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  • Dicer
  • MicroRNAs (miRNAs) are transcribed as ~70 nucleotide precursors and subsequently processed by the RNase-III type enzyme Dicer to give a ~22 nucleotide mature product. (wikipedia.org)
  • therapeutic
  • 25th April), Israeli researchers from Rosetta Genomics, a biotechnology company developing microRNA-based technologies for diagnostic and therapeutic applications, described a test that may help make crucial distinctions between types of lung cancer. (blogspot.com)
  • Several cardiac biomarkers have already been shown to be useful in the evaluation of a variety of diseases (BOSWOOD, 2009) and, similarly, the evaluation of microRNA expression in heart diseases may well provide a noninvasive technique for gathering information to aid diagnosis and prognosis which could lead to the development of new therapeutic protocols. (thefreedictionary.com)
  • In terms of developing therapeutic agents for cancer, for example, we need to identify small molecules that can get into the bloodstream and get into the cells. (medindia.net)
  • regulatory
  • Because they are single molecular entities that dictate the expression of fundamental regulatory pathways, microRNAs represent potential drug targets for controlling many biologic and disease processes. (drugs.com)
  • tissue
  • Smolle MA, Leithner A, Posch F, Szkandera J, Liegl-Atzwanger B, Pichler M. MicroRNAs in Different Histologies of Soft Tissue Sarcoma: A Comprehensive Review. (mdpi.com)
  • They demonstrated that the method can accurately distinguish between squamous and non-squamous forms of non-small-cell lung cancer, based on the levels of different microRNA molecules found in tissue samples. (blogspot.com)
  • scientists
  • Last fall Dr. Peter Sarnow and a team of Stanford University scientists reported that the hepatitis C virus needs a specific microRNA, named miR-122, in order to replicate in cultured liver cells. (innovations-report.com)
  • When the scientists inactivated the microRNA, the amount of hepatitis C virus RNA was reduced by approximately 80 percent. (innovations-report.com)
  • November 15, 2017 -- Scientists here have partly solved a long-unanswered basic question about stem cells: Why are pluripotent stem cells that have mutations to block the production of microRNAs unable to differentiate? (thefreedictionary.com)
  • A molecule that can regulate microRNAs has been identified by US scientists. (medindia.net)
  • transcription factors
  • Here we show that the transcription factors Ets-1 and Ets-2 regulate miR-126 expression. (ahajournals.org)
  • The E26 transformation-specific sequence (ETS) factors are a family of transcription factors that share a highly conserved DNA binding domain and regulate cell development, senescence, death, and tumorigenesis. (ahajournals.org)
  • biology
  • Studying different aspects of biology from molecules to tissues. (muni.cz)
  • Principally funded through venture capital investments, miRagen combines world recognized leadership in cardiovascular medicine with unprecedented in-house expertise in microRNA biology and chemistry. (drugs.com)
  • Therapeutics
  • As a leader in the microRNA field, Rosetta Genomics continues to advance and develop microRNA -based technologies that can potentially be applied in a wide range of diagnostics and therapeutics. (thefreedictionary.com)
  • He is a recognized world expert in the preclinical and clinical development of oligonucleotide-based therapeutics and led the project that brought the first microRNA inhibitor into human clinical trials. (thefreedictionary.com)
  • 14 January 2014 - US Regulus Therapeutics (NASDAQ:RGLS), a developer of drugs targeting microRNAs , said yesterday it had set up a new R&D division, Regulus microMarkers, focused on expansion of its novel biomarkers platform for discovery of microRNAs as disease biomarkers. (thefreedictionary.com)
  • miRagen Therapeutics, Inc., was founded in 2007 to develop innovative microRNA-based therapeutics for cardiovascular and muscle disease. (drugs.com)
  • development
  • miR-223 is a hematopoietic specific microRNA with crucial functions in myeloid lineage development. (mirbase.org)
  • He believes that with further development, the molecule has the potential to boost patient response to existing chemotherapies, as well as to become a stand-alone cancer drug. (medindia.net)
  • genomic
  • Short genomic distance between members suggests that they may function collaboratively and are highly related in sequence. (mirbase.org)
  • cell
  • Mechanical loading was performed in monolayers using uni-axial cell diameter alteration by 1000 µE (1E = 1 micro-strain = 1/1,000,000 alteration of the cell's diameter) for 30 min every other day. (intechopen.com)
  • found
  • The research team, led by Zhi-Ming Zheng, M.D., Ph.D., at NCI's Center for Cancer Research, first compared microRNA levels in cervical cancer cells and normal cervical cells and found that levels of miR-34a were much lower in the cancer cells than the normal cells. (nih.gov)
  • experimental
  • The publication describes a new software tool for desing microRNA sponges, it also provides an experimental evidence of functionality of this tool. (muni.cz)
  • Specific
  • You can also create new pages at Wikipedia about microRNA families that do not currently have specific entries there. (mirbase.org)