Sex cord gonadal stromal tumors. Medical search. Frequent questions

Large-cell calcifying Sertoli cell tumor is also a rare variant of a Sertoli cell tumor. (medscape.com)
In large-cell calcifying Sertoli cell tumor, patients are young, with age at diagnosis ranging from 16-37 years. (medscape.com)

Background: Sertoli-Leydig cell tumors are rare sex-cord stromal tumors, and seldom seen at postmenapausal women. (ispub.com)
Steroid cell tumors (SCTs) are very rare sex cord-stromal tumors and account only for less than 0.1% of ovarian neoplasms. (biomedcentral.com)

Leydig cell tumour. (wikipedia.org)
This tumour produces Leydig cells, which normally are found in the testicle and tend to secrete androgens. (wikipedia.org)
This tumour produces both Sertoli and Leydig cells. (wikipedia.org)
A very rare tumour producing both ovarian (granulosa and/or theca) and testicular (Sertoli and/or Leydig) cells or tissues. (wikipedia.org)
citation needed] Granulosa cell tumors and Sertoli-Leydig cell tumors have specific genetic mutations that are characteristic and can help support the diagnosis. (wikipedia.org)
A retrospective study of 83 women with sex cord-stromal tumours (73 with granulosa cell tumour and 10 with Sertoli-Leydig cell tumour), all diagnosed between 1975 and 2003, reported that survival was higher with age under 50, smaller tumour size, and absence of residual disease. (wikipedia.org)
Testicular sex cord stromal tumors include Leydig cell tumors, Sertoli cell tumors, and granulosa cell tumors. (medscape.com)
Leydig cell tumors (see the image below) are derived from normal Leydig cells that produce testosterone and are located in the interstitium of the testis. (medscape.com)
Leydig cell tumor. (medscape.com)
Leydig cell tumors constitute about 3% of testicular neoplasms and occur in both adults (80% of cases) and children. (medscape.com)
In boys, Leydig cell tumors are benign. (medscape.com)
from the gonadal stroma, LEYDIG CELL TUMOR and THECOMA . (nih.gov)
Sertoli-Leydig Cell Tumor" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (wakehealth.edu)
Most such tumors produce ANDROGENS in the Leydig cells, formerly known as androblastoma or arrhenoblastoma. (wakehealth.edu)
This graph shows the total number of publications written about "Sertoli-Leydig Cell Tumor" by people in this website by year, and whether "Sertoli-Leydig Cell Tumor" was a major or minor topic of these publications. (wakehealth.edu)
Below are the most recent publications written about "Sertoli-Leydig Cell Tumor" by people in Profiles. (wakehealth.edu)
Pathological examination revealed the presence of a colonic adenocarcinoma coexistent with bilateral ovarian Sertoli-Leydig cell tumor.Conclusion: Clinical awareness and recognition of second tumors are important as they can change treatment strategies. (ispub.com)
Sertoli-Leydig cell tumor (SLCT) belongs to the group of sex cord-stromal tumors of the ovary and constitutes less than 0.5% of primary ovarian tumors 1 . (ispub.com)
Sertoli-Leydig cell tumors usually occur in young women and 70-75% of these tumors occur during the second and third decade of life 2 . (ispub.com)
To our knowledge, the following description of a postmenopausal woman is the first case in the literature with the synchronous tumors of colonic adenocarcinoma and ovarian Sertoli-Leydig Cell tumor found in an inguinal hernia sac. (ispub.com)
Non- germ cell testicular tumors come from the Sertoli cells, which don't produce hormones, or the Leydig cells which can secrete excess male and female sex hormones . (osmosis.org)
Data from 32 MOGCT (6 dysgerminomas, 6 yolk sac tumors, 17 immature teratomas, and 3 mixed germ cell tumors) and 9 SCST (4 granulosa cell tumors and 5 sertoli-leydig cell tumors) aged from 18 to 35, treated in the Obstetrics and Gynecology Hospital of Fudan University from October 2003 to October 2013 were collected and analyzed. (biomedcentral.com)
SCSTs develop from the gonadal non-germ-cell components [ 1 ], including granulosa cell tumors, granulosa-theca tumors, and Sertoli-Leydig cell tumors. (biomedcentral.com)
Histologically, they can be divided into several subtypes, such as stromal luteoma, Leydig cell tumor, or SCTs- not otherwise specified (NOS), according to their cell components [ 2 ]. (biomedcentral.com)
Leydig cell tumors account for approximately 1-3% of adult testicular tumors. (jurolsurgery.org)
This case is about an incidentally diagnosed Leydig cell testis tumor in a patient who was investigated for primary infertility. (jurolsurgery.org)
He underwent left radical orchiectomy and pathological diagnosis was testicular Leydig cell tumor. (jurolsurgery.org)
New developments in ultrasound imaging have increased the number of Leydig cell tumors discovered (2). (jurolsurgery.org)
In this report, we present a case of Leydig cell testis tumor incidentally diagnosed during primary infertility investigation. (jurolsurgery.org)
Pathological investigation revealed a testicular Leydig cell tumor measuring 15 mm in diameter, diffuse positive for inhibin and calretinin while surgical margins were negative and no tumor necrosis, nuclear atypia or vascular invasion was detected ( Figure 1 ). (jurolsurgery.org)
Leydig cell tumors are relatively rare testicular tumors accounting for 1-3% of all testicular tumors in adults (1). (jurolsurgery.org)
3) reported that 80% of 37 patients with Leydig cell tumor had low testosterone and high estrogen, estradiol, LH and FSH levels while no patient showed increased testicular markers. (jurolsurgery.org)
It is estimated that about 30% of patients with Leydig cell tumors have endocrine symptoms due to abnormal hormone levels (4). (jurolsurgery.org)
As in our patient, cases of Leydig cell tumors incidentally diagnosed during infertility investigation have been reported in the literature (5,6). (jurolsurgery.org)
Malignant transformation of Leydig cell tumors occurs in approximately 10% of patients. (jurolsurgery.org)
Histopathological and clinical findings of malignant Leydig cell tumors include increased mitotic activity, vascular invasion, large size (>5 cm), necrosis, cytological atypia, extension beyond the testicular parenchyma, increased MIB-1 expression, infiltrative margins and DNA aneuploidy (7). (jurolsurgery.org)

CD56 may be useful for distinguishing sex cord-stromal tumours from some other types of tumours, although it does not distinguish them from neuroendocrine tumours. (wikipedia.org)
A prospective study of ovarian sex cord-stromal tumours in children and adolescents began enrolling participants in 2005. (wikipedia.org)
Ovarian sex cord-stromal tumours and their mimics. (nih.gov)
This document addresses post-pubertal testicular germ-cell tumours (TGCTs) in the male including spermatocytic tumour and sex cord/gonadal stromal tumours. (uroweb.org)
Since 2008, the TC Guidelines contains a separate chapter on testicular stromal tumours. (uroweb.org)
EN":"Top five tumours most diagnosed in Veneto and proportion with the total number of tumours by sex"},"freq_title_inc_asl":{"IT":"Primi cinque tumori pi\u00f9 frequentemente diagnosticati nella ASLX e proporzione sul totale dei tumori per sesso. (registrotumoriveneto.it)
EN":"Exclusions: DCO, lost to follow-up, incompatible morfology or topografy according to 2016 AIRTUM monography 'La sopravvivenza dei pazienti oncologici in Italia', multiple tumours cases on the same site. (registrotumoriveneto.it)

Sex cord-gonadal stromal tumour is a group of tumors derived from the stromal component of the ovary and testis, which comprises the granulosa, thecal cells and fibrocytes. (wikipedia.org)
The pattern-based (Silva) classification of invasive HPV-associated endocervical adenocarcinomas (HPVA) is an established and reproducible method to predict outcomes for this otherwise stage-dependent group of tumors. (stanford.edu)

It produces both male and female GONADAL STEROID HORMONES . (nih.gov)
Her gonadal hormones returned remarkably to the prepubertal range the day after surgery, and histology of the ovary mass demonstrated SCTs containing abundant luteinized stromal cells. (biomedcentral.com)
The case highlighted that SCTs causing isosexual PPP should be taken into consideration in any young children coexistent with rapidly progressive puberty given a remarkable secretion of sex hormones. (biomedcentral.com)
These tumors usually produce hormones. (jurolsurgery.org)
Scrotal ultrasonography is the primary imaging method used in the diagnosis, however, investigation of tumor markers, hormones (testosterone, LH, FSH, estrogen, estradiol, progesterone and cortisol) and CT examination of chest and abdomen for distant metastasis should be performed. (jurolsurgery.org)
The differences in immune responses between the sexes and the reproductive phases in women are accompanied by variations in sex hormones. (brainimmune.com)
Therefore, these variations in levels of sex hormones have been suggested to cause the different immune responses. (brainimmune.com)
The actions of sex hormones, however, are extremely complex. (brainimmune.com)
In this overview, we will therefore discuss what is known about the effects of sex hormones on the function of the different immune cells in isolation. (brainimmune.com)
Moreover, we will also discuss briefly how sex hormones affect immune responses in complex situations like models of immune-mediated diseases related to specific and non-specific immune responses. (brainimmune.com)
Three classes of sex hormones exist: androgens (mainly testosterone), estrogens (which is mainly 17beta-estradiol in the ovarian cycle), and progesterone. (brainimmune.com)
In females, the production of sex hormones 17beta-estradiol and progesterone fluctuates during the menstrual cycle. (brainimmune.com)
Elevated levels of prolactin decrease the levels of sex hormones- estrogen in women and testosterone in men. (wikipedia.org)
This hormones produced by the major endocrine organs, only gonadal and adrenocortical hormones are steroids. (slideshare.net)

In this study, we examined three previously unreported myoid gonadal stromal tumors of the testis to better characterize their clinicopathologic features, including their immunoreactivities for a comprehensive panel of sex cord-stromal markers. (medscape.com)
Tumor markers were normal. (ispub.com)
Diagnosis of MOGCT or SCST was revealed by pelvic mass, abdominal pain, growing ascites, and arising of tumor markers like α-fetoprotein (AFP), human choionic gonadotophin (HCG) and inhibin. (biomedcentral.com)
Improved understanding of the histology, mechanisms of tumor spread, and tumor markers, combined with the improved quality of radiographic imaging for accurate staging, have greatly contributed to the management of testicular cancer. (medscape.com)
Evaluation usually includes ultrasonography, CT or MRI, and measurement of tumor markers (eg, cancer antigen 125). (msdmanuals.com)
FSH, LH, testosterone, prolactin, cortisol, progesterone, and estrogen levels and testicular tumor markers (alpha-feto protein, beta-human chorionic gonadotropin and lactate dehydrogenase) were normal and no abnormality was detected in the spermiogram ( Table 1 ). (jurolsurgery.org)
In our case, testicular tumor markers were negative and LH, FSH, testosterone and estrogen levels were normal ( Table 1 ). (jurolsurgery.org)

10. Sex cord-stromal tumors of the ovary and testis: their similarities and differences with consideration of selected problems. (nih.gov)

In contrast, the epithelial cells originate from the outer epithelial lining surrounding the gonad while the germ cell tumors arise from the precursor cells of the gametes, hence the name germ cell. (wikipedia.org)
8. Germ cell tumors of the gonads: a selective review emphasizing problems in differential diagnosis, newly appreciated, and controversial issues. (nih.gov)
13. [Testicular germ cell tumors: Histopathological and molecular features]. (nih.gov)
Adult-type granulosa cell tumors of the testicle are much less common than in the adult female ovary. (medscape.com)
Sertoli cell tumors account for less than 1% of testicular tumors, and they occur both in children (15% of cases) and in middle-aged adults and can be malignant (about 10% of cases) in both. (medscape.com)
Age-incidence profiles for extracranial, extragonadal germ cell tumors (left graph) and for gonadal germ cell tumors (right graph). (kaiserpermanente.org)
The accurate management of testicular germ cell tumors (TGCTs) depends on identifying the individual histological tumor components. (bvsalud.org)
and embryonal carcinomas, which are rare as pure carcinomas but a common element of mixed germ cell tumors. (osmosis.org)
To retrospectively investigate reproductive outcomes after fertility-sparing surgery and postoperative adjuvant chemotherapy in malignant ovarian germ cell tumors (MOGCT) and sex cord-stromal tumors (SCST). (biomedcentral.com)
Malignant ovarian germ cell tumors (MOGCT) and sex cord-stromal tumors (SCST) are not common. (biomedcentral.com)
germ cell tumors , sex cord-stromal tumors, and extragonadal tumors . (medscape.com)
Germ cell tumors, which are the most common, are classified histologically as either seminoma or nonseminoma. (medscape.com)
Of the three main types of testicular cancer, nonseminomatous germ cell tumors (NSGCTs) are second only to seminomas in terms of frequency. (medscape.com)
As many as 90% of germ cell tumors are associated with intratubular germ cell neoplasia (ITGCN). (medscape.com)
Stromal tumors of the ovary include germ-cell tumors, sex-cord stromal tumors, and other more rare types. (medscape.com)
Germ cell tumors are relatively common in young men. (biomedcentral.com)

For females, the peak in young children is present only for extragonadal tumors, with rates increasing after the age of puberty for both extragonadal and gonadal sites. (kaiserpermanente.org)

The tumour is almost exclusively benign and unilateral. (wikipedia.org)
5 cm) than benign tumors. (medscape.com)
The risk of malignancy in this age group is increased from 13% in premenopausal to 45% in postmenopausal women, however 55% of postmenopausal women with palpable ovaries do have a benign tumor. (elsevierpure.com)

11 ] Gonadal dysgenesis, as well as the presence of Y-chromosome material in an abdominal gonad, also increases the risk of developing a gonadal GCT, especially gonadoblastoma. (kaiserpermanente.org)

Sex-cord stromal tumors of the ovary are uncommon ovarian malignancies, which account for less than 8% of all ovarian tumors 4 . (ispub.com)
The most common ovarian tumors in this age group include epithelial ovarian tumors followed by stromal tumors and sex-cord tumors. (elsevierpure.com)

Tumor histology (see Histologic Findings ) and tumor stage (see Staging ) are of primary importance in determining the prognosis for patients with testicular tumors. (medscape.com)
CNA burden increased from pattern A to C.Our findings further indicate that key molecular events in HPVA correlate with the morphologic invasive properties of the tumor and their aggressiveness. (stanford.edu)
The present findings suggest that the detection of immune complexes in unfractionated samples of late tumour-bearer serum using a C1q-binding assay is masked by the increasing production of tumour-specific antibodies and by a shift from complement fixing to non-complement-fixing tumour-specific antibodies. (nih.gov)

Malignant tumors may occur and are usually sporadic (with one report of a malignant tumor associated with Carney syndrome ). (medscape.com)
Necrosis can be seen in malignant tumors. (medscape.com)
Malignant tumors are larger and may have areas of necrosis. (medscape.com)

12. Classification and pathology of testicular germ cell and sex cord-stromal tumors. (nih.gov)

Ovarian sex cord-stromal tumors are uncommon tumors and clinically differ from epithelial tumors. (nih.gov)

19. OCT4 staining in testicular tumors: a sensitive and specific marker for seminoma and embryonal carcinoma. (nih.gov)

Granulosa cell tumour. (wikipedia.org)
Uncommonly, a similar but possibly distinct tumour, juvenile granulosa cell tumour, presents in pre-pubertal girls with precocious puberty. (wikipedia.org)
For diagnosis of granulosa cell tumour, inhibin is under investigation. (wikipedia.org)
Low magnification micrograph of a granulosa cell tumour. (wikipedia.org)
In patients with granulosa cell tumor, the average age is 42 years, and 20% of male patients present with gynecomastia. (medscape.com)

3. Testicular Tumors: A Contemporary Update on Morphologic, Immunohistochemical and Molecular Features. (nih.gov)
Dr. Howitt is a gynecologic and sarcoma pathologist, with academic interests in gynecologic mesenchymal tumors and morphologic and clinical correlates of molecular alterations in gynecologic neoplasia. (stanford.edu)

Myoid gonadal stromal tumor of the testis is an uncommon spindle cell tumor hypothesized to arise from peritubular myoid cells or intertubular primitive mesenchymal cells. (medscape.com)

Patients with Sertoli cell sex cord stromal tumors present with a testicular mass, and estrogen production by the tumor can result in gynecomastia and impotence . (medscape.com)
In sclerosing Sertoli cell tumor, patients present with a testicular mass and without endocrinologic symptoms. (medscape.com)
The classic presentation of a testicular tumor is as a painless testicular mass in an otherwise healthy man in the third or fourth decade of life. (medscape.com)

5. [Germ cell and sex cord-stromal tumors of the testis : WHO classification 2016]. (nih.gov)

Prostate cancer , usually refers to prostate adenocarcinoma , where adeno- means gland and carcinoma refers to uncontrolled growth of cells - so prostate cancer is a tumor or growth that originates in the prostate gland . (osmosis.org)

4 cm) indolent testicular tumors distinctly different from other sex cord-stromal tumors and are adequately managed by orchiectomy. (medscape.com)

Inhibin is considered a tumor suppressor, but its role in the breast is unclear. (e-crt.org)
The inhibin-α expression was compared with those of β-hCG, ER, PR and HER-2/ neu , as well as the tumor characteristics and recurrences. (e-crt.org)
Inhibin-α was found in 25.1% of infiltrating ductal carcinomas (67/267), 26.7% of intraductal carcinomas (8/30), 33.3% of lobular tumors (3/9), 80.0% of apocrine carcinomas (4/5) and 21.7% of the other types (5/23). (e-crt.org)
The treatment of young virgin rats with human chorionic gonadotrophin (hCG), which produced effects similar to a full-term pregnancy, induced the profuse lobular development of the mammary gland, reduced the proliferative activity of the mammary epithelium, and induced inhibin synthesis a secreted protein with tumor-suppressor activity ( 1 ). (e-crt.org)
Therefore, inhibin may act as a gonadal tumor suppressor, while activin may promote tumor growth ( 4 , 5 ). (e-crt.org)
Inhibin-α has been demonstrated to be a sensitive marker for the majority of sex cord-stromal tumors of the ovary ( 5 ). (e-crt.org)

Their diagnosis is histological: only a biopsy of the tumour can make an exact diagnosis. (wikipedia.org)

Although both cell types normally occur in the testicle, this tumour can occur in the ovary. (wikipedia.org)
7 , 8 ] Despite the small percentage of malignant teratomas that occur in this age group, perinatal tumors have a high morbidity rate caused by hydrops fetalis and premature delivery. (kaiserpermanente.org)

Testicular lymphatics follow the vessels of the spermatic cord through the inguinal canal and into the retroperitoneum. (medscape.com)
As such, a radical orchiectomy should be performed through an inguinal route to avoid tumor spillage into the inguinal drainage basin. (medscape.com)

This tumour produces theca of follicle, a tissue normally found in the ovarian follicle. (wikipedia.org)

Pathological diagnosis was confirmed according to the 2014 World Health Organization classification of tumors of female reproductive organs by expert gynecological pathologists in our hospital. (biomedcentral.com)
After surgical removal, breast development remitted and her gonadal hormone also returned to the prepubertal range, revealing that SCTs-NOS could be effectively managed with surgical intervention upon prompt and precise diagnosis. (biomedcentral.com)

In more severe cases, symptoms may arise from a malignant tumor metastasizing to other organs. (osmosis.org)
Testicular tumors may arise in males of nearly any age but are most often seen in men 20-34 years old. (medscape.com)
The right and left gonadal arteries arise from the abdominal aorta at approximately the level of the second lumbar vertebra. (medscape.com)

Etiologically, central precocious puberty (CPP) caused by early activation of the hypothalamic-pituitary-gonadal axis (HPG axis) is noticeably different from pseudoprecocious puberty (PPP) caused by endogenous sex-hormone producing tumors or exogenous hormone exposure [ 1 ]. (biomedcentral.com)

This tumour occurs in both men and women. (wikipedia.org)
The juvenile type of this condition is a rare sex cord stromal tumor that occurs in males in the first few months of life. (medscape.com)
The tumor occurs both as a part of the Carney complex and in patients with Peutz-Jeghers syndrome . (medscape.com)

The rarity, overlapping histomorphology and immunoprofile of various sex cord-stromal tumors often contributes to diagnostic difficulties. (nih.gov)

Ovarian cancer is the most common cause of cancer death from gynecologic tumors in the United States. (medscape.com)

Trans-scrotal biopsy or a scrotal approach to orchiectomy should never be performed in cases of suspected neoplasm, as it can cause contamination of the scrotum and alter patterns of lymphatic spread of tumor as well as complicate subsequent management. (medscape.com)

Neoplasms derived from the primitive sex cord or gonadal stromal cells of the embryonic GONADS . (nih.gov)

1 , 2 ] Childhood extracranial GCTs can generally be divided into gonadal and extragonadal. (kaiserpermanente.org)
These tumors can also be broadly classified as teratomas, malignant GCTs, or mixed GCTs. (kaiserpermanente.org)
The incidence of extracranial GCTs according to age group, sex, and gonadal versus extragonadal primary site is shown in Table 1. (kaiserpermanente.org)

It typically secretes estrogen, and as a result women with this tumour often present with postmenopausal bleeding. (wikipedia.org)

Gonadoblastoma is a rare gonadal tumor consisting of a mixture of germ cells and sex-cord stromal derivatives resembling immature granulosa and Sertoli cells. (kaiserpermanente.org)

This tumour produces granulosa cells, which normally are found in the ovary. (wikipedia.org)
6. Perspectives on testicular sex cord-stromal tumors and those composed of both germ cells and sex cord-stromal derivatives with a comparison to corresponding ovarian neoplasms. (nih.gov)
A typical Sertoli cell tumor (see the images below) is a tumor derived from Sertoli cells, located within seminiferous tubules, which help support spermatogenesis. (medscape.com)
A sex cord-gonadal stromal tumor, composed of cells of both the OVARY and the TESTIS . (nih.gov)
Typically, when there's a prostate cancer it's considered malignant, meaning that the tumor cells can metastasize, or invade and destroy surrounding tissues as well as tissues throughout the body . (osmosis.org)
Under appropriate hormonal stimulation, the subcapsular cells can transdifferentiate into sex-steroid-producing cells resembling stromal gonadal cells. (nih.gov)
Isolated fractions were examined for their capacity to bind [125I]C1q as a measure of immune complex levels, and for their ability to bind soluble tumour-specific antigen as well as to react with antigens expressed at the surface of viable hepatoma cells. (nih.gov)

For symptoms, a testicular tumor most often comes up as a small, firm lump that is typically painless, but can sometimes cause a sharp or dull pain in the testicles and lower abdomen. (osmosis.org)

20. Testicular and paratesticular tumors and tumor-like lesions in the first 2 decades. (nih.gov)

3 ] For males, there is a peak in incidence in children younger than 2 years for both extragonadal and gonadal sites, which is followed by low rates between the ages of 2 and 12 years, and then higher rates throughout adolescence. (kaiserpermanente.org)
However, the incidence of each tumor is lower for females during adolescence than for males during adolescence. (kaiserpermanente.org)
15 , 18 ] The age of tumor presentation is younger in patients with Klinefelter syndrome, and testing all younger males for Klinefelter syndrome should be considered. (kaiserpermanente.org)
In fact, testicular tumors are the most common solid malignancy in males between 20 and 35 years old. (osmosis.org)

Tumors are unilateral, with rare exceptions. (medscape.com)

HCG is a glycoprotein hormone, consisting of two non-covalently linked subunits (α and β), with the free β subunit being the main form produced by non-trophoblastic tumors ( 7 ). (e-crt.org)
In response to pituitary luteinizing hormone (LH) and follicle stimulating hormone (FSH), fluctuations in sex hormone concentrations in the menstrual cycle include increasing 17beta-estradiol, but low progesterone plasma concentrations in the follicular phase and high plasma 17beta-estradiol and progesterone concentrations in the luteal phase (see also Fig. 1). (brainimmune.com)

1. Key changes in WHO classification 2022 of testicular tumors. (nih.gov)
9. [WHO classification of testicular tumors]. (nih.gov)
This article describes the various types of ovarian sex cord-stromal tumors and includes practical approaches to differential diagnoses and updates in classification. (nih.gov)

On magnetic resonance imaging, a fibroma may produce one of several imaging features that might be used in the future to identify this rare tumour prior to surgery. (wikipedia.org)

Anatomy22

Organisms6

Diseases90

Chemicals and Drugs37

Analytical, Diagnostic and Therapeutic Techniques and Equipment56

Psychiatry and Psychology2

Phenomena and Processes31

Disciplines and Occupations1

Information Science5

Named Groups1

Health Care15

Calcifying Sertoli cell2

Rare sex-cord stromal tumors2

Leydig36

Tumours7

Group of tumors2

Hormones14

Markers7

Ovary and testis1

Cell tumors16

Extragonadal tumors1

Benign3

Dysgenesis1

Ovarian tumors2

Findings3

Malignant tumors3

Pathology1

Epithelial1

Seminoma1

Granulosa cell5

Morphologic2

Uncommon1

Testicular mass3

Germ-cell1

Carcinoma1

Indolent1

Inhibin6

Histological1

Occur2

Inguinal2

Tissue1

Diagnosis2

Arise3

Puberty1

Occurs3

Rarity1

Gynecologic1

Orchiectomy1

Gonads1

GCTs3

Estrogen1

Gonadoblastoma1

Cells7

Symptoms1

Lesions1

Males4

Unilateral1

Hormone2

Classification3

Fibroma1