Implicated in the pathogenesisMicro-angiopathyRetinopathyPathogenesisLower limbNephropathyComplicationsAtherosclerosisPatientsPrevention of diabeticDiabetesOLETFIschemicCardiacProgressionCerebralOccurrenceFunctionalOnsetPrognosisStronglyHyperglycemiaNervesDiagnosisNeuropathyMortalityRatsDisordersDurationAnalyzeRisk factorsFindingsDevelopmentAdmissionDiseaseFactorsSignificantStudy
Implicated in the pathogenesis1
- in particular, oxidant stress has been implicated in the pathogenesis of diabetic angiopathies ( 7 ). (diabetesjournals.org)
Micro-angiopathy1
- The occurrence of diabetic foot is closely related to micro-angiopathy, micro-thrombosis in the lower limb, which may predate the presentation of diabetic foot. (biomedcentral.com)
Retinopathy5
- Patients with diabetic retinopathy (DR) comprised 68% of the group with CIMT ≥1.0 mm, while they were 28% of the group without CIMT thickening ( P =0.003). (e-enm.org)
- This publication is dedicated to the application of a complex of peptide bioregulators being highly effective in treatment of different retinal diseases (diabetic retinopathy, pigment retinitis, age-related macular degeneration etc. (antiaging-peptides.com)
- Among the most frequent retinal diseases there are age-related macular degeneration, hereditary retinal degenerations (including retinitis pigmentosa), complicated myopia, diabetic retinopathy. (antiaging-peptides.com)
- Diabetic retinopathy (DR), one of the leading causes of blindness and vision impairment, is suggested to exhibit functional and structural changes in retinal neurons as the earliest manifestation, which could be used to predict the progression of related angiopathy. (biomedcentral.com)
- Although diabetic nephropathy, neuropathy and retinopathy are the most common microvascular complications of hyperglycemia, it also affects choroid plexus. (scialert.net)
Pathogenesis4
- [ 13 ] Indeed, the proportion of patients with acalculous cholecystitis in association with emphysematous cholecystitis exceeds that of patients with ordinary acute calculous cholecystitis, suggesting that gallstones may not be central to its underlying pathogenesis. (medscape.com)
- Recent studies have shown that diabetic microangiopathies are associated with macroangiopathies and suggest that microangiopathies may have a prominent role in the pathogenesis of microangiopathy development [ 2 ]. (e-enm.org)
- Connective Tissue Growth Factor (CTGF) has recently been shown to be over-expressed in kidney, myocardium and aorta in diabetic animals, implicating CTGF role in the pathogenesis of both microvascular and macrovascular diabetic complications ( Brownlee, 2001 ). (scialert.net)
- Moreover, NGFs and receptors are also expressed in retina and renal mesangial cells, suggesting their possible role in the common pathogenesis of diabetic microvascular complications. (e-dmj.org)
Lower limb1
- A course method of AP (10 sessions) using body- AP points of general and segmental action and some Ear-points was used for therapy of the functional stage of lower limb diabetic angiopathy in 55 patients with insulin-dependent diabetes mellitus. (med-vetacupuncture.org)
Nephropathy5
- Diabetic nephropathy (DN) is one of the most serious complications of DM. (biomedcentral.com)
- Protective Effects of Lithospermic Acid B on Diabetic Nephropathy in OLETF Rats Comparing with Amlodipine and Losartan. (e-dmj.org)
- We examined the effects of LAB on the prevention of diabetic nephropathy compared with amlodipine, a calcium channel blocker, and losartan, an angiotensin receptor blocker, in Otsuka Long-Evans-Tokushima Fatty (OLETF) rats, an animal model of type 2 diabetes. (e-dmj.org)
- CONCLUSION: These results suggest that LAB has beneficial effects on the diabetic nephropathy in OLETF rats by decreasing oxidative stress and inflammation as potent as losartan. (e-dmj.org)
- Activation of NF-kappaB and AP-1 in Peripheral Blood Mononuclear Cells Isolated from Patients with Diabetic Nephropathy. (e-dmj.org)
Complications6
- Superoxide anion can modulate vascular smooth muscle tone and is potentially involved in diabetic vascular complications. (diabetesjournals.org)
- Cardiac autonomic neuropathy (CAN) is one of the most common complications of diabetes, and represents a significant cause of morbidity and mortality in diabetic patients. (e-enm.org)
- But, if a diabetic patient takes Ayurvedic treatment of diabetes, the chances of complications are less and the condition can be reversed naturally. (deepayurveda.com)
- Diabetic microvasular complications, which are considered as an important group of hyperglycemia imperfections, caused by increased endothelial permeability and can progress to severe impairments in several organs. (scialert.net)
- In vivo Corneal Confocal Microscopy and Nerve Growth Factor in Diabetic Microvascular Complications. (e-dmj.org)
- CONCLUSION: Our results provide a possibility of using novel tools, IVCCM and NGF, as common diagnostic tools for diabetic microvascular complications, but it should be followed by a large population study. (e-dmj.org)
Atherosclerosis5
- The most well-known of these early agents was Lipostabil Endovena® (Aventis Pharma, Germany), an intravenous agent for the treatment of hyperlipidemia, fat emboli, diabetic angiopathy, atherosclerosis, and other intravascular lipid abnormalities. (jcadonline.com)
- Although the precise underlying mechanisms linking the diabetic microangiopathies and macroangiopathies are unclear, some evidence suggests that the effects of microangiopathies may be linked to subclinical atherosclerosis [ 3 - 5 ]. (e-enm.org)
- Carotid atherosclerosis as estimated by carotid intima-media thickness (CIMT) and plaques is considered to reflect an early stage of atherosclerotic disease and is therefore used as a surrogate marker for diabetic macroangiopathies [ 6 - 8 ]. (e-enm.org)
- So far, studies on the relationship between diabetic microangiopathies and carotid atherosclerosis have yielded inconsistent results. (e-enm.org)
- Aassociations between carotid atherosclerosis and both urine albumin excretion (UAE) and glomerular filtration rate (GFR) in diabetic patients have been investigated, but these studies showed only inconsistent results [ 5 , 13 , 14 ]. (e-enm.org)
Patients23
- Research suggests that fibrinogen (Fib) concentrations are used to assess the occurrence and severity of diabetic foot (DF) and to monitor the progression of diabetic foot in patients. (biomedcentral.com)
- A large clinical study found that the prevalence of PAD in patients with T2DM was 23.5% [ 2 ], and diabetic patients with combined PAD are more likely to develop ulceration and gangrene of the limb, significantly increasing the risk of amputation. (biomedcentral.com)
- This study aimed to evaluate the clinical features and the clinical factors associated with prognosis of sudden sensorineural hearing loss (SSNHL) in diabetic patients. (ejao.org)
- Simultaneous intratympanic dexamethasone (ITD) injections with systemic steroid did not confer an additional hearing gain or an earlier recovery rate in diabetic patients with SSNHL. (ejao.org)
- In the multivariate analysis, initial hearing thresholds of affected ear and timing of steroid treatment were significantly associated with hearing prognosis in diabetic patients with SSNHL. (ejao.org)
- Diabetic patients with SSNHL tended to have increased NLR, LMR, and PLR, which are reported to be associated with microvascular angiopathy. (ejao.org)
- Simultaneous ITD injections to improve hearing recovery in diabetic patients with SSNHL seems unnecessary. (ejao.org)
- Additionally, microvascular problems in diabetic patients can affect the delivery and efficacy of systemic steroid in the cochlea [ 6 , 7 ]. (ejao.org)
- Also, the use of systemic steroids can worsen glycemic control in diabetic patients. (ejao.org)
- Given this, systemic steroid use for SSNHL in diabetic patients may lead to poorer outcomes than are observed in those without DM [ 8 , 9 ]. (ejao.org)
- However, previous studies of SSNHL have seldom focused on diabetic patients. (ejao.org)
- Therefore, we conducted a retrospective review to evaluate the clinical factors associated with prognosis and compare the efficacy of simultaneous and sequential systemic steroid and ITD treatment in diabetic patients with SSNHL. (ejao.org)
- Also, we evaluated the clinical features of SSNHL in diabetic patients including the laboratory data which are known to be related to systemic inflammation and glycemic control. (ejao.org)
- We retrospectively reviewed the medical records of all diabetic patients who admitted to Dankook University Hospital for SSNHL between January 2014 and July 2018. (ejao.org)
- Diabetic patients are at higher risk of developing tuberculosis and the bi-directional association is a major concern for clinicians. (ijmrhs.com)
- A higher number of acid-fast bacilli was observed on sputum microscopy in diabetic tuberculosis patients (3+ in 56%) while the majority of non-diabetic tuberculosis patients fall into the 1+ and 2+ categories. (ijmrhs.com)
- Patients with diabetes mellitus who consume a carbohydrate-rich diet, smoke, and consume alcohol had a higher association with tuberculosis. (ijmrhs.com)
- 12 ] demonstrated that the critically ill patients occurred severe IR on the first day after admission to ICU, and IR was related to the severity of their condition rather than the different admission diagnoses of ICU patients. (biomedcentral.com)
- However, current data about associations between TyG index and critically ill patients are limited, whether TyG index was an independent factor of prognosis in ICU patients has not been determined yet. (biomedcentral.com)
- Although in all diabetic patients, GFR is initially normal or mildly elevated with no histological alterations, it progresses to produce thick glomerular basement membrane and expand to mesangial, followed by high glomerular capillary pressure and microalbuminuria. (scialert.net)
- However, data are relatively scarce on the association between hyper-inflammatory response and cardiac injury among COVID-19 patients. (nutrition-evidence.com)
- We plan to examine corneal structures of diabetic patients and compare IVCCM with conventional tools and analyze their serum and tear NGF levels. (e-dmj.org)
- METHODS: IVCCM, nerve conduction velocity (NCV), and serum, urine, and tear samplings were done to 42 diabetic patients. (e-dmj.org)
Prevention of diabetic1
- T he biomechanical interaction between the foot and the shoe, three-dimensional appearance of the foot and the relationship between foot anthropometrics and the shoe have been shown to be important in the prevention of diabetic foot ulcers (DFU) [1-3]. (faoj.org)
Diabetes3
- In clinical strdies the emphasis has been on blood glucose values during the first few days after stroke The clinical relevance of the blood glucose level is difficult to assess as the level is modified by many factors such as diabetes, latent diabetic state, timing of blood sampling, intravenous infusions containing glucose, and stress. (docksci.com)
- Nearly 80% of cases of tuberculosis are from urban areas and there is no significant difference in the association of diabetes with tuberculosis between urban and rural populations. (ijmrhs.com)
- The bidirectional association between Tuberculosis (TB) and Diabetes Mellitus (DM) is currently one of the major concerns for clinicians, as DM affects the disease presentation and clinical outcome of TB and vice versa [ 2 ]. (ijmrhs.com)
OLETF1
- In the thoracic aorta of OLETF rats, endothelium-dependent relaxation was markedly attenuated compared with that of control (LETO) rats in association with a significant increase in superoxide production (2,421.39 ± 407.01 nmol · min −1 · mg −1 ). (diabetesjournals.org)
Ischemic1
- The Framingham study revealed that the risk of ischemic brain infarction in diabetics, after adjustment for several other risk factors, is twice that of non-diabetics (Kannel and McGee 1979). (docksci.com)
Cardiac3
- however, information regarding the prognostic value of cardiac biomarkers as it relates to disease severity and cardiac injury are inconsistent. (nutrition-evidence.com)
- Cardiac biomarkers add prognostic value to the determination of the severity of COVID-19 and can predict mortality. (nutrition-evidence.com)
- This meta-analysis was done to summarize available findings on the association between cardiac injury and severity of COVID-19 infection. (nutrition-evidence.com)
Progression2
- Therefore, finding indicators that predict the risk of occurrence and progression of diabetic foot and early intervention can help improve the quality of life. (biomedcentral.com)
- There is a lack of uniform quantitative standards for biomarkers that predict the risk of diabetic foot occurrence and progression. (biomedcentral.com)
Cerebral3
- Hypertension and cerebral amyloid angiopathy (CAA) are the most common causes of primary ICH, but the mechanism of hemorrhage in both conditions is unclear. (nature.com)
- In primary ICH, hypertension is thought to be the underlying cause in 65% of cases, followed by cerebral amyloid angiopathy (CAA). (nature.com)
- Less frequently, hemorrhagic strokes can also be due to angiopathies, which can be diagnosed with a cerebral angiogram. (statpearls.com)
Occurrence2
- Here, angle α and k value, reflecting the Fib function, were used to analyse its correlation with DF, and their potential as biological indicators for evaluating the occurrence and severity of DF was explored. (biomedcentral.com)
- Angle α, k-value and fibrinogen have clinical significance on the risk of occurrence and development of diabetic foot, which can contribute to early diagnosis and early clinical intervention in DF. (biomedcentral.com)
Functional2
- The case fatality rate, severity of hemiparesis, functional outcome, and infarct size did not differ between these 2 groups. (docksci.com)
- This study primarily aimed to investigate mitochondrial functional changes in a diabetic rodent model. (biomedcentral.com)
Onset1
- On the basis of in vitro and clinical studies on brain activity, modulation by ELF-EMFs could possibly counteract the aberrant pro-inflammatory responses present in neurodegenerative disorders reducing their severity and their onset. (maxwellmagneticmeds.co.za)
Prognosis1
- Thus, a crucial question concerning the association of post-stroke hyperglycemia and unfavourable prognosis is whether the high glucose values are the primary cause of more severe strokes or are they only a reflection, a stress response, of more severe strokes and brain lesions? (docksci.com)
Strongly1
- On the other hand, fasting blood glucose level of the non-diabetics correlated strongly with the severity of hemiparesis and predicted stroke outcome. (docksci.com)
Hyperglycemia1
- Although all diabetic cells are exposed to elevated levels of plasma glucose, hyperglycemic damage is limited to those cell types that are unable to down regulate glucose transport into the cell (e.g., endothelial cells), leading to intra-cellular hyperglycemia ( Brownlee, 2001 ). (scialert.net)
Nerves1
- Nerve growth factors (NGF) are believed to regulate peripheral and central nervous system, neuronal differentiation, and regeneration of damaged nerves, and their role in diabetic neuropathy is being emphasized these days. (e-dmj.org)
Diagnosis2
- The International Working Group on the Diabetic Foot has developed guidelines for the diagnosis of the diabetic foot. (biomedcentral.com)
- Current diagnosis, severity grading, and treatment for DR ultimately focus on the related vascular lesions. (biomedcentral.com)
Neuropathy1
- In vivo corneal confocal microscopy (IVCCM) is being recognized as a non-invasive, early diagnostic tool for diabetic neuropathy, for it provides a clear image of corneal subbasal nerve plexus in detail. (e-dmj.org)
Mortality1
- Cox proportional hazards analyses were performed to examine the association between TyG index and all-cause mortality. (biomedcentral.com)
Rats1
- The present study was undertaken to characterize both vascular production and the enzymatic source of superoxide anion in type 2 diabetic rats. (diabetesjournals.org)
Disorders1
- Association of Aquaporin-3, Aquaporin-7, NOS3 and CYBA polymorphisms with hypertensive disorders in women. (ircabral.com)
Duration1
- These findings underscore the association between the duration of non-REM/REM sleep stages and elevated BP, providing substantial evidence. (bvsalud.org)
Analyze1
- This systematic review aims to identify and analyze publications exploring the associations between sleep architecture and arterial hypertension. (bvsalud.org)
Risk factors1
- However, most of the relevant studies have focused on the analysis of risk factors associated with the diabetic foot and comprehensive management. (biomedcentral.com)
Findings1
- The findings revealed several notable associations. (bvsalud.org)
Development2
- However, previous research leading to the development of this drug proposed that including phosphatidylcholine to a more appealing cosmetic result, with decreased severity of injection-site reactions. (jcadonline.com)
- A poorly fitted shoe is one of many contributory factors in the development of diabetic foot ulcers. (faoj.org)
Admission1
- The severity of hemiparesis was assessed on admission, at 1 week, 3 weeks, and 3 months. (docksci.com)
Disease1
- specify fewer variants of interest a priori, and aim to establish if a disease association can be confirmed. (biomedcentral.com)
Factors1
- The selected isolates were applied through seed to ensure endophytic association in controlled condition of seed bed and to avoid the inhibitory factors of field like presence of excess chemical nitrogen, residual pesticides etc. (journalcra.com)
Significant1
- A statistically significant correlation was observed between blood glucose values and the volumes of cortical infarcts in non-diabetics. (docksci.com)
Study1
- Follow-up results will be featured in an oral presentation (Abstract #OA14.03) and have been selected for the official press program at the IASLC 2023 World Conference on Lung Cancer (#WCLC23) hosted by the International Association for the Study of Lung Cancer on September 11, 2023, from 2:32 a.m. to 2:42 a.m. (advfn.com)