• Morbidity and mortality associated with hypernatremia in patients with severe traumatic brain injury. (medscape.com)
  • OBJECTIVE There is no consensus on the optimal timing and specific brain MRI sequences in the evaluation and management of severe pediatric traumatic brain injury (TBI), and information on current practices is lacking. (cmich.edu)
  • Purpose: Intracranial hypertension (ICH) is a common and treatable complication after severe traumatic brain injury (sTBI) in children. (wustl.edu)
  • For cases of severe traumatic brain injury, during primary operation, neurosurgeons usually face a dilemma of whether or not to remove the bone flap after mass lesion evacuation. (biomedcentral.com)
  • In the present study, we designed a prospective, randomized, controlled trial to clarify the effect of decompressive craniectomy in severe traumatic brain injury patients with mass lesions. (biomedcentral.com)
  • This study will provide evidence to optimize primary decompressive craniectomy application and assess outcomes and risks for mass lesions in severe traumatic brain injury. (biomedcentral.com)
  • Severe traumatic brain injury (STBI) is a major cause of death in young adults in developed countries [ 1 ]. (biomedcentral.com)
  • Diffuse axonal injury (DAI) is a pathological substrate responsible for much of the white matter (WM) damage in patients with traumatic brain injury (TBI). (fapesp.br)
  • The Brain Trauma Foundation supported the first edition of the Guidelines for the Management of Severe Traumatic Brain Injury in 1995 and revised it in 2000. (tmu.edu.tw)
  • Secondary brain insults after traumatic brain injury such as electrolyte dysfunctions are associated with poor outcomes. (annalsofafricansurgery.com)
  • Serum sodium abnormalities are common in traumatic brain injury (TBI), and are usually associated with the primary brain injury or interventions such as hyperosmolar therapies used in the management of raised intracranial pressure (1, 2). (annalsofafricansurgery.com)
  • The pathophysiology of traumatic brain injury can be divided into primary and secondary injuries. (surgicalneurologyint.com)
  • Two studies on brain temperature in severe traumatic brain injury reported higher than the average body temperature in the post-traumatic days. (surgicalneurologyint.com)
  • Injuries from the propeller are typically multiple, deep, parallel lacerations that can result in permanent scarring, substantial blood loss, traumatic or surgical amputation, or death (2). (cdc.gov)
  • Operation scars of POP-SPS had better cosmesis then the conventional TAPP or SPS TAPP, and there were no difference between POP-SPS TAPP and conventional method in operation time and the complication rate. (sages.org)
  • Pneumothorax: a rare complication of electric injury. (ijcdas.com)
  • Radiotherapy, the commonly used treatment for thoracic malignant tumor, can lead to severe complications in some patients, like radiation-induced lung injury (RILI). (hindawi.com)
  • abstract = "Background: Road traffic injuries (RTI) are on increase in developing countries. (aku.edu)
  • ABSTRACT In Saudi Arabia, road traffic crashes are becoming a serious public health problem and there are no recent, large-scale, published reports discussing maternal and fetal injuries. (who.int)
  • It reportedly handles the highest number of trauma patients in Singapore, admitting over 1,000 serious trauma patients yearly (Injury Severity Score [ISS] 9 and above), hence may be considered the busiest trauma and acute care hospital in Singapore. (smj.org.sg)
  • The incidence rate of severe irradiation-induced lung injuries reported is 15% among patients treated by thoracic radiotherapy [ 4 ]. (hindawi.com)
  • This study aimed at determining the incidence of serum sodium ion abnormalities in severe TBI patients, and their association with specific clinical and radiological parameters. (annalsofafricansurgery.com)
  • Low tidal volume, moderate to high PEEP, or protective ventilation were not associated with mortality and lower incidence of ARDS in patients with acute brain injury undergoing invasive mechanical ventilation. (biomedcentral.com)
  • The US Army decreased the incidence of cold injury of all types in soldiers from 1985-1999. (medscape.com)
  • Approximately 35% of significant injuries occur as the result of accidents in the very environment that should be the most sheltering and nurturing to children. (medscape.com)
  • The study confirms our hypothesis that SI injuries tend to be less severe than IO injuries and are more likely to occur at home rather than at a public area. (smj.org.sg)
  • Most spinal injuries in children occur in the neck. (msdmanuals.com)
  • In children 8 years, cervical spine injuries occur most commonly above C4 and are most commonly caused by motor vehicle crashes, falls, and child abuse. (msdmanuals.com)
  • When did the injury occur? (qivantage.com)
  • Ates I, Ozkayar N, Toprak G, Yılmaz N, Dede F. Factors associated with mortality in patients presenting to the emergency department with severe hypernatremia. (medscape.com)
  • Hypernatremia and moderate-to-severe hyponatremia are independent predictors of mortality in septic patients at emergency department presentation: A sub-group analysis of the need-speed trial. (medscape.com)
  • This finding may be useful in the triage of patients with stab wound injuries. (smj.org.sg)
  • After obtaining exempt status from our institutional review board, we reviewed the TTSH Trauma Registry, a prospectively maintained database, and identified all patients with penetrating injuries who were admitted to TTSH from 1 January 2005 to 31 December 2010. (smj.org.sg)
  • Subsequently, we identified all stab wound injuries and classified these patients into two groups, SI and IO. (smj.org.sg)
  • Refeeding syndrome occurs in patients with severe malnutrition when refeeding begins after a long period of starvation. (scielo.br)
  • Refeeding syndrome (RS) is a common condition occurring in patients with severe malnutrition ( 1 1. (scielo.br)
  • Multiple-choice questions addressed the percentage of patients with TBI who have MRI studies, timing of MRI, MRI sequences used to investigate TBI, as well as the magnetic feld strength of MR scanners used at the participating institutions and use of standardized MRI protocols for imaging after severe pediatric TBI. (cmich.edu)
  • Differences were observed in the frequency of MRI use between US and international sites, with the US sites obtaining MRI in a higher proportion of their pediatric patients with severe TBI (94% of US vs 44% of international sites reported MRI in at least 70% of patients with severe TBI). (cmich.edu)
  • Responses indicated that MRI sequences sensitive for diffuse axonal injury and ischemia are frequently obtained in patients with TBI, whereas perfusion imaging and spectroscopy techniques are less common. (cmich.edu)
  • A prospective cross-sectional study of one hundred and seventeen patients with severe head injury. (annalsofafricansurgery.com)
  • All consecutive patients presenting with severe head injury defined by GCS ≤ 8 and whose next of kin had given informed consent were recruited into the study. (annalsofafricansurgery.com)
  • Patients with acute brain injury (trauma or haemorrhagic stroke) with invasive mechanical ventilation for ≥ 24 h. (biomedcentral.com)
  • The exact role of ventilatory management on the outcome of patients with a severe brain injury needs to be more accurately delineated. (biomedcentral.com)
  • In the most severe form, patients with BI require invasive mechanical ventilation. (biomedcentral.com)
  • Such patients may include those with inadequate gastrointestinal function (e.g., short-bowel syndrome or chronic intestinal obstruction), as well as those with severe oropharyngeal dysfunction or permanent neurological impairment. (nationalacademies.org)
  • Inform patients that the injury site is more prone to recurrent damage when exposed to even moderate changes in environmental temperature. (medscape.com)
  • Mortality after acute kidney injury and acute interstitial nephritis in patients prescribed immune checkpoint inhibitor therapy. (yale.edu)
  • Variation in Best Practice Measures in Patients With Severe Hospital-Acquired Acute Kidney Injury: A Multicenter Study. (yale.edu)
  • Thirteen hospitals near the lakes reported to TDH data about patients treated in the emergency department (ED) or admitted to the hospital for a boat-propeller-related injury. (cdc.gov)
  • Four hundred burn patients were admitted injury, and comorbidity (e.g. cardiac, respiratory, and liver to different wards of the hospital [i.e. female, male, and disease, and diabetes) are well-known predictors of burn paediatric wards, and intensive care unit (ICU)] during mortality ( 6 ). (who.int)
  • Other complications were 1 spermatic cord injury and 1 postoperative seroma that required the percutaneous puncture. (sages.org)
  • They can affect the patient's quality of life with severe adverse complications [ 2 ]. (hindawi.com)
  • 8 years, injuries at C5 to C8 are more common and are due to motor vehicle crashes and sports injuries, particularly gymnastics, diving, horseback riding, American football, and wrestling. (msdmanuals.com)
  • This is used as a therapy for musculoskeletal injuries, skin diseases, arthritic complaints, sports injuries as well as to promote relaxation. (pharmiweb.com)
  • Basic demographic information, injury severity characteristics and outcome data were compared between these two groups. (smj.org.sg)
  • Less quantity of transplanted mesenchymal stem cells (MSCs) influences the therapeutic effects on radiation-induced lung injury (RILI). (hindawi.com)
  • MSCs are able to ameliorate various kinds of lung injury and are intensively investigated to develop a therapeutic approach for treating lung diseases such as RILI, idiopathic pulmonary fibrosis (IPF), and emphysema which are lacking a specific and effective therapy [ 8 , 9 ]. (hindawi.com)
  • Some previous studies also demonstrated that MSCs act as gene therapy delivery vehicles and attenuate lung injury through enhancing the target gene expression in specific damaged tissue sites in the lungs [ 14 , 15 ]. (hindawi.com)
  • In the general intensive care unit (ICU) population, the use of high tidal volumes (Vt) and inspiratory pressures have been shown to overstretch the alveoli and to be the leading cause of ventilator-induced lung injury (VILI) [ 5 , 6 ]. (biomedcentral.com)
  • Some groups reported SP-A in serum as a tool to evaluate the integrality of alveolus-capillary membrane and the degree of lung injury [ 11 , 12 ]. (hindawi.com)
  • Lowvoltage electricity-induced lung injury. (ijcdas.com)
  • These bad outcomes may be associated with secondary brain insults such as electrolyte abnormalities that arise from inflammatory and biochemical cascades initiated by the primary injury insult to the brain (9, 17, 18). (annalsofafricansurgery.com)
  • The secondary injuries are related to increased cell death and poor neurological outcomes. (surgicalneurologyint.com)
  • Long-Term Kidney Outcomes Following Dialysis-Treated Childhood Acute Kidney Injury: A Population-Based Cohort Study. (yale.edu)
  • 1 ) Age-standardised death rates (per 100,000 population) from homicide and injury purposely inflicted by others in 1995 was reported to be low at 1.5, compared to 1.7 in Australia, 1.0 in the United Kingdom and 9.4 in the United States,( 2 ) where weapons for self-defence are more readily available. (smj.org.sg)
  • Electrical injuries: morbidity, outcome and treatment rationale. (ijcdas.com)
  • may cause cryogenic burns or injury. (goodfellow.com)
  • Soni AK, Deepali, Garg K, Dutta K. An Unusual Case of Pulmonary Injury Due to Electrical Burns. (ijcdas.com)
  • Islamic Republic of Iran, burns and subsequent injuries are significant causes of death, and adult women and This descriptive, analytical, cross-sectional study was children aged 1-9 years are high-risk groups for burn undertaken at Ayatollah Taleghani Trauma and Burn injuries, in comparison with adult men ( 4 ). (who.int)
  • Entered into competition in the FIM Superbike World Championship with the Honda CBR1000RR SP, he was hit by a car on public roads while riding a bicycle, near Rimini (Italy) on May 17, 2017. (masterlap.com)
  • On May 22, 2017, he died due to the seriousness of the injuries. (masterlap.com)
  • Severe inpatient hypertension prevalence and blood pressure response to antihypertensive treatment. (yale.edu)
  • 1 diabetes mellitus, insulin-dependent type 2 diabetes, advanced rheumatic heart disease, cardiomyopathy, severe hypertension and moderate to severe persistent asthma. (who.int)
  • A review of stab wound injuries at a tertiary trauma centre in Singapore: are self-inflicted ones less severe? (smj.org.sg)
  • Additionally, we anecdotally observed that self-inflicted stab wound (SI) injuries appeared to be less severe than those inflicted by others (IO). (smj.org.sg)
  • Tragically, the home environment is the next most common scene of pediatric injury. (medscape.com)
  • Most pediatric trauma occurs as a result of blunt trauma, with penetrating injury accounting for 10-20% of all pediatric trauma admissions at most centers. (medscape.com)
  • Morton, RP & Ellenbogen, RG 2015, ' Commentary: Severe Pediatric Head Injury During the Iraq and Afghanistan Conflicts ', Neurosurgery , vol. 77, no. 1, pp. 8. (uthscsa.edu)
  • The authors performed a survey of MRI practices among sites participating in a multicenter study of severe pediatric TBI to provide information for designing future clinical trials using MRI to assess brain injury after severe pediatric TBI. (cmich.edu)
  • CONCLUSIONS Results from this survey suggest that despite the lack of consensus or guidelines, MRI is commonly obtained during the acute clinical setting after severe pediatric TBI. (cmich.edu)
  • Single port surgery plus one puncture (POP-SPS): A novel less invasive transabdominal preperitoneal repair for groin hernia. (sages.org)
  • POP-SPS TAPP was demonstrated as a novel minimally invasive approach for laparoscopic inguinal hernia repair. (sages.org)
  • SUMMARY: Advances in neurophysiology and neuroimaging, in combination with computational methods, represent a novel paradigm for prediction of consciousness and functional recovery after severe brain injury. (johnshopkins.edu)
  • Methods: STF injury claims in the Ohio construction industry from 20102017 were manually reviewed. (cdc.gov)
  • Strengthening capacity for management of severe NCDs at this level of health service delivery is important for reducing premature mortality from NCDs. (who.int)
  • It also proposes approaches to improve efficiency by providing standardized protocol-based management of severe NCDs. (who.int)
  • Once the diagnosis of TAPS has been established, cerebral ultrasound, hearing screening, and long-term follow-up are strongly recommended as these twins have increased risk for severe cerebral injury, hearing loss, and long-term neurodevelopmental impairment. (amsterdamumc.org)
  • Male children younger than 18 years have higher injury and mortality rates, perhaps in part because of their more aggressive behavior and exposure to contact sports. (medscape.com)
  • It is hoped that the guidelines will provide concepts and recommendations to promote the quality of care for severe TBIs in Taiwan. (tmu.edu.tw)
  • It offers solutions to bridging the gap in access to care for severe NCDs in addition to strengthening the implementation of WHO PEN. (who.int)
  • Visceral injury in electrical shock trauma: proposed guidelines for the management of abdominal electrocution and literature review. (ijcdas.com)
  • To characterize the occurrence of boat-propeller-related injuries in Texas, the Texas Department of Health (TDH) and the Texas Parks and Wildlife Department (TPWD) investigated boat-propeller-related injuries that occurred in four lakes in Texas during May 24-September 1, 1997, the time of year when boating activities are most common. (cdc.gov)
  • I mean, yeah, it's obviously better, but will I still sustain certain injuries and which kind. (sciencemadness.org)
  • Health care services for severe NCDs such as type 1 diabetes, advanced rheumatic heart disease, and sickle cell disease, are usually provided at tertiary facilities in most countries. (who.int)
  • In in vivo and in vitro studies, MSCs were found to alleviate irradiation-induced lung injuries not only by the secretion of cytokines, growth factors, and paracrine molecules but also by immunomodulatory effect. (hindawi.com)
  • 24 gestational weeks), fetal abuse and assaults, puncture wounds women in Eastern Saudi Arabia who death at any gestational duration, or pre- and burn injuries [3,4]. (who.int)
  • The Association of COVID-19 With Acute Kidney Injury Independent of Severity of Illness: A Multicenter Cohort Study. (yale.edu)
  • Injury severity characteristics included anatomic and physiologic measures of injury severity, namely ISS and Revised Trauma Score (RTS), respectively. (smj.org.sg)
  • In Singapore, as strict laws are a strong deterrent against armed violence, little is known about the epidemiology of penetrating stab wound injuries. (smj.org.sg)
  • Our study aimed to investigate the epidemiology of stab wound injuries at a major trauma centre in Singapore and determine if there was a difference in severity between self-inflicted stab wound (SI) injuries and those inflicted by others (IO). (smj.org.sg)
  • We retrospectively reviewed all penetrating injuries at Tan Tock Seng Hospital, and identified and categorised all stab wound injuries as SI or IO. (smj.org.sg)
  • Between 2005 and 2010, there were a total of 149 stab wound injuries, of which 24 (16.1%) were SI and 125 (83.9%) were IO injuries. (smj.org.sg)
  • In stab wound injuries, thrusting may also transmit more force than a slash injury that inadvertently breaches the cavity. (smj.org.sg)
  • 3 ) this is roughly equivalent to 2.4 stab wound injuries per year per trauma centre. (smj.org.sg)
  • Little is known about the epidemiology of stab wound injuries in Singapore. (smj.org.sg)
  • The aim of our study was to investigate the epidemiology of stab wound injuries at a major trauma centre in Singapore and determine if there was a difference in severity between SI and IO injuries. (smj.org.sg)
  • There were injuries all over the body, including a grievous wound to her head, police said. (kractivist.org)
  • [ 2 ] Gunshot wounds are responsible for most penetrating injuries and carry a significantly higher mortality compared with blunt mechanism injuries. (medscape.com)
  • This type of injury occurs almost exclusively in children and often occurs in the cervical spine. (msdmanuals.com)
  • Spinal Trauma Trauma to the spine may cause injuries involving the spinal cord, vertebrae, or both. (msdmanuals.com)
  • Your daily life may be permanently changed if you get a spine injury. (alltriallawyers.com)
  • Opioids treat moderate-to-severe pain, and benzodiazepine medications (sometimes called "benzos", including diazepam and alprazolam) are sedatives often used to treat anxiety, insomnia, and other conditions [2]. (cdc.gov)
  • Severe primary injury and exasperate condition necessitate emergent surgical intervention. (biomedcentral.com)
  • 145 mmol/L, can result from a primary brain injury resulting in central diabetes insipidus or as a result of hyperosmolar therapies such as the use of hypertonic saline (3, 4). (annalsofafricansurgery.com)
  • The pathogenesis of Reye syndrome, while not precisely elucidated, appears to involve mitochondrial injury resulting in dysfunction that disrupts oxidative phosphorylation and fatty-acid beta-oxidation in a virus-infected, sensitized host potentially with an underlying occult inborn error of fatty acid oxidation, urea cycle or mitochondrial disorder. (medscape.com)
  • The pathogenesis of Reye syndrome, while not precisely elucidated, appears to involve mitochondrial injury resulting in dysfunction that inhibits oxidative phosphorylation and fatty-acid beta-oxidation in a virus-infected, sensitized host. (medscape.com)
  • OBJECTIVE: This study aims to investigate the effects of hydralazine on inflammation induced by spinal cord injury (SCI) in the central nervous system (CNS) and its mechanism in promoting the structural and functional recovery of the injured CNS. (bvsalud.org)
  • 20 , 23 ] Secondary injuries mainly involved the hypoxic-ischemic event, inflammatory cytokines, and free radicals. (surgicalneurologyint.com)
  • A study of severe vehicular accidents. (upenn.edu)
  • RÉSUMÉ En Arabie saoudite, les accidents de la circulation deviennent un problème de santé publique majeur. (who.int)
  • Injury by electrical forces: pathophysiology, manifestations and therapy. (ijcdas.com)
  • Grades 3 and 4 involve more severe bleeding. (medlineplus.gov)
  • The review authors suggested models to describe how workplace and personal risk factors that involve prescription drugs might affect illness and injury [4], using information from published scientific studies. (cdc.gov)
  • He suffered severe trauma to the head and chest, and was taken to a local hospital, where he was diagnosed with brain damage, several broken ribs, femur and pelvis. (masterlap.com)
  • Ravi Shankar was left with severe injuries and was rushed to the Silchar Medical College and Hospital for treatment. (assamtribune.com)
  • In this study, in order to identify the reactive metabolite of NVP mainly responsible for CYP inhibition and liver injury, we synthesized five NVP analogs designed to avoid the proposed bioactivation pathway and evaluated their metabolic stabilities, CYP3A4 time-dependent inhibitory activities, and cytotoxicity. (unboundmedicine.com)
  • This study describes the burden and circumstances surrounding injuries related to compensable slip, trip, and fall (STF) claims from private construction industries covered by the Ohio Bureau of Workers Compensation. (cdc.gov)
  • Immunofluorescence and quantitative real-time polymerase chain reaction were employed to examine the levels of acrolein, acrolein-induced inflammation-related factors, and macrophages at the injury site and within the CNS. (bvsalud.org)
  • Urine Biomarkers of Kidney Tubule Health, Injury, and Inflammation are Associated with Progression of CKD in Children. (yale.edu)
  • NOIRS was held entirely virtually in response to concerns of the COVID-19 pandemic and honoring the symposium theme 'Preventing Workplace Injuries in a Changing World. (cdc.gov)
  • Each year, approximately 20,000 children and teenagers die as a result of injury. (medscape.com)
  • Incomplete injuries may gradually get better with time, and the patient may potentially regain approximately 50% of their capability. (alltriallawyers.com)
  • however, the existence of approximately 600,000 motorboats in the state exposes many Texans to the potential risk for propeller-related injury. (cdc.gov)
  • Death from unintentional injury accounts for 65% of all injury deaths in children younger than 19 years. (medscape.com)
  • A review of the literature on the involvement of alcohol in pedestrian collisions resulting in death and injury. (upenn.edu)
  • In a way of creating awareness for such youths, Chengalpattu SP Suguna Singh, on Saturday, uploaded a video in his official Twitter handle which shows a youth miserably failing in his stunt and getting severely injured, nearly escaping from death. (chennaimemes.in)
  • The mechanisms of these adverse reactions are not yet clear, but the metabolic activation of NVP is thought to be related to the injury process. (unboundmedicine.com)
  • The information in this survey describes current clinical MRI practices in children with severe TBI and identifies important challenges and objectives that should be considered when designing future studies. (cmich.edu)
  • Three of these are rated as grade A, 13 as grade B, 21 as grade C, and 5 as grade D. Conclusions: We have completed the first evidence-based, clinical practice guidelines for severe TBIs. (tmu.edu.tw)
  • Compared with adults, children have distinct anatomic features (eg, larger head size-to-body ratio, elasticity of spinal ligament capsules) that predispose them to hypermobility of the spinal column without apparent bony injury. (msdmanuals.com)
  • In spinal cord injury without evidence of radiologic abnormality, the patient has neurologic findings suggestive of spinal cord injury (eg, paresthesias, weakness) but normal anatomic alignment, and no bone abnormalities are seen on imaging studies (plain x-rays, CT, and/or MRI). (msdmanuals.com)
  • PURPOSE OF REVIEW: Recovery after severe brain injury is variable and challenging to accurately predict at the individual patient level. (johnshopkins.edu)
  • Symptoms of interhemispheric disconnection after acquired brain injury are unusual in the current clini- cal practice. (bvsalud.org)
  • Nevirapine (NVP) is widely used as a non-nucleoside reverse transcriptase inhibitor of HIV-1, however, it is associated with severe skin and liver injury. (unboundmedicine.com)
  • Surfactant protein A (SP-A) is a main inhibitor of sPLA2 and serves as an integral component of alveolar surfactant consisting of 85~90% phosphatides, 5~10% protein, and 5% sugar [ 9 ]. (hindawi.com)
  • 4. The regional strategy aims to address the burden of severe NCDs among rural and unreached populations through decentralized, integrated outpatient services in first-level referral health facilities. (who.int)
  • Cardiovascular diseases, diabetes, cancer, and chronic respiratory diseases account for 70% of the burden of NCDs in the Region.3 The Region also has a high burden of severe NCDs, which are those that result in significant loss of healthy life for affected individuals due to early and high levels of disability and mortality in the absence of treatment. (who.int)
  • The most common circumstances surrounding boat-propeller- related injuries were 1) getting into or out of the boat (five persons), 2) participating in a water activity (e.g., personal watercraft use or skiing) (four), and 3) falling or being thrown from the boat (four). (cdc.gov)
  • These results indicated that the epoxide intermediate of NVP might play an important role in NVP-induced liver injury. (unboundmedicine.com)
  • An autopsy showed fulminant hepatitis-like hepatocellular injury and fibrogenesis in the liver and a lack of uniformity in skeletal muscle, accompanied by the disruption of striated muscle fibers. (elsevierpure.com)