• Pigs are common research models and are strong animals that can be difficult to restrain. (awionline.org)
  • Training pigs for oral glucose tolerance test-Six years' experience of a refined model. (awionline.org)
  • 2021. Pain management in farm animals: Focus on cattle, sheep and pigs. (awionline.org)
  • Photo credit Monica Westman Foot-and-mouth is an extremely infectious disease that infects cattle, sheep and pigs. (liu.se)
  • Bhanu Telugu, PhD, an assistant professor in the Department of Animal & Avian Sciences (ANSC) and Ki-Eun Park, PhD, a faculty research assistant in ANSC, successfully produced genome-edited pigs using a recently developed, groundbreaking technique called the CRISPR system. (phys.org)
  • The disease is known as African Swine Fever and has a similar effect on pigs as Ebola has on humans, causing massive internal hemorrhaging and very high death rate. (nakedcapitalism.com)
  • So far, over one million pigs in China have been culled-slaughtered, that is-to stop the spread of the disease. (nakedcapitalism.com)
  • However, China has over 440 million pigs, half of the world's total pig population, and experts estimate that up to 200 million pigs will have to be killed this year alone to slow down the spread of the disease. (nakedcapitalism.com)
  • CF models have been generated in 4 species (mice, rats, ferrets, and pigs) to enhance our understanding of the CF pathogenesis. (ox.ac.uk)
  • Dr Lindström's and Professor Uno Wennergren's part of the work was to build a statistical model of how cattle are transported across the United States. (liu.se)
  • The Impact of Movements and Animal Density on Continental Scale Cattle Disease Outbreaks in the United States. (liu.se)
  • Furthermore, the book provides useful information on the use of animals (e.g., cattle, swine, sheep, chickens, and fish) as models in biomedical research to prevent and treat human diseases, develop infant formulas, and improve the cardiovascular and metabolic health of offspring with prenatal growth restriction. (hoepli.it)
  • 1/160 using a serum agglutination test with animals (goats, cattle, sheep, camels, (tube and slide). (who.int)
  • Researchers are investigating infectious diseases that might circulate in wild antelope and domestic ungulates (like camels, cattle, goats and sheep) in Chad. (si.edu)
  • We classified livestock ownership by summing reported household numbers of goats, sheep, cattle and chickens, as well as calculating a weighted score to combine multiple species. (cdc.gov)
  • Before the importance of BSE in cows was recognized, a lot of infected cattle were recycled in animal feed and some was fed to sheep. (nmaonline.org)
  • They also were cited as finding farms raising sheep and cattle were no more likely to have scrapie, and no regional correlation between scrapie and BSE cases. (nmaonline.org)
  • Additionally, we produced maps quantifying the disease transmission risk associated with anthrax to cattle, sheep, and goat populations. (cdc.gov)
  • Rift Valley Fever is spread by mosquitoes and mainly sickens cattle, sheep, goats, and camels. (cdc.gov)
  • The biblical sickness has been historically found in regions of eastern and southern Africa where sheep and cattle are raised, but has also caused outbreaks in the sub-Sahara, and up through Saudi Arabia and Yemen. (cdc.gov)
  • We first got involved in the Madagascar outbreak in February when an increase in an unknown disease was noticed in cattle. (cdc.gov)
  • Based on mathematical modeling of the BSE epidemic, estimates suggest that 1-3 million cattle may have been infected with the BSE agent in the United Kingdom. (medscape.com)
  • The associated human disease, variant CJD, was not defined until 1996, 7 years after a ban was introduced in Britain on the use of specified offal from cattle in human food. (medscape.com)
  • Field evidence indicates that livestock producers are motivated by access to products that readily deliver pain management during husbandry interventions and, more recently, viral epidermal infectious diseases, including FMD. (awionline.org)
  • Sheep are quadrupedal, ruminant mammals typically kept as livestock. (earthscape.org)
  • This resulted in public concern about the potential effects of selenium on livestock grazing in the vicinity, and ultimately possible effects in humans consuming food products from plants and animals raised in those areas. (cdc.gov)
  • Call it the downside of globalized agriculture: As nations get hooked on imported hamburgers, foreign hams, and other specialty meats, they increase the risk of spreading livestock-borne diseases around the world. (csmonitor.com)
  • Although the answers are not clear-cut, they suggest the United States and other countries with strong agriculture inspection and protection measures may be able to keep such livestock diseases at bay. (csmonitor.com)
  • In addition, we have included selected livestock species (i.e. pig, sheep and goat) and unconventional animal species such as reservoir species (i.e. rodents and bats). (nih.gov)
  • We consolidate a national database of wildlife, livestock, and human anthrax case records across Uganda built across multiple sectors bridging human and animal partners using a One Health approach. (cdc.gov)
  • Bacillus anthracis, the causative agent of anthrax, is a spore-forming bacterium that primarily affects herbivorous livestock, wildlife, and humans exposed to direct contact with infected animal carcasses or products. (cdc.gov)
  • In all, 17 risk factors were examined related to: contact with various livestock, milk and milk product consumption, drinking-water treatment and disease awareness. (who.int)
  • The Communicable Diseases in the Ministry of Epidemiology and Surveillance Unit of the Health and Population. (who.int)
  • Genetic factors should be considered when investigating risk factors for atypical scrapie because some mutations of the prnp gene, which codes for prion protein (PrP), modify the risk for this disease ( 2 , 18 , 19 ). (cdc.gov)
  • Because all described genotypes of the prnp gene confer susceptibility to sheep, a purely genetic origin is unlikely but a confounding effect could occur. (cdc.gov)
  • Jesse Jacobson, working in the lab of Prof Russell Snell at the University of Auckland in New Zealand, has developed a sheep model of HD, by giving them a mutant huntingtin gene. (hdbuzz.net)
  • The prion gene and its encoded prion protein have long been known to play a central role in prion diseases. (usda.gov)
  • Among other factors, natural variation in the prion gene has been associated with disease susceptibility. (usda.gov)
  • Recently, a second gene and its protein (shadoo) have also been implicated in prion disease. (usda.gov)
  • However, sheep populations harbored a number of different versions of the shadoo gene that were predicted to encode significantly different shadoo proteins. (usda.gov)
  • This raises the possibility that, like the prion gene, genetic variation in shadoo may influence prion disease. (usda.gov)
  • Significance: Frequent coding polymorphisms are a hallmark of the sheep PRNP gene, and our data indicate a similar situation applies to ovine SPRN. (usda.gov)
  • A nucleotide substitution in exon 8 of the glucosylceramidase beta gene is associated with Gaucher disease in sheep. (omia.org)
  • In conclusion, this study of gene transcription and protein expression and distribution confirm CAPN6, GALA1, MTNR1B and MT2A as potential targets for further prion disease research. (altmetric.com)
  • They are being used to explore gene function and create disease models and they hold great promise for human gene therapy. (ddw-online.com)
  • For many scientists, the next step is to begin to manipulate these genome sequences for a variety of specific goals, including analysis of gene function, creating models of human disease, generating better models for drug discovery and, ultimately, human gene therapy. (ddw-online.com)
  • Lecture: Stem Cell & Gene Therapy for Ocular Genetic Disease: What Technologies are Already Transforming the Ophthalmic World? (cybersight.org.cn)
  • I've been asked to talk about stem cell and gene therapy for ocular and genetic disease. (cybersight.org.cn)
  • But knowing the patient's gene also helps us understand how the disease happens, how it works. (cybersight.org.cn)
  • Some of you may remember the case of Jesse Gelsinger, a patient at the University of Pennsylvania over a decade ago who got gene therapy for hepatic disease and subsequently died. (cybersight.org.cn)
  • The Wilson disease gene ( WND ) is expressed predominantly in the liver, whereas the Menkes disease gene ( MNK ) is not expressed in the liver. (medscape.com)
  • Cystic fibrosis (CF) is a genetic disease caused by mutations in the CF transmembrane conductance regulator (CFTR) gene. (ox.ac.uk)
  • A matched case-control study (95 cases and 220 controls) was designed to study risk factors for atypical scrapie in sheep in France. (cdc.gov)
  • The prototype prion disease is scrapie in sheep, and, whereas, Prnp exhibits common missense polymorphisms for V136A, R154H and Q171R in ovine populations, genetic variation in mouse Prnp is limited. (usda.gov)
  • Scrapie in sheep, bovine spongiform encephalopathy (BSE), chronic wasting disease (CWD) of deer and elk, and Creutzfeldt-Jakob disease in humans are chronic neurodegenerative diseases associated with the accumulation of the protease-resistant, disease-associated isoform of the prion protein (PrP Sc ) in selected regions of the central nervous system. (biomedcentral.com)
  • The US may well serve as an important model for how government, private veterinarians, and farmers can prevent outbreaks of such diseases. (csmonitor.com)
  • To reduce the veterinary, public health, environmental, and economic burden associated with anthrax outbreaks, it is vital to identify the spatial distribution of areas suitable for Bacillus anthracis, the causative agent of the disease. (cdc.gov)
  • Outbreaks of emerging infectious diseases often cause serious problems because of their epidemic potential, the often high case-fatality ratio, difficulties in their treatment and prevention, and often unpredictable societal reactions. (who.int)
  • Outbreaks tend to emerge at the human-animal interface, in remote rural areas and in vulnerable populations with limited medical services. (who.int)
  • Outbreaks of human disease can be severe. (who.int)
  • Commonly recommended large animal models of OA include the dog, sheep, goat, or horse. (hindawi.com)
  • milking sheep and goats (OR 3.5), consumption of raw feta cheese made from sheep and goat milk (OR 2.8) and consumption of cows' milk (OR 0.4) and boiled feta cheese (OR 0.4). (who.int)
  • If atypical scrapie had an infectious origin, it could be influenced by risk factors associated with a pattern of infectious disease transmission as described for classical scrapie ( 12 - 14 ). (cdc.gov)
  • The NITD is plugging into the country's strengths in infectious disease research by concentrating on developing new treatments for dengue fever and tuberculosis. (newscientist.com)
  • The platform was developed to counteract emerging neglected viral pathogens with low worldwide infectious disease impact but of significant local/regional public health concern utilizing the concept of emergency immunization in the form of ring vaccination. (nih.gov)
  • Prion diseases are a group of fatal brain-wasting diseases in humans and animals. (usda.gov)
  • Shadoo expression has been linked to mouse and human prion diseases, thus, investigating shadoo will shed light onto prion diseases and their potential prevention and cure. (usda.gov)
  • This protein is expressed in the central nervous system (CNS) and serves as a precursor to the misfolded PrP**S**c isoform in prion diseases. (usda.gov)
  • The molecular pathogenic mechanisms of prion diseases are far from clear. (altmetric.com)
  • Some have suggested that "the experimental genetic manipulation of the animal germline initially by pronuclear injection of cloned DNA into zygotes represents one of the most significant milestones in the history of human civilization," Behringer et al, in Manipulating the Mouse Embryo (Cold Spring Harbor Laboratory Press, pg14, 2014). (wikipedia.org)
  • During the 1960s, Brinster pioneered the development of techniques to manipulate mouse embryos, and his techniques have made the mouse the major genetic model for understanding the basis of human biology and disease. (wikipedia.org)
  • Atypical scrapie could be a spontaneous disease influenced by genetic and metabolic factors. (cdc.gov)
  • Anthony Chan, at the Emory University in Atlanta, has developed a monkey model of HD - in fact, it's the first monkey model of any human genetic disease. (hdbuzz.net)
  • Thus, the objectives of this study were twofold: 1) to compare four alternative non-linear models: Poisson, negative binomial, zero-inflated Poisson and zero-inflated negative binomial based on their goodness of fit for quantifying genetic variation, as well as heritability for tick-count and 2) to investigate potential response to selection against tick-count based on truncation selection given the estimated genetic parameters from the best fit model. (nofima.no)
  • The present study examined the natural genetic variation in shadoo genes from humans and the model organisms mice and sheep. (usda.gov)
  • Shadoo from human and mouse populations showed relatively little genetic diversity compared to sheep. (usda.gov)
  • Genomic analyses have revealed genetic biomarkers potentially involved in prion neuropathology in naturally scrapie-infected sheep, a good animal model of infectious prionopathies. (altmetric.com)
  • The museum has some 10,000 preserved anatomical specimens - including human cyclopses, conjoined twins and massively deformed fetuses - plus animal skeletons, anatomical models and reconstructions of various genetic mishaps. (mentalfloss.com)
  • This live webinar will focus on state-of-the-art development of treatment technologies for genetic eye diseases. (cybersight.org.cn)
  • Moreover, the generation of specific human CF disease-associated mutations in sheep may advance personalized medicine for this common genetic disorder. (ox.ac.uk)
  • Here we report the identification of a likely disease-causing variant and propose an ovine model for human 3M syndrome-2. (nih.gov)
  • The opportunity for an ovine model for human 3M syndrome and ensuing therapeutic research is promising given the availability of carrier ram semen for BCRHS. (nih.gov)
  • Glycosphingolipid analysis in a naturally occurring ovine model of acute neuronopathic Gaucher disease. (omia.org)
  • Some of these diseases are transmitted from animals to humans (zoonotic diseases), threatening also the health of producers as well as people who handle and consume animal source foods. (ilri.org)
  • EB127/3 partners formulated a general strategy, similar to WHO's global alert and response strategy for emerging zoonotic diseases, for the renewal or intensification of efforts to prevent and control the disease. (who.int)
  • Other possible origins for atypical scrapie could involve exposure to toxic substances, particularly pesticides, which were shown to be involved with other neurodegenerative diseases involving protein disorders such as Parkinson disease and Alzheimer disease ( 20 , 21 ). (cdc.gov)
  • She also is known for studies of neurodegenerative processes, with numerous original contributions to the transmission and pathogenesis of human Creutzfeldt-Jakob Disease and sheep scrapie agents. (yale.edu)
  • Menkes disease, also known as kinky hair disease, is an X-linked neurodegenerative disease of impaired copper transport. (medscape.com)
  • The researchers are hopeful the animals will prove useful for research into diseases that impair the cognitive abilities of patients, such as Huntington's disease (HD) and Alzheimer's disease. (earthscape.org)
  • There is no doubt that there will be more drugs to treat cancer, Alzheimer's disease and other diseases. (parliament.uk)
  • This disease has been transmitted experimentally to Tg-mice ( 9 ) and sheep ( 10 ), but histopathologic features of atypical scrapie have suggested similarities with human spontaneous TSE (Gerstmann-Sträussler-Scheinker syndrome) ( 2 , 11 ). (cdc.gov)
  • But if scientists test the motor coordination of HD model mice or rats, by getting them to run on a rotating bar, they do fall off more quickly than regular mice. (hdbuzz.net)
  • Roughly ninety-five percent of all lab animals are special-bred mice and rats. (bartleby.com)
  • Scientsts call these genetically-modified organisms 'models' of HD. (hdbuzz.net)
  • A sustainable strategy to control tick-infestation is to breed for genetically robust animals. (nofima.no)
  • Using a sheep model also enables the use of individuals that are almost genetically identical and many sheep models provide data that has good predictive value for appraisal of arthritis treatments [ 8 ]. (hindawi.com)
  • Domestic and other wild cats are the definitive hosts of T. gondii , and ingestion of oocysts excreted by cats is the main source of infection in intermediate hosts (humans and animals) 1 , 8 . (nature.com)
  • Selenium is an essential micronutrient for humans and animals that is found ubiquitously in the environment, being released from both natural and anthropogenic sources. (cdc.gov)
  • Therefore, the potential benefits of animal experimentation are greatly outweighed by the risks and collective harm of humans and animals which is why resources should be directed towards more human-based testing procedures. (bartleby.com)
  • Bovine spongiform encephalopathy (BSE), also known as mad cow disease, and variant Creutzfeldt-Jakob disease (CJD) are related disorders. (medscape.com)
  • Incidence of bovine spongiform encephalopathy (BSE) and variant Creutzfeldt-Jakob disease (CJD) in Great Britain. (medscape.com)
  • In preparation for human uterus transplantation trials, most teams use the sheep as a model system for research and team training, since the vasculature and the uterus is of similar size as in the human. (nih.gov)
  • Huntington's disease research news. (hdbuzz.net)
  • New Zealand sheep farmers were surveyed and invited to rank the importance of research areas with a score of 1 being not important and 4 being very important. (lincoln.ac.nz)
  • This database, created in 2000, is updated every three months with newly published scientific articles, books, and other publications related to improving or safeguarding the welfare of animals used in research. (awionline.org)
  • Research primates may undergo surgical procedures making effective pain management essential to ensure good animal welfare and unbiased scientific data. (awionline.org)
  • Animal models of human diseases are important in biomedical research. (awionline.org)
  • However, new research recently published in the journal PLoS ONE shows that sheep are indeed smarter than previously believed. (earthscape.org)
  • On another floor is Paradigm Therapeutics, which plans to extend the genomics-driven research on the central nervous system and metabolic diseases that it does at its UK home in Cambridge. (newscientist.com)
  • The research animals are to be housed in a vast complex in the basement. (newscientist.com)
  • He plans to further that research using this new technique and to look for ways to study other human diseases through the pig model, such as diabetes and obesity. (phys.org)
  • This Real News Network interview with Rob Wallace of the Agroecology and Rural Economics Research Corps discusses what's caused the current outbreak of African swine flu - the largest animal epidemic in history - which is currently rampaging throughout China and other parts of Asia. (nakedcapitalism.com)
  • Contributing to a better understanding of the spreading of infectious diseases has always been one of the research objectives of the SocioPatterns project. (sociopatterns.org)
  • The cranial cruciate ligament desmotomy (CCLD, commonly referred to as an anterior cruciate ligament transection-ACLT) is one of the earliest and most well-known OA models and is the most commonly used surgical model in OA research [ 1 ]. (hindawi.com)
  • Because of their anatomic similarities to humans, sheep have become popular as models for orthopedic research. (hindawi.com)
  • Members are our strongest champions of animal conservation and wildlife research. (si.edu)
  • Animals are used by scientists to develop research for new medications and experiments daily. (bartleby.com)
  • According to the US-based foundation of Biomedical Research, animal testing has made a major advance within the last century- for veterinary health and humans. (bartleby.com)
  • Does federal law ensure that animals used in research are treated humanely? (bartleby.com)
  • The essential need for animal research and observation is supported by health agencies and medical associations around the world. (bartleby.com)
  • As of 2015, 200 to 225 million animals are said to used in laboratory research for the biomedical industry annually worldwide. (bartleby.com)
  • First off, the laboratory conditions that are instigated upon millions of animal models for the sake of medical research has been said to be unethical and cruel. (bartleby.com)
  • Launched today on behalf of Honorable Joy Kabatsi, Minister of State for Animal Industry in the Uganda Ministry of Agriculture, Animal Industry and Fisheries (MAAIF), Rose Ademun, Commissioner of Animal Production (MAAIF), #BuildUganda is a research for development collaboration to prevent and tackle animal diseases and zoonoses in Uganda. (ilri.org)
  • Dieter Schillinger, Deputy Director General Research and Development for Biosciences said "I am very pleased that the German government through BMZ is supporting the Ugandan government to improve animal health strategies in the country. (ilri.org)
  • The proposed research is multidisciplinary and will develop basic knowledge on RAS, photo-thermal history, diet and vaccine effects on fish physiology that may predispose fish to disease at sea. (ukri.org)
  • The 'Disease Modeling and Transmission' (DMT) Section was established in August 2008 and conducts innovative research on viral pathogens requiring high or maximum containment. (nih.gov)
  • DMT's general work philosophy/strategy combines areas such as 'molecular biology', 'tissue culture', 'immunology' and 'animal models' with the goal to develop vaccines and therapeutics for emerging zoonotic viruses, the mission of the Laboratory of Virology, Division of Intramural Research (DIR) and NIAID. (nih.gov)
  • His postdoctoral research was conducted in the field of virology (filoviruses and hantaviruses) at the Institute of Virology in Marburg and the Centers for Disease Control and Prevention in Atlanta, USA ('National Research Council' fellowship). (nih.gov)
  • Animal research" redirects here. (wmflabs.org)
  • Animal testing , also known as animal experimentation , animal research , and in vivo testing , is the use of non-human animals in experiments (although some research about animals involves only natural behaviors or pure observation, such as a mouse running a maze or field studies of chimp troops ). (wmflabs.org)
  • The research is conducted inside universities, medical schools, pharmaceutical companies, farms, defense establishments, and commercial facilities that provide animal-testing services to industry. (wmflabs.org)
  • Animals are also used for education, breeding, and defense research. (wmflabs.org)
  • The terms animal testing, animal experimentation , animal research, in vivo testing , and vivisection have similar denotations but different connotations . (wmflabs.org)
  • From past research we know that grain supplements offered to grazing animals at a rate above 0.4% of their body weight will decrease forage intake/digestibility. (steerplanet.com)
  • The re-emergence of Rift Valley in Madagascar baffles current predictive models, and provides strong support for more ecological research on the disease. (cdc.gov)
  • Objective: to examine the influence of rhBMP-2 in bucco- facial grafts, presenting recent research on animals and humans, as well as different approaches to clinical application and the results obtained by the authors. (bvsalud.org)
  • Each disease changes individual metabolic steps in the body, which is a topic of research in metabolomics. (medscape.com)
  • A girl with the Menkes disease phenotype and an X:autosome chromosomal translocation was described in 1987, which led to the identification of the locus on the X chromosome in 1993. (medscape.com)
  • The phenotype of CFTR-/- sheep suggests this large animal model will be a useful resource to advance the development of new CF therapeutics. (ox.ac.uk)
  • The Parkinson's Disease Society regards stem cells as a potential great way forward to controlling problems. (parliament.uk)
  • Service dogs help patients with multiple sclerosis , spina bifida , Parkinson's disease , cerebral palsy, or other diseases through targeted assistance. (medscape.com)
  • Thus, the generation of transgenic animals is an extraordinary, creative development in man's historical interaction with other species and of enormous importance in biology and medicine (see NICHD 2003 Hall of Honor and 2012 Colloquium External links below). (wikipedia.org)
  • Although the name "sheep" applies to many species in the genus Ovis, in everyday usage it almost always refers to Ovis aries. (earthscape.org)
  • Numbering a little over one billion, domestic sheep are also the most numerous species of sheep. (earthscape.org)
  • The Food and Drug Administration (FDA) guidelines for preclinical and clinical evaluation of orthopedic agents recommend evaluation in two different species, including one nonrodent, large animal model. (hindawi.com)
  • Sheep may be a particularly relevant animal to model CF in humans due to the similarities in lung anatomy and development in the two species. (ox.ac.uk)
  • Animal testing is not only beneficial to human but also animals, at least to those who are not used in the experiments, such as pets and endangered species. (bartleby.com)
  • The INLA framework successfully identified known areas of species suitability in Uganda, as well as suggested unknown hotspots across Northern, Eastern, and Central Uganda, which have not been previously identified by other niche models. (cdc.gov)
  • This suggests that anthrax should be defined by the exotoxins encoded for by the pXO1 plasmid rather than the bacterial species it has historically been associated with, and that the definition of anthrax should be expanded to include disease caused by any member of the B. cereus group containing the toxin-producing pXO1 plasmid or anthrax toxin genes specifically. (cdc.gov)
  • Modeling studies, involv- another species) red foxes and spread southward ( 9 ). (cdc.gov)
  • Additionally, it has been debated that the results of animal experimentation are unreliable across a wide range of areas. (bartleby.com)
  • As one of the earliest and most serious countries, PPR has seriously threatened India's animal husbandry economy. (bvsalud.org)
  • In the past 30 years, more than 30 new emerging infectious diseases have been reported globally. (who.int)
  • Animal Technology and Welfare 21(1), 58-61. (awionline.org)
  • Pain causes behavioral, autonomic, and neuroendocrine changes and is a common cause of animal welfare compromise in farm animals. (awionline.org)
  • Current societal and ethical concerns demand better agricultural practices and improved welfare for food animals. (awionline.org)
  • 2021. Refining procedures within regulatory toxicology studies: Improving animal welfare and data. (awionline.org)
  • Now that the researchers have been successful using this revolutionary technology, they plan to look for applications that would improve animal welfare, including disease resistance. (phys.org)
  • A Judeo-Christian interpretation from the Bible stated that "dominion over animals meant that any degree of exploitation was acceptable has changed for most people to mean that each person has responsibility for animal welfare (Aquinas T., 2006). (bartleby.com)
  • In addition, small-scale experiments will test the effects of increased CO2 on salmon physiology, the effects of freshwater history on smolt immune function (using double stranded RNA challenge) and post-smolt amoebic gill disease susceptibility when challenged with infectious agent N. Peruvans. (ukri.org)
  • This study compiled occurrence data (n = 874) of confirmed human and animal cases from 1954 to 2021 in 94 countries. (cdc.gov)
  • How smart are sheep, and why do HD researchers care? (hdbuzz.net)
  • The researchers' computer model will be an important tool for local and national decision-makers, in the event of an outbreak in the United States. (liu.se)
  • In addition, all chapters provide general and specific references to nutrition and metabolism for researchers and practitioners in animal agriculture (including aquaculture), dietitians, animal and human medicines, and for government policy makers. (hoepli.it)
  • Researchers are investigating whether dogs can sniff out various diseases, such as cancer, COVID-19, or bacterial infections. (medscape.com)
  • Since the beginning of the pandemic, researchers such as Holger Volk, PhD, chair of small animal diseases at the University of Veterinary Medicine in Hannover, Germany, have been investigating whether dogs can recognize SARS-CoV-2 infections. (medscape.com)
  • To assess the animals' performance, the researchers collected real-world data from 2802 attendees at four concerts. (medscape.com)
  • Some biochemical mechanisms for these diseases could be similar. (cdc.gov)
  • Menkes and Wilson disease ATPases use common biochemical mechanisms, but the tissue-specific expression differs. (medscape.com)
  • and metabolic disorders (or diseases) resulting from nutrient deficiencies. (hoepli.it)
  • The lives of these animals are threatened by a host of pathogens and animal losses by disease threaten the livelihoods of their owners and keepers. (ilri.org)
  • When emerging pathogens are successfully transmitted between humans, they can be amplified in conditions that favour spread of disease, such as overcrowded areas or hospitals with poor infection control. (who.int)
  • Affected lambs are stillborn with various congenital defects as reflected in the name of the disease, as well as short stature, a short and broad cranium, a small thoracic cavity, thin ribs and brachysternum. (nih.gov)
  • The main indications for tracheal reconstruction include malignant tumours (squamous cell carcinoma, adenoid cystic carcinoma), tracheoesophageal fistula, trauma, unsuccessful surgical results for benign diseases and congenital stenosis. (ersjournals.com)
  • Tracheal reconstruction and replacement is a complex and vital surgical procedure with several indications, including primary tracheal neoplasm (adenoid cystic carcinoma and squamous cell carcinoma), thyroid cancer, extensive tracheoesophageal fistulas, unsuccessful previous surgery for benign tracheal diseases (re-stenosis, long-term stenosis that has been dilated or been non-surgically repaired) and, rarely, congenital tracheal stenosis. (ersjournals.com)
  • There are minimal data on the use of venoarterial extracorporeal membrane life support (VA-ECLS) in adult congenital heart disease (ACHD) patients presenting with cardiogenic shock (CS). (bvsalud.org)
  • Readers will also learn from well-written chapters about the use of new genome-editing biotechnologies to generate animals (e.g., cows and swine) as bioreactors that can produce large amounts of pharmaceutical proteins and other molecules to improve the health and well-being of humans and other animals, as well as the growth and productivity of farm animals. (hoepli.it)
  • From a bio-medical standpoint, the pig is really one of the most important animals," said Telugu, noting that other large animal models like cows or sheep don't have digestive systems, diets or physiology similar enough to humans' to provide insight into human diseases. (phys.org)
  • Animal modeling plays a pivotal role in all projects and therefore pathology and pathogenesis are key components of DMT's work. (nih.gov)
  • Centers for Disease Control and Prevention. (cdc.gov)
  • The Centers for Disease Control and Prevention (CDC) cannot attest to the accuracy of a non-federal website. (cdc.gov)
  • Data on the prnp genotype were collected for some case and control animals and included in a complementary analysis. (cdc.gov)
  • The participants' vaccination status, whether they had been previously infected with SARS-CoV-2, whether they had chronic diseases, and medications the participants were taking had no effect on the dogs' performance. (medscape.com)
  • An advanced computer model could save the United States from a catastrophic outbreak of foot-and-mouth disease. (liu.se)
  • What some are calling the largest animal disease outbreak in history is currently ravaging pig farms in China and in other Asian countries. (nakedcapitalism.com)
  • was there a large increase in this kind of disease during that time (of the BSE outbreak)? (nmaonline.org)
  • We, therefore, aimed to develop an ex vivo sheep uterus reperfusion platform that mimics the reperfusion situation so that initial assessments and comparisons can be performed without the need for costly and labor-intensive in vivo transplantation experiments. (nih.gov)
  • Most sheep joint destabilization experiments report induction of OA between 6 months and one year postoperatively [ 3 , 4 ]. (hindawi.com)
  • Is it morally right or wrong to use animals during experiments? (bartleby.com)
  • Due to experiments on animals we have treatments for diabetics, tuberculosis, breast cancer, malaria and brain injuries. (bartleby.com)
  • Literally, "vivisection" means the "cutting up" of a living animal, and historically referred only to experiments that involved the dissection of live animals. (wmflabs.org)
  • Aristotle and Erasistratus were among the first to perform experiments on living animals. (wmflabs.org)
  • Large animal models are necessary for gaining regulatory approval for clinical use in humans. (hindawi.com)
  • Compared to the more severe meniscectomy model, the OA lesions in CCLD models better replicate the natural disease process, but clinical signs develop more slowly. (hindawi.com)
  • The changes were more substantial in clinical animals compared to preclinical animals. (altmetric.com)
  • The distribution of the GALA1 was identified in glial cells from the cerebellum of scrapie-infected animals, GALA1 protein expression was increased in clinical animals in the majority of regions, and the increase of MT2A was in agreement with previous reports. (altmetric.com)
  • The deficiency or impaired function of these enzyme systems is thought to be responsible for the clinical findings of Menkes disease. (medscape.com)
  • Animal work is supported by the Rocky Mountain Veterinary Branch with board-certified clinical veterinarians and veterinary pathologists. (nih.gov)
  • [ 10 , 11 ] Most of these infected animals were slaughtered for human consumption before any clinical signs of BSE were noted. (medscape.com)
  • The translational benefits of sheep as large animal models of human neurological disorders. (omia.org)
  • Easily one of the most published experts on nutrition, cancer, neurological diseases and the effects that micronutrients and antioxidants have on each, Dr. Prasad is frequently sought after for his expertise and extensive experience with nutrition. (countryhealthstore.com)
  • There are also flayed human fetuses dancing a jig, plus weird veterinary specimens like like two-headed calf, a 10-legged sheep, a one-eyed horse and other animals with more or less body parts than there are supposed to be. (mentalfloss.com)
  • Toxoplasmosis, a common parasitic disease, is caused by Toxoplasma gondii , which infects approximately 30% of the world's population. (nature.com)
  • Like all ruminants, sheep are members of the order Artiodactyla, the even-toed ungulates. (earthscape.org)
  • BACKGROUND: Peste des petits ruminants (PPR) is a serious disease that affects goats, sheep and other small ruminants. (bvsalud.org)
  • Crimean-Congo haemorrhagic fever virus, a member of the Nairovirus genus, is transmitted by ticks and causes serious disease in human beings but is not pathogenic for ruminants, its amplifying host. (who.int)
  • With animals being transported such long distances the risk of infection is high, and computer simulations indicate that in the event of a widespread epidemic, some 120,000 farms would be affected. (liu.se)
  • A study, carried out by scientists at the Institute for Animal Health in Berkshire, England, and published in the journal Nature , found no evidence of an increase in scrapie during the country's BSE epidemic. (nmaonline.org)
  • What we essentially find is a very similar disease called scrapie didn t change in incidence during the time of the BSE epidemic. (nmaonline.org)
  • A number of procedures have been described to decontaminate surfaces or reusable medical devices, [ 3 - 7 ] but few of these methods are appropriate for decontamination of large volumes of animal tissue from TSE-infected animals. (biomedcentral.com)
  • Lastly, animal testing not only leads away from the direction of resources from more effective testing methods but also prolongs the duration of time humans may need to wait for an effective cure. (bartleby.com)
  • Here, we describe the generation of a sheep model for CF using CRISPR/Cas9 genome editing and somatic cell nuclear transfer (SCNT) techniques. (ox.ac.uk)
  • The present study was carried out on 10 clinically affected copper poisoned cases (in each season) from autumn 2015 to the end of summer 2016, in four seasons in Kerman province to evaluate the seasonal effects of CCP in sheep. (ac.ir)
  • Our model was able to produce clinically detectable signs of osteoarthritis in a relatively short period (14 weeks). (hindawi.com)
  • Infection with these Bacillus cereus group organisms produces a disease clinically similar to anthrax. (cdc.gov)
  • 2023). OMIA:000405-9940: Online Mendelian Inheritance in Animals (OMIA) [dataset]. (omia.org)
  • The newborn CFTR-/- sheep developed severe disease consistent with CF pathology in humans. (ox.ac.uk)
  • Keeping animals healthy through accurate disease prediction, prevention and treatment and keeping foods safe during handling and processing leads to more productive animals as well as healthier diets and improved livelihoods for people. (ilri.org)
  • The prediction maps generated using this model can guide future anthrax prevention and surveillance plans by the relevant stakeholders in Uganda. (cdc.gov)
  • Using an ensemble ecological niche model (ENM) framework, we developed updated maps of the global predicted environmental suitability of anthrax to measure relative risk at multiple scales of analysis, including a model for circumpolar regions. (cdc.gov)
  • The emergence of new infectious diseases is a consequence of ecological and environmental changes, human demographics and behaviour, increasing international travel, more intensive agricultural practices, changes in technological and industrial practices, microbial adaptation and change, and infrastructural shortcomings for both public health and animal health. (who.int)
  • Etruscan bronze model of a sheep's liver (third century B.C. (collectmedicalantiques.com)
  • Since the liver was felt to be the center of life, the source of blood, and the residence of the soul, it was not surprising that animal livers were examined by priests in order to help determine the causes of disease. (collectmedicalantiques.com)
  • To Babylonian physicians, a small left lobe of the liver meant weakness and disease, while others looked to variations in the surface of the organ for guidance. (collectmedicalantiques.com)
  • Severity of the copper toxicity (judged by the liver copper concentration) is season-dependent in sheep and seasonal variations affect this toxicity. (ac.ir)
  • Environmental climate and stressors may be the main causes of copper contents of different tissues and the liver is the main organ to reserve copper in poisoned sheep. (ac.ir)
  • Also, substantial liver and gallbladder disease may reflect CF liver disease that is evident in humans. (ox.ac.uk)
  • Occasionally people are also affected, and experience a range of symptoms from uncomplicated flu-like illness to hemorrhagic disease with severe liver involvement and eye or brain lesions. (cdc.gov)
  • A lysosomal storage disease in which there is a buildup (storage) of glucocerebroside in various tissues, due to the lack of the enzyme beta-glucocerebrosidase, whose task is to break down glucococerebroside into its constituent molecules. (omia.org)
  • The host of any particular prion disease determines the potential distribution of PrP Sc in the tissues. (biomedcentral.com)
  • The virus is transmitted to humans either by tick bites or through contact with viraemic tissues during and immediately after the slaughter of an animal. (who.int)
  • Tissues such as brain, spinal cord, and small intestine, which may have a higher likelihood of containing the pathogenic agent of BSE, were removed during slaughter and sent for rendering (often to be used as nonruminant animal feed). (medscape.com)
  • We developed a novel ex vivo sheep uterus model for prolonged perfusion. (nih.gov)
  • Refinement of animal models is essential to ensure best use of. (awionline.org)
  • 1 case of atypical scrapie in the same flock provide insufficient information to draw conclusions on natural transmission of this disease ( 3 ). (cdc.gov)
  • This approach enabled us to discriminate shedding of prions in saliva and detection of prions in saliva -- a distinction crucial to understanding the role of prion shedding in disease transmission and for diagnosis. (iowawhitetail.com)