PathwaySTAT3PathwaysIntracellularPhosphorylationCytokinesStat2Tyrosine kinasesInterferonsCanonicalMoleculesRegulatesInflammatoryProteinsTumorTranscriptionalKINASEGenesDownstreamFamily of transcription factorsMolecule in the regulationBindsProteinInhibitionInduceStimulationSuppressesCell-mediatedInflammationTransductionGene expressionPromoterInhibitorPromotesRoleLipidLigandResponsesMechanismsNuclearInterleukinExpressionKnockout
Pathway23
- Therefore, our study suggests that the STAT1 pathway can be manipulated to limit autoreactive T cells during autoimmunity directed against the CNS. (jci.org)
- These results identify PIAS1 as a specific inhibitor of Stat1-mediated gene activation and suggest that there may exist a specific PIAS inhibitor in every STAT signaling pathway. (nih.gov)
- It has also been demonstrated that STAT1 (Signal Transducer And Activator Of Transcription 1), a transcription factor (TF) crucially involved in the IFNγ pathway, binds consensus sequences that, in humans, are located with a high frequency in the LTRs (Long Terminal Repeats) of the MER41 family of primate-specific HERVs (Human Endogenous Retrovirus). (biorxiv.org)
- However, the putative role of an IFNγ/STAT1/MER41 pathway in human cognition and/or behavior is still poorly documented. (biorxiv.org)
- The biological effects of IFNs are mediated through the Janus kinase/signal transducer and activator of transcription (JAK/STAT) pathway. (wikipedia.org)
- Signaling through TLRs can broadly be categorized into two pathways the MyD88 and the Trip-dependent pathway. (wikipedia.org)
- All TLRs except TLR3 signal through the MyD88-dependent pathway. (wikipedia.org)
- Only TLR3 and TLR4 signal through the TRIF-dependent pathway. (wikipedia.org)
- The MyD88-dependent pathway recruits several effector molecules such as IRAK1/4 and tumor necrosis factor receptor-associated factor 6 (TRAF6). (wikipedia.org)
- These molecules are linked to at least three major downstream pathways: the NF-κB pathway, the pathway involving mitogen-activated protein kinases (MAPKs) and IRF pathways, depending on the stimulus and the responding cell types activation of these pathways results in transcription of various cytokines including IFN-α/β. (wikipedia.org)
- The functional enrichment and gene interaction network analysis emphasized the importance of cytokine/chemokine signalling, T cell receptor signalling route, NF-kappa B signalling pathway and Jak-STAT signalling system. (springeropen.com)
- For example, it is well known that the activation of the signal transducer and activator of transcription (STAT) signaling pathway plays a central role in interferon-gamma (IFN-gamma)-induced microglial CD40 expression. (alstuttu.org)
- However, the signaling pathway involved in B7-H1 expression in MSCs remains largely undefined. (korea.ac.kr)
- In vitro , GnRH neuronal cell lines respond to a variety of ligands that activate the Jak (Janus-activated kinase)/STAT (signal transducers and activators of transcription) intracellular signaling pathway. (jneurosci.org)
- Human granulocytic anaplasmosis (HGA) is caused by the obligate intracellular bacterium induces an immunopathologic response by activating IFN�� production through the signal transducer and activation of transcription 1 (Stat1) signaling pathway. (bio-biz-navi.com)
- We tested the role of the JAK/ STAT1 signaling pathway in Leishmania pathogenesis by utilizing knockout mice lacking the signal transducer and activator of transcription 1 (Stat1) and derived macrophages. (wustl.edu)
- The JAK-STAT pathway transmits signals from many cytokines arriving at the plasma membrane to the cell nucleus, resulting in a modulation of gene expression. (uni-goettingen.de)
- Non-canonical or alternative type I IFN signaling can activate additional pathways such as Crk-like protein (CrkL), the phosphatidyl-inositol 3-kinase (PI3K) pathway, and the mitogen-activated protein kinase (MAPK) pathway [ 15 ]. (scientificarchives.com)
- The Type I IFN-induced PI3K pathway is involved in the production of antiviral effectors and in the regulation of the transcription and translation of ISGs [ 19 ]. (scientificarchives.com)
- The glycolysis-dependent anti-inflammatory property of MSCs conferred by inflammatory cytokines is mediated by PI3K-AKT signaling pathway. (biomedcentral.com)
- Ingenuity Pathway Analysis indicated that this differentially expressed genes formed a network centered on STAT1, a grasp transcription factor of the IFN response (Physique 1B). (thetechnoant.info)
- The metabolic abnormalities of type 2 diabetes, including hyperglycemia, dyslipidemia, and insulin resistance, activate the Janus kinases/signal transducer and activator of transcription (JAK/STAT) signaling pathway, a major intracellular inflammatory cascade that transmits the intracellular signaling to the nucleus ( 2 ), promoting inflammatory response, inducing insulin resistance ( 3 ), and accelerating the development of cardiovascular complications ( 4 ). (diabetesjournals.org)
- Upon the occupancy of ACE2 by SARS-CoV-2, the increased serum level of free Angiotensin II (Ang II) due to a reduction of ACE2-mediated degradation promotes activation of the NF-kappa B pathway via Ang II type 1 receptor (AT1R), followed by interleukin-6 (IL-6) production. (kegg.jp)
STAT311
- Coimmunoprecipitation analysis showed that PIAS1 was associated with Stat1 but not Stat2 or Stat3 after ligand stimulation. (nih.gov)
- Interestingly, ID-associated genes exhibit promoter-localized MER41 LTRs that harbor TF binding sites (TFBSs) for not only STAT1 but also other immune TFs such as, in particular, NFKB1 (Nuclear Factor Kappa B Subunit 1) and STAT3 (Signal Transducer And Activator Of Transcription 3). (biorxiv.org)
- Signal transducer and activator of transcription 3 (STAT3) was initially showed to control acute-phase genes in response to interleukin-6 (IL-6) and epidermal growth factor (EGF) during inflammatory processes (1). (abwizbio.com)
- STAT3 belongs to the STAT family of cytoplasmic transcription factors that induces cell membrane-mediated nuclear signal transduction in various cellular activities (2). (abwizbio.com)
- Upon cytokine and growth factor stimulation STAT3, a transcription factor, is activated. (abwizbio.com)
- STAT3 in turn induces both canonical and non-canonical signaling. (abwizbio.com)
- Upon phosphorylation, STAT3 proteins dimerize and translocate to the nucleus where they bind to promoter elements of target genes and modulate their transcription (4). (abwizbio.com)
- It had been shown that STAT3 can also autoregulate its own transcription. (abwizbio.com)
- STAT3 protein belongs to a group of intracellular transcription factors that mediate a variety of functions such as cellular differentiation, proliferation, and apoptosis. (biolegend.com)
- Type I IFN activated STAT1 and STAT2 also form other heterodimers, including STAT1-STAT3, STAT1-STAT4, STAT1-STAT5, and STAT2-STAT3 in specific cell types such as endothelial cells or cells of lymphoid origin [ 3 , 12 - 14 ]. (scientificarchives.com)
- In the vasculature, activation of STAT1 and STAT3 promotes inflammatory response ( 5 ), increases neointimal formation ( 6 ), and accelerates the development of atherosclerosis ( 7 ), a chronic disease characterized by inflammation in the artery wall ( 8 ). (diabetesjournals.org)
Pathways9
- In addition to antiviral activity, it activates NATURAL KILLER CELLS and B-LYMPHOCYTES , and down-regulates VASCULAR ENDOTHELIAL GROWTH FACTOR expression through PI-3 KINASE and MAPK KINASES signaling pathways. (lookformedical.com)
- Signaling via cytosolic viral sensors can also activate similar pathways and result in transcription of IFN-α/β. (wikipedia.org)
- Their expression in tumour cells is modulated by a complex interplay of genomic, transcriptomic and post translational factors involving multiple intracellular antigen processing pathways. (portlandpress.com)
- Furthermore, these two genes are modulators in clusters C4 and C5, abundant in cytokine/chemokine signalling and Jak-STAT signalling pathways. (springeropen.com)
- Our analyses highlight the role of ITGAM and STAT1 in T2DM-TB-associated pathways and advances our knowledge of the genetic processes driving this comorbidity. (springeropen.com)
- STAT proteins (signal transducers and activators of transcription) play an essential part in one of the oldest and highly conserved signal transduction pathways. (uni-goettingen.de)
- However, the signaling pathways downstream of the cytokines remain to be elucidated. (biomedcentral.com)
- Transcriptome analysis revealed that Th1/Th2 differentiation, NK cells, Th17 cell, complement system and calcium signaling pathways were down-regulated post-treatment of Pam3CSK4. (bvsalud.org)
- First, we are interested in Epstein Barr Virus-mediated mechanisms of immune evasion with particular emphasis on pathways that promote survival and proliferation of EBV B cell lymphomas, the characterization of the human T cell and NK cell response to EBV and the identification of novel therapeutics for treatment of EBV B cell lymphomas. (stanford.edu)
Intracellular4
- The cytokine receptors lack intrinsic kinase activity and require interaction with members of the Jak family of intracellular signaling molecules. (jneurosci.org)
- Intracellular parasites of the genus Leishmania generate severe diseases in humans, which are associated with a failure of the infected host to induce a protective interferon c (IFNc)-mediated immune response. (wustl.edu)
- Unexpectedly, infection of Stat1-deficient macrophages in vitro with promastigotes from Leishmania major and attenuated LPG1 knockout mutants (lpg2) specifically lacking lipophosphoglycan (LPG) resulted in a twofold increased intracellular growth, which was independent of IFNc and associated with a substantial increase in phagosomal pH. (wustl.edu)
- However, they utilized approaches that may not be ideal to reveal more technical features of B cells, specifically those mediated through the creation of cytokines, whose relevance during infections by intracellular bacterial pathogens provides received raising experimental proof (16C18). (thetechnoant.info)
Phosphorylation8
- STAT (signal transducer and activator of transcription) proteins are latent cytoplasmic transcription factors that become activated by tyrosine phosphorylation in response to cytokine stimulation. (nih.gov)
- The in vivo PIAS1-Stat1 interaction requires phosphorylation of Stat1 on Tyr-701. (nih.gov)
- After phosphorylation by JAK tyrosine kinases, STAT1 enters the nucleus to regulate transcription of many different genes. (thermofisher.com)
- PHOSPHORYLATION of IRF-3 causes the protein to be translocated from the CYTOPLASM to CELL NUCLEUS where it binds DNA , and activates transcription. (lookformedical.com)
- In addition, apigenin and luteolin markedly inhibited IFN-γ-induced phosphorylation of STAT1 with little impact on cell survival. (alstuttu.org)
- In addition, apigenin and luteolin markedly inhibited IFN-gamma-induced phosphorylation of STAT1 with little impact on cell survival. (alstuttu.org)
- The loss of STAT1 function in humans or mice results in a dramatically increased susceptibility to viral bacterial and protozoan infections (13 14 16 infection-induced IFN�� signaling leads to phosphorylation of Stat1 in mice (17) and dexamethasone suppression of STAT1 expression reduces inflammatory signaling and disease severity in infection has not been otherwise studied. (bio-biz-navi.com)
- Gene silencing of MKP-1 increased STAT1 phosphorylation and prevented 5-aminoimidazole-4-carboxyamide ribonucleoside-reduced STAT1 phosphorylation. (diabetesjournals.org)
Cytokines5
- Effector CD4 + T cell subsets have been defined based on their secretion of cytokines, as well as based on transcription factors and cytokines required for their development and maintenance. (jci.org)
- STAT1 is activated to regulate gene expression in response to extracellular signaling polypeptides including cytokines, interferons, and growth factors. (thermofisher.com)
- Herein, we describe spontaneous tumor development in gene-targeted mice lacking interferon (IFN)-γ and/or perforin (pfp), or the immunoregulatory cytokines, interleukin (IL)-12, IL-18, and tumor necrosis factor (TNF). (silverchair.com)
- Treatment of HCEpiC with 1 ng/ml IL-1β for 18 h significantly increased release of the cytokines/chemokines granulocyte colony-stimulating factor (G-CSF), granulocyte-macrophage colony-stimulating factor (GM-CSF), interleukin-6 (IL-6), interleukin-8 (IL-8), and monocyte chemotactic protein-1 (MCP-1), while hyperosmolarity-induced release of IL-6 and MCP-1. (molvis.org)
- Moreover, TAMs usually display M2-like phenotypes that exert tumor-promoting role in TME, and promote production of related immunosuppressive factors that trigger immunotherapy resistance, including cytokines, chemokines, growth factors and soluble signaling mediators [ 12 ]. (thno.org)
Stat25
- STAT1 and STAT2 are activated by these tyrosine kinases, and STAT1 and STAT2 mediate the antiviral and inflammatory effects of IFN-α/IFN-β. (wikipedia.org)
- STAT1 and STAT2 form a complex with IFN-regulatory factor 9 (IRF) forming the transcription factor complex ISGF3, which then translocates to the nucleus and binds to IFN-stimulated response elements (ISREs) in the promoters of IFN-regulated genes (IRGs). (wikipedia.org)
- Studies have shown that all type I IFNs exclusively bind to and signal through ubiquitously expressed heterodimeric transmembrane (TM) receptors composed of two subunits-IFNAR1 and IFNAR2 [ 3 ], which are constitutively associated with tyrosine kinases TYK2 and JAK1/STAT2 (signal transducer and activator of transcription 2), respectively, under normal physiological conditions [ 4 , 5 ]. (scientificarchives.com)
- Although activated TYK2 and JAK1 phosphorylate and activate STAT2, which is a critical early step for STAT1 activation by type I IFN in canonical signaling [ 6 ], the mechanism of STAT2-dependent STAT1 activation after stimulation of type I IFN is poorly understood. (scientificarchives.com)
- Activated STAT1 and STAT2 monomers dimerize and interact with IRF9 (IFN-regulatory factor 9) in the cytoplasm, which is known as the ISGF3 (IFN-stimulated gene (ISG) factor 3) complex [ 1 , 7 ]. (scientificarchives.com)
Tyrosine kinases1
- Two cytoplasmic tyrosine kinases provide downstream signaling after type I IFN binds to the IFNAR receptor, Janus kinase 1 (JAK1) and tyrosine kinase 2 (TYK2). (wikipedia.org)
Interferons1
- A signal transducer and activator of transcription that mediates cellular responses to INTERFERONS . (lookformedical.com)
Canonical1
- In addition, canonical type I IFN signalling may activate STAT1 homodimers that bind to interferon-gamma-activating factor (GAF), which also translocates to the nucleus and activates transcription of IFN-stimulated genes. (wikipedia.org)
Molecules2
- The CNS response is thought to be mediated, at least in part, through intermediate signaling molecules that affect GnRH neuronal activity. (jneurosci.org)
- STAT1 and STAT6 are the key signaling molecules mediating M1 and M2 polarization, respectively. (amegroups.org)
Regulates6
- Using mice with selective deletion of STAT1 in T cells (STAT1 CD4-Cre ), we identified a potentially novel mechanism by which STAT1 regulates neuroinflammation independently of Foxp3 + Tregs. (jci.org)
- Stat1 interacts with P53 TUMOR SUPPRESSOR PROTEIN and regulates expression of GENES involved in growth control and APOPTOSIS . (lookformedical.com)
- Gonadotropin-releasing hormone (GnRH) neurons represent the final common output of signals from the brain that regulates reproductive function. (jneurosci.org)
- RUNX1 belongs to the runt domain family of transcription factors and regulates target gene expression through forming a heterodimeric DNA-binding complex with CBFB. (biolegend.com)
- RUNX1 regulates CD4 gene transcription during multiple stages of T cell development and represses the CD4 gene in CD4-CD8- (double negative) T cells. (biolegend.com)
- To test our hypothesis that histone H4R3 and H3R17 methylation regulates ferritin transcription, H4R3 and H3R17 protein arginine (R) methyltransferases 1 and 4 (PRMT1 and PRMT4) were investigated. (embl.de)
Inflammatory8
- Experimental autoimmune encephalomyelitis (EAE), which serves as an animal model of MS, is also induced by the activation of myelin reactive CD4 + T cells and their subsequent migration in the CNS, where they mediate inflammatory responses, resulting in demyelination and neurodegeneration. (jci.org)
- Biochemical and pharmacological studies revealed that the anti-inflammatory effect of luteolin was accompanied by down-regulation of extracellular signal-regulated kinase (ERK), p38, c-Jun N-terminal kinase (JNK), Akt and Src. (alstuttu.org)
- Anti-inflammatory effects and mechanisms were confirmed by ELISA for interleukin-6 (IL-6) and TNF-alpha, lactate dehydrogenase (LDH) assay, and STAT1 Western blotting. (alstuttu.org)
- Therefore the aim of this study was to determine what if any role STAT1 and related signaling play in inflammatory lesions and disease with contamination. (bio-biz-navi.com)
- Improper induction or regulation of type I IFN signaling can lead to chronic infection-induced inflammation-related diseases, including septic shock, autoimmune diseases, and inflammatory syndromes [ 2 ]. (scientificarchives.com)
- The immunomodulatory property of MSCs is induced or licensed by inflammatory factors such as TNF α , IFN γ , and IL1. (biomedcentral.com)
- Many studies demonstrated that human MSCs stimulated by inflammatory factors TNF α and IFN γ exert their anti-inflammatory effects via IDO, TSG-6, and PGE2. (biomedcentral.com)
- More importantly, these acute activation processes of PI3K-AKT signaling were critical for the production of anti-inflammation factors such as IDO1 and TSG-6 and anti-inflammatory therapeutic effect in the inflammatory bowel disease (IBD) model. (biomedcentral.com)
Proteins4
- PIAS1, but not other PIAS proteins, blocked the DNA binding activity of Stat1 and inhibited Stat1-mediated gene activation in response to interferon. (nih.gov)
- The phosphorylated receptor provides multiple docking sites that recruit STAT proteins, of which there are six family members (STAT1-6) ( Pellegrini and Dusanter-Fourt, 1997 ). (jneurosci.org)
- Transcription factors are proteins that regulate the transcription of genes, or the production of mRNA from DNA. (biolegend.com)
- Results showed that three critical amino acid residues in the STAT1 linker domain (E559, E563 and K567) are located in a homologous sequence pattern which is highly conserved among the seven STAT human proteins. (uni-goettingen.de)
Tumor3
- Luteolin concentration-dependently abolished LPS/IFN-γ-induced NO, tumor necrosis factor α (TNF-α) and interleukin 1β (IL-1β) production as well as inducible nitric oxide synthase (iNOS) protein and mRNA expression. (alstuttu.org)
- In this paper, the potential linkage between these three factors and the possible therapeutic implications of probiotics to modulate T H 17-mediated response for tumor growth will be discussed. (hindawi.com)
- Targeting METTL3 by single-guide RNA, nanoparticle small interfering RNA (siRNA), or pharmacological inhibitor (STM2457) in combination with anti-programmed cell death protein 1 (PD-1) synergized to reinvigorate cytotoxic CD8+ T cells and mediate tumor regression. (bvsalud.org)
Transcriptional3
- An interferon regulatory factor that binds upstream TRANSCRIPTIONAL REGULATORY ELEMENTS in the GENES for INTERFERON-ALPHA and INTERFERON-BETA . (lookformedical.com)
- It functions as a transcriptional activator for the INTERFERON TYPE I genes. (lookformedical.com)
- Effects of EGCG on nuclear factor kappa B (NFκB) and activator protein-1 (AP-1) transcriptional activity were assessed by reporter gene assay. (molvis.org)
KINASE2
- The interferon alpha-beta receptor signals through the action of JANUS KINASES such as the TYK2 KINASE. (lookformedical.com)
- induced immunosuppressive properties of B7-H1 in human BM- and WJ-MSCs were mediated by STAT-1 signaling, and not by PI3K/RAC-a serine/threonine-protein kinase signaling. (korea.ac.kr)
Genes7
- STAT1 is known to regulate several genes which are involved in cell growth, apoptosis, immune responses, and lipid metabolism. (thermofisher.com)
- The virus-induced expression of IFNA/IFNB genes is primarily controlled at the gene transcription level, by the interferon regulatory factors (IRFs) and IFN-stimulated genes. (wikipedia.org)
- The underphosphorylated, active form of Rb interacts directly with E2F1 , leading to cell cycle arrest, while the hyperphosphorylated form decouples from E2F1, thus promoting the transcription of genes promoting entry into the S phase. (biolegend.com)
- Antioxidant genes such as ferritin are transcriptionally activated in oxidative stress via the antioxidant responsive element (ARE), to which nuclear factor-E2-related factor 2 (Nrf2) binds and activates transcription. (embl.de)
- Transcription factor that binds to the interleukin-6 (IL-6)-responsive elements identified in the promoters of various acute-phase protein genes. (lu.se)
- Type I IFN- activated STAT1 can also form a homodimer known as IFNγ-Activated Factor (GAF), which migrates into the nucleus, and binds to IFNγ-Activated Sequences (GAS), to induce proinflammatory genes [ 10 , 11 ]. (scientificarchives.com)
- The higher expression of the STAT1 signature genes (signal transducer and activator of transcription 1), (immunity-related GTPase family M member 1), (colony-stimulating factor 1), (C-C motif chemokine receptorClike 2), (C-C motif chemokine ligand 5), and (C-X-C motif chemokine ligand 9) in B cells from the lungs of infected mice was confirmed by quantitative reverse transcriptaseCpolymerase chain reaction (Figures 1C and 1D). (thetechnoant.info)
Downstream1
- Signal transducer and activator of transcription 1 (STAT1) is a transcription factor that predominantly mediates signaling downstream of IFN-α, IFN-β, IFN-γ, and IFN-λ. (jci.org)
Family of transcription factors2
- STAT1 (signal transducers and activators of transcription 1) is a member of the STAT family of transcription factors. (thermofisher.com)
- A family of transcription factors that share an N-terminal HELIX-TURN-HELIX MOTIF and bind INTERFERON-inducible promoters to control GENE expression . (lookformedical.com)
Molecule in the regulation2
- and report here a role for the Jak2 signaling molecule in the regulation of reproductive development and function in female mice. (jneurosci.org)
- This review is mainly focused on the possible mechanistic roles of the transmembrane Perforin-2 molecule in the regulation of type I IFNinduced signaling. (scientificarchives.com)
Binds1
- Once the transcription factor binds to an enhancer region, this can cause stimulation or repression of gene transcription. (biolegend.com)
Protein5
- Different members of the STAT protein family have distinct functions in cytokine signaling. (nih.gov)
- The encoded protein contains two different binding sites that are known to bind DNA and function as a regulator of gene transcription. (biolegend.com)
- The point mutant K350A in the STAT1 DNA-binding domain did not provide any further information about molecular mechanisms of signal-dependent target gene recognition, since the mutant did not differ from the wild type protein. (uni-goettingen.de)
- The assembly of PRMT6 protein network allowed us to formulate functional hypotheses which led to the discovery of new molecular partners for the architectural transcription factor HMGA1a, a known substrate for PRMT6, and to provide evidences for a modulatory role of HMGA1a on the methyltransferase activity of PRMT6. (embl.de)
- Mechanistically, METTL3 mediates sterol regulatory element-binding protein (SREBP) cleavage-activating protein (SCAP) mRNA m6A to promote its translation, leading to the activation of cholesterol biosynthesis. (bvsalud.org)
Inhibition2
- Apigenin and luteolin modulate microglial activation via inhibition of STAT1-induced CD40 expression. (alstuttu.org)
- In cultured human aortic smooth muscle cells, pharmacologic or genetic activation of AMPK inhibited the signal transducer and activator of transcription-1 (STAT1), while inhibition of AMPK had opposite effects. (diabetesjournals.org)
Induce2
Stimulation3
- During Th1 differentiation, the transcription factor T-bet, which is weakly induced by TCR stimulation, is further upregulated by IFN-γ/STAT1-mediated signaling ( 13 ) and promotes the expression of IL-12Rβ2. (jci.org)
- Biochemical and genetic analysis has demonstrated that Stat1 is essential for gene activation in response to interferon stimulation. (nih.gov)
- Lamina propria T lymphocytes (T-LPL) isolated from the intestine of patients with active CD released interferon (IFN)-γ in response to gluten stimulation, and neutralisation of endogenous IFN-γ prevented the gliadin mediated morphological changes in an ex vivo organ culture of treated CD biopsies. (bmj.com)
Suppresses1
- We conclude that AMPK activation suppresses STAT1 signaling and inhibits vascular inflammation through the upregulation of MKP-1. (diabetesjournals.org)
Cell-mediated4
- The unifying feature of these heterogeneous disorders is impaired cell-mediated immunity against Candida species. (medscape.com)
- Chronic mucocutaneous candidiasis (CMC) is associated with a defect in cell-mediated immunity that may either be limited to Candida antigens or be part of a more general immune abnormality. (medscape.com)
- Interleukin-27 (IL-27) is a key immunosuppressive cytokine that counters T helper 17 (Th17) cell-mediated pathology. (elsevierpure.com)
- CMC is associated with a defect in cell-mediated immunity that may either be limited to Candida antigens or be part of a more general immune abnormality. (medscape.com)
Inflammation3
- BACKGROUND: It is well known that most neurodegenerative diseases are associated with microglia-mediated inflammation. (alstuttu.org)
- Apart from a minor direct effect on the proliferation and survival of cancer cells in other systems [ 15 ], and the recent report on its role in immune evasion via mediating B7-H1 expression on monocytes to suppress cytotoxic T cell activity [ 13 ], the major protumor role of IL-17 in inflammation-associated cancer relies on fostering angiogenesis. (hindawi.com)
- Chronic low-grade inflammation is an important pathogenic factor in the development of type 2 diabetes and cardiovascular diseases ( 1 ). (diabetesjournals.org)
Transduction1
- however both chains are required for signal transduction . (lookformedical.com)
Gene expression1
- The capability of these cells to differentiate depends on the stem cell type, the regulation of gene expression by various transcription factors and interaction with the stem cell niche 1,4 . (biolegend.com)
Promoter2
- Unexpectedly, we found that alisertib disrupted Aurora-A binding with ubiquitin-like with plant homeodomain and ring finger domain 1 (UHRF1), leading to UHRF1 mediated ubiquitination and degradation of DNA methyltransferase 1 (DNMT1), which in turn resulted in demethylation of CpG islands of STAT1 promoter and STAT1 overexpression. (medsci.org)
- It has histone deacetylase activity and represses transcription when tethered to a promoter. (cancerindex.org)
Inhibitor2
- Here, we found that signal transducer and activator of transcription 1 (STAT1) was highly expressed in colorectal cancer (CRC) xenograft mouse models that were resistant to alisertib, an Aurora-A inhibitor. (medsci.org)
- Deletion of AMPKα1 or AMPKα2 resulted in activation of STAT1 and in increases in proinflammatory mediators, both of which were attenuated by administration of STAT1 small interfering RNA or fludarabine, a selective STAT1 inhibitor. (diabetesjournals.org)
Promotes1
- This process was caused by acutely activated PI3K-AKT signaling, which subsequently augments glucose uptake and promotes HKII enzyme activity. (biomedcentral.com)
Role10
- Genetic factors might play a substantial role in the incidence of YEL-AVD. (cdc.gov)
- The transcription factor STAT1 plays a critical role in modulating the differentiation of CD4 + T cells producing IL-17 and GM-CSF, which promote the development of experimental autoimmune encephalomyelitis (EAE), an animal model of multiple sclerosis (MS). The protective role of STAT1 in MS and EAE has been largely attributed to its ability to limit pathogenic Th cells and promote Tregs. (jci.org)
- Further, STAT1 plays an important role in mediating cell viability in response to different cell stimuli and pathogen exposure. (thermofisher.com)
- These results demonstrate an essential role for Jak2 signaling in GnRH neurons for normal reproductive development and fertility in female mice. (jneurosci.org)
- These Nutlin 3b results show that Stat1 plays an important role in controlling bacterial loads but also by unexpectedly providing an undefined mechanism for dampening of the immunopathologic response observed with infection. (bio-biz-navi.com)
- There are many shreds of evidence that suggest that the extrinsic antigens, environmental conditions, and genetic factors play a crucial role in the development of sarcoidosis through an exaggerated immune response. (ijpsr.com)
- Our results suggest a role of acidic pH in the control ofintracellular Leishmania growth early during infection and identify for the first time an unexpected role of Stat1 in natural anti-microbial resistance independent from its function as IFNc-induced signal transducer. (wustl.edu)
- This novel Stat1 function may have important implications to studies of other pathogens, as the acidic phagolysosomal pH plays an important role in antigen processing and the uncoating process of many viruses. (wustl.edu)
- Transcription factors have an important role in the ability of a cell to self-renew and also differentiate into most cell types, also known as pluripotency 1 . (biolegend.com)
- however, its role in antioxidant gene transcription remains elusive. (embl.de)
Lipid1
- Impaired insulin signalling, glucose and lipid homeostasis alter the gene signalling profile in both organs and serum during prediabetic and diabetic conditions [ 9 ]. (springeropen.com)
Ligand1
- We found that IL-27 priming of naive T cells upregulated expression of programmed death ligand 1 (PD-L1) in a signal transducer and activator of transcription 1 (STAT1)-dependent manner. (elsevierpure.com)
Responses3
- Furthermore, network analysis revealed significant DEGs such as ITGAM and STAT1 , which may be necessary for T2DM-TB immune responses. (springeropen.com)
- Our previous research demonstrates that the CD40 signaling is critically involved in microglia-related immune responses in the brain. (alstuttu.org)
- Gene sequencing identified mutations in signal transducer and activator of transcription 1 ( STAT1 ), leading to defective immune responses in type 1 and type 17 helper T cells. (medscape.com)
Mechanisms1
- Since the exact mechanisms of signal dependent target recognition by tyrosine phosphorylated STAT have not yet been thoroughly investigated, directed mutagenesis was used in this study to introduce point mutations in the STAT1 linker and DNA-binding domain. (uni-goettingen.de)
Nuclear1
- Luteolin exerted an inhibitory effect on transcription factor activity including nuclear factor κB (NF-κB), signal transducer and activator of transcription 1 (STAT1) and interferon regulatory factor 1 (IRF-1) in LPS/IFN-γ-activated BV-2 microglial cells. (alstuttu.org)
Interleukin1
Expression2
- To analyse expression of transcription factors which control the Th1 cell commitment in CD. (bmj.com)
- Ikezoe, T. Simultaneous silencing Aurora-A and UHRF1 inhibits colorectal cancer cell growth through regulating expression of DNMT1 and STAT1. (medsci.org)
Knockout1
- Materials and Methods Mice and contamination Six week old 129Sv WT mice and Stat1 knockout (KO) mice (129S6/SvEv-Webster strain was used. (bio-biz-navi.com)