DNA DamageProtein Sorting SignalsDNA RepairComet AssaySignal TransductionAtaxia Telangiectasia Mutated ProteinsCell Cycle ProteinsUltraviolet RaysDNA-Binding ProteinsDeoxyguanosineTumor Suppressor Protein p53Checkpoint Kinase 2Protein-Serine-Threonine KinasesDNA Breaks, Double-StrandedCell CycleOxidative StressApoptosisTumor Suppressor ProteinsDNAMolecular Sequence DataPhosphorylationMutationGamma RaysNuclear ProteinsCell LineHistonesMethyl MethanesulfonateMutagensCell Line, TumorAmino Acid SequenceGenomic InstabilityG2 PhaseCells, CulturedDNA ReplicationCell SurvivalBase SequenceModels, BiologicalReactive Oxygen SpeciesHeLa CellsCell NucleusHydrogen PeroxideDose-Response Relationship, RadiationTime FactorsDNA Repair EnzymesDNA AdductsSaccharomyces cerevisiae ProteinsDNA BreaksPoly(ADP-ribose) PolymerasesRadiation ToleranceSaccharomyces cerevisiaeGenes, cdcCell Cycle CheckpointsFibroblastsProtein KinasesIntracellular Signaling Peptides and ProteinsDNA Breaks, Single-StrandedRad51 RecombinaseDNA GlycosylasesS PhaseMitosisTranscription, GeneticSignal Processing, Computer-AssistedBRCA1 ProteinBlotting, WesternCell AgingGene Expression RegulationTranscription FactorsRNA, MessengerMicronucleus TestsNuclear Localization SignalsProtein Structure, TertiaryAntioxidantsOxidation-ReductionMice, KnockoutRNA, Small InterferingTransfectionChromatinMice, Inbred C57BLHydroxyureaX-RaysDNA-Activated Protein KinaseCell DeathEnzyme ActivationG2 Phase Cell Cycle CheckpointsDose-Response Relationship, DrugAlkylating AgentsRecombinant Fusion ProteinsTumor Cells, CulturedReplication Protein ARecombination, GeneticCell ProliferationRecombinational DNA RepairDNA HelicasesUbiquitinationMicroscopy, FluorescenceProtein BindingRNA InterferencePoly Adenosine Diphosphate RiboseProto-Oncogene Proteins c-mdm2Protein Transport