innate immunity to viruses involves receptors such as RIG-I, which senses viral RNA and triggers an IFN-β signaling pathway involving the outer mitochondrial membrane protein MAVS. (nih.gov)
  • Downregulation of Herg1 suppresses osteosarcoma proliferation and invasion by targeting Hippo signaling pathway]. (cancerindex.org)
  • We aimed to determine the signaling pathway regulating cell metabolism and the mechanism related to the regulation of human tumor-associated macrophages (TAMs) in gastric cancer (GC). (cancerindex.org)
  • Involvement of C/EBPβ-related signaling pathway in methamphetamine-induced neuronal autophagy and apoptosis. (cancerindex.org)
  • This was studied in SK-N-SH neuroblastoma cells, which possess a muscarinic receptor-regulated PLCβ 1 -signaling pathway. (jneurosci.org)
  • In particular, the EVC2 protein is thought to help regulate a signaling pathway known as Sonic Hedgehog, which plays roles in cell growth, cell specialization, and the normal shaping (patterning) of many parts of the body. (medlineplus.gov)
  • Problems with this signaling pathway may ultimately lead to the abnormal bone growth and heart defects seen with this condition. (medlineplus.gov)
  • Although all Ca2+ mobilizing agonists in pancreatic acinar cells utilize the phosphoinositide-signaling (PI) pathway, stimulation by individual agents results in markedly different temporal and spatial patterns of Ca2+ signaling. (rochester.edu)
  • Given that tremendous molecular diversity is expressed at all levels of this signaling pathway, our working hypothesis is that individual agonists do not couple to the signaling machinery in an identical fashion. (rochester.edu)
  • We are utilizing fluorescence imaging techniques including high-speed confocal microscopy to monitor [Ca2+]i while manipulating the signaling pathway with neutralizing antibodies and antisense technology. (rochester.edu)
  • Beta-catenin participates in signal transduction and developmental patterning in Xenopus and Drosophila embryos as a component of the Wnt signaling pathway. (embl.de)
  • Several anterograde and retrograde signaling pathways, including the canonical Bone Morphogenic Protein (BMP) pathway , regulate synaptic development in vertebrates and invertebrates. (sdbonline.org)
  • Neuronal loss of the serine-threonine protein kinase Tao , a regulator of the Hippo signaling pathway, results in supernumerary boutons, each of which contain a normal number of active zones. (sdbonline.org)
  • For example, recent work demonstrates that transcriptional regulators of the sonic hedgehog signaling pathway localize to primary cilia and participate in sensing and transducing signals regarding the cellular environment. (cdc.gov)
Pathways5
  • It is well-established that early embryonic signaling pathways are critical for growth and patterning of new tissue during regeneration. (frontiersin.org)
  • The EVC2 protein is found in primary cilia, which are microscopic, finger-like projections that stick out from the surface of cells and are involved in signaling pathways that transmit information between cells. (medlineplus.gov)
  • More generally, these observations delineate an approach that can be used to identify druggable synthetic lethal interactions with signaling pathways that are frequently activated in cancer but are difficult to target with the currently available small molecule inhibitors. (plos.org)
  • Describe how intervention in key signalling pathways may be used to treat inflammatory disease of the CNS. (southampton.ac.uk)
  • This effect was associated with decreased activation of pathways linked to neurotrophin and glutamate receptor signaling. (researchgate.net)
Transduction10
Molecules5
  • They generally contain several modular domains, each of which having its own binding activity, and act by forming complexes with other intracellular-signaling molecules. (childrensmercy.org)
  • Evidence is presented to demonstrate that murine B lymphocytes receive growth stimulatory signals from their surface class II molecules. (uky.edu)
  • Analysis of early gene expression revealed that signaling through class II molecules led to an increase in anti-μ-induced expression of c-myc, a proto-oncogene, and of ornithine decarboxylase, a key enzyme in polyamine biosynthesis that has been shown to be intimately related to increased cell proliferation. (uky.edu)
  • Our results thus indicate that the expression of signalling molecules may be modulated by tissue mechanics, which has important implications given that tissue stiffness changes throughout development as well as during ageing and disease. (cam.ac.uk)
  • For this purpose, WIN 55,212-2 was injected in pregnant wistar rats from gestation day 5 to 20 and a detailed analysis of the levels of the neurotrophin brain-derived neurotrophic factor (BDNF) as well as of the signaling molecules extracellular signal-regulated kinase (ERK)1/2 and alpha-calcium/calmodulin-dependent protein kinase II (alpha-CaMKII) was carried out in adult offspring. (researchgate.net)
Adaptor4
  • This protein associates with JAK3 and JAK2 kinases via its ITAM region, and is phosphorylated by the JAK kinases upon cytokine stimulation, which suggests the function of this protein is as an adaptor molecule involved in the downstream signaling of cytokine receptors. (wikipedia.org)
  • Signal transducing adaptor molecule has been shown to interact with HGS, Janus kinase 2. (wikipedia.org)
  • Hrs is associated with STAM, a signal-transducing adaptor molecule. (wikipedia.org)
  • Signal transducing adaptor family member 2. (invivogen.com)
Receptors7
  • Our findings provide insight into the activation mechanism of this highly expanded family of plant receptors that have essential roles in hormone, developmental and innate immunity signalling. (nature.com)
  • This distribution of receptors is the major factor in defining the spatial characteristics of the Ca2+ signal. (rochester.edu)
  • In addition the regulation of these receptors by phosphorylation and the consequences this may have for Ca2+ signaling are also being studied. (rochester.edu)
  • Neuronal responsiveness to the neurotrophins is determined not only by restricted expression and regulated release of the neurotrophins but also by the expression pattern of neurotrophin receptors and components of the signaling complex. (jneurosci.org)
  • The trk receptors, a family of receptor tyrosine kinases including trkA, trkB, and trkC, serve as the principal signal-transducing receptors for the neurotrophins ( Barbacid, 1994 ). (jneurosci.org)
  • We found that HAMP1 to 3 influence PAS signaling over a considerable distance, as the majority of HAMP1, 2 and 3 mutations, and deletions of helical phase stutters, led to nonresponsive signal-off or off-biased receptors. (llu.edu)
  • Multiple cell-surface receptors are responsible for transducing and/or regulating HH signals. (antibodies-online.com)
Extracellular1
  • Alternative splicing affects both the extracellular ligand-binding domains and the intracellular signal-transducing domains of the trks ( Barbacid, 1994 ). (jneurosci.org)
Kinase1
Canonical2
  • Menden H, Xia S, Mabry SM, Noel-MacDonnell J, Rajasingh J, Ye SQ, Sampath V. Histone deacetylase 6 regulates endothelial MyD88-dependent canonical TLR signaling, lung inflammation, and alveolar remodeling in the developing lung. (childrensmercy.org)
  • Canonical Wnt/β-catenin signaling is initiated by binding of Wnt ligands to Frizzled (Fzd)-LRP5/6 receptor complexes, leading to inactivation of the destruction complex and stabilization of β-catenin. (plos.org)
Primary cilia1
  • Dorn KV, Hughes CE, Rohatgi R. A Smoothened-Evc2 complex transduces the Hedgehog signal at primary cilia. (medlineplus.gov)
Downstream2
  • These experiments identify a novel residue of MAVS that is crucially involved in the recruitment of TRAF3/TRAF6 and in downstream propagation of MAVS signaling. (nih.gov)
  • However, the development of integrin targeting medications has been impacted by unexpected downstream effects, reflecting originally unforeseen interference with the bidirectional signalling and cross-communication of integrins. (bvsalud.org)
Phosphorylation1
  • A tyrosine-scanning mutational analysis revealed that MAVS tyrosine-9 (Y9) is a phosphorylation site that is required for IFN-β signaling. (nih.gov)
Regulate1
  • Because most tubulin is not membrane associated, this study investigates whether tubulin translocates to the membrane in response to an agonist so that it might regulate G-protein signaling. (jneurosci.org)
MTOR1
  • Interactúa directamente con mTOR para incrementar su actividad cinasa y estabiliza la interacción de la PROTEÍNA RPTOR con mTOR en condiciones de escasez de nutrientes, favoreciendo la inhibición que la PROTEÍNA RPTOR ejerce sobre la actividad de mTOR. (bvsalud.org)
Cues1
  • Mechanosensitive ion channels (MSCs) are key players in transducing these mechanical cues into intracellular signals. (cam.ac.uk)
Regulates4
  • Genetic interaction of mammalian IFT-A paralogs regulates cilia disassembly, ciliary entry of membrane protein, Hedgehog signaling, and embryogenesis. (childrensmercy.org)
  • The microtubule protein tubulin regulates adenylyl cyclase and phospholipase Cβ 1 (PLCβ 1 ) signaling via transactivation of the G-protein subunits Gαs, Gαi1, and Gαq. (jneurosci.org)
  • Instead, the experiments suggest that Tao negatively regulates BMP signaling as reduction of Tao leads to an increase in pMad levels in motor neuron nuclei and an increase in BMP target gene expression. (sdbonline.org)
  • Regulator of G-protein signaling 5 regulates the shift from perivascular to parenchymal pericytes in the chronic phase after stroke. (lu.se)
Neurons4
  • Magnesium Acts as a Second Messenger in the Regulation of NMDA Receptor-Mediated CREB Signaling in Neurons. (rochester.edu)
  • During nervous system development, growing neurons respond to mechanical as well as chemical signals in their environment. (cam.ac.uk)
  • How these different signals interact, to guide neurons to their end target, is currently poorly understood. (cam.ac.uk)
  • Taken together, these results support a role for Tao as a novel inhibitor of BMP signaling in motor neurons during synaptic development and function. (sdbonline.org)
Underlie1
  • Research in this laboratory focuses on gaining a better understanding of the mechanisms which underlie these signaling patterns with a primary goal of relating this knowledge to the physiology and pathophysiology of exocrine cells. (rochester.edu)
Sonic Hedgehog2
  • Although it is unclear how the loss of this protein's function underlies the signs and symptoms of Ellis-van Creveld syndrome, researchers believe that it may prevent normal Sonic Hedgehog signaling in the developing embryo. (medlineplus.gov)
  • Studies suggest that it interferes with Sonic Hedgehog signaling in the developing embryo, disrupting the normal formation and growth of the teeth, nails, and bones. (medlineplus.gov)
Cilia4
  • Evc2 is a positive modulator of Hedgehog signalling that interacts with Evc at the cilia membrane and is also found in the nucleus. (medlineplus.gov)
  • In contrast, motile cilia are traditionally viewed as mechanical machinery, vital for the movement of solutes and clearance of bacteria and debris, but not participants in cellular sensing and signaling mechanisms. (cdc.gov)
  • Furthermore, inhibition of SRF signaling using the small molecule CCG-1423 reduces organic dust-induced IL-8 release from bronchial epithelial cells and stimulates cilia beat frequency in ciliated mouse tracheal epithelial cells. (cdc.gov)
  • These data challenge current dogma regarding motile cilia functioning and may lead to significant contributions in understanding motile ciliary signaling dynamics, as well as mechanisms involving SRF-mediated responses to inflammation and injury. (cdc.gov)
Hippo1
  • Regulation of organ size is essential in animal development, and Hippo (Hpo) signaling is a major conserved mechanism for controlling organ growth. (sdbonline.org)
Mechanisms1
  • In this issue, we generally review the mechanisms of cellular senescence in diabetic nephropathy, which involve telomere attrition, DNA damage, epigenetic alterations, mitochondrial dysfunction, loss of Klotho, Wnt/ β -catenin signaling activation, persistent inflammation, and accumulation of uremic toxins. (hindawi.com)
Roles2
  • Many studies have reported their regulatory roles in immunity through cytokines and cell signaling. (cancerindex.org)
  • Employing HAMP as a clustering and localization determinant, as well as a facilitator of PAS signaling, are newly recognized roles for HAMP domains. (llu.edu)
Inhibitor1
  • The HHIP encoded by this gene is a highly conserved, vertebrate-specific inhibitor of HH signaling. (antibodies-online.com)
Gene2
  • Signal transducing adapter molecule 1 is a protein that in humans is encoded by the STAM gene. (wikipedia.org)
  • Loss-of-function mutations in APC or AXIN or activating mutations in the gene encoding β-catenin, CTNNB1 , lead to aberrant activation of Wnt/β-catenin signaling and have been causally linked to tumorigenesis of the colon, liver and skin [1] , [4] . (plos.org)
Regulator3
  • They undergo activation, morphological changes and express a protein called Regulator of G-protein Signaling 5 (RGS5) (1, 2). (lu.se)
  • Berger M, Bergers G, Arnold B, Hammerling GJ, and Ganss R. Regulator of G-protein signaling-5 induction in pericytes coincides with active vessel remodeling during neovascularization. (lu.se)
  • Loss of Regulator of G-Protein Signaling 5 Leads to Neurovascular Protection in Stroke. (lu.se)
Amino acids1
  • In E. coli CadC, a cytoplasmic linker comprising approximately 50 amino acids is essential for transmission of the signal from the sensor to the DNA-binding domain. (cipsm.de)
Cell proliferation2
  • The signals through surface immunoglobulin (Ig) and Ia appeared to act sequentially since preexposure to anti-μ was required to observe anti-la-induced increase in B cell proliferation. (uky.edu)
  • It is believed that TGF-β1 signalling is involved in controlling epithelial cell proliferation, to drive epithelial-mesenchymal transition (EMT) and it plays a major role in lung fibrosis and emphysema. (springer.com)
Cells3
  • To uncover genetic dependencies in breast cancer cells that harbor active β-catenin signaling, we performed RNAi-based loss-of-function screens in breast cancer cell lines in which we had characterized β-catenin activity. (plos.org)
  • Furthermore, we demonstrate that breast cancer cells that harbor activated β-catenin activity exhibit enhanced sensitivity to pharmacological blockade of Wnt/β-catenin signaling. (plos.org)
  • Here, we investigated DSA from 20 pre-transplant patients, all of whom showed negative CDC-crossmatch results with donor cells and SAB signals ranging between 571 and 14899 mean fluorescence intensity (MFI). (bvsalud.org)
Defects1
  • In summary, the present data suggest that deficits of BDNF levels and signaling through ERK1/2 and alpha-CaMKII might contribute to cognitive and neuroplastic defects associated with prenatal exposure to cannabinoids. (researchgate.net)
Cellular1
  • This variation in cytosolic domains is responsible for the wide range of cellular and environmental signals sensed and transduced by TRP channels. (lu.se)
Harbor1
  • These studies identify CK1ε as a critical contributor to activated β-catenin signaling in cancer and suggest it may provide a potential therapeutic target for cancers that harbor active β-catenin. (plos.org)
Involvement1
  • These observations presented a spatial and temporal resolution of the sequence of events underlying receptor-evoked involvement of tubulin in G-protein-mediated signaling. (jneurosci.org)
Response2
  • Thus, we propose that the disordered CadC linker is required for transducing the pH-dependent response of the periplasmic sensor into a structural rearrangement that facilitates dimerization of the cytoplasmic CadC DNA-binding domain. (cipsm.de)
  • However, changes in cell signalling in response to hypoxia that are mediated by RGS5 stroke. (lu.se)
Function1
  • This indicates that HAMP1 to 3 are critical coupling partners for PAS signaling and likely function as a cohesive unit and moveable scaffold to correctly orient and poise PAS dimers for O2-mediated signaling in Aer2. (llu.edu)