Sialic acid residues n acetylneuraminic acid. Medical search. Frequent questions

A cooperative and competitive interaction between multiple enzymes, cell lines, and cell culture conditions causes processing of the oligosaccharide structure during which some of the already attached moieties like mannose are trimmed to yield a fiveâ residue core (Man3GlcNAc2), to which N-acetylglucosamine (GlcNAc), fucose, galactose, and N-acetylneuraminic acid (sialic acid or Neu5Ac) residues get added in a probabilistic fashion. (chromatographyonline.com)
Although both CHO and NS0-derived oligosaccharides were predominantly of the standard complex type with variable sialylation, 30% of N-glycan antennae associated with NS0-derived TIMP-1 terminated in alpha1,3-linked galactose residues. (kent.ac.uk)
The glycan sequence N-acetylgalactosamine, galactose, and sialic acid was consistently expressed on serine 94, threonine 194, and threonine 289 of APOE in L5 and was predicted to contribute to L5's negative surface charge and hydrophilicity. (ncku.edu.tw)
The known "essential sugars" are Mannose , Glucose , Galactose , Xylose , N-acetylglucosamine , N-acetylgalactosamine , Fucose (not fructose ) and N-acetylneuraminic acid . (glycop.com)
It appears to be from the soapwort plant containing saccharides like glucose , fucose , galactose , arabinose , xylose , rhamnose and glucuronic acid and may form the images we see. (glycop.com)

Among their many biological functions, these structures are substrates for neuraminidase enzymes which cleave neuraminic acid residues. (wikipedia.org)
Treating neurons with neuraminidase, which cleaves sialic acid residues from the surface of cells, also diminished the effect. (wustl.edu)
Treatment of both the rat liver and cerebral cortex mitochondria with 50 µg neuraminidase (dry weight) /mg protein resulted in the release of about 50% of the available outer membrane sialic acid residues. (silverchair.com)
Removal of the sialic acid component of the carbohydrate from wild-type TfR by treatment of live cells with neuraminidase enhances TfR cleavage. (elsevierpure.com)
Treatment of IdID cells with neuraminidase reveals that the sialic acid of the O-linked carbohydrate protects against TfR cleavage, whereas the core sugars GalNAc and Gal do not protect as much. (elsevierpure.com)

The N- or O-substituted derivatives of neuraminic acid are collectively known as sialic acids, the predominant form in mammalian cells being N-acetylneuraminic acid. (wikipedia.org)
As a family, these residues are known as sialic acids. (wikipedia.org)
Bird's nest acid, also known as sialic acid, sialic acid, scientific name "N-acetylneuraminic acid", is a naturally occurring carbohydrate. (meetsupplement.com)

Sialidase (EC 3.2.1.18) catalyzes the release of sialic acid from sialo-oligosaccharides, gangliosides, or sialo-glycoproteins. (elsevierpure.com)
Treatment of all of the particles with trypsin caused release of sialic acid but did not greatly affect the particle electrophoretic mobility. (silverchair.com)

Neuraminic acid (5-amino-3,5-dideoxy-D-glycero-D-galacto-non-2-ulosonic acid) is an acidic (in particular ulosonic) amino sugar with a backbone formed by nine carbon atoms. (wikipedia.org)
Although 9-carbon sugars do not occur naturally, neuraminic acid may be regarded as a theoretical 9-carbon ketose in which the first link of the chain (the -CH2OH at position 1) is oxidised into a carboxyl group (-C(=O)OH), the hydroxyl group at position 3 is deoxidised (oxygen is removed from it), and the hydroxyl group at position 5 is substituted with an amino group (-NH2). (wikipedia.org)
Neuraminic acid may also be visualized as the product of an aldol-condensation of pyruvic acid and D-mannosamine (2-amino-2-deoxy-mannose). (wikipedia.org)
Neuraminic acid does not occur naturally, but many of its derivatives are found widely distributed in animal tissues and in bacteria, especially in glycoproteins and gangliosides. (wikipedia.org)
The name "neuraminic acid" was introduced by German scientist E. Klenk in 1941, in reference to the brain lipids from which it was derived as a cleavage product. (wikipedia.org)
The IUPAC symbol used for neuraminic acid is Neu, and the residue is typically found with additional chemical modifications in biological systems. (wikipedia.org)

The addition of a precursor 13-residue oligosaccharide moiety GlcNAc2Man8Gluc3 to the nascent polypeptide chain occurs in the endoplasmic reticulum, following which the assembly folds and acquires its secondary, tertiary, and quaternary structure. (chromatographyonline.com)
N-acetylneuraminate (N-acetylneuraminic acid, also called sialic acid) is often found as a terminal residue of oligosaccharide chains of glycoproteins. (studyres.com)
In the present set of studies, the influence of amino acid substitution and the composition of the oligosaccharide at amino acid 104 on the cleavage of the TfR was examined. (elsevierpure.com)

Paracoccidioides brasiliensis, the agent of paracoccidioidomycosis, when grown in a synthetic medium, expresses at the cell surface of both yeast and mycelial forms acidic glycoconjugates containing N-acetylneuraminic acid units. (unifesp.br)
An analysis of the sialic acids present in the cells' own glycoconjugates revealed a decrease in the percentage of Neu5Gc residues from 4% in the parental cells to less than 1% in the CHO-AsUH2 cell line. (univ-lorraine.fr)

Gangliosides, complex glycosphingolipids on the plasma membrane containing one or more sialic acid residues, are key components of microdomains. (jneurosci.org)

APOE structures with various glycan residues were predicted. (ncku.edu.tw)
The electrostatic force between the negatively charged sialic acid-containing glycan residue of APOE and positively charged amino acids at the receptor-binding area suggested that glycosylation interferes with APOE's attraction to receptors, lipid-binding ability, and lipid transportation and metabolism functions. (ncku.edu.tw)
The size of networks produced in simulations can be limited by decreasing the maximum number of GlcNAc residues per glycan using the Control panel. (glycologue.org)

Any compound containing one or more monosaccharide residues bound by a glycosidic linkage to a hydrophobic moiety such as an acylglycerol (see GLYCERIDES), a sphingoid, a ceramide (CERAMIDES) (N-acylsphingoid) or a prenyl phosphate. (lookformedical.com)

Sialic acid imparts negative charge to glycoproteins, because its carboxyl group tends to dissociate a proton at physiological pH, as shown here. (studyres.com)

Amino acid sequence identities to rat and hamster sialidases (84% and 77%, respectively) suggest that this form of sialidase is conserved in rodents. (elsevierpure.com)
Mouse brain sialidase has two amino acid sequence motifs common to bacterial sialidases: the 'F/YRIP' motif and the 'Asp-box' motif. (elsevierpure.com)

Acidic amino acids are not catalyze by DAOO. (smpdb.ca)

In each instance, curves of pH vs. electrophoretic mobility indicated that the particle surface contained an acid dissociable group, most likely a carboxyl group of sialic acid with pK a ∼ 2.7. (silverchair.com)

Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories. (lookformedical.com)
These results suggest that wheatgerm agglutinin reversibly inhibits ionotropic quisqualate receptor desensitization by interacting with carbohydrate residues on or near the quisqualate receptor complex. (wustl.edu)
In tissue culture cells elimination of the O-linked carbohydrate at Thr 104, four amino acids from the cleavage site, results in enhanced cleavage of the TfR (Rutledge et al. (elsevierpure.com)
These results show that the terminal charged sialic acid residues are important for protection from proteolytic cleavage and suggest that cleavage could be regulated in the cell by removal of all or part of the carbohydrate. (elsevierpure.com)

For the typical bacterium that can make all 20 amino acids, there are 1-2 gaps in amino acid biosynthesis pathways. (lbl.gov)
For more information, see the paper from 2019 on GapMind for amino acid biosynthesis, the paper from 2022 on GapMind for carbon sources, or view the source code . (lbl.gov)

Furthermore, NS0 cells conferred a greater proportion of terminal N-glycolylneuraminic (sialic) acid residues as compared with the N-acetylneuraminic acid variant. (kent.ac.uk)

EC 1.14.13.45) which is the key enzyme in the formation of the sialic acid, N-glycolylneuraminic acid (Neu5Gc). (univ-lorraine.fr)

The repartition and availability of sialic acid derivatives in the gut have a significant impact on the modulation of gut microbes and host susceptibility to infection and inflammation. (diamond.ac.uk)
It also acts on N -glycoloylneuraminate and on O -acetylated sialic acids, other than 4- O -acetylated derivatives. (qmul.ac.uk)
It is then transported back into intracellular space, where after its used in 3 different reactions, its derivatives interact with intestinal microflora in the extracellular space to become lithocholyltaurine, lithocholic acid glycine conjugate, and lithocholic acid. (smpdb.ca)
Revisiting 7a-hydroxy-cholestene-3-one, the second chain of reactions it is involved in follows a similar path as the first, moving through the mitochondria, endoplasmic reticulum and peroxisome until choloyl-CoA is formed, which then is used in three reactions so that its derivatives may leave the cell to interact with intestinal microflora and become taurodeoxycholic acid, deoxycholic acid glycine conjugate and deoxycholic acid. (smpdb.ca)

D-Amino acid oxidase (DAAO) is one of the main enzymes that metabolize D-Amino acids via deamination. (smpdb.ca)

As a model for LSDs we are studying the lysosomal free sialic acid storage disorders. (stanford.edu)
These diseases are the result of a defect in transport of sialic acid across lysosomal membranes and are associated with mutations in the gene encoding the sialic acid transporter sialin. (stanford.edu)
We are using molecular, genetic and biochemical approaches to better define the normal function of sialin and to determine how loss of sialin function leads to neurodevelopmental defects and neurodegeneration associated with the lysosomal free sialic acid storage disorders. (stanford.edu)

L-Lysine and oxoglutaric acid will be combined to form saccharopine by facilitation of mitochondrial alpha-aminoadipic semialdehyde synthase, and then, mitochondrial alpha-aminoadipic semialdehyde synthase will further breaks saccharopine down to allysine and glutamic acid. (smpdb.ca)

Wheatgerm agglutinin and other lectins belonging to the glucose/mannose, N-acetylglucosamine, and sialic acid classes inhibited desensitization. (wustl.edu)

This enzyme is used another time, to create 3a,7a-dihydroxycoprostanic acid. (smpdb.ca)

10% of the liver mitochondrial protein and 27.5% of the sialic acid was solubilized in the mitoplast and outer membrane isolation procedure. (silverchair.com)

We conclude that the composition of residues within the capsid variable region 1 (VR1) of AAV1 and AAVrh.10 profoundly influences tropism, with altered SIA interactions playing a partial role in this phenotype. (duke.edu)
I. Preparation, amino acid composition and molecular weight. (qmul.ac.uk)
Artificial formula and human milk differ considerably in fatty acid composition and concentrations of cholesterol , phytosterols , monosaccharides and sugar alcohols . (glycop.com)

The order of amino acids as they occur in a polypeptide chain. (lookformedical.com)

DAAO is highly specific towards D-amino acids and favours free neutral D-amino acids or those with hydrophobic, polar or aromatic groups. (smpdb.ca)

These calculations predict that bacterial neuraminidases have a binding site which can accommodate only two sugar residues and virus neuraminidases have a binding site which can accommodate more than two sugar residues. (iisc.ac.in)

Inclusion of the nucleotide-sugar precursors, glucosamine (10 mM, plus 2 mM uridine) and N-acetylmannosamine (20 mM), in culture media were shown to significantly increase the intracellular pools of UDP-N-acetylhexosamine and CMP-sialic acid, respectively, in both NS0 and CHO cells. (kent.ac.uk)
The elevated CMP-sialic acid content induced by N-acetylmannosamine had no effect on the overall level of sialylation of TIMP-1 produced by both CHO and NS0 cells, although the ratio of N-glycolylneuraminic acid:N-acetylneuraminic acid associated with NS0-derived TIMP-1 changed from 1:1 to 1:2. (kent.ac.uk)
In COS-7 cells transiently transfected with the cDNA, a 250-fold increase was observed in specific activity toward 2'-(4-methylumbelliferyl)-α-D-N-acetylneuraminic acid. (elsevierpure.com)

Twenty alpha-amino acids are the subunits which are polymerized to form proteins. (lookformedical.com)

sugar and the amino acid will react together forming a complex series of compounds and the whole process is called the Maillard Reaction. (studyres.com)

Oxoadipic acid is formed from catalyzation of mitochondrial kynurenine/alpha-aminoadipate aminotransferase on aminoadipic acid. (smpdb.ca)

The main functions of sialic acid are to improve the memory and intelligence of infants and young children, anti-senile dementia, anti-recognition and improve intestinal absorption of vitamins and minerals, antibacterial detoxification and antiviral, inhibit white blood cell adhesion and anti-inflammatory, improve human immunity, etc. (meetsupplement.com)

Scholars@Duke publication: Modulation of Sialic Acid Dependence Influences the Central Nervous System Transduction Profile of Adeno-associated Viruses. (duke.edu)

A bile acids life begins as cholesterol is catabolized, as bile acid is a derivative of cholesterol. (smpdb.ca)
There are two more important components of this pathway, both depicting the breakdown of cholesterol into bile acid. (smpdb.ca)

Expression of sialic acids on virulent yeast forms of P. brasiliensis (3.7 X 10(6) residues per cell) may inhibit fungal phagocytosis during early infection, when the immunological response is still being built up. (unifesp.br)

D-Amino acids have been show to be present in high concentrations in humans and play a role in biological functions. (smpdb.ca)

Bile acids play a very important part in the digestion of foods, and are responsible for the absorption of water soluble vitamins in the small intestine. (smpdb.ca)

The fully hydrated form of silica gel has distinct properties and is referred to as SILICIC ACID. (lookformedical.com)
Allysine will be degraded to form aminoadipic acid through alpha-aminoadipic semialdehyde dehydrogenase. (smpdb.ca)

Anatomy12

Organisms14

Diseases2

Chemicals and Drugs124

Analytical, Diagnostic and Therapeutic Techniques and Equipment39

Phenomena and Processes63

Disciplines and Occupations1

Information Science5

Health Care3

Galactose5

Neuraminidase5

Known as sialic3

Release of sialic acid2

Neuraminic acid6

Oligosaccharide3

Glycoconjugates2

Gangliosides1

Glycan3

Monosaccharide1

Glycoproteins1

Amino Acid Seq2

Acidic1

Carboxyl1

Carbohydrate4

Biosynthesis2

Terminal1

Neu5Gc1

Derivatives4

Enzymes1

Lysosomal3

Glutamic Acid1

Mannose1

Enzyme1

Outer1

Composition3

Polypeptide chain1

Hydrophobic1

Binding1

Cells3

Proteins1

Sugar1

Mitochondrial1

Human1

Publication1

Cholesterol2

Cell1

Concentrations1

Vitamins1

Form2