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  • ischemia
  • The hypoxic, acidotic, and hyperosmolar environment of the inner medulla are known to promote sickling of red blood cells (RBCs) with resultant impairment in renal medullary blood flow, ischemia, microinfarction, and papillary necrosis. (medscape.com)
  • The underlying mechanisms of renal injury or sickle cell nephropathy (SCN) relate mainly to hypoxia and ischemia. (medscape.com)
  • RBC sickling and congestion in the vasa recta leads to ischemia and associated impairment of solute reabsorption by the ascending limb of the loop of Henle and impairs urinary concentrating ability. (medscape.com)
  • inhibit
  • Although substances present in serum may inhibit leucocyte migration, 5, 8 the exact nature of the mechanisms leading to impaired function of these cells is still largely unknown. (bmj.com)
  • severe
  • The low oxygen tension or relatively hypoxic, hypertonic, and acidotic environment of the inner medulla predisposes RBCs in the vasa recta to sickle, particularly in the settings of severe intravascular volume depletion. (medscape.com)
  • infection
  • In contrast, as dis- a secondary gain from continuing ing infection in the etiology adhesive side down and fills a pot because hypnos came from within, not from you as parents. (wellchild.org)
  • Intervention
  • Adaptive intervention design in mobile health: Intervention design and development in the Cell Phone Intervention for You trial. (duke.edu)
  • adult
  • The only known cure for SCD involves adult stem cells, either from a bone marrow or from an umbilical cord blood transplant. (baltimoresun.com)
  • density
  • Design and Methods Cold-induced changes in cell volume were monitored using ektacytometry and density gradient centrifugation. (haematologica.org)
  • tissue
  • BRANCHED CHAIN Amino Acids are essential for your body to make more cells and hence more body tissue and protein. (wordpress.com)
  • pain
  • The computerized tools could lead to improved pain relief said Di. (bio-medicine.org)
  • The computerized tools could lead to improved pain relief, said Diana Wilkie, professor of medical-surgical nursing, who along with UIC research specialist Shiping Zong and eNURSING IIc founder and president M. Kay Judge, developed the computer program. (bio-medicine.org)
  • Sickle cell-related pain, however, can be partially or totally relieved through deliberate use of medications and learned behavioral interventions, such as patient education. (bio-medicine.org)
  • The sickle cell pain management process is complex and often requires more time than is available during a typical doctor's appointment," Wilkie said. (bio-medicine.org)
  • Managing sickle cell pain requires new strategies. (bio-medicine.org)
  • METHODS
  • METHODS A retrospective review of laboratory and follow up records to establish workload and costs, and estimation of costs in a range of circumstances was made in a haematology department and sickle cell and thalassaemia centre, providing antenatal and neonatal screening programmes in Inner London. (bmj.com)
  • blood cell
  • The XN-30 analyzer allowed not only the detection of iRBCs but also the monitoring of RBC, white blood cell, and platelet counts, as well as haematocrit, mean corpuscular volume and mean platelet volume values in the mouse blood sample. (springer.com)