• The IL20RA receptor is involved in both pro-inflammatory and anti-inflammatory responses, signaling through the JAK-STAT pathway. (wikipedia.org)
  • Receptors made up of IL20RA signal through a JAK-STAT signaling pathway. (wikipedia.org)
  • In this pathway, after a cytokine binds IL20RA and the beta subunit, JAKs linked to intracellular domains of IL20R activate and phosphorylate tyrosine residues found in the longer alpha chains of IL20RA. (wikipedia.org)
  • Impaired insulin signalling was shared by neurovascular unit cells with, additionally, apoptotic pathway changes in astrocytes and dysregulation of advanced glycation end-product signalling in endothelial cells. (biomedcentral.com)
  • Peptides #7 and #2 were identified as having the strongest inhibitory activity on the IL-23 signaling pathway. (rowan.edu)
  • Upon the occupancy of ACE2 by SARS-CoV-2, the increased serum level of free Angiotensin II (Ang II) due to a reduction of ACE2-mediated degradation promotes activation of the NF-kappa B pathway via Ang II type 1 receptor (AT1R), followed by interleukin-6 (IL-6) production. (kegg.jp)
  • In Cell biology, John W. Regan works on issues like EP4 Receptor, which are connected to CREB and MAPK/ERK pathway. (research.com)
  • IL20RA, along with the IL-20 receptor, beta subunit, form the heterodimeric interleukin-20 receptor, which binds the cytokines IL-19, IL-20 and IL-24. (wikipedia.org)
  • The activation of a resting helper T cell causes it to release cytokines and other stimulatory signals (green arrows) that stimulate the activity of macrophages , killer T cells and B cells , the latter producing antibodies . (wikidoc.org)
  • In addition, the signaling beta and gamma chains are shared by other cytokines (e.g. (unideb.hu)
  • As is the case with many other cytokines, the functional high-affinity receptor for IL-5 is a complex consisting of a ligand binding subunit ( alpha chain) and a second subunit ( beta chain) that can modulate the ligand binding affinity of the receptor complex. (rndsystems.com)
  • The beta chain does not bind any of the cytokines in question but is indispensable for the cytokine-mediated signaling. (rndsystems.com)
  • Interleukin-12 (IL-12) and interleukin-23 (IL-23), which belong to the IL-12 family of cytokines, have a key role in intestinal homeostasis and inflammation and are implicated in the pathogenesis of inflammatory bowel disease. (nature.com)
  • Its biological activities are shared by IL-6-family of cytokines such as leukemia inhibitory factor and oncostatin M. IL-6 exerts its biological activities through interaction with specific receptors expressed on the surface of target cells. (sbhsciences.com)
  • Interleukin (IL)-12 and IL-23, cytokines induced during early stages of IBD, play important roles in differentiation of interferon (IFN)-γ/tumor necrosis factor (TNF)-producing Th1 cells as well as IL-17-producing Th17 cells. (frontiersin.org)
  • In addition to the cDNA clone encoding the full-length transmembrane protein, cDNA clones that arise from alternative splicing and that encode soluble secreted forms of IL-5 R alpha have been isolated from mouse as well as human cells. (rndsystems.com)
  • A naturally-occurring soluble form of the IL-5 R alpha has been detected in biological fluids of autoimmune-prone mice and mice bearing chronic B cell leukemia (BCL 1 ). (rndsystems.com)
  • A recombinant human IL-5 soluble receptor alpha has been shown to bind the human IL-5 dimer in a 1:1 ratio and acts as a human -IL-5 antagonist. (rndsystems.com)
  • Such treatment was associated with upregulation of invasion- and inflammation-promoting soluble factors, such as matrix metalloproteinase 2 (MMP2), its activator MMP14, tissue inhibitors of matrix metalloproteinase 2 (TIMP2), chemokine ligand 2 (CCL2), and urokinase-type plasminogen activator (uPA), the latter two being linked to the recruitment of the monocytic cells. (biomedcentral.com)
  • Interestingly, the association of IL-6 with the soluble form of IL-6R alpha is capable of eliciting a biological response in cells that express only the membrane gp130. (sbhsciences.com)
  • Increased serum level of soluble interleukin-2 receptor is associated with a worse response of metastatic clear cell renal cell carcinoma to interferon alpha and sequential VEGF-targeting therapy. (cusabio.com)
  • A low affinity interleukin-5 receptor subunit that combines with the CYTOKINE RECEPTOR COMMON BETA SUBUNIT to form a high affinity receptor for INTERLEUKIN-5. (harvard.edu)
  • The 55 kDa IL-2 R alpha is specific for IL-2 and binds with low affinity. (rndsystems.com)
  • The 75 kDa IL-2 R beta, which is also a component of the IL-15 receptor, binds IL-2 with intermediate affinity. (rndsystems.com)
  • Rafts may promote rapid formation of a high affinity IL-2R complex, even at low levels of IL-2 stimulus, and may also form a platform for the regulation of IL-2 induced signals by GPI-proteins (e.g. (unideb.hu)
  • IL-2R has a high binding affinity to IL-2 and is expressed by antigen-activated T lymphocytes (T cells). (transcriptionfactor.org)
  • In the case of IL-5, the beta subunit is shared with the high affinity receptor complexes for IL-3 and GM-CSF. (rndsystems.com)
  • cDNA clones for the alpha chain (IL-5 R alpha ) of both the mouse and human high affinity IL-5 receptor complexes have been isolated. (rndsystems.com)
  • The low affinity form is a monomer of the alpha subunit and is not involved in signal transduction. (cancer-genetics.org)
  • The intermediate affinity form consists of an alpha/beta subunit heterodimer, while the high affinity form consists of an alpha/beta/gamma subunit heterotrimer. (cancer-genetics.org)
  • Both the intermediate and high affinity forms of the receptor are involved in receptor-mediated endocytosis and transduction of mitogenic signals from interleukin 2. (cancer-genetics.org)
  • Il-2R exist in 3 different forms: a high affinity dimer, an intermediate affinity monomer (beta chain), and a low affinity monomer (alpha chain). (lu.se)
  • Interleukin 15 (IL-15RA) is a cytokine receptor that specifically binds IL-15 with high affinity. (thermofisher.com)
  • The IL-15 and IL-2 receptors share two subunits, IL-2R beta and IL-2R gamma, and IL-15RA is structurally related to IL-2RA, an additional IL-2-specific alpha subunit necessary for high affinity IL-2 binding. (thermofisher.com)
  • Unlike IL-2RA, IL-15RA is capable of binding IL-15 with high affinity independent of the other subunits. (thermofisher.com)
  • IL20RA also forms a complex with the IL-10 receptor, beta subunit, which binds the cytokine IL-26. (wikipedia.org)
  • The specific genes expressed are dependent on the specific JAK, STAT, as well as by SOCS proteins, which can inhibit the JAK-STAT signal, regulating it.where the transcription factor STAT3 binds to IL20RA and STAT3 becomes activated. (wikipedia.org)
  • Interleukin-2 receptor (IL-2R) is a heterotrimeric protein expressed on the surface of certain immune cells, such as lymphocytes, that binds and responds to the cytokine IL-2. (transcriptionfactor.org)
  • The p40 is also part of IL-12 and binds to the IL-12 receptor beta 1 (IL-12Rβ1) subunit. (rowan.edu)
  • Upon ligand binding, signal transduction is performed by both IL-2 R beta and gamma c. (rndsystems.com)
  • Programmed death ligand 1 (PD-L1), a mediator of the PD-1 receptor, plays an inhibitory role in cancer immune responses. (cancer-genetics.org)
  • The receptors are responsive to one or more B7 ANTIGENS found on ANTIGEN-PRESENTING CELLS and, depending upon the specific ligand-receptor combination, modulate a variety of T-cell functions such as the rate of clonal expansion, CELL SURVIVAL and cytokine production. (edu.au)
  • Many members of this class of receptors occur in the cytoplasm and are transported to the CELL NUCLEUS upon ligand-binding where they signal via DNA-binding and transcription regulation. (edu.au)
  • The interleukin 2 receptor, which is involved in T cell-mediated immune responses, is present in 3 forms with respect to ability to bind interleukin 2. (cancer-genetics.org)
  • Natural killer cell stimulatory factor (interleukin 12 [IL-12]) induces T helper type 1 (T h 1)-specific immune responses and inhibits the development of IL-4-producing Th cells. (nature.com)
  • Interleukin-6 (IL-6) is a multifunctional cytokine that regulates pleiotropic roles in immune regulation, inflammation, hematopoiesis, and oncogenesis. (sbhsciences.com)
  • This type of activation, called "trans-signalling", renders virtually all cells capable of responding to IL-6/sIL-6R alpha complexes, making for a large new spectrum of IL-6 activities, ranging from the control of the immune response to involvement in pathological states. (sbhsciences.com)
  • The receptor is involved in the regulation of immune tolerance by controlling regulatory T cells (TREGs) activity. (cusabio.com)
  • His G protein-coupled receptor research is multidisciplinary, incorporating perspectives in PELP-1 and Immune receptor. (research.com)
  • Brinkman et al5 examined whether the presence and foods.1,2 However, much less is known about the poten- severity of AD was predictive of the occurrence and mag- tial influence that skin challenges have on the systemic nitude of early and late asthmatic responses to inhaled immune response, in particular whether sensitization allergens. (cdc.gov)
  • Here we show, in four cell lines of human adult T cell lymphoma/leukemia origin, that the three IL-2R subunits are compartmented together with HLA glycoproteins and CD48 molecules in the plasma membrane, by means of fluorescence resonance energy transfer (FRET), confocal microscopy and immuno-biochemical techniques. (unideb.hu)
  • Depletion of membrane cholesterol using methyl-beta-cyclodextrin substantially reduced co-clustering of CD25 with CD48 and HLA-DR, as well as the IL-2 stimulated tyrosine-phosphorylation of STATs (signal transducer and activator of transcription). (unideb.hu)
  • The protein encoded by this gene represents the beta subunit and is a type I membrane protein. (cancer-genetics.org)
  • They bind to extracellular signaling molecules that migrate through or are transported across the CELL MEMBRANE. (edu.au)
  • ATP synthase membrane subunit c locus 1. (gsea-msigdb.org)
  • brain abundant membrane attached signal. (gsea-msigdb.org)
  • IL23 is the Janus mitochondria JAK2 and TYK2, rotting in membrane of the combination senescence, which is the being enzymes for Signal efficiency and water of library 3( STAT3) and STAT4 to be and be Prolonged. (evakoch.com)
  • The heparan Golgi-resident selenide receptors in interconnectivity a state of interactions that are to mitochondrial influx membrane used by the irreversible expression( HA) response, and the sustained polypeptide of the archival distinct knot km2 into the tail of the complex dementia. (evakoch.com)
  • The interleukin 20 receptor is a heterodimeric complex consisting of the encoded protein and interleukin 20 receptor beta. (nih.gov)
  • IL-23 is a heterodimeric protein, composed of a p19 alpha chain and a p40 beta chain. (rowan.edu)
  • Changes in cortical neurones included alterations in insulin and other signalling pathways, cell cycle, cellular senescence, inflammatory mediators, and components of the mitochondrial respiratory electron transport chain. (biomedcentral.com)
  • Cancer cell biology takes advantage of identifying diverse cellular signaling pathways that are disrupted in cancer. (eurekaselect.com)
  • Signaling pathways are an important means of communication from the exterior of cell to intracellular mediators, as well as intracellular interactions that govern diverse cellular processes. (eurekaselect.com)
  • Unraveling of dysregulated signaling pathways may advance the understanding of tumor pathophysiology and lead to the improvement of targeted tumor therapy. (eurekaselect.com)
  • In this review article, different signaling pathways and how their dysregulation contributes to the development of tumors have been discussed. (eurekaselect.com)
  • Enzymes and receptors of prostaglandin pathways with arachidonic acid-derived versus eicosapentaenoic acid-derived substrates and products. (research.com)
  • Seder, R. A., Gazzinelli, R., Sher, A. & Paul, W. E. Interleukin 12 acts directly on CD4+ T cells to enhance priming for interferon gamma production and diminishes interleukin 4 inhibition of such priming. (nature.com)
  • Included under this heading are signaling receptors, non-signaling receptors and accessory proteins required for receptor signaling. (edu.au)
  • In contrast, nonpathogenic SIVagm infection induced DNA methylation in genes coding for regulatory proteins such as LAG-3, arginase-2, interleukin-21 and interleukin-31. (biomedcentral.com)
  • variety + an N- proteins are possible and in channels, 2 suppressors do involved, NAT1 and NAT2. (evakoch.com)
  • Human and mouse IL-5 R alpha are both members of the hematopoietin receptor superfamily characterized by the presence of the WSXWS, and a four cysteine residue motif in the extracellular domain of the transmembrane protein. (rndsystems.com)
  • Interleukin-7 receptor (IL7R) ,is a hematopoietin receptor superfamily member. (prospecbio.com)
  • The activation of T cells is typically accompanied by inhibitory mechanisms within which the programmed cell death (PD1) receptor stands out. (bvsalud.org)
  • Peptide #2-Fc and its unmodified counterpart, Peptide #2, were tested and compared using cell-free and cell-based systems to ensure minimal loss of inhibitory activity upon fusion. (rowan.edu)
  • EP(4) prostanoid receptor coupling to a pertussis toxin-sensitive inhibitory G protein. (research.com)
  • Oncogenic mutations or abnormal expression of signaling components disrupt the regulatory networks that govern cell function, thus enabling tumor cells to undergo dysregulated mitogenesis, to resist apoptosis, and to promote invasion to neighboring tissues. (eurekaselect.com)
  • Data show that interleukin-2 receptor alpha, tumor necrosis factor receptor 1, serum STimulation-2 (IL1RL1 gene product), and regenerating islet-derived 3-alpha were significantly associated with non-relapse mortality. (cusabio.com)
  • signal transducer and activator of. (wikigenes.org)
  • Interleukin (IL)-12, which is secreted by antigen-presenting cells, acts via signal transducer and activator of transcription (STAT)4 to promote the differentiation of naïve T cells into Th1 cells ( 9 - 11 ). (frontiersin.org)
  • This gene encodes a member of the type II cytokine receptor family. (nih.gov)
  • MbIL-15 on the target did not interfere with resting NK cell activation and target cell cytolysis but rescued NK cells from IL-2 starvation-induced apoptosis through contact-dependent interaction. (nih.gov)
  • CD80/86-CD28 interaction and others), these signals initiate a program of cell division and differentiation. (frontiersin.org)
  • The receptor for IL-2 consists of three subunits that are present on the cell surface in varying preformed complexes (5-7). (rndsystems.com)
  • Upon binding of IL-6 to the receptor (alpha subunit), gp130 is homodimerized and is subsequently involved in down-stream signal processes binding tyrosine kinases and activating STAT1 and STAT3 transcriptional factors. (sbhsciences.com)
  • This protein has been shown to bind tyrosine kinase TYK2, and thus may mediate the signaling processes that lead to the activation of JAK1, STAT3 and STAT6 induced by IL13 and IL4. (thermofisher.com)
  • Subunits (alpha, beta and gamma) of the interleukin-2 receptor complex (IL-2R) are involved in both proliferative and activation-induced cell death (AICD) signaling of T cells. (unideb.hu)
  • These data indicate a GPI-microdomain (raft)-assisted recruitment of CD25 to the vicinity of the signaling beta and gamma(c) chains. (unideb.hu)
  • This gene and interleukin 20 receptor beta are highly expressed in skin, and are upregulated in psoriasis. (nih.gov)
  • The IL-2R is made up of 3 subunits - alpha (α), beta (β) and gamma (γ). (transcriptionfactor.org)
  • Non covalent dimer of an alpha and a beta chains. (lu.se)
  • The encoded protein is a subunit of the receptor for interleukin 20, a cytokine that may be involved in epidermal function. (nih.gov)
  • Nasal insufflation of IL-11 causes AHR in wild-type mice while lung inflammation induced by antigen sensitization and challenge, which mimics features of atopic asthma in humans, is attenuated in mice genetically deficient in IL-11 receptor subunit alpha-1 (IL-11Ra1-deficient mice), a transmembrane receptor that is required along with glycoprotein 130 to transduce IL-11 intracellular signaling. (cdc.gov)
  • IL-6 Receptor (IL-6R, gp80) is 80 kDa alpha subunit, transmembrane glycoprotein that is 449 aa long. (sbhsciences.com)
  • IL20RA is an alpha-chain with a long intracellular domain. (wikipedia.org)
  • Intracellular receptors that can be found in the cytoplasm or in the nucleus. (edu.au)
  • IL-2 is expressed by CD4+ and CD8+ T cells, gamma δ T cells, B cells, dendritic cells, and eosinophils (1-3). (rndsystems.com)
  • The 64 kDa common gamma chain gamma c/IL-2 R gamma, which is shared with the receptors for IL-4, -7, -9, -15, and -21, does not independently interact with IL-2. (rndsystems.com)
  • IL-7 (interleukin-7) is a 25 kDa cytokine of the hemopoietin family that plays important roles in lymphocyte differentiation, proliferation, and survival (1-4). (bio-techne.com)
  • STAT4 also signals activation of the TF T-bet, a lineage-defining factor for Th1 differentiation, which upregulates the IL-12 receptor, IFN-γ expression, and causes further expansion of Th1 cells (Figure 1 ) ( 12 ). (frontiersin.org)
  • Thus, it follows that the IL-23 receptor is comprised of the IL-12Rβ1 and IL-23 receptor alpha (IL23Rα) subunits. (rowan.edu)
  • This work generated a Peptide #2-Fc fusion protein with the capability to bind the IL23Rα chain and thus block IL-23 binding and inhibit subsequent signaling, as well an increased serum half-life over the original Peptide #2. (rowan.edu)
  • The viral download Ethos Of Pluralization for IL23 is of Interleukin-12 electron production mutation( IL12RB1), which plays reviewed with the Humanitarian inactivation, and Interleukin-23 fraction( IL23R). (evakoch.com)
  • The protein encoded by this gene is a subunit of the interleukin 13 receptor. (thermofisher.com)
  • His Molecular biology research integrates issues from Alpha, Gene expression, Complementary DNA, Protein kinase C and Gene isoform. (research.com)
  • Recombinant Interleukin-2 (IL-2) is expressed in E. coli and has been engineered to contain the serine for cysteine substitution found in Proleukin ® (aldesleukin). (rndsystems.com)
  • Recombinant IL-2 is widely used in cell culture for the expansion of T cells. (rndsystems.com)
  • In the presence of 1 ng/ml of recombinant IL-2, ED50 for this effect is (transcriptionfactor.org)
  • SARS-CoV-2 Mutant (L452R, T478K)Alternates names: N/ATaglines: Recombinant Spike RBD mutant of the SARS-CoV-2. (transcriptionfactor.org)
  • Intact mass analysis of recombinant human IL-2 confirms the predicted molecular mass of 15549 Da. (bio-techne.com)
  • Recombinant Human IL-2 GMP Protein Bioactivity GMP-grade Recombinant Human IL-2 (Catalog # 202-GMP) stimulates cell proliferation of the CTLL‑2 mouse cytotoxic T cell line. (bio-techne.com)
  • Recombinant Human IL-2 GMP Protein SDS-PAGE 1 μg/lane of GMP-grade Recombinant Human IL-2 (Catalog # 202-GMP) was resolved with SDS-PAGE under reducing (R) conditions and visualized by silver staining, showing a single band at 13 kDa. (bio-techne.com)
  • Equivalent Bioactivity of GMP and Animal-Free grades of Recombinant Human IL-2 Equivalent bioactivity of GMP (Catalog # 202-GMP) and Animal-Free ( AFL202 ) grades of Recombinant Human IL-2 as measured in a cell proliferation assay using CTLL 2 mouse cytotoxic T cells (orange and green, respectively). (bio-techne.com)
  • Recombinant Human IL-2 GMP Protein Mass Spectrometry MALDI-TOF analysis of GMP-grade Recombinant Human IL-2 (Catalog # 202-GMP). (bio-techne.com)
  • Upon their secretion by antigen-presenting cells, they exert both pro-inflammatory and anti-inflammatory receptor-mediated effects. (nature.com)
  • T helper cells recognize antigen presented in the context of major histocompatibility complex II on antigen-presenting cells in a T cell receptor-dependent fashion (not shown). (frontiersin.org)
  • Due to their role as major hemoglobinases, FP-2 and FP-3 have been targeted in studies aiming to discover new antimalarials and numerous inhibitors with activity against these enzymes, and parasites in culture have been identified. (bvsalud.org)
  • In this article, we have reviewed key functional and structural properties of FP-2/3 and described different compound series reported as inhibitors of these proteases during decades of active research in the field. (bvsalud.org)
  • Finally, we provide guidelines that, in our understanding, will help advance the rational discovery of new FP-2/3 inhibitors. (bvsalud.org)
  • chain that inhibits cytokine signaling and exacerbates inflammation. (harvard.edu)
  • Dysregulation of mTOR signaling in fragile X syndrome. (colorado.edu)
  • His study of G protein-coupled receptor is a part of Receptor. (research.com)
  • Like all T cells, they express the T cell receptor / CD3 complex. (wikidoc.org)
  • The T cell receptor (TcR) consists of both constant and variable regions, the latter of which determines what antigen the T cell can respond to. (wikidoc.org)
  • PBMC stimulated with 1 μg/mL of aCD3 and 3 ug/ml of aCD28 for 2 days were treated with Tocris cell activation cocktail 500x (Catalog # 5476 ) and Brefeldin A (Catalog # 1231/5 ) for 3 hours or naïve PBMC lymphocytes. (rndsystems.com)
  • Furthermore, we show that MbIL-15 from renal cell carcinoma cells is functional and involved in rapid nuclear translocation of phosphorylated signal transducers and activators of transcription 3 in IL-2-starved NK cells. (nih.gov)
  • However, the molecular mechanisms responsible for recruiting/sorting the alpha chains to the signaling chains at the cell surface are not clear. (unideb.hu)
  • Interleukin 5, produced primarily by activated T cells and mast cells, has diverse biological effects on a variety of cell types. (rndsystems.com)
  • The multiple effects of IL-5 are mediated by binding of the cytokine to specific cell surface receptors expressed on target cells. (rndsystems.com)
  • Cell surface receptors that are specific for INTERLEUKIN-1. (edu.au)
  • Immunobiology of natural killer cell receptors / E. Vivier and M. Colonna (eds. (edu.au)
  • A family of receptors that modulate the activation of T-LYMPHOCYTES by the T-CELL ANTIGEN RECEPTOR. (edu.au)
  • IL-15RA is thought to enhance cell proliferation and expression of apoptosis inhibitor Bcl-xL and Bcl-2. (thermofisher.com)
  • A single E.coli bacterium contains ~2 million LPS molecules (2 - 20 fg/cell). (transcriptionfactor.org)
  • They can be subdivided based on such as age of onset, presence of allergy (skin prick test or systemic allergen specific immunoglobulin E (IgE)), with or without nasal polyps and/or T helper (Th) cell 2 prominent inflammation. (encyclopedia.pub)
  • Note: Certain human cell lines or cell types (e.g., neutrophils, monocytes) can first be treated with reagents that block receptors for the Fc regions of immunoglobulin to avoid nonspecific immunofluorescent staining mediated by Fc receptors. (bdbiosciences.com)
  • In these studies, CD4 + T cell-depleting and blocking antibodies caused remission from disease in a number of CD and UC patients examined, suggesting a prominent role of CD4 + T cells in propagating disease ( 1 , 2 ). (frontiersin.org)
  • IL7R protein signaling is vital for T-cell development and regulation of native and memory T-cell homeostasis. (prospecbio.com)
  • Deregulation of cell signaling in cancer. (eurekaselect.com)
  • Cell signaling and cancer. (eurekaselect.com)
  • Measured in a cell proliferation assay using CTLL‑2 mouse cytotoxic T cells. (bio-techne.com)
  • His primary scientific interests are in Receptor, Biochemistry, Molecular biology, Prostaglandin E2 receptor and Cell biology. (research.com)
  • The scientist's investigation covers issues in Receptor, Biochemistry, Cell biology, Molecular biology and Endocrinology. (research.com)
  • The various areas that John W. Regan examines in his Cell biology study include HEK 293 cells, Downregulation and upregulation and EP4 Receptor. (research.com)
  • Here, we designed three d-GLP-2 agonists that activated the glucagon-like peptide-2 receptor (GLP-2R) cyclic adenosine monophosphate (cAMP) accumulation without stimulating the glucagon-like peptide-1 receptor (GLP-1R). (bvsalud.org)
  • Human IL‑7 cDNA encodes 177 amino acids (aa) that include a 25 aa signal peptide (3). (bio-techne.com)
  • With the histone of synthesis, the signaling glutamate is to introduce released well nuclear after protein. (evakoch.com)
  • Fig. 1: Cellular sources, target cells, signalling and downstream effects of IL-12. (nature.com)
  • The mitogen-activated protein kinase homolog, WNK lysine deficient protein kinase 1 (WNK1), is activated downstream of epidermal growth factor receptor during decidualization. (bioone.org)
  • Detects human IL-2 in direct ELISA. (rndsystems.com)
  • Mature human IL-2 shares 56% and 66% amino acid (aa) sequence identity with mouse and rat IL-2, respectively. (rndsystems.com)
  • Human and mouse IL-2 exhibit cross-species activity (4). (rndsystems.com)
  • During the intraerythrocytic stage in the human hosts, malaria parasites multiply and degrade hemoglobin (Hb) using a battery of proteases, which include two cysteine proteases, falcipains 2 and 3 (FP-2 and FP-3). (bvsalud.org)
  • Detects human IL‑5 R alpha /CD125 in direct ELISAs. (rndsystems.com)
  • 5.0 x 10 6 IU/mg, which is calibrated against the human IL-2 WHO International Standard (NIBSC code: 86/500). (bio-techne.com)