• Potassium voltage-gated channel subfamily A member 2 also known as Kv1.2 is a protein that in humans is encoded by the KCNA2 gene. (wikipedia.org)
  • This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. (wikipedia.org)
  • This gene encodes a member of the potassium channel, voltage-gated, shab-related subfamily. (nih.gov)
  • Previous work has shown that the Shal potassium channel subfamily underlies the predominant fast transient outward current in Drosophila neurons (Tsunoda, S., and Salkoff, L. (1995) J. Neurosci. (wikigenes.org)
  • Homo sapiens potassium voltage-gated channel subfamily A regulatory beta subunit 2 (KCNAB2), transcript variant 2, mRNA. (ucsc.edu)
  • This gene encodes a member of the potassium channel, voltage-gated, shal-related subfamily, members of which form voltage-activated A-type potassium ion channels and are prominent in the repolarization phase of the action potential. (utsouthwestern.edu)
  • 3. Neither are the Shaker (Kv1), Shab (Kv2) & Shaw (Kv3) subfamilies of currents, nor HERG, KvLQT1/IsK, inhibited by phrixotoxins which appear specific of the Shal (Kv4) subfamily of currents & also block I(to1) in isolated murine cardiomyocytes. (smartox-biotech.com)
  • Potassium voltage-gated channel subfamily D member 1 (KCND1), also known as Kv4.1, is is a shal-related voltage-gated potassium channel that is encoded by the KCND1 gene in human. (bicellscientific.com)
  • This member is a delayed rectifier potassium channel and its activity is modulated by some other family members. (nih.gov)
  • SHL-1 currents strongly resembled Shal currents in other species except that they were active in a more depolarized voltage range. (wikigenes.org)
  • This model allows us to investigate the contributions of the two major types of A-type currents Shal and Shaker that are different in spatial expression over the neuron and in terms of electrophysiological and activity-related characteristics. (biomedcentral.com)
  • In the present study, two new peptides, phrixotoxins PaTx1 & PaTx2 (29-31 amino acids), which potently block A-type potassium currents, have been purified from the venom of the tarantula Phrixotrichus auratus. (smartox-biotech.com)
  • 6. It was concluded that phrixotoxins, are new & specific blockers of Kv4.3 & Kv4.2 potassium currents, & hence of I(to1) that will enable further studies of Kv4.2 & Kv4.3 channel &/or I(to1) expression. (smartox-biotech.com)
  • channel properties depend on the type of alpha subunits that are part of the channel (By similarity). (nih.gov)
  • Channel properties are modulated by cytoplasmic beta subunits that regulate the subcellular location of the alpha subunits and promote rapid inactivation (By similarity). (nih.gov)
  • Belongs to the shaker potassium channel beta subunit family. (ucsc.edu)
  • Crystal structure of the tetramerization domain of the Shaker potassium channel. (embl.de)
  • We have determined the crystal structure of the T1 domain of a Shaker potassium channel at 1.55 A resolution. (embl.de)
  • A delayed rectifier subtype of shaker potassium channels that is commonly mutated in human episodic ATAXIA and MYOKYMIA. (ucdenver.edu)
  • These results imply that channels potentially involved in volume regulation of murine spermatozoa include the voltage-dependent Kv1.4 (also known as KCNA1), Kv1.5 (KCNA5), Kv4.1 (KCND1), Kv4.2 (KCND2), Kv4.3 (KCND3), mink (KCNE1), & acid-sensitive TASK2 (KCNK5) & TASK3 (KCNK9). (smartox-biotech.com)
  • KCND3 encodes the voltage-gated potassium channel KV4.3 that is highly expressed in the cerebellum, where it regulates dendritic excitability and calcium influx. (bvsalud.org)
  • By targeted NGS sequencing, we identified two novel KCND3 missense variants of the KV4.3 channel: p.S347W identified in a patient with adult-onset pure cerebellar syndrome and p.W359G detected in a child with congenital nonprogressive ataxia. (bvsalud.org)
  • Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). (wikipedia.org)
  • KV4.3 expression studies in HEK293T cells showed 53% (p.G345V), 45% (p.S347W) and 75% (p.W359G) reductions in mutant protein levels compared with the wildtype. (bvsalud.org)
  • Forms tetrameric potassium-selective channels through which potassium ions pass in accordance with their electrochemical gradient (PubMed:2347305, PubMed:14575698). (nih.gov)
  • Voltage-dependent, ion-selective channels such as Na+, Ca2+ and K+ channel proteins function as tetrameric assemblies of identical or similar subunits. (embl.de)
  • Most of the important membrane ion channel genes, such as voltage-gated sodium and potassium channels, were first identified and isolated in the fruit fly. (biomedcentral.com)
  • Significant changes shared by the fly species belong to the expression of genes involved in processes such as oxidation-reduction process, iron-ion binding, and voltage-gated potassium-channel activity. (nature.com)
  • Technical advances have now made possible direct electrophysiological recording of channels in central neurons, allowing the genetic advantages of this system to be applied to analysis of cellular and circuit function and homeostasis. (biomedcentral.com)
  • Xenopus embryonic spinal neurons express potassium channel Kvbeta subunits. (ucdenver.edu)
  • Primary sensory neurons express a Shaker-like potassium channel gene. (ucdenver.edu)
  • As the specific mechanisms behind this phenomenon are unknown, spermatozoa from mice were screened for sensitivities to inhibitors known to affect specific channels involved in volume regulation of somatic cells. (smartox-biotech.com)
  • Volume regulation of spermatozoa may involve novel voltage-gated & pH-sensitive potassium channels, which could be valuable targets for the development of a posttesticular male contraceptive. (smartox-biotech.com)
  • Using iterative database searches, a statistically significant sequence similarity was detected between the POZ (poxvirus and zinc finger) domains found in a variety of proteins involved in animal transcription regulation, cytoskeleton organization, and development, and the tetramerization domain of animal potassium channels. (embl.de)
  • KCNE Regulation of K(+) Channel Trafficking - a Sisyphean Task? (uni-bielefeld.de)
  • Accessory potassium channel protein which modulates the activity of the pore-forming alpha subunit. (ucsc.edu)
  • Overall, this neuron model will enable us to investigate the effect Na channel splice variants by varying half-activation and inactivation voltages and ratio of a persistent component. (biomedcentral.com)
  • Lin WH, Wright DE, Muraro NI, Baines RA: Alternative Splicing in the Voltage-Gated Sodium Channel DmNa(v) Regulates Activation, Inactivation, and Persistent Current. (biomedcentral.com)
  • Homotetrameric channels display rapid activation and slow inactivation (PubMed:2347305). (nih.gov)
  • We assessed the effect of the mutations on channel gating by measuring steady-state voltage-dependent activation and inactivation properties: no significant alterations were detected in p.G345V and p.S347W disease-associated variants, compared to controls. (bvsalud.org)
  • Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. (embl.de)
  • The syndrome is caused by changes in the structure and function of certain cardiac ion channels and reduced expression of Connexin 43 (Cx43) in the Right Ventricle (RV), predominantly in the Right Ventricular Outflow Tract (VSVD), causing electromechanical abnormalities. (bvsalud.org)
  • Different gene expression patterns, shown by tools such as quantitative PCR, microarrays, and high-throughput RNA sequencing, reveal how organisms respond to different environments. (nature.com)
  • SHL-1 channels are apparently important in fine-tuning complex behaviors, such as mating, that play a crucial role in the survival and propagation of the species. (wikigenes.org)
  • Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. (wikipedia.org)
  • Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. (nih.gov)
  • These results show that transcription stress is an important contributor to SETX mutation-associated chromosome fragility and AOA2. (bvsalud.org)
  • We show how the Shal channel properties change between the larval stages of 1st and 3rd instar, and we show the effect of this change on neuronal activity characteristics. (biomedcentral.com)
  • Homogeneous development of electrical excitability via heterogeneous ion channel expression. (ucdenver.edu)
  • Vullhorst D, Klocke R, Bartsch JW, Jockusch H. Expression of the potassium channel KV3.4 in mouse skeletal muscle parallels fiber type maturation and depends on excitation pattern. (uni-bielefeld.de)
  • Fold prediction and evolutionary analysis of the POZ domain: structural and evolutionary relationship with the potassium channel tetramerization domain. (embl.de)
  • the E-value for the BTB domain shown below is 1.67e-8. (embl.de)
  • Using the crystal structure of the Aplysia Shaker channel tetramerization domain as a template, the common structure of the POZ domain class was predicted. (embl.de)
  • The role of the voltage-gated potassium channel, Kv2.1 in prostate cancer cell migration. (nih.gov)
  • This graph shows the total number of publications written about "Kv1.1 Potassium Channel" by people in this website by year, and whether "Kv1.1 Potassium Channel" was a major or minor topic of these publications. (ucdenver.edu)