• General transcription factor II-I is a protein that in humans is encoded by the GTF2I gene. (wikipedia.org)
  • Histone deacetylase 3 binds to and regulates the multifunctional transcription factor TFII-I". The Journal of Biological Chemistry. (wikipedia.org)
  • A multifunctional DNA-binding protein that promotes the formation of serum response factor/homeodomain complexes: identity to TFII-I". Genes & Development. (wikipedia.org)
  • It may have the ability to interact with other HLH-proteins and function as a transcription factor or as a positive transcriptional regulator under the control of Retinoblastoma protein. (nih.gov)
  • PURPOSE: Human epidermal growth factor receptor 2 (HER2)-targeted therapies improve survival for patients with HER2-positive breast cancer but carry risks of hematologic, cardiopulmonary, gastro-hepatobiliary, and other adverse events (AEs). (bvsalud.org)
  • The multifunctional transcription factor TFII-I, encoded by the GTF2I gene, is implicated in various biological pathways, and associated with multiple human disorders. (nih.gov)
  • Role of multifunctional transcription factor TFII-I and putative tumour suppressor DBC1 in cell cycle and DNA double strand damage repair. (nih.gov)
  • Histone deacetylase 3 binds to and regulates the multifunctional transcription factor TFII-I". The Journal of Biological Chemistry. (wikipedia.org)
  • We show ICP4 forms complexes with TFIID, thus verifying previous in vitro data. (pitt.edu)
  • Direct role for Myc in transcription initiation mediated by interactions with TFII-I". Nature. (wikipedia.org)
  • Using deletion mutants spanning this region, we show that the entire region is necessary for ICP4 function, but that loss of aa 30-142 has a greater detrimental impact on the ability of ICP4 to transactivate E and L genes. (pitt.edu)
  • Based on this role, TFII-I is called a transcription factor. (medlineplus.gov)
  • Mediator was also recruited to viral promoters in an ICP4-dependent manner, showing a direct role for Mediator in ICP4-mediated transcription. (pitt.edu)
  • 17. A role for transcription factor GTF2IRD2 in executive function in Williams-Beuren syndrome. (nih.gov)
  • We previously showed that defective DNase activity augments NETs-mediated occlusive clot formation and organ damage in non-viral systemic inflammation sepsis models [16,17]. (exposed-skin-care.net)
  • The pH profile for laccase activity showed a peak at pH 7.4, and the optimal temperature was found to be 45 °C. However, the pH and temperature stability of the CotA laccase was lower than that of the spore laccase.Conclusion: The purified recombinant CotA-laccase showed high stability towards alkaline pH, high temperatures, and a broad pH range for catalyzing substrates. (ijabbr.com)
  • Studies show it may be important in a process called myelination, which is the formation of the protective coating around nerve cells called the myelin sheath. (medlineplus.gov)
  • In patients with del(5q) myelodysplastic syndrome (MDS), the transcription factor FOXM1 is frequently downregulated in CD34+ cells. (bvsalud.org)
  • 15. Extensive characterization of a Williams syndrome murine model shows Gtf2ird1-mediated rescue of select sensorimotor tasks, but no effect on enhanced social behavior. (nih.gov)