CatalaseEnzymesManganese superoxide dismutaseSOD1Anti-oxidantsOxidative stress1.15.1.1RadicalsReactiveLipid peroxidationSODsMitochondrialSupplementationGliSODinAcetylcholine2000PatientsGeneDefenseExposureStatistically significantBrainReductionSupplementsMalondialdehydeAntioxidant capacityPotent antioxidantLevelsAssaysActivityProteinsSubstancesHumansCopperNanoparticlesStudiesResultsZincProtein analysisDopamineExtract showedMolecularStudyClinicalInhalationEffectsStructuresMethodsTreatmentActivitiesGroupDeclineLiver
Catalase6
- The protective potential was carried on superoxide dismutase (SOD), catalase and peroxidases. (degruyter.com)
- Activities of antioxidant enzymes, superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPX) were measured in ellagic acid-treated V79-4 cells. (nutrimedical.com)
- Among antioxidant enzymes, catalase, superoxide dismutase, and glutathione peroxidase were decreased and lipid peroxidation was increased with regional alterations. (fluoridealert.org)
- Moreover, superoxide dismutase and catalase activities showed a significant increase in relation to their contact with CBZ. (scielo.br)
- Além disso, as atividades de superóxido dismutase e catalase apresentaram aumento significativo em relação ao contato com CBZ. (scielo.br)
- Molecular docking analysis for different enzymes involved in aging (collagenase, elastase and hyaluronidase), antioxidant enzymes (superoxide dismutase, glutathione-s-transferase, glutathione peroxidase and catalase) and mitochondrial enzymes (nicotinamide adenine dinucleotide (NAD)+hydrogen (H) dehydrogenase, succinate dehydrogenase, cytochrome c oxidase and adenosine triphosphate synthase) was carried out for epigallocatechin gallate alone (1), withaferin A alone (2), epigallocatechin gallate and withaferin A in combination (3) and a reference molecule. (ijpsonline.com)
Enzymes4
- A previous study showed that treatment with orange peel essential oil decreased oxidative injury by decreasing the serum malondialdehyde (MDA) level and increasing the activities of antioxidant enzymes in subjects [ 12 ], and these effects may help prevent physical fatigue. (hindawi.com)
- Free radicals are normally scavenged from tissues by the a. enzymes superoxide dismutase and glutathione peroxidase. (theodora.com)
- In addition, a number of nutrient substances, vitamins, and minerals have been shown to contribute to a. functions, generally by serving as co-factors or co-enzymes. (theodora.com)
- Superoxide dismutases (SODs) are the primary reactive oxygen species (ROS)-scavenging enzymes of the cell and catalyze the dismutation of superoxide radicals O2- to H2O2 and molecular oxygen (O2). (nih.gov)
Manganese superoxide dismutase3
- You don't hear a lot about manganese, but it plays a role in creating a potent mitochondrial antioxidant: manganese superoxide dismutase. (marksdailyapple.com)
- Without adequate manganese, you won't make enough superoxide dismutase, and without enough mitochondrial manganese superoxide dismutase, you run the risk of developing a neuropathology or suffering an ischemic brain injury (what often happens after stroke). (marksdailyapple.com)
- Other studies have shown elevated serum levels of manganese superoxide dismutase and tissue inhibitor of metalloproteinase (TIMP-1). (medscape.com)
SOD15
- Researchers delayed signs of amyotrophic lateral sclerosis (ALS) in rodents by injecting them with a second-generation drug designed to silence the gene, superoxide dismutase 1 (SOD1). (sciencedaily.com)
- SOD1 XII MNs and lumbar MNs, but not trochlear MNs showed vacuolization from the same time-points. (frontiersin.org)
- However, on April 25, 2023, the FDA granted accelerated approval to tofersen (Qalsody), an antisense oligonucleotide, indicated to treat patients with ALS associated with a mutation in the SOD1 (superoxide dismutase 1) gene. (uspharmacist.com)
- The first familial ALS pathogenic gene, the SOD1 (superoxide dismutase 1) gene, was discovered in 1993. (uspharmacist.com)
- At week 24, those receiving tofersen showed a reduction in concentrations of toxic SOD1 protein and markers of neuronal injury. (cdc.gov)
Anti-oxidants2
- Extremely potent booster of one of the body's natural anti-oxidants systems (superoxide dismutase AKA SOD). (turnkeylinux.org)
- Another 2012 study showed that Cordyceps lowered inflammatory markers in the brain of D-galactose injected mice and increased key anti-oxidants such as superoxide dismutase and glutathione. (naturalnews.com)
Oxidative stress5
- The correlation coefficient values among oxidative stress markers and biometals were either positive or negative and showed less significance during correlation. (fluoridealert.org)
- The results showed that although the sulfluramid may cause the production of ROS, its slow action in the organism does not lead to oxidative stress. (springer.com)
- CONCLUSION: We show the persistence of lung inflammation and oxidative stress in mice chronically-exposed to WPS and demonstrate, for the first time, the occurrence of DNA damage and enlargement of alveolar spaces and ducts associated with impairment of lung function. (who.int)
- Mn, serum Mn, urine Mn, Centromere-positive micronuclei in periphery blood lymphocytes, DNA protein-crosslinks in peripheral white blood cells, oxidative stress as urinary 8OHdG, and long-term oxidative damage measured as erythrocytic superoxide dismutase (SOD) activity (measure of systemic oxidative stress) and serum malondialdehyde (MDA) (product of lipid peroxidation and reflect tissue injuries). (who.int)
- Supplementation with plant origin superoxide dismutase (GliSODin) in a randomized, double-blind, placebo controlled study conducted to assess the effects of supplementation on exercise-induced oxidative stress, exercise-induced inflammation and performance in athletes. (who.int)
1.15.1.11
- Superoxide dismutase (SOD, EC 1.15.1.1) is an enzyme that alternately catalyzes the dismutation (or partitioning) of the superoxide (O− 2) radical into ordinary molecular oxygen (O2) and hydrogen peroxide (H 2O 2). (wikipedia.org)
Radicals3
- Since the metalloprotein superoxide dismutase, SOD, is the key enzyme involved in the detoxification of superoxide radicals, it may play a vital role in interindividual variation in superoxide radical turnover. (nature.com)
- It breaks down superoxide radicals, which are toxic to living cells and cause DNA mutations, into harmless components consisting of oxygen and hydrogen peroxide. (mskcc.org)
- The results showed that both the ethanolic (BEE) and the hydroethanolic (BEH) extracts from the barks of X. aethiopica scavenged all the tested radicals. (degruyter.com)
Reactive2
- Additionally, AMP and TB supplementation reduced the levels of reactive oxygen species (ROS) and malonaldehyde (MDA), while increasing superoxide dismutase (SOD) levels and serum immunoglobulin M (IgM) levels. (bvsalud.org)
- In lung tissue, lipid peroxidation, reactive oxygen species, superoxide dismutase activity and reduced glutathione were all increased by WPS exposure. (who.int)
Lipid peroxidation1
- RESULTS: Ellagic acid showed high DPPH radical scavenging and lipid peroxidation inhibition activities. (nutrimedical.com)
SODs1
- SODs catalyze the disproportionation of superoxide: 2H+ + 2O− 2 → O 2 + H 2O 2 In this way, O− 2 is converted into two less damaging species. (wikipedia.org)
Mitochondrial1
Supplementation4
- This pilot open-label study assessed the effects of baicalin supplementation (50 mg daily for 3 months) in cancer patients who showed involuntary weight loss >5% over the past 6 months. (nel.edu)
- Furthermore, MSM supplementation showed statistically significant improvements over placebo by expert grading in crow's feet and skin firmness, and statistically significant improvements from baseline in crow's feet, skin firmness, tone, and texture. (naturalmedicinejournal.com)
- A 2014 study published in Evidence Based Complimentary and Alternative Medicine showed that Cordyceps supplementation reduced inflammatory markers in the hippocampus of the brain . (naturalnews.com)
- The 16S rRNA results showed that AMP supplementation significantly increased the relative abundance of Rikenellaceae_RC9_gut_group, Ruminococcaceae_UCG-014 and [Eubacterium]_coprostanoligenes group (p (bvsalud.org)
GliSODin1
- Scientific research shows that GliSODin supports the natural production of superoxide dismutase in your body. (seacoast.com)
Acetylcholine1
- Dietary copper deficiency has been shown to significantly reduce acetylcholine (Ach)‐induced vascular smooth muscle relaxation. (iospress.com)
20001
- Superoxide Dismutase (from porcine) (providing 2000 M.F.U. (seacoast.com)
Patients1
Gene1
- 1 This gene is involved in the production of the enzyme copper-zinc superoxide dismutase 1. (uspharmacist.com)
Defense3
- Results also show that as the pathogen switched its strategy of infection, the host tailored its defense strategy to meet the changing situation. (nature.com)
- A total of twenty genes functioning in different aspects of plant defense that were monitored over a time course during the changing infection phases showed a coordinated response. (nature.com)
- In humans, avenanthramides increase antioxidant defense by elevating superoxide dismutase activity and glutathione redox status. (preparedfoods.com)
Exposure2
- We have shown previously that ACN potentiates NIHL, even with noise exposure approaching permissible occupational levels. (cdc.gov)
- Marine tests showed an inhibition of growth with the two different algal species (P. tricornutum and D. tertiolecta), an inhibition of bioluminescence in the bacterium A. fischeri, an alteration on the correct early development of the serpulid F. enigmaticus larvae and immobilization of the copepod A. tonsa individuals at both 24 and 48 hours of exposure. (easychair.org)
Statistically significant1
- Freshwater tests showed again an inhibition of the bioluminescence with A. fischeri together with a significant stimulation of radical apparatus elongation in two different superior plants (C. sativus and L. sativum), while S. saccharatum showed no statistically significant differences with controls, even if a biostimulation was again registered. (easychair.org)
Brain2
- Brain tissue and ascorbic acid are shown to protect catecholamines for long periods of time but are shown to have little or no effect on the rate of air oxidation of 6-hydroxydopamine at physiological pH. (erowid.org)
- Our data shows that SIRT1 expression increases with age, concurrently with increased acetylated p53 levels in all brain regions investigated. (frontiersin.org)
Reduction2
- SIRT3-5 expression declined significantly in the hippocampus and frontal lobe, associated with increases in superoxide and fatty acid oxidation levels, and acetylated CPS-1 protein expression, and a reduction in MnSOD level. (frontiersin.org)
- Reduction Potentials and Acidity Constants of Mn Superoxide Dismutase Calculated by QM/MM Free-Energy Methods. (lu.se)
Supplements1
- Superoxide dismutase supplements have not been shown to confer any health benefits. (mskcc.org)
Malondialdehyde2
- Irradiated group pretreated with leaf extract of M. piperita showed significant decrease in malondialdehyde (MDA) formation in liver. (unboundmedicine.com)
- After continuous inhalation for 3 days, the swimming time, blood glucose, blood lactic acid (BLA), blood urea nitrogen (BUN), superoxide dismutase (SOD), glutathione peroxidase (GSH-PX), and malondialdehyde (MDA) in blood were determined. (hindawi.com)
Antioxidant capacity2
- The sample BEH showed the highest total antioxidant capacity both in the FRAP and the PAP. (degruyter.com)
- We evaluated the effects of two insecticides (fipronil, sulfluramid) and metallic insecticide complex (magnesium complex [Mg(hesp)2(phen)] (1)) on the superoxide dismutase (SOD), glutathione (GSH) and the overall antioxidant capacity using two different methodologies: total radical-trapping potential (TRAP) and oxygen radical absorbance capacity (ORAC). (springer.com)
Potent antioxidant1
- Avenanthramides are unique antioxidants found only in oats and have been shown to possess potent antioxidant activity. (preparedfoods.com)
Levels2
- Of the phenolics in whole grains, alk(en)ylresorcinols are found in high levels in wheat and rye, and ferulic acid makes up 90% of the phenolic compounds found in wheat. (preparedfoods.com)
- GrassrootsHealth announced a study published in The Journal of Steroid Biochemistry and Molecular Biology showed a 59-percent lower risk for premature birth by pregnant women who had blood levels of vitamin D (25(OH)D) at or over 40 ng/ml by their third trimester than women who had levels below 20 ng/ml. (naturalproductsinsider.com)
Assays1
- The leaf extract of M. piperita showed strong radical scavenging activity in both the 1, 1 diphenyl-2-picryl hydrazyl radical (DPPH*) and 2, 2 azinobis (3-ethylbenzothiazoline-6-sulfonic acid) radical cation (ABTS*+) assays. (unboundmedicine.com)
Activity6
- Irwin Fridovich and Joe McCord at Duke University discovered the enzymatic activity of superoxide dismutase in 1968. (wikipedia.org)
- The D. lanuginosum isolate that displayed the greatest tolerance retained SOD activity while leaf SOD activity was significantly reduced in the isolate showing the least tolerance. (usda.gov)
- Now, whole grains also have been shown to possess a high level of antioxidant activity. (preparedfoods.com)
- In addition, as yet unpublished in vitro data show avenanthramides to possess a higher antioxidant activity compared with ferulic acid by the oxygen radical absorbance capacity (ORAC) assay. (preparedfoods.com)
- Taken together, oat avenanthramides have both high bioavailability and in vitro antioxidant activity in comparison to ferulic acid and alk(en)ylresorcinols. (preparedfoods.com)
- Although the senescent cells remain viable, they show typical changes with enlarged and flattened cell bodies, apoptosis resistance, increased activity of senescence-associated β -galactosidase (SA- β -gal), and upregulation of cyclin-dependent kinase (CDK) inhibitors including p16 INK4A , ARF proteins, and p21 [ 13 - 16 ]. (hindawi.com)
Proteins2
- The protein analysis appeared to show that two proteins (an arginine kinase and superoxide dismutase) were expressed more frequently in stressed crabs compared to unstressed crabs. (scribd.com)
- We show that ALS heritability is enriched in splicing variants and in binding sites of 6 RNA-binding proteins including TDP-43 and FUS. (cdc.gov)
Substances1
- Our study showed that these substances are low molecular weight compounds that appear to be charged. (usda.gov)
Humans2
- Three forms of superoxide dismutase are present in humans, in all other mammals, and most chordates. (wikipedia.org)
- Lead has been shown to affect virtually every organ and system in the body in both humans and animals. (cdc.gov)
Copper2
- There are three major families of superoxide dismutase, depending on the protein fold and the metal cofactor: the Cu/Zn type (which binds both copper and zinc), Fe and Mn types (which bind either iron or manganese), and the Ni type (which binds nickel). (wikipedia.org)
- However, the combined results showed an exponential increase in 10^{-5} M Ach‐induced vasodilation as liver copper concentration increases from 0 \mu g Cu/g dry wt. (iospress.com)
Nanoparticles2
- In this report ceria nanoparticles are shown to act as catalysts that mimic superoxide dismutase (SOD) with the catalytic rate constant exceeding that determined for the enzyme SOD. (rsc.org)
- 2008), nanoparticles in mild steel metal active gas welding showed a mass median diameter (MMMD) of 200-300 nm. (who.int)
Studies10
- A few studies support the use of superoxide dismutase injections to prevent cystitis. (mskcc.org)
- Vitamin D administration has been shown to enhance lead absorption in animal studies. (cdc.gov)
- Studies have also shown that ellagic acid may protect against chromosome damage and reduce the effects of chemically induced hepatic structural degeneration. (nutrimedical.com)
- Studies show that a diet rich in whole grains could help reduce the risk of cardiovascular disease, diabetes and cancer. (preparedfoods.com)
- The bioavailability of ferulic acid, avenanthramides and alk(en)ylresorcinols in commonly consumed whole-grain cereals has recently been assessed in human studies. (preparedfoods.com)
- During the process of classification of the human agent, phylogenetic studies showed taxonomic disarray among organisms broadly referred to as ehrlichiae, and a careful reorganization now places those bacteria previously classified as E . phagocytophila , E . equi , and the HGE agent into a different genus as a single species, A . phagocytophilum ( Figure 2 ) ( 1 , 3 ). (cdc.gov)
- Through observation and stomach content studies, octopuses have been shown to feed on practically anything they come across while they are foraging. (scribd.com)
- In recent studies, a unique seaweed extract showed promise for the treatment of Helicobacter pylori (H. pylori)-related diseases and gastric cancer, while palm tocotrienol complex demonstrated gastroprotective effects. (naturalproductsinsider.com)
- Besides age, other studies have also shown some clinical differences that might be unique to persons with DS. (medscape.com)
- In previous studies, garlic has been shown to protect, rat liver against DEN-induced carcinogenesis. (who.int)
Results2
- Similar results were obtaind with the freshwater microalga R. subcapitata, which showed biostimulation of algal growth. (easychair.org)
- The results show good correlation with those obtained using the Technicon 12/60 AutoAnalyser. (erowid.org)
Zinc4
- RÉSUMÉ Les informations concernant les bénéfices d'une supplémentation en zinc chez l'enfant asthmatique sont contradictoires. (who.int)
- L'étude a examiné les effets d'une supplémentation en zinc chez des enfants asthmatiques suivis dans un service de consultations externes à Sari (République islamique d'Iran). (who.int)
- Dans un essai clinique randomisé d'une durée de 8 semaines, en double aveugle et contrôlé contre placebo, 284 enfants sous corticostéroïdes inhalés ont été répartis entre un groupe recevant une supplémentation en zinc (50 mg/jour) (n = 144) et un groupe sous placebo (n = 140). (who.int)
- Les cas comme les témoins présentaient des concentrations sériques en zinc initiales faibles [61,8 (E.T. 7,3) µg/dL et 60,9 (E.T. 4,3) µg/dL]. (who.int)
Protein analysis1
- Likewise, Brewer (1967) identified a protein that later became known as superoxide dismutase as an indophenol oxidase by protein analysis of starch gels using the phenazine-tetrazolium technique. (wikipedia.org)
Dopamine1
- In animals, lead has been shown to alter a number of neurotransmitter systems including dopamine, norepinephrine, serotonin, and gamma- aminobutyric acid systems (ATSDR 1999). (cdc.gov)
Extract showed2
- In OFT, the extract showed significant increase in number of rearings, assisted rearings and number of square crossed, all of which are demonstrations of exploratory behavior. (ijp-online.com)
- A unique seaweed extract showed promise for the treatment of Helicobacter pylori (H. pylori)-related diseases and gastric cancer, according to new research undertaken at the University of Western Australia. (naturalproductsinsider.com)
Molecular1
- The use of molecular mechanics calculations to supplement experimental data in standard X-ray crystallography and NMR refinements is discussed and it is shown that structures can be locally improved by the use of quantum chemical calculations. (lu.se)
Study2
- Another study has show that the fascial inflammatory infiltrate is predominately composed of CD8 + T lymphocytes, macrophages, and fewer eosinophils, suggesting a possible cytotoxic immune reaction in response to possible infectious or environmental agents. (medscape.com)
- However, in this study, tests for dementia given to persons older than 30 years showed some performance decline from 40 to 45 years. (medscape.com)
Clinical2
- Recent reports show that CKD presents as a clinical model of premature aging. (hindawi.com)
- The case group showed significant improvements in clinical symptoms such as cough, wheezing and dyspnoea and in all spirometry parameters (FVC, FEV1 and FEV1/FVC). (who.int)
Inhalation1
- 7 ] showed that the inhalation of the Citrus sinensis flower essential oil could improve athletic performance. (hindawi.com)
Effects1
- Dogs treated with deprenyl showed similar anti-aging effects. (turnkeylinux.org)
Structures2
- The 3D structures of the homologous Mn and Fe superoxide dismutases have the same arrangement of alpha-helices, and their active sites contain the same type and arrangement of amino acid side-chains. (wikipedia.org)
- They have shown that metal sites in crystal structures are frequently photoreduced or disordered, which makes the interpretation of the structures hard. (lu.se)
Methods1
- It is shown that these methods can be useful in the quantitation of drug samples from the street. (erowid.org)
Treatment2
- Histologic examination showed that the degrees of atelectasis and edema in the SOD treatment group were milder than those of the control group. (karger.com)
- Treatment with superoxide dismutase (SOD) enhanced the generation of H202, but the cell death was unaffected. (fao.org)
Activities1
- There has been increasing evidence that deranged superoxide dismutase (SOD) activities might be a risk factor for schizophrenia and/or tardive dyskinesia (TD). (nature.com)
Group3
- Additionally, the EOM group also showed marked changes of the rise of blood glucose and the decrease of BUN and GSH-PX. (hindawi.com)
- Haematoxylin and Eosin staining of liver sections confirmed the HA and revealed altered hepatocyte nodules which may progress to HA.DEN and decoction treated group showed no HA. (who.int)
- DEN control group showed well-preserved reticulin framework of normal liver, which confirms that HA , has not yet progressed up to HCC. (who.int)
Decline1
- The non-treated mice showed signs of early mental decline while the Cordyceps treated mice showed great ability to think and function at a high level (3). (naturalnews.com)