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Lymphocyte DepletionAutoimmunityLymphocytesLymphocyte ActivationT-LymphocytesB-LymphocytesHistiocytesLymphocyte CountCD4-Positive T-LymphocytesAntibodies, Monoclonal, Murine-DerivedAntibodies, MonoclonalCircoviridae InfectionsHodgkin DiseaseAutoimmune DiseasesLymphopeniaLymph NodesCD8-Positive T-LymphocytesSpleenAntibodies, NeoplasmAntilymphocyte SerumSimian Acquired Immunodeficiency SyndromeAntigens, CD20Flow CytometryThymus GlandMice, Inbred C57BLAutoantibodiesLymphocyte SubsetsLymphoid TissueSimian immunodeficiency virusMacaca mulattaImmunosuppressive AgentsApoptosisPrednisoloneAutoantigensCyclophosphamideAntibodies, Monoclonal, HumanizedHIV-1Cells, CulturedT-Lymphocytes, RegulatoryT-Lymphocyte SubsetsLymphocyte Culture Test, MixedMice, Inbred BALB CImmune ToleranceLupus Erythematosus, SystemicDiabetes Mellitus, Type 1HIV InfectionsLymphocytes, Tumor-InfiltratingT-Lymphocytes, CytotoxicMice, TransgenicMice, KnockoutMercuric ChlorideLymphocyte TransfusionAntigens, CDInterleukin-2Cytotoxicity, ImmunologicPhytohemagglutininsInterferon-gammaImmunity, CellularMice, Inbred NODAntibodies, AntinuclearLeukocyte CountReceptors, Antigen, T-CellImmunoglobulin GAntigens, CD3Concanavalin ACytokinesThyroiditis, AutoimmuneSelf ToleranceKiller Cells, NaturalDendritic CellsAdoptive TransferCell LineT-Lymphocytes, Helper-InducerMice, Inbred MRL lprSignal TransductionDisease Models, AnimalMice, Inbred StrainsMolecular Sequence DataImmunophenotypingReceptors, Antigen, B-CellCell SeparationEncephalomyelitis, Autoimmune, ExperimentalLymphocyte CooperationAntigens, Differentiation, T-LymphocyteB-Lymphocyte SubsetsMice, Inbred NZBImmunoglobulinsAntibody FormationCell DifferentiationTime FactorsAntigensMitogensEpitopesAntigens, SurfaceImmunoglobulin MModels, ImmunologicalLymphocyte Function-Associated Antigen-1Receptors, Interleukin-2Membrane GlycoproteinsMacrophages
AntigenPathogenesis of autoimmunityMacrophagesTransplantationTregCytotoxicSubsetsRegulatoryMiceVitroDifferentiationInhibitionSuppressTumorInhibitsAntibodyDendritic cellsCellsInterferonReceptorInduceMitogenicAutoimmuneResponsesImmunotherapyRolesMechanismsTumourSecondaryDevelopmentCellProteinImmune systemSystemicClinicalTissueDisordersDiseaseProteinsThyroidMultipleBone marrowInfectionsRoleEfficacyMedianStudiesActivation
Antigen7
  • Cytotoxic T lymphocyte-associated antigen-4 (CTLA-4) (also known as CD152) is a major negative regulator of T cell responses which interacts with the B7-1 (CD80) / B7-2 (CD86) ligands on the surface of an antigen-presenting cell. (scielo.br)
  • Evidence has recently been obtained that two very different recombinatorial systems for lymphocyte antigen receptor diversification appeared at the beginning of vertebrate evolution approximately 500 million years ago. (scielo.br)
  • Jawed vertebrates (gnathostomes) generate a diverse repertoire of B and T cell antigen receptors through the rearrangement of immunoglobulin V, D, and J gene fragments, whereas jawless fish (agnathans) assemble diverse lymphocyte antigen receptor genes through the genomic rearrangement of leucine-rich repeat (LRR) - encoding molecules. (scielo.br)
  • All pets succumbed to tumors and the ones treated using the monovalent non-depletion of porcine antigen showing cells (APCs) for research looking Xanthiazone into the induction of transplantation tolerance autoimmune disease and tumor treatment. (scienceexhibitions.org)
  • Cytotoxic T-Lymphocyte Antigen-4 Xanthiazone (CTLA-4) also called CD152 can be an essential co-stimulatory molecule which acts as a poor regulator for T cell proliferation and differentiation. (scienceexhibitions.org)
  • These genes are involved in T cell regulation, including interferons, interleukin (IL),tumor necrosis factor (TNF), as well as linker for activation of T cells (LAT), cytotoxic T-lymphocyte-associated antigen 4 (CTLA4), and adapter proteins. (frontiersin.org)
  • Ly6C is a monocyte/macrophage and endothelial cell differentiation antigen regulated by interferon gamma, and may play a role in the development and maturation of lymphocytes. (hycultbiotech.com)
Pathogenesis of autoimmunity2
Macrophages3
Transplantation5
  • Subsequently, a murine model of HSC transplantation shown successful in vivo detection of T cell repopulation at 2, 4, and 8 weeks post-HSC transplant using the 89Zr-radiolabeled anti-CD4 and -CD8 cDbs. (bioskinrevive.com)
  • manifestation 1 Intro Blocking co-stimulation pathways continues to be broadly useful to modulate the immune system response for research concerning transplantation tolerance and autoimmunity. (scienceexhibitions.org)
  • This technology exploits the unique qualities of the BCR to reversibly suppress signaling for therapeutic use in autoimmunity, cancer and transplantation. (nationaljewish.org)
  • Prior investigations from the tolerogenic properties from the liver organ either centered on settings beyond cancer (such as for example infectious disease, transplantation, and autoimmunity) or recommended which the premetastatic potential from the liver organ and cancer-related immunosuppression was predicated on regional effects inside the confines of/ the liver organ parenchyma (13C16). (geogise.com)
  • Female records break, but play clearly treated to, stimuli Black as how to do theaters, systemic Saxons, volunteers of Depletion studies, endogenous and eight-week-old library, the name of interesting function, and the Arab-Israeli transplantation. (kloevekorn.com)
Treg3
  • citation needed]9 Through their roles in immune homeostasis, it has been shown that depletion of the Treg cell population in murine models for disease lead to enhanced immune responses to a variety of infectious agents including hepatitis C virus (HCV). (wikipedia.org)
  • citation needed]10 Additionally, patients with a chronic HCV infection were shown to have higher counts of Treg cells in peripheral blood when compared with successfully treated or healthy controls. (wikipedia.org)
  • MDSC or Treg depletion can boost tumor rejection in mice with experimental Sarolaner liver organ metastasis. (geogise.com)
Cytotoxic4
  • This shows that sFGL2 largely inhibits the Th1 type response needed to activate cytotoxic lymphocytes to clear HCV infections. (wikipedia.org)
  • CD8+ T cells, also called cytotoxic T lymphocytes (CTL), are one subtype of T cell ( 6 ), characterized by robust production of interferon (IFN)-γ and cytolytic activities via perforin (PRF)/granzymes (GZM) or Fas mechanisms to kill target cells ( 7 ). (frontiersin.org)
  • Results: MBP-CAAR T cells showed higher cytotoxic activity against autoreactive B cells in all effector-to-target ratios compared to Mock T cell (empty vector-transduced T cell) and Un-T cells (un-transduced T cell). (bvsalud.org)
  • Activated γδ T cells exhibit strong cytotoxic activity and cytokine secretion functions and are effective antitumor lymphocytes with simple and direct recognition modes and rapid responses. (explorationpub.com)
Subsets2
Regulatory4
  • Recent studies in mouse tumor models have shown that T RM cells are induced by cancer vaccines delivered in peripheral tissue sites, or by the depletion of regulatory T cells. (frontiersin.org)
  • Accumulating evidence has shown that the immunosuppressive CD4+CD25+Foxp3+ regulatory T cells (T Reg ) play a critical role in the suppression of anti-tumor immunity. (dukecancerinstitute.org)
  • Additionally, these cells show highly flexible and dynamic plasticity and are extremely easily polarized into regulatory phenotypes. (explorationpub.com)
  • Depletion of CD4 + CD25 + regulatory T cells (T reg ) in mice leads to a polyglandular autoimmune syndrome (PGAIS). (biomedcentral.com)
Mice8
  • Anti-CD3 Ab therapy has been used in NOD mice to suppress b cell autoimmunity and has shown effectiveness. (expertsguys.com)
  • in vivo in the spleen and lymph nodes of crazy type mice, with specificity confirmed through in vivo obstructing and depletion studies. (bioskinrevive.com)
  • Target cell depletion was determined using a newly developed porcine B-cell lymphoma tumor mouse model in which mice were injected with LCL13271 cells. (scienceexhibitions.org)
  • Adoptive transfer of B1a cells exacerbated arthritic severity and joint damage while intraperitoneal depletion of B1 cells ameliorated both arthritic symptoms and joint pathology in CIA mice. (oncotarget.com)
  • B cell depletion with anti-CD79 mAbs ameliorates autoimmune disease in MRL/lpr mice. (nationaljewish.org)
  • Treatment with antibodies in vivo leads to neutropenia and has inhibitory effect on local immune responses.Furthermore, it has been shown to be useful for depletion of neutrophils in mice. (hycultbiotech.com)
  • NOD/SCID mice that received lymphocytes from transgenic mice became diabetic at a slower rate than mice receiving control lymphocytes. (diabetesjournals.org)
  • Moreover, lymphocytes collected from recipients transferred by lymphocytes from transgenic mice revealed less proliferative potential than lymphocytes obtained from control recipients. (diabetesjournals.org)
Vitro2
  • A study published in Neurology by Genzyme researchers in April 2017 showed that GZ402668 worked by binding to a different epitope on CD52 than Lemtrada-achieving similar levels of lymphocyte depletion as Lemtrada but with reduced cytokine release in vitro , suggesting a potentially improved infusion-associated reaction profile. (genengnews.com)
  • In vitro, both compounds suppress lymphocyte mitogenic and antigenic responses that are partially reversed by exogenous ADA [ 13 ]. (medilib.ir)
Differentiation3
  • We show that NAD + regulates CD4 + T-cell differentiation through tryptophan hydroxylase-1 ( Tph1 ), independently of well-established transcription factors. (nature.com)
  • BACKGROUND: Gene regulation by microRNA (miRNA) is central in T lymphocytes differentiation processes. (bvsalud.org)
  • This study indicates that the transfection of miR-29b mimics into T lymphocytes through AMSC-Exo can alter the CD4+ T cells' differentiation into other types of T cells. (bvsalud.org)
Inhibition1
  • These anti-CD79 mAbs show therapeutic potential to induce reversible inhibition of BCR signaling and B cell function. (nationaljewish.org)
Suppress1
  • Based on these observations they produced antibodies against the BCR transducers, CD79a and b, and found that they "desensitize" the BCR and suppress the immune response, autoimmunity, and growth of non-Hodgkin's B lymphoma. (nationaljewish.org)
Tumor3
  • Characterized by cell-surface molecules including CD103, CD69, and CD49a, T RM -like tumor-infiltrating lymphocytes (TILs) can be found in a wide range of human cancers, where they portend improved prognosis. (frontiersin.org)
  • Lymphocyte monitoring during immunotherapy protocols, such as for example recognition of circulating lymphocytes from entire tumor or bloodstream infiltrating lymphocytes from tissues biopsy, will not supply the whole selection of spatial and dynamic Kaempferol information required. (bioskinrevive.com)
  • Our group provides showed in melanoma sufferers that Sarolaner the current presence of liver organ metastases previously, instead of various other metastatic sites, correlated with the decreased appearance of activation and useful markers on Compact disc8+ tumor-infiltrating lymphocytes Sarolaner (TILs) when pre-CPI treatment cutaneous tumor biopsies had been examined (11, 12). (geogise.com)
Inhibits2
  • This new type of treatment inhibits T-lymphocyte activation. (expertsguys.com)
  • Depletion of CD52-positive cells inhibits the development of central nervous system autoimmune disease, but deletes an immune-tolerance promoting CD8 T-cell population. (qmul.ac.uk)
Antibody2
Dendritic cells1
Cells26
  • These cells also play a fundamental role in maintaining self tolerance by suppressing the activation and expansion of self-reactive lymphocytes that may instigate autoimmunity. (wikipedia.org)
  • Informed by studies in infectious disease models, and instructed by a clear role for T RM cells in autoimmunity, we will discuss strategies for therapeutically promoting T RM responses in settings where they don't naturally occur. (frontiersin.org)
  • In a growing number of cases, CD8 T cells have been shown to mediate the regression of large bulky tumors, resulting in durable long-term disease remissions ( 5 ). (frontiersin.org)
  • whereas T EM cells were shown to recirculate predominantly through blood, and peripheral tissues ( 10 ). (frontiersin.org)
  • CD4 + T cells are involved in the development of autoimmunity, including multiple sclerosis (MS). Here we show that nicotinamide adenine dinucleotide (NAD + ) blocks experimental autoimmune encephalomyelitis (EAE), a mouse model of MS, by inducing immune homeostasis through CD4 + IFNγ + IL-10 + T cells and reverses disease progression by restoring tissue integrity via remyelination and neuroregeneration. (nature.com)
  • More recently, the role of Th1 and Th17 CD4 + cells in the pathogenesis of experimental autoimmune encephalomyelitis (EAE), the most commonly used experimental model for human MS, has been challenged, and it has been demonstrated that the transcription factor T-bet (also known as Tbx21 ) is critical for controlling Th1/Th17-mediated autoimmunity 12 . (nature.com)
  • It has been shown that Th17 cells can also co-express Foxp3 or T-bet 18 , 19 , which are the master regulators of Tregs and Th1 cells, respectively. (nature.com)
  • Moreover, Th1 IFN-γ-producing cells have been shown to have the capacity to produce the immunosuppressive cytokine IL-10, initially considered a Th2 cytokine 20 . (nature.com)
  • Studies have shown that Th1 IFN-γ-producing cells that co-produce IL-10 have immunosuppressive properties and can protect from tissue damage 21 , 22 . (nature.com)
  • In addition, it was recently shown that Th17 cells that were generated with transforming growth factor (TGF)-β and IL-6 were not pathogenic and did not induce EAE without exposure to IL-23 (ref. 23 ). (nature.com)
  • Mouse monoclonal to CD22.K22 reacts with CD22, a 140 kDa B-cell specific molecule, expressed in the cytoplasm of all B lymphocytes and on the cell surface of only mature B cells. (bioskinrevive.com)
  • This membrane glycoprotein is found on almost all mature leucocytes but critically not on their haematopoeitic precursor CUDC-101 stem cells, allowing for a 'reboot' of the immune system with rapid depletion and gradual reconstitution of the immune system [2]. (thebiotechdictionary.com)
  • Remarkably, depletion of B1a cells by osmotic pressure ameliorates the development of type I diabetes [ 5 ], and reduces renal injury after kidney ischemia or reperfusion [ 9 ], indicating the involvement of B1a cells in disease progression. (oncotarget.com)
  • In addition, this modality does not eliminate all B lineage cells and thus may not be appropriate for all pathologic conditions involving B lymphocytes. (nationaljewish.org)
  • Low-power view of hematoxylin-eosin-stained bone marrow showing hypocellularity, with increased adipose tissue and decreased hematopoietic cells in the marrow space. (medscape.com)
  • Therefore, our study suggests that the STAT1 pathway can be manipulated to limit autoreactive T cells during autoimmunity directed against the CNS. (jci.org)
  • In recent years, epigenetic modifications have been shown to play an important role in the fate of CD8+ T cells. (frontiersin.org)
  • The discovery of these modifications that contribute to the activation or suppression of CD8+ cells has been concurrent with the increasing evidence that CD8+ T cells play a role in autoimmunity. (frontiersin.org)
  • According to Principia, the role of B cells in autoimmunity has been clinically validated with B-cell-depleting therapy in MS and other diseases that affect the nervous system. (genengnews.com)
  • We report a blood-induced microglia gene network and show that blood proteins elicit distinct receptor-mediated transcriptional changes and signaling programs in innate immune cells. (nature.com)
  • 3 A number of biological drugs are now approved for use in RA and target tumour necrosis factor (TNF)α, interleukin (IL) 1 receptor, IL-6 receptor, costimulation through CTLA-4 and B cells through depletion with anti-CD20. (bmj.com)
  • There is a decrease in deoxyribonucleic acid (DNA) synthesis in replicating cells because of the depletion of deoxynucleotides. (medilib.ir)
  • Conclusion: Based on these findings, CAAR T cells are promising for curing or modulating autoimmunity and can be served as a new approach for clone-specific B cell depletion therapy in multiple sclerosis. (bvsalud.org)
  • His research has involved both translational research and clinical trials including the role of B cell depletion and mesenchymal stem cells in systemic lupus erythematosus. (rochester.edu)
  • Similar to αβ T cells, γδ T cells also develop in embryos, and their intra-thymic development shows strict regulation and flexible plasticity [ 2 ]. (explorationpub.com)
  • Enteropathy with complete depletion of goblet cells was also associated with IPEX syndrome. (medscape.com)
Interferon1
  • It has been shown to decrease both the annualised relapse rate as well as reduce the overall accumulation of disability compared with interferon beta-1a treatment [10, 11]. (thebiotechdictionary.com)
Receptor1
  • Functional annotation clustering of the microarray data showed that gene clusters involved in immune and antiviral responses ranked highly, involving genes such as chemokine (C-C motif) ligand 2 ( CCL2 ), chemokine (C-C motif) ligand 5 ( CCL5 ), chemokine (C-X-C motif) ligand 10 ( CXCL10 ), and toll like receptor 3 ( TLR3 ). (molvis.org)
Induce1
Mitogenic1
  • The principal immunological abnormalities described for this syndrome include hypogammaglobulinaemia, B-cell lymphopaenia, CD4/CD8 ratio inversion, low T CD4 lymphocyte counts, and alteration of the mitogenic T cell response [ 4 ]. (ecancer.org)
Autoimmune3
Responses1
  • The proliferation and trafficking of T lymphocytes in immune responses are necessary events in determining inflammatory responses. (bioskinrevive.com)
Immunotherapy1
Roles1
  • Collectively, these findings show the potential roles of T1IFN in ILC2s that contribute to colitis manifestation. (keio.ac.jp)
Mechanisms11
Tumour1
  • A computed tomography (CT) scan of the thorax showed an anterior mediastinal tumour, with no evidence of spreading to adjacent tissue ( Figure 1 ). (ecancer.org)
Secondary1
  • However, the principal adverse effect is the development of secondary autoimmunity during immune reconstitution, occurring in 12C48% of treated patients [15, 16]. (thebiotechdictionary.com)
Development1
  • Initial, the 2/1 subunit shows up sooner than the 1 subunit and its own levels stay high during skeletal muscle tissue development. (cell-signaling-pathways.com)
Cell5
  • citation needed]12 When the supernatants of these T cell cultures are analyzed, they showed a predominant Th2 type polarization with upregulated levels of expression of interleukin-4 (IL-4) and Interleukin-10 (IL-10). (wikipedia.org)
  • In a very interesting chapter, Z. PANCER and M. D. COOPER first consider the emergence of lymphocytes as a novel circulatory cell type in vertebrates and then discuss phylogenetic aspects of the superfamily of LRR - containing proteins and their role in immunity. (scielo.br)
  • In addition, B cell depletion has been shown to delay the onset of diabetes. (expertsguys.com)
  • Direct cell labeling is suffering from restrictions of radionuclide half-life, probe dilution Kaempferol because of cell department, and potential dangerous effects because of the radiosensitivity of lymphocytes. (bioskinrevive.com)
  • Since the mid-1990's I became interested in investigator-initiated trials of new agents for immune-mediated diseases, most notably one of the very first trials of B cell targeted therapy for autoimmunity (anti-CD20 for SLE). (rochester.edu)
Protein1
  • Furthermore, HCV's core protein has been found to increase the levels of expression of sFGL2 and cause virus-specific CD4+ T lymphocytes to skew largely toward a Th2 lineage, allowing for the establishment of a chronic infection. (wikipedia.org)
Immune system1
Systemic1
  • This is especially interesting as we have shown in our previous work that regulation of apoptosis might be disturbed, especially in systemic lupus erythematosus. (biomedcentral.com)
Clinical2
  • From 2003 to 2014 most of my research effort was through the NIH Autoimmunity Centers of Excellence (ACE) as a member of the steering committee and as the Clinical Director for the Rochester ACE. (rochester.edu)
  • We use our results to guide a propensity-score-matched, retrospective cohort study of 64,349 COVID-19 patients, showing that a top candidate drug, spironolactone, is associated with improved clinical prognosis, measured by intensive care unit (ICU) admission and mechanical ventilation rates. (stanford.edu)
Tissue1
  • In exploratory analyses, a decreased 4COL7S at the end of treatment was correlated with a matrix-degrading phenotype that showed higher serum metalloproteinase to tissue inhibitors of metalloproteinase-1 ratios and characteristic metabolic fingerprints such as increased butyrate, some medium-chain fatty acids, anabolic amino acids, and decreased uremia toxins. (keio.ac.jp)
Disorders1
  • Data table showing topics related to specific cancers and associated disorders. (cancerindex.org)
Disease1
  • Autosomal-recessive defects in ADA2 cause autoinflammatory disease and autoimmunity and are discussed separately. (medilib.ir)
Proteins2
  • How the deletion from the 2/1 subunit offers such disparate outcomes as lethality in a single set of conditions and little impact in another can be intriguing and shows that this proteins may perform essential functions not linked to EC coupling. (cell-signaling-pathways.com)
  • Although the complete proteins topology isn't known, evidence shows that a little part of the peptide can be a transmembrane section with a brief cytoplasmic tail. (cell-signaling-pathways.com)
Thyroid1
Multiple1
Bone marrow1
  • B lymphocytes, named after their site of origin in the bursa of Fabricius in birds or in the bone marrow in humans, form the basis for humoral immunity by their production of immunoglobulins. (medscape.com)
Infections1
  • The presence of inter-current infections, especially diarrhoea and pneumonia, in the presence of lymphocyte B depletion and hypogammaglobulinaemia is known as Good's syndrome and may affect up to 5% of patients with thymoma. (ecancer.org)
Role1
  • MiRNAs also play a role in the pathogenesis of these diseases and several known miRNAs that are involved in these diseases have also been shown to play a role in CD8+ regulation. (frontiersin.org)
Efficacy1
  • Nevertheless, for melanoma, lung, kidney, and many various other malignancies where CPIs show efficacy, accumulating proof suggests that the current presence of liver organ metastasis decreases response price, progression-free and general success (1C7). (geogise.com)
Median1
  • Results from studies examining concentrations of CDDs, p,p' -DDE, hexachlorobenzene, mercury, and PCBs in breast milk indicate that mean or median concentrations show a 10- to 100-fold range among studies for each of these chemicals (Table 2). (cdc.gov)
Studies1
  • The functional status and medical fragility of the patient - Studies have shown that hospitalized patients, those with poor functional status or comorbid conditions, and older adults are more likely to develop immune complications when treated with glucocorticoids, and this is likely to be the case for other immunosuppressant drugs [ 4 ]. (medilib.ir)
Activation1
  • In contrast, activation of the noncanonical NF-κB signaling pathway has been shown to rely on the processing of p100. (xiahepublishing.com)