Loading...
  • antibody
  • The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. (bioon.com.cn)
  • siglecs
  • Binding affinity is increased by up to 1500-fold compared to the monovalent ligand, while maintaining the selectivity for hCD22 over other Siglecs. (nih.gov)
  • multivalent
  • Therefore, we evaluated binding of highly multivalent PA conjugates (1,000 kD) carrying sialosides (n ≈ 400) and biotin tags to facilitate their detection. (nih.gov)
  • mice
  • Early treatment (low tumor volume, non-established tumors) was at least as effective as the same dose and schedule of HB22.7 given to mice with small established tumors, Fig. 2. (nih.gov)
  • type
  • A hallmark of this class is the presence of a von Willebrand factor type A domain (Pfam:PF00092) (I-domain) of approximately 200 amino acid residues at the N terminus, which confers divalent cation binding properties. (githubusercontent.com)
  • Obesity-induced changes in their number and activity result in the activation of local and later systemic inflammatory response, marking the transition from simple adiposity to diseases such as type 2 diabetes mellitus, arterial hypertension, and ischemic heart disease. (bioscientifica.com)
  • The main burden of obesity lies in its interconnection with a number of metabolic and non-metabolic diseases including type 2 diabetes mellitus (T2DM), dyslipidemia, arterial hypertension, and atherosclerosis, leading to substantially increased cardiovascular and cerebrovascular morbidity and mortality. (bioscientifica.com)
  • domain
  • The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases. (abcam.com)
  • We show that Src homology region 2 domain-containing phosphatase-1 (SHP-1) is an important inhibitor of DC signaling, targeting multiple activation pathways. (jimmunol.org)
  • analysis
  • The articular localization of autologous granulocytes, separated in vitro and labeled with 111In, was studied by analysis of gamma-camera images both before and 2 weeks after treatment. (ox.ac.uk)