The fraction of Ki-67-positive tumor cells (the Ki-67 labeling index) is often correlated with the clinical course of cancer. (wikipedia.org)
There is tumor cell positivity in 70% of the cells: Ki-67 labelling index = 70% Counting positive versus negative nuclei with Ki-67 labeling, in this case in a neuroendocrine tumor of the small intestine. (wikipedia.org)
In studies of tumor cells, the "Ki-67 labeling index" refers to the number of Ki-67 positive cells within the population and this is used to predict outcome of particular cancer types. (thermofisher.com)
and cell differentiation ( SOX2 and TGFB3 ) as well as immunohistochemical assay for VEGFA, TP53, Bcl2, TGFB1, and Ki67 protein expression have been performed in 85 FFPE RCC tumor specimens. (hindawi.com)
Iron-based nanomaterials have shown great promise for tumor ferrotherapy in recent years. (bvsalud.org)
IL-13Rα2 is one of the most widely studied tumor-associated antigens in glioma research. (biomedcentral.com)
Multivariate analysis showed that tumor grade, Ki-67, P53 and IL-13Rα2 could be the independent prognostic factors for OS. (biomedcentral.com)
In addition, xenograft tumor experiments showed that circIFT80 accelerated the tumorigenesis of CRC in vivo. (hindawi.com)
TLR2 was localized in the cell membrane of the colorectal epithelium of the NC group and of the colorectal tumors of the NT group and was highly expressed in the NT group, while antigen Ki67 was localized in the nucleus of the colorectal tumor cells of the NT group and the KT group, and its expression was reduced in the KT group. (biomedcentral.com)
Recent studies in mouse tumor models have shown that T RM cells are induced by cancer vaccines delivered in peripheral tissue sites, or by the depletion of regulatory T cells. (frontiersin.org)
T RM responses against tumor/self-antigens can concurrently result in the development of pathogenic T RM responses to self, with a growing number of autoimmune diseases and inflammatory pathologies being attributed to T RM responses. (frontiersin.org)
While innate immune cells are important for early tumor immune surveillance, T cells are fundamentally recognized for their crucial role in the antigen-specific recognition and elimination of malignantly transformed cells ( 2 ). (frontiersin.org)
Monoclonal antibody5
Antigen Kiel 67, also known as Ki-67 or MKI67 (marker of proliferation Kiel 67), is a protein that in humans is encoded by the MKI67 gene (antigen identified by monoclonal antibody Ki-67). (wikipedia.org)
The Ki-67 protein was originally defined by the prototype monoclonal antibody Ki-67, which was generated by immunizing mice with nuclei of the Hodgkin lymphoma cell line L428. (wikipedia.org)
The following product was used in this experiment: Ki-67 Monoclonal Antibody (SolA15), Brilliant Ultra Violet™ 615, eBioscience™ from Thermo Fisher Scientific, catalog # 366-5698-82, RRID AB_2925428. (thermofisher.com)
Cells were then surface-stained with CD45R (B220) Monoclonal Antibody, FITC (Product # 11-0452-82) and stained intracellularly, using the Foxp3/Transcription Factor Staining Buffer Set (Product # 00-5523-00) and protocol, with 1.0 µg of Ki-67 Monoclonal Antibody, Brilliant Ultra Violet 615. (thermofisher.com)
Description: The monoclonal antibody SolA15 recognizes mouse and rat Ki-67, a 300 kDa nuclear protein. (thermofisher.com)
Protein12
Antigen KI-67 is a nuclear protein that is associated with cellular proliferation and ribosomal RNA transcription. (wikipedia.org)
The Ki-67 protein (also known as MKI67) is a cellular marker for proliferation, and can be used in immunohistochemistry. (wikipedia.org)
During interphase, the Ki-67 antigen can be exclusively detected within the cell nucleus, whereas in mitosis most of the protein is relocated to the surface of the chromosomes. (wikipedia.org)
Ki-67 protein is present during all active phases of the cell cycle (G1, S, G2, and mitosis), but is absent in resting (quiescent) cells (G0). (wikipedia.org)
Cellular content of Ki-67 protein markedly increases during cell progression through S phase of the cell cycle. (wikipedia.org)
Ki-67 (protein) has been shown to interact with CBX3. (wikipedia.org)
Protein Ki-67 in human MCF-7 cells Ki-67 protein (red), tubulin (green) and DNA (blue) in HeLa cells. (wikipedia.org)
Ki-67 has been shown to interact with the DNA-bound protein chromobox protein homolog 3 (CBX3) (heterochromatin). (thermofisher.com)
The advanced pathological grade was associated with strong TGFB1, VEGFA, and Ki67 protein expression and absent Tp53 staining. (hindawi.com)
Recently, immune checkpoint blockade therapies (ICBs) blocking programmed cell death protein 1 (PD-1) and its ligand (PD-L1) have shown tremendous benefit for the treatment of advanced NSCLC [ 4 ]. (biomedcentral.com)
Antigens Tuberculosis antigens used were early secreted antigen-6 (ESAT-6) and culture filtrate protein-10 (CFP-10) (both from Fitzgerald Industries Intl. Inc., Acton, MA). (fabretp.org)
Ki-67 is detected within the nucleus during interphase but redistributes to the chromosomes during mitosis. (thermofisher.com)
Intracellular3
Please refer to "Staining Intracellular Antigens for Flow Cytometry, Protocol B: One step protocol for intracellular (nuclear) proteins" located at Flow Protocols . (thermofisher.com)
The gating strategy for T-cell phenotyping is usually shown in the Supporting information, Fig. S1(b). intracellular staining for Ki-67 expression on CD8+ T and NK cells was performed. (fabretp.org)
We know today that to activate a CD8+ or CD4+ T cell, that T cell needs to see antigens (intracellular and extracellular, respectively). (dermatologytimes.com)
The epidermis is derived primarily from surface ectoderm but is colonized by pigment-containing melanocytes of neural crest origin, antigen-processing Langerhans cells of bone marrow origin, and pressure-sensing Merkel cells of unclear origin. (medscape.com)
Gene1
circRNAs can interact with miRNAs and thereby regulate miRNA-targeted gene expression by competitively binding to miRNA response elements [ 12 ]. (biomedcentral.com)
Vivo4
Inactivation of antigen KI-67 leads to inhibition of ribosomal RNA synthesis, but does not significantly affect cell proliferation in vivo: Ki-67 mutant mice developed normally and cells lacking Ki-67 proliferated efficiently. (wikipedia.org)
JNK1 KO OPCs also show smaller occupancy territories and a less complex branching architecture in vivo. (nature.com)
Our results unveil a novel player in the complex regulation of OPC biology, on the one hand showing that JNK1 ablation cell-autonomously determines alterations of OPC proliferation and branching architecture and, on the other hand, suggesting that JNK1 signaling in OLs participates in myelination in vivo. (nature.com)
Results of in-vivo nude mouse xenograft studies of SCLC and NSCLC, which showed that orally administered 2HF inhibited growth of both histological types of lung cancer, confirmed in-vitro study results. (oncotarget.com)
Marker2
Ki-67 is an excellent marker to determine the growth fraction of a given cell population. (wikipedia.org)
Ki-67 is used as a marker for determining the growth fraction of a given population of cells. (thermofisher.com)
Cancer4
In breast cancer Ki67 identifies a high proliferative subset of patients with ER-positive breast cancer who derive greater benefit from adjuvant chemotherapy. (wikipedia.org)
High Ki-67 expression in an invasive breast cancer, with cancer nuclei being stained (brown). (wikipedia.org)
Here, we show that DRAM2 may act as an oncogenic regulator in non-small cell lung cancer (NSCLC). (cancerindex.org)
Our results show that 2HF induced apoptosis in both histological types of lung cancer and inhibited proliferation and growth through suppression of CDK4, CCNB1, PIK3CA, AKT and RPS6KB1 (P70S6K) signaling. (oncotarget.com)
Cell5
Dividing cells show strong Ki-67 staining in cell nuclei while all cells contain large amounts of tubulin, the major component of microtubules. (wikipedia.org)
Immunohistochemical (Ki67) staining of hyperkeratotic skin invariably shows that virtually every basal cell is in cycle, versus very few basal cells in background skin. (dermatologytimes.com)
Several other environmental factors including oxy- gen concentration and mechanical, metabolic, and bio- chemical conditions have been shown relevant in cell differentiation and have been reviewed extensively (Fig. 1) [3]. (unicyte.ch)
T cell memory is antigen-specific, and can provide durable host-wide protection. (frontiersin.org)
Tumors2
Molecular targeting agents have become formidable anticancer weapons, which show much promise against the refractory tumors. (aacrjournals.org)
In a growing number of cases, CD8 T cells have been shown to mediate the regression of large bulky tumors, resulting in durable long-term disease remissions ( 5 ). (frontiersin.org)
Tissues3
whereas T EM cells were shown to recirculate predominantly through blood, and peripheral tissues ( 10 ). (frontiersin.org)
In the early 2000's, large and persistent populations of antigen (Ag)-specific CD8 T cells in peripheral tissues were initially classified as T EM cells in recirculation from the blood ( 8 , 11 ). (frontiersin.org)
In contrast to animals, wherein they have been shown to infect several tissues causing a large variety of diseases, mainly human respiratory infections with mild common cold-like symptoms, with occasional gastrointestinal problems have been reported. (scitcentral.com)
Human1
The SolA15 antibody also recognizes human, non-human primate and canine Ki-67. (thermofisher.com)
Mouse1
Immunofluorescent antibody staining against neurofilament (green) and Ki-67 (red) in a mouse embryo 12.5 days after fertilization. (wikipedia.org)
Volume1
in Feb 2007 of its first issue, it contained 5 articles only, and now in its recent volume published in April 2011, it contained 67 manuscripts. (jcdr.net)
Large1
Their nuclei are relatively large, round to oval in shape, and show mild pleomorphism with mostly small, round, regular nucleoli. (atlasgeneticsoncology.org)
Growth2
Myelinating OLs originate from parenchymal precursors expressing the neuron-glia antigen 2 (NG2) chondroitin sulphate proteoglycan and the platelet derived growth factor receptor alpha (PDGFRα), commonly referred to as oligodendrocyte progenitor cells (OPCs) 4 . (nature.com)
But the dominant hypothesis was that keratinocytes were growing autonomously by overproduction of growth factors (transforming growth factor alpha) that would interact with overactive EGF receptors, producing a proliferative reaction. (dermatologytimes.com)
Studies2
Studies collected in this review showed that GSM mobile phone RFR could be associated with alterations in T3, T4, and TSH serum hormone levels. (saferemr.com)
Background Earlier studies have demonstrated that smoking and genetic risk factors interact in providing an increased risk of rheumatoid arthritis (RA). (bmj.com)
Surface1
Moreover, JNK1 KO and WT D-JNKI-1 treated OLs, while not showing overt alterations of differentiation in vitro, display a reduced surface compared to controls. (nature.com)
Specific1
Data table showing topics related to specific cancers and associated disorders. (cancerindex.org)
Variety1
The integument consists of 2 layers, the epidermis and dermis, which form a variety of structures that allow us to interact with our environment. (medscape.com)