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  • kinase
  • Loss of RAF kinase inhibitor protein is involved in myelomonocytic differentiation and aggravates RAS-driven myeloid leukemogenesis. (nih.gov)
  • Increased Expression of miR-23a Mediates a Loss of Expression in the RAF Kinase Inhibitor Protein RKIP. (nih.gov)
  • However, the protein kinase(s) involved has not been identified. (pnas.org)
  • We find that Polo-like kinase 1 (Plk1), a protein kinase that accumulates in mitosis, markedly stimulates the ligation of Emi1 to ubiquitin by purified SCF β-TrCP . (pnas.org)
  • Cdk1-cyclin B, another major mitotic protein kinase, has no influence on this process by itself but stimulates the action of Plk1 at low, physiological concentrations. (pnas.org)
  • Mitotic phosphorylation of APC/C is carried out by the protein kinases Cdk1-cyclin B and Polo-like kinase (Plk1) ( 8 - 10 ). (pnas.org)
  • eggs
  • More recently, Jackson and coworkers ( 11 , 12 , 14 ) have shown that in Xenopus eggs and in mammalian cells, Emi1 blocks the degradation of both cyclin A and cyclin B by inhibiting the activity of both APC/C Cdc20 and APC/C Cdh1 . (pnas.org)
  • levels
  • Because other vitamin carrier proteins (VCP) have been shown to be overexpressed in patients with malignant disease, we evaluated serum RCP levels in patients with adenocarcinoma of the breast. (aacrjournals.org)
  • These results show increased serum levels of RCP in breast adenocarcinoma patients and suggest that RCP levels may be useful as a new marker for breast cancer. (aacrjournals.org)
  • We hypothesized that we would observe an increased synthesis and secretion of RCP by the breast cancer cell, and that this up-regulated synthesis would be reflected by elevated levels of the protein in the blood of women with breast cancer. (aacrjournals.org)
  • complex
  • Given that proteins of the mitochondrial carrier family also pass through the TOM (translocase of outer membrane) complex as a loop, our study suggests that this translocation mechanism may be conserved. (rupress.org)
  • types
  • Ubiquitin-mediated protein degradation and protein phosphorylation are two basic, often intertwined, regulatory mechanisms in the control of the cell cycle and in other types of cellular regulation. (pnas.org)