• studied the antioxidant and anticancer potential of Chenopodium quinoa leaves' phenolic compounds that has been demonstrated. (hindawi.com)
  • A review of quercetin: antioxidant and anticancer properties. (emanresearch.org)
  • Pickled onions include numerous antioxidants, consisting of quercetin, a flavonoid with effective anti-inflammatory homes. (blogzah.com)
  • Red onions are known to be particularly rich in quercetin , a plant pigment or flavonoid present in many fruits, vegetables, and grains. (minuteman-militia.com)
  • Again, the benefit here comes from the flavonoid antioxidant quercetin, which may inhibit the growth of tumors. (minuteman-militia.com)
  • The ethanolic extracts of the plant were examined for the presence of bioactive components and their total flavonoid content, with focusing on quercetin detection using thin layer bioautography (TLB) and brine shrimp lethality assay (BSLA) for cytotoxicity. (who.int)
  • L. egeregia was regarded as the prototype of the anticancer species due to its profound flavonoid concentration (85.40 µg/mL) and cytotoxicity (9.46 µg/mL) compared to other extracts. (who.int)
  • ... [Show full abstract] absence of amino acids, proteins and acidic compounds.Total phenol and flavonoid content were evaluated for all the extracts of both plants. (researchgate.net)
  • [3] The total flavonoid content of hydroethanol extracts from fresh and dried Bauhinia forficata leaves is in the range between 572.08 and 1,102.99 μg/mL, with the flavonoid kaempferitrin and other kaempferol and quercetin derivatives being predominant. (herbshealthhappiness.com)
  • Many epidemiological studies have shown that regular flavonoid rich fruit intake is associated with delayed Parkinson's disease (PD), Alzheimer's disease (AD), ischemic diseases and aging effects (Ono et al. (lww.com)
  • It contains flavonoid compounds like kaempherol and quercetin, which could be contributing in this regard. (simplythegreat.com)
  • For cancer relief, the most frequently used Sahajana anti-cancer medications, such as kaempferol and iso-quercetin are used. (cowurine.com)
  • A 2015 phytochemical screening of the water extract of pata de vaca leaves evidenced the presence of gallic acid (6.53%), chlorogenic acid (2.08%), caffeic acid (1.72 %), rutin (0.91%), isoquercitrin (4.45%), quercetin (7.19%), and kaempferol (2.30%), with HPLC analysis revealing hydrolysable tannins, flavonoids, and phenolics as the extract's chief constituents. (herbshealthhappiness.com)
  • Luciferase reporter assays showed that galangin and kaempferol decrease transcription of MMP-9 mRNA. (molcells.org)
  • Galangin (purity ≥ 95.0%), kaempferol (purity ≥ 90.0%), fisetin (purity ≥ 98.0%), quercetin (purity ≥ 98.0%), morin (purity ≥ 85.0%), and myricetin (purity ≥ 96.0%) were obtained from Sigma-Aldrich (USA). (molcells.org)
  • The neuroprotective effects of berry fruits on neurodegenerative diseases are related to phytochemicals such as anthocyanin, caffeic acid, catechin, quercetin, kaempferol and tannin. (lww.com)
  • A large body of epidemiological studies has proven the bioactivities of phenolics in both standard compounds and natural extracts: namely, anticancer, anti-inflammatory, and antibacterial activities as well as reducing diabetes, cardiovascular disease, and neurodegenerative disease. (mdpi.com)
  • Quantification by UPLC-DAD-ESI-QToF/MS identified up to 23 individual phenolic compounds, with freeze-dried samples showing higher amounts of individual compounds compared with oven-dried. (bvsalud.org)
  • Sonth is a part of the herbal meal, consisting of shogaol that carries gingerol with many phenolic compounds that have been shown to have an anti-cancer and antioxidant impact. (cowurine.com)
  • 13,14 Among the secondary metabolites, the flavonoids are a group of compounds synthesized from cinnamic acid derivatives coupled with three acetate units that display several biological roles. (rsc.org)
  • The results of this in-silico study showed that the docking scores of the 10 compounds were higher than those of the co-crystallized compound. (ijpsr.com)
  • Using the triazole of diclofenac 12 as a lead compound, we synthesized a variety of analogs as multipotent inhibitors concomitantly targeting COX-2, 5-LOX, AChE, BChE, MAO-A and MAO-B. A number of compounds showed excellent in vitro inhibition of the target biological macromolecules in nanomolar concentration. (inra.fr)
  • In a reversibility assay, all the studied active compounds showed reversibility and thus were found to be devoid of side effects. (inra.fr)
  • MTT assay results on neuroblastoma SH-SY5Y cells showed that the tested compounds were non-neurotoxic. (inra.fr)
  • An in vivo acute toxicity study showed the safety of the synthesized compounds up to a 2000 mg kg(-1) dose. (inra.fr)
  • [viii] Consuming onion peel itself, found to contain quercetin in abundance, may also benefit obese individuals as a way to reduce oxidative stress to help prevent the onset of chronic disease. (minuteman-militia.com)
  • They boost circulation, strengthen the immune system, and even contain quercetin. (emergencymedicine.news)
  • The flavonoids diversity showed a significant content of luteolin and its derivatives, except for Landoltia punctata that had significant apigenin content. (rsc.org)
  • Several in vitro studies have demonstrated that artemisinin and its derivatives possess promising anticancer, antiproliferative, and antiapoptotic properties in tumor cell lines of colon, breast, and lung. (wjtcm.net)
  • Pyrazoline-pyrimidine hybrid (23g), (3-acetylcoumarin derivative of pyrrolidin-1-yl)benzenesulfonamide (27), and tacrine derivatives of (pyrrolidin-1-yl)benzenesulfonamide (31, 38) displayed excellent in vitro COX-2 inhibition having IC(50) value in the nanomolar range. (inra.fr)
  • Quercetin and its derivatives constitute about 99% of the flavonoids in apple peel (5), and it is also one of the ma- jor constituents in foods consumed in the United States (6,7). (vdocuments.net)
  • [6] Pata de vaca has been traditionally used by the local communities near the tropical forests where this plant thrives as antidiabetic and anticancer herbs . (herbshealthhappiness.com)
  • Furthermore, it displayed higher levels of total phenolics and flavonoids compared to other extracts. (emanresearch.org)
  • Fisetin & Quercetin are examples of potential micronutrients (polyphenol) and flavonoids that demonstrate efficacy against ageing and age-related changes. (rescence.com)
  • 16,18-21 Flavonoids display several other properties such as immunomodulation, apoptotic effects, and consolidation of applications on carcinogenesis, inflammation, atherosclerosis, and thrombosis. (rsc.org)
  • Both plants showed good amount of phenol and flavonoids. (researchgate.net)
  • Several antioxidants like SOD, CAT, epigallocatechin-3-O-gallate, lycopene, ellagic acid, coenzyme Q10, indole-3-carbinol, genistein, quercetin, vitamin C and vitamin E have been found to be pharmacologically active as prophylactic and therapeutic agents for above mentioned diseases. (nutrimedical.com)
  • In the middle of 2021, he indicated that he was trying out a new formulation that included the antioxidants fisetin and quercetin. (rescence.com)
  • The anticancer model's overal antioxidant activity (34.72 µg/mL) was slightly lower than quercetin (30.44 µg/mL) but higher than ascorbic acid (41.68 µg/mL). (who.int)
  • These in-vitro investigations suggest that Quercetin, in particular, could be a strong therapeutic agent with greater therapeutic efficacy than Cytochalasin B in the therapy of cancer by inhibiting GLUT4. (ijpsr.com)
  • It is reported to display diverse biological activities including anti-microbial, anti-cancer, and anti-inflammation as determined by in vitro or in vivo studies. (researchgate.net)
  • Artemisinin dimer oxime - dimer molecule synthesized from artemisinin possesses high bioavailability and marked in vitro anticancer activities against solid tumor-derived cell lines, endothelial cell proliferation, migration, and angiogenic processes. (wjtcm.net)
  • [2] Artemisinin dimer oxime (Ox) - dimer molecule synthesized from artemisinin possesses high bioavailability and marked in vitro anticancer activities compared to its monomers. (wjtcm.net)
  • Numerous in vitro and animal model studies using quercetin alone or quercetin in combination with other bioactive com- pounds have shown the anticancer activities of the compound (8-15). (vdocuments.net)
  • The anticancer activity of biosynthesized ZnO NPs and C. citratus ALE was in vitro tested against seven human cancer cell lines (HCCL) (i.e. (springeropen.com)
  • [xvi] Justifying their strong antioxidant properties, garlic, white onion, and purple onion display antidiabetes as well as antihypertensive properties. (minuteman-militia.com)
  • Although several previous reports showed diverse biological effects for piperine and bioactive constitutes of BPEO. (springeropen.com)
  • and a flavonol glycoside, quercetin-3-rutinoside (rutin), and one compound from the leaves: a sterol, 24-ethyl-5,22-cholestadien-3-b-ol (stigmasterol). (researchgate.net)
  • The antioxidant capability of the resulting plant extracts against a stable radical DPPH was evaluated and the most of plant extracts showed high efficiency in the DPPH test. (europa.eu)
  • Experimental evidence identified quercetin, a natural senolytic drug, as a cardioprotective agent against inflammatory injuries. (frontiersin.org)
  • Anthocyanins, flavanols, flavanols and resveratrol are the most important grape polyphenols because they possess many biological activities such as antioxidant, cardioprotective, anticancer, anti-inflammation, antiaging and antimicrobial properties. (oatext.com)
  • In an exploratory way, quercetin supplementation could also improve endothelial function by eliminating senescent vascular endothelial cells. (frontiersin.org)
  • In laboratory research , Fisetin was shown to decrease vascular endothelial growth factor (VEGF) development by as much as 92% in human umbilical vein endothelial cells. (rescence.com)
  • In a 2012 study, quercetin displayed a protective effect against sodium fluoride-induced oxidative stress in the heart in an animal model. (minuteman-militia.com)
  • Quercetin attenuates oxidative stress-induced apoptosis via SIRT1/AMPK-mediated inhibition of ER stress in rat chondrocytes and prevents the progression of osteoarthritis in a rat model. (nih.gov)
  • Coriander is brimming with cancer prevention agents that show safe supporting, anticancer, mitigating, and neuroprotective impacts. (allnewshype.com)
  • The TLB also demonstrated the presence of quercetin, with a dose-dependent antioxidant property. (who.int)
  • Al- though quercetin induced cell death in a dose-dependent manner, 12.5-50 µ M quercetin inhibited the activity of both taxol and noco- dazole to induce G2/M arrest in various cell lines. (vdocuments.net)
  • RESULTS: Ellagic acid showed high DPPH radical scavenging and lipid peroxidation inhibition activities. (nutrimedical.com)
  • The ethanol extract of the leaves showed remarkable DPPH scavenging effect with IC 50 = 29.87µg/ml. (emanresearch.org)
  • SOR), hydrogen peroxide, and 2, 2-Diphenyl-2-picrylhydrazyl (DPPH) radical activity by a model (most biological y active) of the anticancer plant was also evaluated. (who.int)
  • Although much is known about the bioactivities and the ma- jor signaling pathways modulated by quercetin (see ref in (16)), less is known about the potentials of the compound as a com- plementary supplement once the cancer has established itself and therapy has been implemented to treat the cancer. (vdocuments.net)
  • More interestingly, the biosynthesized ZnO NPs displayed remarkable selective cytotoxicity against all tested cancer cell lines without any effect on normal cells. (springeropen.com)
  • Samples of commonly utilized anticancer plants obtained from the chosen areas using physical and virtual oral seminars were studied for physiochemical composition and a possible antioxidant and cytotoxic potential to validate the basis for the use of the selected anticancer plants. (who.int)
  • Figure 2a shows the most commonly used pump was the Medtronic Paradigm device (57.6%), and insulin aspart (Novorapid) and insulin lispro (Humalog) were the insulins most commonly infused (Figure 2b). (achrsignals.com)
  • Isoeugenol (2-methoxy-4-(prop-1-en-1-yl)phenol), a component of from clove (Eugenia caryophylata) oil, is a starting material for both the biotechnological and synthetic production of vanillin and vanillic acid. (researchgate.net)
  • At low concentrations (10(-7) to 10(-9) M), this compound displayed a small but significant estrogenic activity via ERalpha, whereas it was a complete estrogen antagonist via ERbeta. (nutrimedical.com)
  • Endometrium-derived epithelial cells (Ishikawa) showed no response to the natural compound by using a cell viability assay (MTT). (nutrimedical.com)
  • Cavicularin is an unusual macrocycle because it was the first compound isolated from nature displaying optical activity due to the presence of planar chirality and axial chirality. (wikipedia.org)
  • [1] Dihydroartemisinin has shown therapeutic activity against gallbladder cancer metastasis. (wjtcm.net)
  • Moringa species are well-known for their antioxidant, anti-inflammatory, anticancer, and antihyperglycemic activities. (frontiersin.org)
  • They also showed anti-microbial activity for both bacterial and fungal which growth rates for both significantly decreased with the increase in ZnO NPs concentration compared to the control. (springeropen.com)
  • In terms of (ii) progression, four articles showed evidence of BME pharmacists in community being under-represented in management positions and over-represented N-acetylglucosamine-1-phosphate transferase among pharmacy owners. (achrsignals.com)
  • 2013) to display antioxidant potential and to partially protect experimental rats against vacuous chewing movements caused by haloperidol. (herbshealthhappiness.com)
  • Quercetin is one of the most abundant dietary flavonoids. (vdocuments.net)
  • Following an acute coronary syndrome, patients display an elevated inflammatory profile, promoted in part by cellular senescence. (frontiersin.org)
  • The Q-CABG study aims to explore the efficacy of quercetin to reduce inflammation, myocardial injury and senescence in patients undergoing CABG following an acute coronary syndrome. (frontiersin.org)
  • The preventive intake of quercetin supplementation may help limit the vigorous inflammatory response triggered by CABG and subsequent postoperative complications in patients suffering from an acute coronary syndrome. (frontiersin.org)
  • We hypothesized an additive or a synergistic effect with this drug-flavonoid com- bination, but unexpectedly, quercetin protected cells from the activity of these antimicrotubule drugs and sustained the via- bility of the cells. (vdocuments.net)
  • Thus, we identify bimodal activity of the flavonoid quercetin, a short-term activity that is cytoprotective against chemotherapeutic drugs and a long-term activity that is inhibitory to cancer cell growth. (vdocuments.net)
  • The ATFM-H showed central antinociceptive effect from the involvement of the δ opioid receptors, without causing alterations in the locomotor activity of the mice, while ATFM-D was effective in decreasing paw oedema and TNF-α and IL-1β production. (jcimjournal.com)
  • Phenolics also display anti-analgesic, anti-allergic, and anti-Alzheimer's properties. (mdpi.com)
  • however, quinoa has gained worldwide attention due to its nutritional value and functional properties [ 1 ], as well as its ability to grow in a wide range of climates, showing a good potential as a grain crop even in new areas outside of its native region [ 12 ]. (hindawi.com)
  • Natural phenols show optical properties characteristic of benzene, e.g. absorption near 270 nm. (wikipedia.org)
  • The oven-dried samples showed an increased concentration of polyphenols after boiling, while the lyophilized samples showed a slightly decreased concentration. (bvsalud.org)
  • Moreover, CTCDOs displayed a distinctive pattern of drug sensitivity that may be helpful for the identification of anti-metastatic strategies. (biomedcentral.com)
  • The status of cell adherence to growth ma- trix was critical in determining the sensitivity of HCT116 cells to quercetin. (vdocuments.net)
  • Creature studies show that coriander removal is close to as successful as Diazepam, a typical nervousness prescription, at lessening the side effects of this condition (22). (allnewshype.com)
  • In this article, the isoeugenol showed excellent inhibitory effects against some metabolic enzymes such as acetylcholinesterase (AChE) enz. (researchgate.net)
  • Studies have also shown that ellagic acid may protect against chromosome damage and reduce the effects of chemically induced hepatic structural degeneration. (nutrimedical.com)
  • The primary endpoint examines the effects of quercetin on blood inflammatory cytokines and markers of myocardial injury and senescence in this patient population. (frontiersin.org)
  • Those effects are likely modulated at the molecular level through selectively modulating the redox balance and displaying anti-oxidant as well as pro-oxidant actions. (oatext.com)
  • In this study, we examined the effects of quercetin on cell cycle, viability, and proliferation of cancer cells, either singly or in combination with the microtubule-targeting drugs taxol and nocodazole. (vdocuments.net)
  • Even though some of the data looks convincing, more well-designed clinical trials in humans are warranted to ascertain the anticancer effects of saffron. (simplythegreat.com)
  • Most animal studies show saffron to exhibit antioxidant, anticancer, anti-inflammatory, and anti-hyperlipidemic effects in treating gastrointestinal disorders. (simplythegreat.com)
  • A study done on healthy men showed that daily use of saffron (about 100 mg) could have temporary immunomodulatory effects without any adverse reactions. (simplythegreat.com)
  • But saffron has shown certain complexion promotion effects. (simplythegreat.com)
  • All proteins are shown as colored arrows, where the path depicts the strand of the feature. (cancercurehere.com)
  • [4] In general, the tree shows high percentages for regeneration and germination and is well-known for being a pioneer plant of rapid growth. (herbshealthhappiness.com)
  • Quercetin also partially restored drug-induced loss in viability of treated cells for up to 72 h. (vdocuments.net)
  • Crystal Structure Elucidation and Anticancer Studies of (-)-Pseudosemiglabrin: A Flavanone Isolated from the Aerial Parts of Tephrosia apollinea. (emanresearch.org)
  • However, studies have shown that eating plenty of fruits and vegetables can lower your risk of developing cancer, especially since these plants have been found to contain some anti-cancer components. (ijpsr.com)
  • Research has also shown that Davidson plum not only has a higher anti-oxidant capacity than blueberry, but also higher levels of lutein than avocado and a high ratio of potassium to sodium. (bestiehealth.com.au)
  • Quercetin, however, was discovered to have a higher docking score than Cytochalasin B and to have broken no rules of the RO5. (ijpsr.com)
  • Functionally, CTCDOs showed a higher migratory/invasive ability and a different response to pathway-targeted drugs as compared to xenograft-derived organoids (XDOs). (biomedcentral.com)
  • Interestingly, (3) displayed a higher binding affinity towards all the aging and antioxidant enzymes as compared to (1), (2) and the references. (ijpsonline.com)
  • A study involving 70 overweight individuals with high blood pressure found that quercetin-rich onion extract, 162 milligrams (mg) per day in particular, notably pushed down systolic blood pressure by 3 to 6 mmHg versus a placebo. (minuteman-militia.com)
  • However, a study in overweight adolescent girls shows that exercise increases free radical stress due to the inefficient utilization of extra oxygen during the exercise process. (selfgrowth.com)
  • Has shown positive results in a clinical experiment with stroke patients and potential in various settings. (rescence.com)
  • In clinical diabetes care, DPP-4 inhibitors have been shown to be effective in reducing glucose levels. (researchgate.net)
  • [x] A study showed that it significantly improved scar softness, redness, texture, as well as appearance at the site at weeks four, six, and 10 during the research. (minuteman-militia.com)
  • [xii] In a 2006 study, a uniquely large data set from southern European populations showed an inverse association between the frequent consumption of the family of allium vegetables, particularly onions and garlic , and the risk of several common cancers . (minuteman-militia.com)
  • A study of 42 Type 2 diabetics, for instance, showed that consuming 3.5 ounces of fresh red onion decreased fasting blood sugar levels by 40 mg/dl after four hours. (minuteman-militia.com)
  • Using these models, we attempted treatment of xenografts with topotecan - a known anticancer drug and artemisinin dimer oxime or combination of these two drugs. (wjtcm.net)
  • Quercetin can assist in enhancing brain health, lower heart problem danger, and lower high blood pressure. (blogzah.com)
  • [xviii] Discover additional onion health benefits and quercetin wellness benefits on GreenMedInfo.com. (minuteman-militia.com)
  • New science is showing that a lack of potassium is a primary reason why salt can cause high blood pressure and cardiovascular damage. (selfgrowth.com)
  • Combination therapy showed a significant reduction in tumor volume and tumor/body weight. (wjtcm.net)