AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesInformation ScienceNamed GroupsHealth CareGeographicals
Lymphoproliferative DisordersKidney TransplantationLiver TransplantationGraft SurvivalGraft RejectionOrgan TransplantationImmunosuppressive AgentsTransplantation, HomologousTransplantationPostoperative ComplicationsTissue DonorsLung TransplantationBone Marrow TransplantationEpstein-Barr Virus InfectionsLiver FailureHeart TransplantationImmunosuppressionTreatment OutcomeTacrolimusPancreas TransplantationCyclosporineHerpesvirus 4, HumanTime FactorsRetrospective StudiesDelayed Graft FunctionIsoantibodiesLiving DonorsHematopoietic Stem Cell TransplantationMycophenolic AcidWaiting ListsHistocompatibility TestingTissue and Organ ProcurementGraft vs Host DiseaseRisk FactorsRecurrenceIslets of Langerhans TransplantationTransplantsCytomegalovirus InfectionsFollow-Up StudiesTransplantation, AutologousMonitoring, ImmunologicWhole-Body IrradiationBiopsyPostoperative PeriodHLA AntigensSurvival RateHistocompatibilityLiver DiseasesCadaverSurvival AnalysisIncidenceAntilymphocyte SerumBronchiolitis ObliteransPolycythemiaThrombotic MicroangiopathiesCytomegalovirusSirolimusEnd Stage Liver DiseaseLeukemiaLymphocyte TransfusionTransplantation ConditioningTransplantation ImmunologyProspective StudiesHepatitis CRisk AssessmentPlasmapheresisBlood Grouping and CrossmatchingPrognosisKidney DiseasesLymphocyte DepletionHerpesviridae InfectionsOrgan PreservationImmunocompromised HostLymphomaCohort StudiesKaplan-Meier EstimateActuarial AnalysisHeart-Lung TransplantationAcute DiseaseChemokine CXCL9Anemia, AplasticKidney Failure, ChronicMultivariate AnalysisTransplantation ToleranceCreatinineRenal InsufficiencyTransplantation, IsogeneicPrednisoneProportional Hazards ModelsAntibodies, NeoplasmKidneyCyclophosphamideBusulfanSteroidsBrain DeathTransplantation, HeterotopicB-LymphocytesT-LymphocytesPredictive Value of TestsLeukocyte Transfusion
Lymphoproliferative diseaseImmunosuppressionGvHDPTLDComplicationAllogeneic Hematopoietic Stem CSolid organ transplantationTransplantationCystic fibrosisGraftTreating severe illnessCombined immunodeficiencyPatientsLiverIncidence of severeFibrosisLymphopeniaAbdominal painAcuteInfectionVaginaInfectionsLungImmune deficiencyBiopsyOccurAnemiaIntravenousRecipientsDiagnosticRiskPreventionCasesCommonSignificantManagement
Lymphoproliferative disease2
Immunosuppression2
  • If the GvHD is severe and requires intense immunosuppression involving steroids and additional agents to get under control, the patient may develop severe infections [12] as a result of the immunosuppression and may die of infection. (wikipedia.org)
  • 1 - 4 BLs that display an intermediate association with EBV have also been documented in Egypt and Brazil, where up to 87% of tumours are EBV positive 5 - 7 and BL occurs in HIV carriers, where tumours can develop prior to the severe immunosuppression coincident with the onset of AIDS. (bmj.com)
GvHD5
  • Mucosal damage to the vagina can result in severe pain and scarring , and appears in both acute and chronic GvHD. (wikipedia.org)
  • Acute GvHD of the GI tract can result in severe intestinal inflammation, sloughing of the mucosal membrane, severe diarrhea, abdominal pain, nausea, and vomiting. (wikipedia.org)
  • Graft versus host disease (GVHD), a severe immunogenic complication of allogeneic hematopoietic stem cell transplantation (HSCT), represents the most frequent cause of transplant-related mortality (TRM). (hindawi.com)
  • Despite a huge progress in HSCT techniques and posttransplant care, GVHD remains a significant obstacle in successful HSCT outcome. (hindawi.com)
  • Moreover, we confirmed a significant reduction of clinically-relevant CMV, and moderate-to- severe chronic GvHD in LTV-cohort. (bvsalud.org)
PTLD1
  • Most cases of PTLD occur within the first posttransplant year. (medscape.com)
Complication1
Allogeneic Hematopoietic Stem C1
  • It should be administered under the supervision of a qualified physician who is experienced in allogeneic hematopoietic stem cell transplantation, the use of cancer chemotherapeutic drugs and the management of patients with severe pancytopenia. (nih.gov)
Solid organ transplantation1
  • 8. Lee JJ, Lam MS, Rosenberg A. Role of chemotherapy and rituximab for treatment of posttransplant lymphoproliferative disorder in solid organ transplantation. (sciendo.com)
Transplantation5
Cystic fibrosis2
  • Cystic fibrosis may make the effects of COVID-19 more severe for some people, so it's important to continue to lower your risk of contracting the disease. (nationaljewish.org)
  • Additional studies resulting from the Cystic Fibrosis Registry Global Harmonization Group related to outcomes in CF and COVID-19 -- published in the April and November 2020 editions of the Journal of Cystic Fibrosis -- suggested that for most people with cystic fibrosis, outcomes are less severe than originally anticipated at the start of the global pandemic. (cff.org)
Graft1
Treating severe illness1
  • In addition, there are medical countermeasures that may have a role in treating severe illness, including oral and intravenous tecovirimat (TPOXX), cidofovir or brincidofovir, and vaccinia immune globulin intravenous (VIGIV), although there are no data on effectiveness in treating human monkeypox with these medical countermeasures. (cdc.gov)
Combined immunodeficiency1
  • Adenosine deaminase (ADA) deficiency is a rare autosomal recessive disorder of purine metabolism that leads to severe combined immunodeficiency (SCID) by primarily affecting lymphocyte development and function. (researchgate.net)
Patients6
  • Treatment of severe acne with isotretinoin in patients with inflammatory bowel disease. (globale-dermatologie.com)
  • The symptoms of hepatic encephalopathy may range from mild to severe and may be observed in as many as 70% of patients with cirrhosis. (medscape.com)
  • 1, 2] However, posttransplant morbidity incidence remains high, which may affect the survival and quality of life of patients. (researchsquare.com)
  • Among patients who underwent HT, cirrhosis on pre-transplant imaging was associated with worse outcomes.CONCLUSIONS: Despite greater inotrope need and more severe liver disease at the time of listing, Fontan recipients undergoing HLT have post-transplant outcomes comparable with those of patients undergoing HT. (stanfordchildrens.org)
  • Patients with class I, II, or III variants are considered to have a more severe genotype that results in little or no CFTR function, whereas patients with 1 or 2 class IV, V, or VI variants are considered to have a milder genotype that results in residual CFTR function. (msdmanuals.com)
  • in 14 patients (31.1%), the recurrent infection was severe. (biu.ac.il)
Liver4
  • CF can be associated with severe liver disease, such as cirrhosis. (cff.org)
  • Other individuals have a multitude of the most severe symptoms of end-stage liver disease and a limited chance for survival. (medscape.com)
  • His cell counts, kidney function and liver tests were within normal range at admission but he later developed severe pancytopenia and a very high ferritin (15,910 ng/mL). (asn-online.org)
  • For gastroenterologists who wish to play a more active role in liver transplant cases, the key to good pre- and posttransplant patient care is to communicate with the local transplant center and develop a proper team dynamic. (tts.org)
Incidence of severe1
  • We hypothesize that the survival benefit is due to reduction in the incidence of severe PGD (from 12% vs 3%, p=0.005)1,2 and reduced need for mechanical circulatory support after transplant. (medtechdive.com)
Fibrosis1
  • The primary endpoint was moderate-to-severe interstitial fibrosis and tubular atrophy assessed by protocol biopsy at 3 years evaluated by a single pathologist blinded to the study group. (biomedcentral.com)
Lymphopenia2
  • Laboratory test results showed moderate anemia, severe lymphopenia, and moderately increased C-reactive protein. (cdc.gov)
  • NK) cells (T-B-NK-SCID) and severe lymphopenia. (researchgate.net)
Abdominal pain1
  • Five months after treatment initiation, the patient experienced severe abdominal pain, diarrhea, and continued weight loss. (cdc.gov)
Acute1
  • The primary objectives of this study are: - To determine the proportion of children with Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) related death, rehospitalization or major complications after infection with SARS-CoV-2 and/or Multisystem Inflammatory Syndrome in Children (MIS-C), and - To determine immunologic mechanisms and immune signatures associated with disease spectrum and subsequent clinical course during the year of follow-up. (stanford.edu)
Infection4
  • In prior monkeypox outbreaks in Nigeria, co-infection with HIV was associated with worse clinical outcomes, including severe manifestations of monkeypox, hospitalization, and death. (cdc.gov)
  • To appreciate how severe the trajectory worsened it is critical to note the patient was not discharged until 7 months after transplant due to what was inevitably determined to be a disseminated mycobacterial infection (see below "source" section). (acsh.org)
  • 6. Yin CC, Medeiros LJ, Abruzzo LV, Jones D, Farhood AI, Thomazy VA.EBV-associated B- and T-cell posttransplant lymphoproliferative disorders following primary EBV infection in a kidney transplant recipient. (sciendo.com)
  • LCMV infection should be considered as a possible cause of severe posttransplant illness. (medscape.com)
Vagina1
  • Lesions in sensitive areas (including mucosal surfaces such as, oropharynx, urethra, rectum, vagina) resulting in severe pain that interferes with activities of daily living. (cdc.gov)
Infections3
  • The company uses its novel allogeneic Epstein-Barr virus (EBV) T-cell platform to develop therapies for the treatment of cancers, other autoimmune diseases, and severe viral infections. (pharmaceutical-technology.com)
  • In both instances, infections are associated severe disease. (medscape.com)
  • Oral-source infections are a potential threat for transplant candidates because oral diseases tend to be more severe and untreated in people who have received transplants. (bvsalud.org)
Lung3
  • In late adolescence or adulthood, people begin to develop severe signs of lung disease: wheezing, digital clubbing, cyanosis, coughing up blood, pulmonary heart disease, and collapsed lung (atelectasis or pneumothorax). (wikipedia.org)
  • What we do know is that those with CF are more at risk to have severe COVID-19 because of their underlying lung disease. (nationaljewish.org)
  • The study concludes that COVID-19 is usually associated with mild illness in children without severe pre-existing lung disease, offering a significantly more reassuring outlook than originally anticipated at the start of the global pandemic. (cff.org)
Immune deficiency1
Biopsy1
  • Duodenal biopsy specimen from the patient with posttransplant cachexia. (cdc.gov)
Occur1
  • Symptoms can occur along a spectrum, but this individual possesses among the most severe mutations and form. (acsh.org)
Anemia2
  • Participants in this study must be 2 years or older and have severe aplastic anemia. (nih.gov)
  • This study is testing whether adding the medicine eltrombopag to standard treatments is a better way to treat severe aplastic anemia. (nih.gov)
Intravenous1
  • But, after a week on immunosuppressive and many antibiotic medications, severe side effects necessitated stopping the intravenous (i.v.) antibiotics and maintaining the patient on i.v. nutrition. (acsh.org)
Recipients2
  • In this cluster, all recipients developed severe illness, but 2 survived. (medscape.com)
  • In February 2011, the Centers for Disease Control and Prevention (CDC, Atlanta, GA, USA) was notified of a cluster of severe illnesses (2 fatal, and 2 in persons who were recovering) among 4 organ recipients linked to 1 donor, who died in late December 2010. (medscape.com)
Diagnostic1
  • There are diagnostic and clinical management strategies that may help address severe manifestations of monkeypox. (cdc.gov)
Risk6
  • If you are post-transplant, you have a lower immune response to vaccines and higher risk for severe disease from COVID-19. (nationaljewish.org)
  • Because people with HIV-associated immunocompromise are at risk for severe manifestations of monkeypox, the HIV status of all sexually active adults and adolescents with suspected or confirmed monkeypox should be determined. (cdc.gov)
  • Healthcare providers should recognize underlying risk factors for severe disease, optimize immune function, and when appropriate, initiate medical countermeasures (such as tecovirimat and vaccinia immunoglobulin) early to prevent or mitigate severe disease. (cdc.gov)
  • Healthcare providers should be aware of risk factors for severe manifestations of monkeypox and should conduct HIV testing for people with confirmed or suspected monkeypox. (cdc.gov)
  • 2 Providers should also consider other immunocompromising conditions * and medications that may increase risk of severe manifestation of monkeypox. (cdc.gov)
  • The CF Foundation continues to recommend that people with CF and those close to them continue taking precautions to protect their health and follow the CDC's guidance for those at higher risk of developing severe illness . (cff.org)
Prevention1
  • The best prevention we have against severe disease from COVID-19 is vaccination, and we strongly encourage all those who are eligible to get vaccinated and boosted. (nationaljewish.org)
Cases1
  • During the current outbreak in the United States, 38 percent of people diagnosed with monkeypox were coinfected with HIV 1 and most reported cases of monkeypox with severe manifestations have been among people living with untreated HIV. (cdc.gov)
Common1
  • It is one of the most common posttransplant malignancies. (medscape.com)
Significant1
  • 0.65, significant coronary artery disease, disorders preventing or contraindicating use of a cycle ergometer, and/or moderate or severe ascites will be excluded. (biomedcentral.com)
Management1
  • Case Report: Airway and Concurrent Hemodynamic Management in a Neonate with Oculo-Auriculo-Vertebral (Goldenhar) Syndrome, Severe Cervical Scoliosis, Interrupted Aortic Arch, Multiple Ventricular Septal Defects, and an Unstable Cervical Spine. (stanford.edu)