Shown to interact with cdk1 cyclin a. Medical search. Frequent questions

Cyclin-dependent kinases (CDKs), are members of the serine-threonine protein kinase family and are responsible for taking control of cell cycle regulation in eukaryotic cells. (spandidos-publications.com)
These changes are orchestrated by a small number of master regulators, including the cyclin-dependent kinases (Cdks) and the anaphase-promoting complex/cyclosome (APC/C). Each Cdk or APC/C isoform has a large number of substrates, and the substrates of each isoform are modified in a specific order that leads to sequential substrate activation or inactivation. (biomedcentral.com)
Most of the other cyclin-dependent kinases are involved in controlling cell division, but CDK5 is not. (mit.edu)
Pharmaceutical companies have tried to target P25 with small-molecule drugs, but these drugs tend to cause side effects because they also interfere with other cyclin-dependent kinases, so none of them have been tested in patients. (mit.edu)
Those tests also showed that the peptide does not inhibit the normal CDK5-P35 complex, nor does it affect other cyclin-dependent kinases. (mit.edu)
Cyclin-dependent kinases and tumor suppressor proteins are stimulators and modulators of cell division. (ptgcn.com)
Cyclin-dependent kinases (CDKs) are serine/threonine protein kinases that act as key regulatory elements in cell cycle progression. (proteopedia.org)
The profiling of compound 51 against a panel of 339 kinases revealed high selectivity for CDKs, with preference for CDK2 and CDK5 over CDK9, CDK1, CDK4, and CDK6. (proteopedia.org)
Development of Highly Potent and Selective Diaminothiazole Inhibitors of Cyclin-Dependent Kinases. (proteopedia.org)
The new analysis, published online September 14 in Molecular Cell , found that the formation of engineered condensates during phase separation offered more "sticky" regions where medically important kinases and their targets could interact and trigger phosphorylation signals. (nyulangone.org)
Among the study kinases seen to be more active in a crowded, condensed environment was Cyclin-Dependent Kinase 2, known to phosphorylate the microtubule-binding protein Tau. (nyulangone.org)
In seeking to engineer useful versions of these computers, the research team tested several artificial condensates, synthesizing different scaffold molecules to see which best pulled sample kinases-MAPK3, Fus3, and Cyclin-Dependent Kinase 1 (Cdk1)-together with their targets to increase signaling. (nyulangone.org)
Homeodomain-interacting protein kinases (HIPKs) belong to the CMGC kinase family and are closely related to dual-specificity tyrosine phosphorylation-regulated kinases (DYRKs). (nature.com)
Homeodomain-interacting protein kinases (HIPKs) are an evolutionarily conserved kinase family comprising the members HIPK1, HIPK2, and HIPK3 in vertebrates, and, additionally, HIPK4 in mammals. (nature.com)
Progression through the cell cycle is driven by the oscillating activity of Cyclin Dependent Kinases (CDKs). (intechopen.com)
A relatively well understood example is the network that controls progression of the cell cycle, where cyclin-dependent kinases (CDKs) couple with various cyclins over the cell cycle to regulate critical processes [ 2 - 4 ]. (biomedcentral.com)
EGCG interacts with important cell cycle regulatory proteins, such as cyclins D1 and E and their cyclin-dependent kinases 2,4 and 6. (lumminary.com)
During the cell cycle, SAMHD1 is regulated through phosphorylation by different cyclin-dependent kinases (CDKs) and cyclins. (biomedcentral.com)

The role of cyclin B1 is to transition the cell from G2 to M phase but becomes unregulated in cancer cells where overexpression of cyclin B1 can lead to uncontrolled cell growth by binding to its partner Cdks. (wikipedia.org)
CDKs show their action by interacting with cyclins and different CDK-cyclin complexes regulate the cell cycle in the G1, S and G2/M phases ( 1 ). (spandidos-publications.com)
The activity of CDKs is controlled by their binding to coactivator subunits termed Cyclins, as well as by CDK inhibitory proteins termed CKIs. (intechopen.com)
We show that it is possible to predict proteins that are likely to be targets of CDKs in S. cerevisiae by searching for proteins that contain clustered matches to the CDK consensus. (biomedcentral.com)

Multiple rounds of centrosome reproduction were blocked by selective inactivation of cyclin-dependent kinase 2-cyclin E (Cdk2-E) and were restored by addition of purified Cdk2-E. Confocal immunomicroscopy revealed that cyclin E was localized at the centrosome. (umassmed.edu)
Cyclin E/CDK2 prevents oxidative stress-mediated Ras-induced senescence by phosphorylating MYC. (proteopedia.org)
NPM1 phosphorylation by cyclin E/CDK2 promotes its dissociates from unduplicated centrosomes, thus initiating centrosome duplication. (proteopedia.org)
Cyclin E/CDK2-mediated phosphorylation of NPAT at G1-S transition and until prophase stimulates the NPAT-mediated activation of histone gene transcription during S phase. (proteopedia.org)
Zhao J, Kennedy BK, Lawrence BD, Barbie DA, Matera AG, Fletcher JA, Harlow E. NPAT links cyclin E-Cdk2 to the regulation of replication-dependent histone gene transcription. (proteopedia.org)
UBF1 is normally turned on during G1 development by phosphorylation of serine 484 by cdk 4/cyclin D1 (42) and serine 388 by cdk2/cyclin E and A (41) leading to complete activation of rRNA transcription. (cancerrealitycheck.com)

Purvalanol, a novel cyclin-dependent kinase inhibitor, is referred to as a strong apoptotic inducer which causes cell cycle arrest in various cancer cells such as prostate, breast and colon cancer cell lines. (spandidos-publications.com)

Cyclin B1 is a regulatory protein involved in mitosis. (wikipedia.org)
Cyclin B1 contributes to the switch-like all or none behavior of the cell in deciding to commit to mitosis. (wikipedia.org)
Cyclin B1-Cdk1 is involved in the early events of mitosis, such as chromosome condensation, nuclear envelope breakdown, and spindle pole assembly. (wikipedia.org)
Once activated, cyclin B1-Cdk1 promotes several of the events of early mitosis. (wikipedia.org)
Just prior to mitosis, a large amount of cyclin B1 is present in the cell, but it is inactive due to phosphorylation of Cdk1 by the Wee1 kinase. (wikipedia.org)
Once cyclin B1-Cdk1 is activated, it remains stably active for the rest of mitosis. (wikipedia.org)
Before mitosis almost all cyclin B1 in the cell is located in the cytoplasm, but in late prophase it relocates to the nucleus. (wikipedia.org)
At the end of mitosis, cyclin B1 is targeted for degradation by the APC through its APC localization sequence, permitting the cell to exit mitosis. (wikipedia.org)
The activator Cdc20 is then replaced by a second activator, Cdh1, and APC/C Cdh1 promotes complete degradation of M cyclin, followed by polo-like kinase 1, Aurora A, and other substrates, to complete mitosis and cytokinesis and drive progression into G1 [ 1 , 2 ]. (biomedcentral.com)
controls the timing of entry into mitosis/meiosis by controlling the subsequent activation of cyclin B/CDK1 by phosphorylation, and coordinates the activation of cyclin B/CDK1 at the centrosome and in the nucleus. (proteopedia.org)
activated by interaction with cyclin E during the early stages of DNA synthesis to permit G1-S transition, and subsequently activated by cyclin A2 (cyclin A1 in germ cells) during the late stages of DNA replication to drive the transition from S phase to mitosis, the G2 phase. (proteopedia.org)
On the entry of mitosis phosphorylation by cdk1/cyclin B network marketing leads to inactivation of UBF1 and SL1. (cancerrealitycheck.com)
Aurora kinase C is a chromosomal passenger protein that interacts with aurora kinase B in the regulation of MITOSIS. (lookformedical.com)

VP2 encountered three significant novel mutations apart from the HVR, including G163E in rA and Y173C and V178A in rB, all residing within interacting motifs. (bvsalud.org)
There are several examples of B-type cyclins identifying certain peptide motifs in their specific substrates through a conserved region in their structure. (umassmed.edu)
These "LP" type docking motifs determine cyclin specificity, promote phosphorylation of suboptimal CDK sites and multi-site phosphorylation of substrates both in vivo and in vitro. (umassmed.edu)
Both N-terminal amphipathic helix as well as the polyproline motifs of NS5A show up needed for rRNA transcription activation. (cancerrealitycheck.com)
We show that cyclin-dependent kinase (CDK) consensus motifs are frequently clustered in CDK substrate proteins. (biomedcentral.com)
Finally, we examine co-clustering of the CDK consensus motifs with the 'cy' or RXL motif [ 17 ], which is known to be important in determining which CDK-cyclin complex will phosphorylate a given substrate. (biomedcentral.com)

Previously, we found that eukaryotic initiation factor (eIF) 4A interacts with cyclin dependent kinase A (CDKA), the plant ortholog of mammalian CDK1. (aber.ac.uk)
As a postdoc, she identified and cloned the CDK5 gene, which encodes a type of enzyme known as a cyclin-dependent kinase. (mit.edu)
We further display that hyperphosphorylation of UBF takes place due to up-regulation of both cyclin D1 and cyclin-dependent kinase 4 (cdk4) with the HCV NS5A polypeptide. (cancerrealitycheck.com)
Recent studies have shown that cyclin-dependent kinase (CDK) inhibitors can have a tremendous impact on cell cycle progression in plants. (uni-bielefeld.de)
Specifically, the study found that when Tau and Cyclin-Dependent Kinase condensed together into dense droplets, there was a three-fold acceleration of a phosphorylation at a group of sites on Tau (the AT8 epitope) linked to Alzheimer's disease. (nyulangone.org)

A possible trigger for activation is phosphorylation by cyclin A-Cdk, which functions before cyclin B1-Cdk in the cell cycle. (wikipedia.org)

Here we show that this interaction occurs only in proliferating cells where the two proteins co-associate with 5'-cap-binding protein complexes, eIF4F or the plant specific eIFiso4F. (aber.ac.uk)
UBF1 a series particular DNA binding proteins interacts using the template rDNA. (cancerrealitycheck.com)
The participation of most three proteins have already been described as getting in charge of cell routine through alteration of or connections with key mobile regulator proteins such as for example p53 p21 cyclins aswell as transcription elements proto-oncogenes and development elements/ cytokines (20). (cancerrealitycheck.com)
In download Dopamine in the Pathophysiology and Treatment of Schizophrenia: to find the place of here shown early ligands, Rev clusters between the synthesis and storage-inducing resulting body homodimer protein proteins( suggested in Li et al. (evakoch.com)
We have shown that this process is triggered by recruitment of ATG16L1 by the vacuolar-type H-translocating ATPase (V-ATPase) proton pump, suggesting a role for pH sensing in recruitment of Atg8-family proteins to single membranes. (babraham.ac.uk)
The accumulation of both Cyclin and CKI proteins is tightly regulated at the level of transcription. (intechopen.com)
In addition, Cyclin and CKI proteins are controlled at the level of their destruction. (intechopen.com)
We also show that human CDK targets are enriched for proteins that contain clustered consensus matches and, by searching human cell cycle genes, we predict several putative CDK targets, including the human orthologs of Schizosaccharomyces pombe CDC5 (CDC5L) and S. cerevisiae Cdc20p (CDC20). (biomedcentral.com)
EGCG has also been shown to interact with apoptotic proteins such as Caspase 3, 7 and 8. (lumminary.com)
Interestingly, it also interacts with antiapoptotic proteins such as Survivin and cFLIP, which regulate the activity of apoptosis protein. (lumminary.com)

We show experimentally that the rate of catalysis varies with different substrates of APC/C Cdc20 . (biomedcentral.com)
It has been known for some time that cyclins not only contribute by activating the CDK but also by choosing substrates and/or specifying the location of the CDK holoenzyme. (umassmed.edu)
In this dissertation, I have presented evidence that some G1 cyclins in budding yeast, Cln1/2, specifically identify substrates by interacting with a leucine-proline rich sequence different from the ones used by B-type cyclins. (umassmed.edu)
Interestingly, this region is close to but not same as the one implicated in B-type cyclins to binding substrates. (umassmed.edu)
Numerous E3 ubiquitin ligases, which facilitate the ubiquitination of specific substrates, have been shown to control G1/S. In this chapter, we will discuss components in the ubiquitin proteasome system that are implicated in G1/S control, how these enzymes are interconnected, gaps in our current knowledge, and the potential role of these pathways in the cancer cycle and disease proliferation. (intechopen.com)

The gene product complexes with p34 (Cdk1) to form the maturation-promoting factor (MPF). (wikipedia.org)
New anticancer therapy strategies refer to the inhibition of CDK-cyclin complexes as an important target to prevent uncontrolled proliferation and induce apoptosis in cancer cells ( 2 ). (spandidos-publications.com)
Several cell cycle events require specific forms of the cyclin-CDK complexes. (umassmed.edu)
As well as the enzyme complexes directly responsible for LC3 lipidation in all contexts, we show the RALGAP complex is important for M2-induced, but not ionophore drug-induced, LC3 lipidation. (babraham.ac.uk)

These paclitaxel resistant ovarian cells demonstrate: (1) Increased IC 50 for paclitaxel and docetaxel (10 to 75-fold) and cross-resistance to anthracyclines (2) Reduced cell apoptosis in the presence of paclitaxel (3) Gene depletion involving mitotic regulators BUB1 mitotic checkpoint serine/threonine kinase, cyclin BI (CCNB1), centromere protein E (CENPE), and centromere protein F (CENPF), and (4) Functional data validating gene depletion among mitotic regulators. (biomedcentral.com)

ClueGO analysis showed that RFC2 and EZH2 were related to cell cycle. (sagepub.com)
RFC2, EZH2, CDK1, PARP3 and NEIL1 may be associated, and together enhance the susceptibility of FaDu cells treated with RITA to the deleterious effects of X-ray. (sagepub.com)

These high levels of cyclin B1 can also be associated to the extent of tumor invasion and aggressiveness therefore concentration of cyclin B1 can be used to determine the prognosis of cancer patients. (wikipedia.org)
For example, an increase in expression of cyclin B1/cdc2 is significantly higher in breast tumor tissue and shown to increase lymph node metastasis in breast cancer. (wikipedia.org)
While the exact mechanism that explains how cyclin B1 becomes overexpressed is not very well understood, previous work has shown that down regulation of cyclin B1 can lead to tumor regression. (wikipedia.org)
By xenografting human breast cancer cells into nude mice, we found that VALD-3 significantly suppressed tumor cell growth while showing low toxicity against major organs. (researchsquare.com)
It also interacts with growth factors including a cytokine called tumor necrosis factor-α (TNF-α) by inhibiting its activity. (lumminary.com)

Another mechanism by which cyclin B1-Cdk1 activity is regulated is through subcellular localization. (wikipedia.org)

G2/mitotic-specific cyclin-B1 is a protein that in humans is encoded by the CCNB1 gene. (wikipedia.org)
Our results show that 2HF induced apoptosis in both histological types of lung cancer and inhibited proliferation and growth through suppression of CDK4, CCNB1, PIK3CA, AKT and RPS6KB1 (P70S6K) signaling. (oncotarget.com)

Cyclin B1 has been shown to interact with Cdk1, GADD45A and RALBP1. (wikipedia.org)

Quite interestingly, we found that a CDK inhibitor, Far1, could regulate the Cln2-CDK1 activity partly by inhibiting the Cln2-substrate interaction, thus demonstrating that docking interactions can be targets of regulation. (umassmed.edu)

We determined the crystal structures of HIPK3 and DYRK1A bound to abemaciclib, showing a similar binding mode to the hinge region of the kinase as observed for Cdk6. (nature.com)

Furthermore, gene-wise phylogenetic analysis showed the entire genes of rA and rB clustered with the vvIBDVs and emphasized their share in IBDV virulence. (bvsalud.org)
2011 ) clearly showed that 1,25(OH) 2 D 3 can modulate gene and microRNA profiles in LCNaP cells and affects processes involved in cell cycle arrest, calcium ion homoeostasis and phosphoinositide-mediated signalling. (biomedcentral.com)

Cyclin B1 can reside in the nucleus or the cytoplasm which can have an effect on the malignant potential of cyclin B1 when overexpressed in each location. (wikipedia.org)

Promotes G0-G1 transition when phosphorylated by CDK3/cyclin-C. Acts as a transcription repressor of E2F1 target genes. (abcam.cn)

Using a computational model based on multi-step ubiquitination, we then show how changes in the interaction between a single substrate and APC/C Cdc20 can alter the timing of degradation onset relative to APC/C Cdc20 activation, while ensuring a fast degradation rate. (biomedcentral.com)
hCDC4 interacts with cyclin E. This interaction was modelled on a demonstrated interaction between human CDC4 and cyclin E from an unspecified species. (uth.edu)

We show experimentally that increased expression of the early APC/C Cdc20 substrate Clb5 does not delay the degradation of the later substrate securin, arguing against a role for competition with Clb5 in establishing securin degradation timing. (biomedcentral.com)

The underphosphorylated, active form of RB1 interacts with E2F1 and represses its transcription activity, leading to cell cycle arrest. (abcam.cn)

The peptide does not interfere with CDK1, an essential enzyme that is structurally similar to CDK5, and it is similar in size to other peptide drugs that are used in clinical applications. (mit.edu)
CDK5 is activated by a smaller protein that it interacts with, known as P35. (mit.edu)

Flow cytometry analysis showed that VALD-3 triggered cell cycle arrest and induced apoptosis of breast cancer cells. (researchsquare.com)

Cortical microtubules in all mutants showed statistically significant increased persistence against anti-microtubule drugs, compared to those of the wild-type. (biomedcentral.com)

2. High accumulation of Cyclin B1 in the nuclei can be used as a marker for studying the G2/M phase (Figure 3). (ptgcn.com)

VP5 showed a virulence marker, MLSL (amino acid sequence). (bvsalud.org)

Using animal models, in vivo and in vitro studies have suggested that green tea polyphenols interact with a number molecular targets that are active in cellular processes involved in a range of diseases such as certain cancer (further discussed in Role of green tea in preventing and fighting cancer). (lumminary.com)

Consequently, depletion of PLK1 has been shown to counteract the PIP4KIIγ depletion-induced instability of spindle pole-associated MT and cell resistance to arsenite. (biomedcentral.com)

The changes in the G1-to-S cell cycle pathway showed that 1,25(OH) 2 D 3 down-regulates the genes influencing the G1-to-S phase transition. (biomedcentral.com)

This is regulated by the phosphorylation of cyclin B1, in contrast to phosphorylation of Cdk1 regulating the activity of the complex. (wikipedia.org)

This antagonism of microtubule-targeting drugs was accompanied by a delay in cell cycle progression and inhi- bition of the buildup of cyclin-B1 at the microtubule organizing center of treated cells. (vdocuments.net)

Phosphorylation of cyclin B1 causes it to be imported to the nucleus, and phosphorylation also prevents export from the nucleus by blocking the nuclear export signal. (wikipedia.org)
We show that ICK1/KRP1 exerts its function in the nucleus and its presence in the nucleus is controlled by multiple nuclear localization signals as well as by nuclear export. (uni-bielefeld.de)

This study is the first to show that VALD-3 induces apoptosis and cell cycle arrest in human breast cancer cells by suppressing Wnt/β-catenin signaling, indicating that it could be a potential drug for the treatment of breast cancer. (researchsquare.com)
The HNSCC cell line JHU-028 can express wild type (wt) p53, but the cells do not undergo apoptosis in response to RITA treatment.10 Previously, we used RITA combined with X-ray to investigate the effect of RITA on X-ray susceptibility for the treatment of HSCC cell line FaDu (which is HPV-negative cell line) and found that RITA could enhance the radiation response of HSCC (data not shown). (sagepub.com)

NQ interacted with HepG2 cell DNA and reduced histone deacetylases to control cell proliferation and arrest the cell cycle at the sub-G stage. (molcells.org)

Duolink In situ Proximity ligation assay clarified that Pc interacts with dJmj at nucleolus in the late growth stage. (sdbonline.org)

In addition, survival analysis results showed that VALD-3 can significantly prolong the survival time of mice ( P =0.036). (researchsquare.com)
Immunotherapy was shown to significantly increase the rate of the abscopal effect and prolong patient survival. (nature.com)

Such interactions were not known for the G1 class of cyclins, which are instrumental in helping the cell decide whether or not to commit to a new cell cycle, a function that is non-redundant with B-type cylins in budding yeast. (umassmed.edu)
Finally, by studying many fungal cyclins exogenously expressed in budding yeast, we discovered that some have the ability to make the CDK hyper-potent, which suggests that these cyclins confer special properties to the CDK. (umassmed.edu)

Nuclear-dominant expression of cyclin B1 leads to poorer prognosis due to its weak activity compared to cytoplasmic cyclin B1. (wikipedia.org)
Jarid2 methylation is shown to be important to promote PRC2 activity at a locus devoid of H3K27me3 and for the correct deposition of this mark during cell differentiation. (sdbonline.org)
Furthermore, we showed that the N-terminal BTB/POZ domain of TZFP has a repressor activity. (lookformedical.com)
We first showed that HIV-1 restriction was not due to SAMHD1 nuclease activity. (biomedcentral.com)

Numerous in vitro and animal model studies using quercetin alone or quercetin in combination with other bioactive com- pounds have shown the anticancer activities of the compound (8-15). (vdocuments.net)

Previous work has shown that high cyclin B1 expression levels are found in variety of cancers such as breast, cervical, gastric, colorectal, head and neck squamous cell, non-small-cell lung cancer, colon, prostate, oral and esophageal. (wikipedia.org)
Data table showing topics related to specific cancers and associated disorders. (cancerindex.org)

Age-standardized incidence rates for breast cancer in Chinese women showed a significant upward trend during the period 2000 to 2011[2]. (researchsquare.com)

Another important function of the cyclin B1-Cdk1 complex is to break down the nuclear envelope. (wikipedia.org)

Here, we show that p16 Ink4a deficiency enhances fasting-induced hepatic glucose production in vivo by increasing the expression of key gluconeogenic genes. (diabetesjournals.org)

Phosphorylation of the lamins by cyclin B1-Cdk1 causes them to dissociate, compromising the structural integrity of the nuclear envelope so that it breaks down. (wikipedia.org)

A phase II study showed that patients with resected local-regionally advanced head and neck squamous cell carcinoma (HNSCC) had improved survival when pembrolizumab was added to adjuvant RT (NCT02641093). (nature.com)
A recent study showed that mitochondria clustering around the perinuclear region can act as signaling for increased oxidative stress affecting hypoxia inducible promoters [ 12 ]. (hindawi.com)

In this work, the persistence of cortical microtubules against anti-microtubule treatment was thoroughly studied in the roots of several cesa mutants, namely thanatos , mre1 , any1 , prc1-1 and rsw1 , and the Cellulose Synthase Interacting 1 protein ( csi1) mutant pom2-4 . (biomedcentral.com)

Purvalanol is a purine-derived CDKI that binds with a high selectivity and competitively to the ATP binding side of CDK1/2 and leads to G2/M cell cycle arrest ( 4 ). (spandidos-publications.com)

Results of in-vivo nude mouse xenograft studies of SCLC and NSCLC, which showed that orally administered 2HF inhibited growth of both histological types of lung cancer, confirmed in-vitro study results. (oncotarget.com)
Our study results show that physical changes like crowding can drive condensate formation that is converted into biochemical signals, as if condensates were squishy computers," says lead study author Liam J. Holt, PhD , a member of the Institute for Systems Genetics at NYU Langone Health. (nyulangone.org)

Immunohistochemistry of paraffin-embedded human breast cancer tissue slide using 55004-1-AP (Cyclin B1 Antibody) at a dilution of 1:200 (under 10x lens). (ptgcn.com)
A ) Simplified representation of the secondary structure showing domain organization of the human p53 protein (Uniprot #P04637). (encyclopedia.pub)

Its activation is well-regulated, and positive feedback loops ensure that once the cyclin B1-Cdk1 complex is activated, it is not deactivated. (wikipedia.org)
We found that CDK1 phosphorylates Ser343 of ERK1c, thereby allowing the binding of phosphorylated ERK1c to a complex that consists of PI4KIIIβ (also known as PI4KB) and the 14-3-3γ dimer (encoded by YWHAB ). (biologists.com)
After vascular complex pathway is caused on a Electrical snRNP, MAML( other) radicals direct in brain with cyclin C, including protein of followed high-affinity ligands in TAD and PEST cilia of NICD1 by CDK8. (evakoch.com)

Ig repeats 16-24, where most FLNa-binding partners interact, do not bind F-actin, and thus F-actin does not compete with Ig repeat 23 ligand, FilGAP. (rupress.org)

Wild-type p53 have been shown to suppress cyclin B1 expression. (wikipedia.org)

Focusing on computational and statistical aspects of MR discovery, the ARACNe-MRA (Algorithm for the Reconstruction of Accurate Cellular Networks-Master Regulator Analysis) method has shown competent performance in this regard [ 4 ]. (aging-us.com)

Anatomy24

Organisms9

Diseases5

Chemicals and Drugs132

Analytical, Diagnostic and Therapeutic Techniques and Equipment16

Phenomena and Processes69

Disciplines and Occupations1

Information Science3

Kinases18

CDKs4

CDK26

Kinase inhibitor1

Mitosis13

Motifs6

Dependent kinase5

Phosphorylation by cyclin1

Proteins10

Substrates5

Complexes4

Serine1

EZH22

Tumor5

Subcellular localization1

CCNB12

RALBP11

Regulate1

CDK61

Gene2

Cytoplasm1

Promotes1

Interaction2

Degradation1

Transcription1

CDK52

Analysis showed1

Statistically1

Accumulation1

Sequence1

Targets1

Spindle1

Transition1

Contrast1

Progression1

Nucleus2

Apoptosis2

Histone1

Assay1

Significantly2

Yeast2

Activity4

Anticancer1

Cancers2

20001

Important1

Genes1

Nuclear1

Study showed2

Mutants1

Cell cycle arrest1

Results2

Human2

Complex3

Bind1

Type1

Regulator1