AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPsychiatry and PsychologyPhenomena and ProcessesAnthropology, Education, Sociology and Social PhenomenaInformation ScienceNamed GroupsHealth Care
Bone Marrow TransplantationBone MarrowTransplantation, HomologousBone Marrow CellsGraft vs Host DiseaseTransplantation, AutologousWhole-Body IrradiationBone and BonesSyndromeAnemia, AplasticTransplantation ConditioningHematopoietic Stem Cell TransplantationLeukemiaLiver TransplantationTransplantation ChimeraTissue DonorsGraft SurvivalBusulfanBone Marrow PurgingHistocompatibility TestingHematopoietic Stem CellsHistocompatibilityCyclophosphamideTransplantation, IsogeneicBone Marrow DiseasesKidney TransplantationHematopoiesisRecurrenceCombined Modality TherapyMice, Inbred C57BLRadiation ChimeraLeukemia, Myelogenous, Chronic, BCR-ABL PositiveLeukemia, Myeloid, AcuteBone Marrow ExaminationTreatment OutcomeImmunosuppressive AgentsRemission InductionTime FactorsHematologic NeoplasmsGraft RejectionHepatic Veno-Occlusive DiseasePrecursor Cell Lymphoblastic Leukemia-LymphomaBone RemodelingMyelodysplastic SyndromesBone Marrow NeoplasmsTransplantation ImmunologyLeukemia, MyeloidGraft vs Host ReactionAcute DiseaseImmunosuppressionLymphocyte DepletionStem Cell TransplantationLymphoma, Non-HodgkinLeukocyte TransfusionHeart TransplantationSevere Combined ImmunodeficiencyRetrospective StudiesT-LymphocytesChimeraSurvival AnalysisColony-Forming Units AssayHLA AntigensLung TransplantationHematologic DiseasesCyclosporineBone DensityActuarial AnalysisLymphocyte TransfusionNuclear FamilyAntineoplastic Combined Chemotherapy ProtocolsFollow-Up StudiesPancytopeniaCarmustineOrgan TransplantationCell DifferentiationGraft vs Tumor EffectLeukocyte CountSurvival RateCytarabineGraft vs Leukemia EffectCytomegalovirus InfectionsSpleenBone ResorptionGranulocyte Colony-Stimulating FactorMelphalanMice, Inbred BALB CFatal OutcomeDisease-Free SurvivalFlow CytometryEtoposideLymphomaMultiple MyelomaCells, CulturedPrognosisMice, KnockoutImmunologic Deficiency SyndromesAntigens, CD34Hodgkin DiseaseInfectionCell Transplantation
Phagocyting erythrocyAplasticAllogeneic Hematopoietic Stem CTransplantBiopsyDiagnosisMyelodysplastic syndromeImmunodeficiencyCurativeStem cellsChronicThrombocytopeniaTransplantsDisorderComplicationsSymptomsInfectionsAbnormalProgenitorLiverCongenitalImmunosuppressiveGeneticPulmonaryMyeloproliferative neoplasmsNeurological impairmentRemissionDysregulated lymphocyteMetabolicUmbilicalAutologous hematopoieticTelomereOncologyAutosomalSpongyTherapiesDiseasesRespiratoryBlood disordersTreatmentsThrombopoietinAbnormalitiesRenalChemotherapyClinicalTreatmentFailureSCIDCancersManifestations
Phagocyting erythrocy1
  • The pathognomonic characteristic of HPS is the activation of well-differentiated macrophages, phagocyting erythrocytes, leukocytes and platelets in bone marrow, lymph nodes, spleen, liver and other organs, which can infiltrate almost anybody district and may account for many of its systemic features [ 3 ]. (biomedcentral.com)
Aplastic8
Allogeneic Hematopoietic Stem C1
Transplant11
  • p>A blood and bone marrow transplant takes unhealthy stem cells out of the bone marrow and replaces them with healthy stem cells, with the intent to treat childhood cancers and nonmalignant blood and bone marrow diseases. (nemours.org)
  • They might involve medicines, blood transfusions or a bone marrow transplant . (medlineplus.gov)
  • To determine the feasibility, efficacy, and safety of a reduced toxicity transplant conditioning regimen in adults with severe SCD receiving related and unrelated donor HCT. (ashpublications.org)
  • Cyclosporine USP 25 Mg Capsule is used to prevent the body from rejecting a new organ after a liver, kidney, heart transplant, or bone marrow transplantation. (brixbiopharma.in)
  • however, severe post-transplant complications reflecting the syndromic nature of their disease appear to occur at higher rates. (ersjournals.com)
  • The purpose of our work was to evaluate pulmonary complications in autologous bone marrow transplant recipients. (nih.gov)
  • A total of 141 consecutive autologous bone marrow transplant recipients were evaluated. (nih.gov)
  • DAH is a frequent cause of respiratory compromise and a major cause of mortality in autologous bone marrow transplant recipients. (nih.gov)
  • In 2014 he received a transplant from the bone marrow of his healthy seven-year-old sister and now seems to have recovered. (solveisraelsproblems.com)
  • Defibrotide: Real World Management of Veno-Occlusive Disease/ Sinusoidal Obstructive Syndrome after Stem Cell Transplant. (harvard.edu)
  • Acute GVHD occurs in approximately 50% of patients who receive an allogeneic bone marrow transplant (BMT). (einpresswire.com)
Biopsy5
Diagnosis9
  • Early diagnosis before the development of permanent lung and liver damage and referral to a specialized center for bone marrow transplantation/HSCT are essential for therapeutic success. (medscape.com)
  • Median ages of liver transplantation and diagnosis of PTLD were 9.5 months (range: 6-51 months) and 31.2 months (range: 10-114 months), respectively. (hku.hk)
  • Median duration from time of transplantation to diagnosis of PTLD was 18.4 months (range: 4.1-65 months). (hku.hk)
  • There are multiple mechanisms and differential diagnosis includes: artifactual thrombocytopenia, accelerated platelet destruction (intra- or extra-corpuscular anomalies), deficient production (bone marrow failure, disordered proliferation or thrombopoietin deficiency), and abnormal distribution (disorders associated with splenomegaly or dilution in massive transfusions) ( 1 ). (spandidos-publications.com)
  • The diagnosis is suspected in patients with unexplained clinical or laboratory evidence of liver disease, particularly in those with known risk factors, such as bone marrow or hematopoietic cell transplantation. (msdmanuals.com)
  • The meeting will be of particular value for clinicians and non-clinical scientists, M.D. and Ph.D. of all ages interested in the biology, pathophysiology, diagnosis and treatment of bone marrow failure syndromes (BMFS). (esh.org)
  • Differential diagnosis includes myelodysplastic syndromes, thalassemias, Gilbert syndrome, hereditary spherocytosis, acute erythroid leukemia (see these terms), folate, iron or vitamin B12 deficiencies as well as infections such as AIDS, malaria (see this term), kala-azar or other acquired or inherited thrombocytopenias. (orpha.net)
  • The presentation of hyper IgE syndrome is highly variable, which makes it easy to confuse the diagnosis with that of severe atopy or other rare immunodeficiency disorders. (ferienwohnung-uelsen.de)
  • Many other clinical conditions present substantial skin fibrosis and may be potentially confused with Scleroderma, sometimes leading to a wrong diagnosis (eosinophilic fasciitis, systemic amyloidosis, scleromyxedema, graft-versus-host disease, progeroid disorders, stiff skin syndrome). (bvsalud.org)
Myelodysplastic syndrome3
Immunodeficiency12
  • Intravenous immunoglobulin (IVIG) replacement therapy may benefit patients with combined immunodeficiencies, such as severe combined immunodeficiency (SCID), X-linked immunodeficiency with hyper IgM syndrome (XHM), Good syndrome, and Wiskott-Aldrich syndrome (WAS). (medscape.com)
  • Allogeneic bone marrow transplantation has become the standard of care for certain patients with SCIDs (eg, X-linked severe combined immunodeficiency [XSCID], ADA deficiency). (medscape.com)
  • Patients with other immunodeficiency syndromes may benefit from bone marrow transplantation or HSCT, including those with WAS or XHM. (medscape.com)
  • Griscelli syndrome is a rare autosomal recessive disorder characterized by albinism (hypopigmentation) with immunodeficiency, that usually causes death by early childhood. (wikipedia.org)
  • Griscelli syndrome is defined by the characteristic hypopigmentation, with frequent pyogenic infection, enlargement of the liver and spleen, a low blood neutrophil level, low blood platelet level, and immunodeficiency. (wikipedia.org)
  • Patients with severe combined immunodeficiency (SCID) may present with residual circulating T cells. (hindawi.com)
  • We suggest that a high-tolerance capacity of the alloreactive transplacentally acquired maternal lymphocytes represents a toleration advantage, yet still associated with severe immunodeficiency. (hindawi.com)
  • Severe combined immunodeficiency (SCID) is typically characterized by significantly low number and/or defective function of T and B cells. (hindawi.com)
  • It is thus not surprising that the absence of MHC-II expression results in a severe primary immunodeficiency disease. (hindawi.com)
  • Primary HLH mainly includes Familial Hemophagocytic Lympho Histiocytosis (FHLH) and immunodeficiency syndrome associated HLH. (ommegaonline.org)
  • It is used to treat HIV (human immunodeficiency virus), the virus that can cause AIDS (acquired immunodeficiency syndrome). (brixbiopharma.in)
  • trailer This site complies with the HONcode standard for trustworthy health information: When infections are recurrent or severe, allergists consider immunodeficiency assessment. (ferienwohnung-uelsen.de)
Curative4
Stem cells11
Chronic8
Thrombocytopenia7
  • Objectives: Familial thrombocytopenia is a relatively rare and heterogeneous group of clinical and genetic syndromes of unknown etiology. (bgu.ac.il)
  • The aim of the present study was to describe the clinical and hematologic picture of members of a Bedouin family with severe congenital thrombocytopenia associated with neutropenia and anemia and to determine the possible involvement of hematopoietic transcription factor genes in their disease. (bgu.ac.il)
  • In the present study, the case of a patient with diffuse large B-cell lymphoma evolving from grade 3a follicular lymphoma, who maintained a complete response for 4-years, and then presented with severe isolated thrombocytopenia, is reported. (spandidos-publications.com)
  • Investigations at admission revealed severe thrombocytopenia (PLT=3x10 9 /l), normal white blood cell count and hemoglobin, without any significant changes in hepatic and renal function tests, electrolyte levels, or coagulation. (spandidos-publications.com)
  • see this term) is a rare hematological disorder, seen almost exclusively in males, characterized by moderate to severe thrombocytopenia with hemorrhages with or without the presence of mild to severe anemia. (orpha.net)
  • It presents in infancy or in neonates (in severe cases) with patients bruising easily along with further manifestations of thrombocytopenia including epistaxis, petechiae, ecchymoses, or splenomegaly. (orpha.net)
  • Consider discontinuing therapy if severe and unremitting thrombocytopenia or neutropenia occurs. (pfizermedicalinformation.com)
Transplants2
  • Three of the four were successfully treated with allogenic human leukocyte antigen (HLA)-matched bone marrow transplants. (bgu.ac.il)
  • This study is designed to estimate the efficacy and toxicity of familial HLA mismatched bone marrow transplants in patients with non-malignant disease who are less than 21 years of age and could benefit from the procedure. (scdstudies.com)
Disorder3
  • Thus, patients with this type of leukocyte adhesion deficiency manifest both severe bacterial infections and bleeding disorder. (medscape.com)
  • Treatments depend on the disorder and how severe it is. (medlineplus.gov)
  • Conclusions: A unique autosomal recessive bone marrow disorder with prominent involvement of megakaryocytes is described. (bgu.ac.il)
Complications3
  • Gene-modified, autologous bone marrow transplantation can circumvent the severe immunologic complications that occur when a related HLA-mismatched donor is used and thus represents an attractive alternative (see below). (medscape.com)
  • Although the initial development was favorable, he started to complain of progressive severe muscle weakness and eventually succumbed to infectious complications in the setting of prolonged hospitalization, corticotherapy, and immobilization. (spandidos-publications.com)
  • 6 Causes of early death include leukemic transformation, complications arising from progressive bone marrow failure, portal/pulmonary hypertension, infections, thrombosis and bleeding. (haematologica.org)
Symptoms7
  • Other individuals have a multitude of the most severe symptoms of end-stage liver disease and a limited chance for survival. (medscape.com)
  • The symptoms of hepatic encephalopathy may range from mild to severe and may be observed in as many as 70% of patients with cirrhosis. (medscape.com)
  • Neurologic symptoms consist of hypotonia, absence of coordinated voluntary movements and severe retarded psychomotor development. (lu.se)
  • 2014) derepress zeta-globin to shed light on the regulation of this gene and investigate whether it may be de-repressed in adulthood to ameliorate the symptoms of severe alpha-thalassemia. (ox.ac.uk)
  • This type of cancer can also cause serious and damaging effects to the body and lead to symptoms such as fatigue, bone and joint pain, night sweats, infections, weakness, weight loss and fever. (fda.gov)
  • The disease was first encountered ten years ago when a 21-month-old boy from Shechem (Nablus) in Samaria was brought to Hadassah suffering from severe symptoms of an unexplained malfunction of the immune system. (solveisraelsproblems.com)
  • Monitor patients for signs and symptoms of cytokine release syndrome. (pfizermedicalinformation.com)
Infections15
  • For example, Omenn syndrome, a typical case of impaired T-cell differentiation with abnormal self-reactive cells, is invariably characterized by autoimmune features such as generalized scaly exudative erythroderma, enlarged lymphoid tissues, and peripheral expansion of oligoclonal T-cells, in addition to increased susceptibility for severe infections [ 3 , 4 ]. (hindawi.com)
  • In patients, children or adults, with severe congenital, cyclic, or idiopathic neutropenia with an absolute neutrophil count (ANC) of ≤ 0.5 × 10 9 /l, and a history of severe or recurrent infections, long term administration of Neupogen is indicated to increase neutrophil counts and to reduce the incidence and duration of infection-related events. (medicines.org.uk)
  • Patients have leukocytosis , recurrent infections (more prominent in infants and toddlers), and severe growth and mental retardation . (medscape.com)
  • Severe pneumococcal infections result from dissemination of bacteria to the bloodstream and the central nervous system. (cdc.gov)
  • As a result, a frequent and serious risk of this treatment is the occurrence of severe and sometimes deadly infections. (fda.gov)
  • The efficacy of Omisirge was based on the amount of time needed for recovery of the subject's neutrophils (a type of white blood cell that helps protect the body from infections) and the incidence of infections following transplantation. (fda.gov)
  • Bacterial or fungal infections by 100 days following transplantation were seen in 39% of subjects receiving Omisirge versus 60% of subjects in the control group who received umbilical cord blood. (fda.gov)
  • Severe defects in T-lymphocyte functions can lead to an increased susceptibility to viral, fungal, and bacterial infections and may also be an indicator of the degree of exposure to environmental carcinogens and toxins (Blumberg and Schooley, 1985). (twoday.net)
  • MONDAY, April 11, 2022 (HealthDay News) -- Real-world evidence shows that patients with cancer have a higher risk for developing breakthrough COVID-19 infections and severe outcomes, according to a study published online March 14 in the Journal of Clinical Oncology . (healthday.com)
  • Qianqian Song, Ph.D., from Indiana University in Indianapolis, and colleagues used data from the National COVID Cohort Collaborative to identify breakthrough infections (Dec. 1, 2020, through May 31, 2021) among more than 64,000 patients partially or fully vaccinated with mRNA COVID-19 vaccines and with no prior severe acute respiratory syndrome coronavirus 2 infection record. (healthday.com)
  • Real-world evidence shows that patients with cancer, especially hematologic malignancies, are at higher risk for developing breakthrough infections and severe outcomes," the authors write. (healthday.com)
  • A low white blood cell count (neutropenia) can increase the risk of infections, which can be severe and frequent. (mds-alliance.org)
  • Allogeneic stem cell transplantation treats the recurring and life-threatening infections this condition causes. (clevelandclinic.org)
  • More than 95% of CVID clinically presents with recurrent sinopulmonary infections just like XLA or other hypogammaglobulinemia syndromes. (ferienwohnung-uelsen.de)
  • In Comèl‐Netherton syndrome, 8/9 described patients showed recurrent or persistent S. aureus skin infections once skin lesions had developed. (ferienwohnung-uelsen.de)
Abnormal2
Progenitor3
  • The respective mice that reconstitute human immune system components upon transplantation with CD34+ human hematopoietic progenitor cells could recapitulate aspects of EBV and HIV immunobiology observed in dual-infected patients. (hku.hk)
  • Pharmacokinetics The pharmacokinetics of BUSULFEX were studied in 59 patients participating in a prospective trial of a BUSULFEX-cyclophosphamide preparatory regimen prior to allogeneic hematopoietic progenitor stem cell transplantation. (clustermed.info)
  • Although bone marrow fibrosis is seen in a variety of malignant and non-malignant disease states, the deposition of reticulin and collagen fibrosis in the bone marrow of patients with myelofibrosis is believed to be mediated by the myelofibrosis hematopoietic stem/progenitor cell, contributing to an impaired microenvironment favoring malignant over normal hematopoiesis. (haematologica.org)
Liver4
  • Hemophagocytic syndrome (HPS) is clinically defined as a combination of fever, liver dysfunction, coagulation abnormalities, pancytopenia, progressive macrophage proliferation throughout the reticuloendothelial system, and cytokine over-production, and may be primary or secondary to infectious, auto-immune, and tumoral diseases. (biomedcentral.com)
  • DESIGN/METHODS: To determine the cumulative incidence and review the clinical data of PTLD diagnosed in the cohort of pediatric patients (<18 years) who had liver transplantation performed between 1 January 2001 and 31 December 2012 in the major liver transplantation centre (Queen Mary Hospital) of Hong Kong. (hku.hk)
  • RESULTS: Among 75 cases of pediatric liver transplantation performed during the study period, 17 cases of PTLD (seven males) were diagnosed, giving cumulative incidence of 6.8% at 1 year and 22% at 5 years. (hku.hk)
  • Budd-Chiari Syndrome Budd-Chiari syndrome is obstruction of hepatic venous outflow that originates anywhere from the small hepatic veins inside the liver to the inferior vena cava and right atrium. (msdmanuals.com)
Congenital1
  • Leukocyte adhesion deficiency II may be classified as one of the congenital disorders of glycosylation (CDG), a rapidly expanding group of metabolic syndromes with a wide symptomatology and severity. (medscape.com)
Immunosuppressive2
  • Breakthrough risk among the vaccinated population was strongly associated with medications with major immunosuppressive effects and bone marrow transplantation. (healthday.com)
  • Different conditions have been associated with PRES, but toxemia of pregnancy, solid organ or bone marrow transplantation, immunosuppressive treatment, cancer chemotherapy, autoimmune diseases, and hypertension are most commonly described. (qxmd.com)
Genetic2
  • FHLH has a clear family genetic or genetic defect, 80% FHLH patients develop the syndromes in infants, but very rare in adulthood. (ommegaonline.org)
  • Telomerase mutations are the most common identifiable genetic cause of IPF, and at times, the telomere defect manifests in extrapulmonary disease such as bone marrow failure. (ersjournals.com)
Pulmonary2
Myeloproliferative neoplasms1
  • A number of studies indicate that bone marrow fibrosis is an adverse prognostic variable in myeloproliferative neoplasms. (haematologica.org)
Neurological impairment1
  • The severe neurological impairment and retarded development of the human does not improve with time. (wikipedia.org)
Remission2
Dysregulated lymphocyte1
  • Hemophagocytic syndrome (HPS) is a potentially fatal condition due to dysregulated lymphocyte activation and proliferation, mainly characterised by impaired or inactive natural killer (NK) cells and cytotoxic T cells, which leads to macrophage hyperactivation and over-expression of cytokines [ 1 ]. (biomedcentral.com)
Metabolic1
Umbilical4
  • Umbilical cord blood stem cell transplantation (UCBSCT) offers several advantages, including ready availability of the unit, a lower risk of transmitting viral diseases, no risk to the donor, and a lower risk of GVHD even in the absence of a perfect HLA match. (medscape.com)
  • The product is intended for use in adults and pediatric patients 12 years and older with blood cancers planned for umbilical cord blood transplantation following a myeloablative conditioning regimen (treatment such as radiation or chemotherapy). (fda.gov)
  • The safety and effectiveness of Omisirge was supported by a randomized, multicenter study comparing transplantation of Omisirge to transplantation of umbilical cord blood, in subjects between the ages of 12 and 65 years. (fda.gov)
  • Eighty-seven percent of subjects who were randomized to receive Omisirge achieved neutrophil recovery with a median of 12 days following treatment with the product, compared to 83% of subjects who were randomized to receive umbilical cord blood transplantation and who achieved neutrophil recovery with a median of 22 days. (fda.gov)
Autologous hematopoietic2
Telomere1
  • Constitutional marrow failure 3: telomere biology diseases and other. (esh.org)
Oncology1
  • Dr. Polina Stepensky, head of the Hadassah's pediatric hemato-oncology and bone marrow transplantation department told reporters that "the Palestinian hospital could not diagnose the disease, and we didn't know at first what it was either. (solveisraelsproblems.com)
Autosomal1
  • Chest radiograph of a patient with autosomal dominant (AD) hyperimmunoglobulin E syndrome (HIES) and a lung abscess following multiple staphylococcal pneumonias. (medscape.com)
Spongy1
  • Bone marrow is the spongy tissue inside some of your bones, such as your hip and thigh bones. (medlineplus.gov)
Therapies1
  • The specific effect on bone marrow fibrosis of JAK2 inhibition, and other rationally based therapies currently being evaluated in myelofibrosis, has yet to be fully elucidated. (haematologica.org)
Diseases7
Respiratory4
  • Estimates of the burden of severe acute respiratory syndrome coronavirus 2 reinfections are limited by the scarcity of population-level studies incorporating genomic support. (cdc.gov)
  • Since the first description of a severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) reinfection on August 24, 2020, in a patient from Hong Kong ( 1 ) who acquired a second infection after having traveled to Europe, several reports have described other individual reinfection cases in different countries. (cdc.gov)
  • Timeline of disease course, treatments, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) reverse transcription-polymerase chain reaction (RT-PCR) tests, antibody tests, and Vero E6 cell line culture from day 0 to day 240. (ajtmh.org)
  • Acute Respiratory Distress Syndrome (ARDS). (drugs.com)
Blood disorders4
Treatments5
Thrombopoietin2
  • Measurements of serum erythropoietin and thrombopoietin levels, bone marrow electron microscopy, and megakaryocytic colony were grown for each patient in addition to DNA amplification and single-strand conformation polymorphism of each exon of the NF-E2, Fli-1, FOG-1, and Gfi-1b in genes. (bgu.ac.il)
  • A low number of bone marrow megakaryocyte colony-forming units was found, as well as a slightly elevated serum thrombopoietin level. (bgu.ac.il)
Abnormalities3
  • Type 2 Griscelli Syndrome have immune system abnormalities in addition to hypopigmentation of skin and hair. (wikipedia.org)
  • People with Griscelli syndrome type 1 have severe problems concerning brain function, typically characterized as delayed development, intellectual disability, seizures, hypotonia, and eye and vision abnormalities. (wikipedia.org)
  • People with Griscelli syndrome type 3 only have the baseline light skin and hair coloring abnormalities. (wikipedia.org)
Renal1
  • DAH was associated with a high inpatient mortality rate (23 of 29 died versus 14 of 112 without DAH, p less than 0.001) and was associated with age over 40 years, solid malignancies, high fevers, severe mucositis, white blood cell recovery, and renal insufficiency (p less than 0.05, compared with patients without DAH). (nih.gov)
Chemotherapy1
Clinical1
  • In 29 patients, a clinical syndrome characterized by progressive dyspnea, hypoxia, cough, diffuse consolidation on chest roentgenography, and characteristic bronchoalveolar lavage findings developed over one to seven days. (nih.gov)
Treatment12
  • 866 Management and treatment is depended upon the type of syndrome one is diagnosed as having. (wikipedia.org)
  • The major treatment for severe alpha-thalassemia is symptomatic care and transfusion of red blood cells as clinically necessary. (ox.ac.uk)
  • Stem cell transplantation is a common treatment for blood cancers. (fda.gov)
  • Treatment with Omisirge has the potential to cause severe side effects, which must be considered in assessing the risks and benefits of using this product. (fda.gov)
  • For those who have a more severe form of the condition, there are a couple of treatment options available. (childrenshospital.org)
  • Ear drops?AutoPap: Computer-assisted cytology interpretation system?AV: Aortic valve?AV: Atrioventricular?A-V: Arteriovenous?AVERT: Atorvastatin Versus Revascularization treatment?AVID: ?AVM: Arteriovenous Malformation?AVNRT: AV nodal reentry tachycardia?AVP: Arginine vasopressin?AVR: Aortic valve replacement?AVR: Augmented V lead, right arm (ECG)?AVRT: ?AVS: Arteriovenous shunt?AWS: Alcohol withdrawal syndrome?AXR: Abdominal X ray?AZF: Azoospermia factor genes?AZT: Azidothymidine (zidovudine)?B & O: Belladonna and opium?B Bx. (kuwaitpharmacy.com)
  • Treatment options can include blood transfusions, medications to stimulate the bone marrow to produce more blood cells, and bone marrow transplantation in severe cases. (mds-alliance.org)
  • However, modern myelofibrosis prognostication systems utilized in risk-adapted treatment approaches do not include bone marrow fibrosis as a prognostic variable. (haematologica.org)
  • However, better understanding of the role of increased JAK-STAT signaling [either through activating mutations ( JAK2 , MPL515L/K ) within the signaling pathway, or mutations involving CALR ], the role of deregulated pro-inflammatory cytokine expression, and the impaired bone marrow microenvironment is transforming the treatment approach for MF. (haematologica.org)
  • Posterior reversible encephalopathy syndrome is best managed by monitoring and treatment in the setting of a neurointensive care unit. (qxmd.com)
  • Treatment of severe hypertension, seizures, and withdrawal of causative agents represent the hallmarks of specific therapy in PRES. (qxmd.com)
  • Mesoblast is a world leader in developing allogeneic (off-the-shelf) cellular medicines for the treatment of severe and life-threatening inflammatory conditions. (einpresswire.com)
Failure3
  • Anaemia results from the failure of adequate production of red blood cells in the bone marrow or insufficient production of the oxygen carrying metalloprotein haemoglobin. (ox.ac.uk)
  • Eventually, most people with DC will develop bone marrow failure. (childrenshospital.org)
  • Congestive heart failure NYHA grade 4 heart function, occurrence of cerebrovascular accident or acute coronary syndrome within 3 months, recent hospitalization or cardiac arrest within 7 days, non infectious cardiogenic shock, uncontrolled acute bleeding. (who.int)
SCID1
Cancers1
Manifestations2
  • Munc13-4 has also drawn attention based on its involvement in causing bleeding manifestations in Griscelli syndrome.Munc13-4 through its interactions with Rab27a appears to be important for the dense granule release from platelets. (wikipedia.org)
  • Cutaneous manifestations of cirrhosis include jaundice, spider angiomata, skin telangiectasias ("paper money skin"), palmar erythema, white nails, disappearance of lunulae, and finger clubbing, especially in the setting of hepatopulmonary syndrome. (medscape.com)