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  • ferric enterobactin
  • Despite its unfolded state, the isolated domain binds ferric enterobactin, the siderophore ligand of FepA, with an affinity of 5 μM, just 100-fold reduced from that of intact FepA. (pnas.org)
  • One such pathway that is used by Escherichia coli involves uptake of a siderophore, ferric enterobactin (Fe-ent), by a series of gene products from the Fep operon. (pnas.org)
  • Fungi
  • Furthermore, most fungi utilize intracellular siderophores as an iron storage compound. (rupress.org)
  • van der Helm, D. and Winkelmann, G. (1994) Hydroxamates and Polycarboxylates as Iron Transport Agents (Siderophores) in Fungi. (scirp.org)
  • other members of this receptor family in E. coli include FhuA, which imports ferrichrome, a siderophore secreted by fungi, and BtuB, which imports vitamin B. Most of the receptors are also used as the recognition and entry points for different colicins and bacteriophage, often in a way that requires the action of TonB. (pnas.org)
  • fungal
  • Combined with the absence of a sidA ortholog-and the fungal siderophore system in general-in mammals, these data demonstrate that the siderophore biosynthetic pathway represents a promising new target for the development of antifungal therapies. (nih.gov)
  • receptor
  • Previous animal studies revealed that vaccination with siderophore receptor proteins protects against UTI. (pnas.org)
  • Experimental infections of salmonid fishes with mixtures consisting of the wild-type strain and a siderophore-deficient, receptor-proficient mutant resulted in recovery of both the wild-type and the mutant strain, while in infections with mixtures consisting of the wild-type strain and a siderophore-deficient, receptor-deficient mutant only the wild-type strain could be recovered. (nih.gov)
  • Siderophore transport through Escherichia coli outer membrane receptor FhuA with disulfide-tethered cork and barrel domains. (semanticscholar.org)
  • TonB-dependent receptors compete for a limited number of TonB molecules ( 7 ), suggesting that the TonB molecule recognizes a change in the receptor conformation at the inner side of the membrane on siderophore binding. (pnas.org)
  • Transport of iron into the cell cytosol is mediated by specific membrane receptor and transport systems which recognize the iron-siderophore complexes. (asm.org)
  • Vibrio
  • Evidence for the role of a siderophore in promoting Vibrio anguillarum infections. (nih.gov)
  • We report that Vibrio harveyi uses a "two-for-one," QS- and Fe-repressed gene cluster to produce cell-associated siderophores at low cell density and accumulate soluble siderophores at high cell density. (pnas.org)
  • We investigated the link between QS, siderophores, and Fe uptake in the model marine organism Vibrio harveyi where QS is thought to repress siderophore production. (pnas.org)
  • Aspergillus
  • The researchers will discuss the use of rabiolabeled siderophores in the detection of Aspergillus fumigatus, a fungus that causes the life-threatening infection invasive aspergillosis (IA). (bruker.com)
  • small molecules
  • Here, we report an immunization approach that targets siderophores, which are small molecules exported by enteric Gram-negative pathogens to acquire iron, an essential nutrient, in the host. (universia.net)
  • FepA
  • Schematic diagram illustrating critical steps in the transport cycle of siderophores by FepA or other TonB-dependent receptors, including two possible ways to open a large transmembrane channel. (pnas.org)
  • production
  • Its siderophore production was inhibited by FeCl3, especially when FeCl3 concentration was higher than 20 μM. (genscript.com)
  • We propose that cell-associated and soluble siderophores are beneficial to V. harveyi in different environmental and growth contexts and that QS allows V. harveyi to exploit "knowledge" of its population size to avoid unnecessary siderophore production. (pnas.org)
  • Several desferrioxamine siderophores including desferrioxamines G1, G1t, X3, X7, D2, and E were isolated from low-iron, culture supernatant and structurally characterized by ESI-MS and ESI- MS/MS. This work represents the first documentation of ferrioxamine production by a haloalkaliphilic bacterium. (openthesis.org)
  • v The fourth part of this dissertation is an assessment of siderophore production in a naturally saline and alkaline environment, the soda lake Soap Lake, located in eastern Washington State, USA. (openthesis.org)
  • Indeed specific siderophore production was not found to be critical for phytopathogenesis of the basidiomycete Ustilago maydis ( 16 ). (rupress.org)
  • inhibit
  • In the study, S. maltophilia 15 showed algicidal activities by secreting siderophore and could inhibit cyanobacterial growth, especially when iron bioavailabity is very low. (genscript.com)
  • Collectively, our results demonstrate that anti-siderophore antibodies inhibit Salmonella colonization. (universia.net)
  • diffusible
  • In line with evolutionary theory, we found that highly diffusible siderophores have preferentially evolved in species living in structured habitats, such as soil and hosts, because struc-turing can keep producers and their shareable goods together. (uzh.ch)
  • Poorly diffusible siderophores, meanwhile, have preferentially evolved in species living in unstructured habitats, such as seawater, indicating that these metabolites are less shareable and more likely provide direct benefits to the producers. (uzh.ch)
  • binds
  • It can be seen in crystal structures of the related FhuA protein bound to its siderophore ( 8 , 9 ) that the siderophore binds to sites where it contacts some of the outer loops as well as several residues from the N-terminal plug domain. (pnas.org)
  • targeted in vivo
  • The researchers will also describe how attaching two arginine-glycine-aspartic acid (RGD) and minigastrin peptides to the 68Ga-labelled siderophore fusarinine C, enables targeted in vivo imaging of tumors in animal models. (bruker.com)
  • FhuA
  • Crystal structures of FhuA with and without its siderophore bound show very little change near the binding site but large changes at the N terminus of the protein, 30 Å away on the inner face of the membrane. (pnas.org)
  • Halomonas
  • Two new members of the aquachelin family of siderophores, aquachelins I and J, which have an hydroxylated C12 fatty acid and a saturated C10 fatty acid, respectively, were produced by Halomonas meridiana str. (nih.gov)
  • The third part of this dissertation involves the identification and characterization of siderophores produced by the halophilic and alkaliphilic bacterium Halomonas campisalis. (openthesis.org)