Loading...
  • membrane
  • The channel alternates between opened and closed conformations in response to the voltage difference across the membrane. (nih.gov)
  • This review article will focus on the signaling pathways leading to segmented expression of voltage-gated potassium and sodium ion channels at the neuronal plasma membrane and the regulatory mechanisms ensuring segregated functions. (frontiersin.org)
  • This review article summarizes current knowledge regarding potassium and sodium channels trafficking and surface expression and highlights the remaining questions regarding the mechanisms by which segregation of these ion channels at the plasma membrane is achieved. (frontiersin.org)
  • proteins
  • These are all highly similar proteins, with only small amino acid changes causing the diversity of the voltage-dependent gating mechanism, channel conductance and toxin binding properties. (ebi.ac.uk)
  • Using iterative database searches, a statistically significant sequence similarity was detected between the POZ (poxvirus and zinc finger) domains found in a variety of proteins involved in animal transcription regulation, cytoskeleton organization, and development, and the tetramerization domain of animal potassium channels. (embl-heidelberg.de)
  • show
  • Finally, we show coupling between I Na ( para ) and I K ( Shal ) such that Pum-mediated change in para results in a compensatory change in Shal . (jneurosci.org)
  • Several studies show an uneven distribution of ion channels and their differential regulation within dendrites and axons, which is a prerequisite for an appropriate integration of synaptic inputs and the generation of adequate action potential (AP) firing patterns. (frontiersin.org)