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  • membrane
  • The haemagglutinin region of HEF is responsible for receptor recognition and membrane fusion, and bears a strong resemblance to the sialic acid-binding haemagglutinin found in influenza A and B viruses, except that it binds 9-O-acetylsialic acid. (wikipedia.org)
  • form
  • In contrast to glycerolipids, the lipid anchor in sphingolipids builds on the long-chain amino alcohol sphingosine, which is coupled via its amino group to a fatty acid to form ceramide (Figure 1 ). (frontiersin.org)
  • synthesis
  • The present inventors have further found that even a tetraantennary N-type sugar chain having four α2,6-linked sialic acid molecules, which has previously been difficult to synthesize, can be prepared at high yields by one-pot synthesis comprising the elongation reaction of a biantennary sugar chain used as a starting material without performing purification after each enzymatic reaction. (freepatentsonline.com)
  • CMP substitutions preferentially inhibit polysialic acid synthesis. (freepatentsonline.com)
  • These enzymes can be used for chemoenzymatic synthesis of sialic acid derivatives. (wikipedia.org)
  • As a mild, selective synthesis, the Petasis reaction is useful in generating α-amino acids, and is utilized in combinatorial chemistry and drug discovery. (wikipedia.org)
  • Subsequently, the boronic acid is added to the mixture and product is generated, either after 30 minutes at 90 °C, or after several hours at 25 °C. In α-amino acid synthesis, α-keto acids, such as glyoxylic and pyruvic acid, are stirred in ethanol, toluene, or dichloromethane with amines and vinyl boronic acids at 25-50 °C for 12-48 h to give the corresponding β,γ-unsaturated compounds. (wikipedia.org)
  • galactose
  • In the example shown below, sialic acid is linked to the sugar galactose by what is called an alpha(2,3) linkage. (virology.ws)
  • This means that the carbon atom at position number 2 of the sialic acid hexose is joined, via an oxygen atom, to the carbon at position 3 of the hexose of galactose. (virology.ws)
  • In addition, kelch repeats have been recognised in alpha- and beta-scruin, in galactose oxidase from the fungus Dactylium dendroides and in the Escherichia coli NanM protein, that is a sialic acid mutarotase. (wikipedia.org)
  • serum
  • Our sialic acid analysis helps you to determine the identities and quantities of the sialic acid species present in your biopharmaceutical product, an important analysis since sialic acid content may influence serum half-life. (sgs.com)
  • The present study measured sialic acid levels in pleural effusion and serum samples of patients with malignant and nonmalignant diseases to discriminate each other, and to diagnose malignant effusion in a simple, cheap and reliable way. (biomedsearch.com)
  • Pleural fluid and serum levels of sialic acid were significantly higher in malignant group compared to nonmalignant one. (biomedsearch.com)
  • In the malignant pleural effusion group, smokers showed a statistically significant higher pleural fluid and serum sialic acid levels as compared to nonsmokers. (biomedsearch.com)
  • Sias
  • Over the years several methodologies have been developed for the structural analysis of naturally occurring sialic acids (Sias), a family with more than 62 members. (springer.com)
  • mutarotase
  • A bacterial enzyme with sialic acid mutarotase activity, NanM, that is able to rapidly equilibrate solutions of sialic acid to the resting equilibrium position of around 90% beta/10% alpha has been discovered. (wikipedia.org)
  • sialidase
  • The possible impact of the sialic acid content and the activity of sialidase on stroke severity was also evaluated. (hindawi.com)
  • This study shows that low sialic acid erythrocyte concentrations with contemporary high sialic acid plasma levels and elevated sialidase activity can be considered as markers of ischemic stroke. (hindawi.com)
  • DAS181 (Fludase), a novel sialidase fusion protein that enzymatically removes sialic acids on respiratory epithelium, exhibits. (ebscohost.com)
  • purification
  • Varki, A. and Diaz, S. (1984) The release and purification of sialic acids from glycoconjugates: methods to minimize the loss and migration of O -acetyl groups. (springer.com)
  • SLC17A5
  • The diagnosis is established either by demonstrating lysosomal (rather than cytoplasmic) localization of elevated free sialic acid or by identifying pathogenic variants in SLC17A5 . (nih.gov)
  • monosaccharides
  • Our workflow delivers trace performance for monosaccharides and sialic acids without cumbersome and time consuming labeling protocols. (thermofisher.com)
  • The versatile Dionex ICS-6000 Hybrid HPIC System is a complete solution for the biopharma carbohydrate applications (monosaccharides, disaccharides, sialic acids, N - and O -linked oligosaccharide analysis, and more). (thermofisher.com)
  • enzymatically
  • The present inventors have newly found the activity of sialyltransferase of degrading sialic acid on a reaction product in the presence of CMP and also found that formed CMP can be degraded enzymatically to thereby efficiently produce a sialic acid-containing sugar chain. (freepatentsonline.com)
  • gene
  • alpha-Linolenic acid, Delta6-desaturase gene polymorphism, and the risk of nonfatal myocardial infar. (biomedsearch.com)
  • biology
  • Many bacteria also use sialic acid in their biology, although this is usually limited to bacteria that live in association with higher animals (deuterostomes). (wikipedia.org)
  • respiratory
  • This is the major type of sialic acid present on human respiratory epithelial cells. (virology.ws)
  • Alpha(2,3) linked sialic acids are found on ciliated epithelial cells, which are a minor population within the human respiratory tract, and also on some epithelial cells in the lower tract. (virology.ws)
  • For example, highly pathogenic avian H5N1 influenza viruses undergo limited replication in the human respiratory tract due to the presence of some cells with alpha(2,3) linked sialic acids. (virology.ws)
  • mannose
  • Agglutination of Rh O (D) erythrocytes by specific antiserum was inhibited by crude and crystalline N-acetylneuraminic acid, less inhibited by its glycoyl derivative, and weakly inhibited by its degradation product, N-acetyl-mannosamine, and by D-mannose. (sciencemag.org)
  • proteins
  • Sialic acid-binding immunoglobulin-like lectins (SIGLECs) are a family of cell surface proteins belonging to the immunoglobulin superfamily. (wikipedia.org)
  • There is now substantial pre-clinical evident correlating with human kidney biopsy samples, that some patients with MCD, FSGS or MN have kidney sialic acid insufficiency on their glomerular proteins. (wikipedia.org)
  • amino acid
  • An amino acid chain that is produced de novo by ribosome-mediated translation of a genetically-encoded mRNA. (githubusercontent.com)
  • A hallmark of this class is the presence of a von Willebrand factor type A domain (Pfam:PF00092) (I-domain) of approximately 200 amino acid residues at the N terminus, which confers divalent cation binding properties. (githubusercontent.com)
  • Genetic mutations in the hemagglutinin gene that cause single amino acid substitutions can significantly alter the ability of viral hemagglutinin proteins to bind to receptors on the surface of host cells. (wikipedia.org)
  • Subsequently, the boronic acid is added to the mixture and product is generated, either after 30 minutes at 90 °C, or after several hours at 25 °C. In α-amino acid synthesis, α-keto acids, such as glyoxylic and pyruvic acid, are stirred in ethanol, toluene, or dichloromethane with amines and vinyl boronic acids at 25-50 °C for 12-48 h to give the corresponding β,γ-unsaturated compounds. (wikipedia.org)
  • 93% Negroid The M and N antigens differ at two amino acid residues: the M allele has serine at position 1 (C at nucleotide 2) and glycine at position 5 (G at nucleotide 14) while the N allele has leucine at position 1 (T at nucleotide 2) and glutamate at position 5 (A at nucleotide 14). (wikipedia.org)
  • There are three differences in the first three amino acid residues: the usual form has Tryptophan1-Serine-Threonine-Serine-Glycine5 while Henshaw has Leucine1-Serine-Threonine-Threonine-Glutamate5. (wikipedia.org)
  • Mi-I (Mia), Mi-II(Vw), Mi-VII and Mi-VIII are carried on glycophorin A. Mi-I is due to a mutation at amino acid 28 (threonine to methionine: C→T at nucleotide 83) resulting in a loss of the glycosylation at the asparagine26 residue. (wikipedia.org)
  • Mi-II is due to a mutation at amino acid 28 (threonine to lysine:C->A at nucleotide 83). (wikipedia.org)
  • Some, however, like Siglec-14, contain positive amino acid residues that help dock ITAM-containing adaptor proteins such as DAP12. (wikipedia.org)
  • This amino acid forms salt bridges with the carboxyl group of the sugar residue. (wikipedia.org)
  • There is a signal sequence of 19 amino acid residues. (wikipedia.org)
  • The leader peptide differs by one amino acid and the next 26 amino acids are identical. (wikipedia.org)
  • stable
  • These initiatives will display exposed if Canada regulates to adopt rabbits and contribute concentrations changed to cybercrime questionnaire, even as financial concentrations reflect second measures and acid-stable students for water server into the Hydrological practices of researchers. (olcperu.org)
  • This is best seen in Sialoadhesin, where arginine at position 97 forms salt bridges with the COO− group of the sialic acid, producing a stable interaction. (wikipedia.org)
  • phosphate
  • Efficacy of cosmetic formulations containing dispersion of liposome with magnesium ascorbyl phosphate, alpha-lipoic acid and kinetin. (lifeextension.com)
  • The present study aimed to evaluate the photoprotective effects of cosmetic formulations containing a dispersion of liposome with magnesium ascorbyl phosphate (MAP), alpha-lipoic acid (ALA) and kinetin, as well as their effects on the hydration and viscoelastic skin properties. (lifeextension.com)
  • migration
  • The irreversible C-C bond migration between 3 and 3'then follows, furnishing desired product 9 with loss of boric acid. (wikipedia.org)
  • reported that the migration of the boronic acid substituent (phenyl group) of the "ate complex" A incurs an energy barrier of 10kcal/mol and a five-membered transition state B. Formation of quaternary boron salts during the reaction has been experimentally confirmed by Hansen and coworkers. (wikipedia.org)
  • methods
  • In comparison to other methods of generating allyl amines, the Petasis reaction tolerates a multifunctional scaffold, with a variety of amines and organoboronic acids as potential starting materials. (wikipedia.org)
  • Other methods of generating boronic acids were also reported. (wikipedia.org)
  • type
  • Salla disease (SD), also called sialic acid storage disease or Finnish type sialuria, is an autosomal recessive lysosomal storage disease characterized by early physical impairment and mental retardation. (wikipedia.org)
  • Each Siglec contains an N-terminal V-type immunoglobulin domain (Ig domain) which acts as the binding receptor for sialic acid. (wikipedia.org)
  • amount
  • Dysfibrinogenemia is also common because of the excessive amount of sialic acid, which is metabolized by the liver. (psychiatryadvisor.com)
  • Note that there are no evidences suggesting that boronic acid alone can directly react with iminium ions: In addition to needing acid for an appreciable amount of iminium salt to be generated, it has been shown that vinyl boronic acids do not react efficiently with preformed iminium salts (like Eschenmoser's salt). (wikipedia.org)
  • process
  • He requires on the oral mice of a download reflections of global personnel in thickness and remains an mutational process of the way Description and Applied Pharmacology and a sialic hard consensus of Environmental Health Perspectives( 2007-2016). (olcperu.org)
  • groups
  • A wide variety of functional groups including alcohols, carboxylic acids, and amines are tolerated in the Petasis Reaction. (wikipedia.org)
  • Sialic acid contains numerous hydroxyl groups which can be involved in the formation of glycosidic linkages. (wikipedia.org)
  • Most sialic acids are bonded via the 2, 3, 6 and occasionally 8 hydroxyl groups (number dependent on the carbon to which they are attached), in an α anomeric configuration. (wikipedia.org)
  • Mannose
  • Agglutination of Rh O (D) erythrocytes by specific antiserum was inhibited by crude and crystalline N-acetylneuraminic acid, less inhibited by its glycoyl derivative, and weakly inhibited by its degradation product, N-acetyl-mannosamine, and by D-mannose. (sciencemag.org)