It interacts with other adhesion molecules, such as lymphocyte function-associated antigen-3 (LFA-3/CD58) in humans, or CD48 in rodents, which are expressed on the surfaces of other cells. (wikipedia.org)
Mouse monoclonal to CD2.This recognizes a 50KDa lymphocyte surface antigen which is expressed on all peripheral blood T lymphocytes,the majority of lymphocytes and malignant cells of T cell origin, including T ALL cells. (irjs.info)
The murine homologue of the T lymphocyte CD2 antigen: molecular cloning, chromosome assignment and cell surface expression. (ox.ac.uk)
The human T lymphocyte antigen CD2 (T11, sheep erythrocyte receptor) is expressed on all peripheral T cells and all but the most immature thymocytes. (ox.ac.uk)
Purified lymphocyte function-associated antigen 3 binds to CD2 and mediates T lymphocyte adhesion. (ox.ac.uk)
CD2 is a T lymphocyte glycoprotein that functions in adhesion of T lymphocytes and also as a putative receptor for activation signals. (ox.ac.uk)
These data demonstrate that LFA-3 is a ligand for CD2 and that LFA-3 can mediate T lymphocyte adhesion. (ox.ac.uk)
Serologic cross-reactivity of T11 target structure and lymphocyte function-associated antigen 3. (ox.ac.uk)
T11 target structure (T11TS) and lymphocyte function-associated antigen (LFA) 3 are the cell-surface glycoproteins on sheep and human erythrocytes (E) binding to cluster differentiation 2 (the E-receptor) on T cells in E rosette formation. (ox.ac.uk)
Definition of the receptor and ligand molecules as CD2 and lymphocyte function-associated antigen 3 (LFA-3). (ox.ac.uk)
CD2, also known as LFA-2, T11, and the E rosette receptor, is a T lymphocyte surface protein functionally important in adhesion to target cells and T cell triggering. (ox.ac.uk)
CD2 interacts with lymphocyte function-associated antigen (LFA-3/CD58) and CD48/BCM1 to mediate adhesion between T-cells and other cell types. (ptglab.com)
Anti-Human CD22
dashed line histogram) or BD Horizon™ BB700 Mouse Anti-Human CD2 antibody (Cat. (bdbiosciences.com)
1X10^6 human PBMCs were surface co-stained with PE Anti-Human CD3 and 5 ul FITC Plus Anti-Human CD2 (FITC-65192, Clone: TS1/8) or Mouse IgG1 Isotype Control. (ptglab.com)
Ligand3
Experiments with monoclonal antibodies against CD2 suggest that CD2 is the cell surface receptor for a natural ligand involved in T cell proliferation. (ox.ac.uk)
Functional data suggest that LFA-3, a widely distributed cell surface glycoprotein, may be the biological ligand of CD2. (ox.ac.uk)
The major ligand for CD2 is CD58 (also known as LFA-3). (biolegend.com)
Rosette formation1
This CD2 monoclonal inhibits E rosette formation. (irjs.info)
Receptor4
It has also been called T-cell surface antigen T11/Leu-5, LFA-2, LFA-3 receptor, erythrocyte receptor and rosette receptor. (wikipedia.org)
CD2 is a 50 kD type I transmembrane glycoprotein also known as LFA-2, T11, and sheep red blood cell receptor (SRBC-R). This immunoglobulin superfamily member is expressed on thymocytes, T lymphocytes, NK cells, and thymic B cell subsets. (biolegend.com)
We find that LFA-3 is expressed on human E, and that CD2 is a receptor for LFA-3 that mediates T cell adhesion to human E. Pretreatment of T lymphocytes with CD2 mAb or of E with LFA-3 mAb inhibits rosetting. (ox.ac.uk)
Antibody4
Amonoclonal antibody (MoAb), designated TCY-3, against Trypanosoma cruzi was obtained from spleen cells of BALB/c mice immunized with crude soluble antigens of T. curzi trypomastigotes. (bvsalud.org)
The configuration of E Rosettes with sheep red blood cells and the expression of the epitope detected for the monoclonal antibody anti-CD2 was detected in mononuclear cells from 9 Cebus apella monkeys. (bvsalud.org)
SHEEP ANTI-CHIKUNGUNYA VIRUS Sheep anti Chikungunya virus antibody has been raised against recombinant CHIKV VLPs, expressed in mammalian cells. (maxanim.com)
MOUSE ANTI-CANINE DISTEMPER VIRUS SURFACE ENVELOPE ANTIBODY (8-1) Mouse anti canine distemper virus surface envelope antibody (8-1) is a monoclonal antibody that is specific for canine distemper virus (canine morbillivirus) surface envelope antigen. (maxanim.com)
Lymphocytes6
Normal B lymphocytes, monocytes or granulocytes do not express surface CD2 antigen, neither do common ALL cells. (irjs.info)
The fluorescence histogram showing CD2 expression (or Ig Isotype control staining) was derived from gated events with the forward and side light-scatter characteristics of intact lymphocytes. (bdbiosciences.com)
Human peripheral blood lymphocytes were stained with CD3 PE and CD2 (clone RPA-2.10) Alexa Fluor® 700 (left), or mouse IgG1, κ Alexa Fluor® 700 isotype control (right). (biolegend.com)
CD2 is a cell surface glycoprotein present on a majority of thymocytes, all mature T cells and subset of NK cells but not on B lymphocytes. (ptglab.com)
Molecule3
CD2 (cluster of differentiation 2) is a cell adhesion molecule found on the surface of T cells and natural killer (NK) cells. (wikipedia.org)
In addition to its adhesive properties, CD2 also acts as a co-stimulatory molecule on T and NK cells. (wikipedia.org)
Together, these findings demonstrate that T11TS on sheep E and LFA-3 on human E are serologically related, providing further support for the notion that T11TS and LFA-3 are the sheep and human forms of the same cell interaction molecule. (ox.ac.uk)
Antibodies1
CANINE DISTEMPER VIRUS ANTIGEN Canine Distemper virus (CDV) antigen has been manufactured for use in the detection of antibodies against CDV for immunoassay development or other applications. (maxanim.com)
Glycoprotein1
A rabbit antiserum raised against purified human CD2, precipitated from surface-labeled mouse thymocytes a glycoprotein of Mr 55,000-66,000 which decreased to Mr 35,000 on digestion with endo-beta-acetylglucosaminidase F. These sizes are consistent with those predicted for the murine CD2 antigen from the cDNA sequence. (ox.ac.uk)
Molecules1
Purified CD2 molecules bind to human E and inhibit rosetting. (ox.ac.uk)
CD481
CD2 has also been reported to bind CD48, CD59, and CD15. (biolegend.com)
Accession1
Uniprot database entry for CD2 (accession number P06729) Wilkins AL, Yang W, Yang JJ (2003). (wikipedia.org)
Gene1
The murine CD2 gene was assigned to chromosome 3 by Southern blot analysis of mouse-hamster somatic cell hybrids. (ox.ac.uk)
Marker1
CD2 is a specific marker for T cells and NK cells, and can therefore be used in immunohistochemistry to identify the presence of such cells in tissue sections. (wikipedia.org)
Cells3
LFA-3 bound specifically to CD2+ cells, and this binding was inhibited by CD2 mAb. (ox.ac.uk)
Conversely, purified LFA-3 inhibited binding of CD2 mAb to cells, and the concentration required for this effect suggests that LFA-3 half-saturated CD2 at 1-5 nM LFA-3. (ox.ac.uk)
CD2 is implicated in the triggering of T-cells, the cytoplasmic domain is implicated in the signaling function. (ptglab.com)
Mouse1
Clarification of the functional role of CD2 would be facilitated by the identification of CD2 in the mouse. (ox.ac.uk)
Structural1
Evidence for structural homology of the sheep and human ligands of CD2. (ox.ac.uk)
Identification1
An alternative approach to the identification of the murine homologue was to use cross-species DNA hybridization, employing human CD2 cDNA as a probe. (ox.ac.uk)
CD2 plays a critical role in alternative T cell activation, T cell signaling, and cell-cell adhesion. (biolegend.com)
Applications1
FITC-65192 targets CD2 in FC applications and shows reactivity with Human samples. (ptglab.com)
Shown1
CD2 has been shown to interact with CD2BP2, Lck and PSTPIP1. (wikipedia.org)
Left1
Two groups of pigs acclimated to diets without or with 8% SDPP were intranasally inoculated with 105 plaque-forming units (PFU) of live attenuated ASFV strain BA71∆CD2 and, three weeks later, left in direct contact with pigs infected with the pandemic Georgia 2007/01 ASFV strain. (bvsalud.org)
Majority1
The great majority of T cell lymphomas and leukaemias also express CD2, making it possible to use the presence of the antigen to distinguish these conditions from B cell neoplasms. (wikipedia.org)