Loading...
  • protein
  • Functional characterisation of these channels has revealed a diversity of properties in that they may show inward or outward rectification, their activity may be modulated in different directions by protein phosphorylation, and their sensitivity to changes in intracellular or extracellular pH varies. (ebi.ac.uk)
  • currents
  • That TWIK-related K+ channels all produce instantaneous and non-inactivating K+ currents, which do not display a voltage-dependent activation threshold, suggests that they are background (leak) K+ channels involved in the generation and modulation of the resting membrane potential in various cell types. (ebi.ac.uk)
  • Inward
  • They are usually referred to as TWIK-related channels (Tandem of P-domains in a Weakly Inward rectifying K+ channel) [ PMID: 8917578 , PMID: 9003761 , PMID: 8605869 , PMID: 9312005 ]. (ebi.ac.uk)
  • cell
  • Moreover, differences in K+ channel expression patterns and densities contribute to the variations in action potential waveforms and repetitive firing patterns evident in different neuronal cell types (Maletic-Savatic et al. (novusbio.com)
  • KV3.1
  • These results clearly demonstrate that the Kv3.1b potassium channel subunit is expressed in both GABAergic and glutamatergic neurones in the NTS of the adult rat medulla oblongata, which are likely to have fast firing phenotypes. (physoc.org)
  • KCNC2
  • Can form functional homotetrameric channels and heterotetrameric channels that contain variable proportions of KCNC2, and possibly other family members as well. (genecards.org)
  • repolarization
  • Suppression of Ca 2+ influx through voltage-activated Ca 2+ channels by 200 μM Cd 2+ resulted mainly in moderate increase of steady-state firing frequency and increase of single AP repolarization rate, however, without abolishing the basic pattern of tonic firing. (50webs.com)
  • Shal
  • Several vertebrate potassium channels with similar amino acid sequences were subsequently found and, together with the D. melanogaster Shal channel, now constitute the Kv4 family. (ebi.ac.uk)
  • sequence
  • Cloned Kir channel cDNAs encode proteins of between ~370-500 residues, both N- and C-termini are thought to be cytoplasmic, and the N terminus lacks a signal sequence. (ebi.ac.uk)
  • activity
  • When highly expressed, they inhibit channel activity, but at lower levels show more specific modulatory actions. (ebi.ac.uk)
  • The tail may be important in modulation of channel activity and/or targeting of the channel to specific subcellular compartments. (abcam.com)
  • PMID
  • Potassium channels are the most diverse group of the ion channel family [ PMID: 1772658 , PMID: 1879548 ]. (ebi.ac.uk)
  • They are usually referred to as TWIK-related channels (Tandem of P-domains in a Weakly Inward rectifying K+ channel) [ PMID: 8917578 , PMID: 9003761 , PMID: 8605869 , PMID: 9312005 ]. (ebi.ac.uk)