• A population-based cohort study was undertaken of severe epilepsies with onset before age 18 months in Victoria, Australia. (cureepilepsy.org)
  • A prospective, register-based cohort study using the entire Danish population born between January 1, 1973, and January 1, 2007, was conducted. (psychiatrist.com)
  • Methods: In this population cohort study, records from 1205 general practices in England that contribute to the QResearch database were linked to Public Health England's database of SARS-CoV-2 testing and English hospital admissions, intensive care unit (ICU) admissions, and deaths for COVID-19. (ox.ac.uk)
  • Preeclampsia and Severe Maternal Morbidity During the COVID-19 Pandemic: A Population-Based Cohort Study in Ontario, Canada. (bvsalud.org)
  • This was a population -based, retrospective cohort study using linked administrative data sets from ICES. (bvsalud.org)
  • Design Population based longitudinal consecutive cohort study. (bmj.com)
  • In 2022, approximately one percent of the population in East Asia were subject to severe food insecurity. (statista.com)
  • The share of population in severe food insecurity stayed consistent in East Asia compared to the previous year. (statista.com)
  • The World Bank defines the situation when the calorie intake remains under 1,800 per day per person as the severe food insecurity and according to the WB definition, 7.8 percent of total population face a greater risk of severe food insecurity in Nepal. (arthasarokar.com)
  • The tumor necrosis factor gene (TNF) and lymphotoxin-α gene (LTA) have long attracted attention as candidate genes for susceptibility traits for malaria, and several of their polymorphisms have been found to be associated with severe malaria (SM) phenotypes. (edu.au)
  • Imputation-based meta-analysis of severe malaria in three African populations. (ox.ac.uk)
  • We analyse genome-wide data from approximately 5,000 individuals with severe malaria and 7,000 population controls from three different locations in Africa. (ox.ac.uk)
  • Our results show that the standard approach is well powered to detect known malaria susceptibility loci when sample sizes are large, and that modern methods for association analysis can control the potential confounding effects of population structure. (ox.ac.uk)
  • Previous reports of mortality and morbidity in pediatric severe traumatic brain injury (TBI) vary considerably, with few population-based studies. (lu.se)
  • The aim of the present study was to retrospectively assess mortality and morbidity in a population of pediatric TBI treated according to the Lund concept. (lu.se)
  • We used Cox regression to estimate adjusted HRs for future inpatient care and mortality in severe liver disease and incidence of hepatocellular carcinoma (HCC) across BMI categories, using BMI of 18.5-22.5 kg/m 2 as reference. (bmj.com)
  • Introduction Mortality from severe sepsis can be improved by timely diagnosis and treatment. (bmj.com)
  • In 2004, the Surviving Sepsis Campaign issued guidelines for the comprehensive management of severe sepsis (updated in 2008 4 ) with the aim of reducing sepsis mortality by 25% in 5 years 5 . (bmj.com)
  • Few data are available for the most severe cases of HSE, those admitted to intensive care units (ICUs), particularly as concerns their epidemiology, initial management, acute-phase mortality, and long-term outcome. (biomedcentral.com)
  • Objective To investigate the variation in severe neonatal morbidity among very preterm (VPT) infants across European regions and whether morbidity rates are higher in regions with low compared with high mortality rates. (bmj.com)
  • Regional severe neonatal morbidity rates were correlated with regional in-hospital mortality rates for live births after adjustment on maternal and neonatal characteristics. (bmj.com)
  • 0.001) and severe neonatal morbidity rates were not correlated with mortality rates (P=0.50). (bmj.com)
  • Conclusion Severe neonatal morbidity rates for VPT survivors varied widely across European regions and were independent of mortality rates. (bmj.com)
  • The prevention and control of anaemia is one of the key strategies of the Health, Nutrition and Population Sector Programme for reducing maternal, neonatal and childhood mortality and improving maternal and childhood nutrition. (who.int)
  • In the univariate Cox regression analysis, the neutrophil‑to‑lymphocyte ratio and haematological malignancy were identified as predictors of progression to severe disease, and albumin levels, the C‑reactive protein‑to‑albumin ratio (CAR) and haematological malignancy were identified as predictors of 28‑day mortality. (spandidos-publications.com)
  • Fast Five Quiz: Severe Asthma - Medscape - Mar 17, 2023. (medscape.com)
  • Background - Bariatric surgery is the most effective treatment for severe obesity but carries potential for significant complications. (ices.on.ca)
  • Development of T2DM further increased the risk for severe liver disease across all BMI categories, for instance, men with obesity and T2DM had a higher risk of severe liver disease (HR 3.28, 95% CI 2.27 to 4.74) than men with obesity free of T2DM (HR 1.72, 95% CI 1.72 to 2.54). (bmj.com)
  • Gastric Bypass Best Option for Severe Obesity With Diabetes? (medscape.com)
  • Overall, Roux-en-Y gastric bypass (RYGB) was preferred when compared to sleeve gastrectomy or medical therapy in patients with severe obesity and type 2 diabetes of varying severity, an economic modeling study has found. (medscape.com)
  • RYGB was projected to result in greater weight loss and type 2 diabetes remission when compared to sleeve gastrectomy or medical therapy in a cohort of US adults with severe obesity (body mass index [BMI] ≥ 40 kg/m 2 ) and type 2 diabetes. (medscape.com)
  • We found that RYGB leads to improved health outcomes without costing a significant amount of money within the United States healthcare system for patients with severe obesity and any severity level of [type 2 diabetes]," he elaborated in an email to Medscape Medical News . (medscape.com)
  • Our study does suggest that all patients with severe obesity and [type 2 diabetes] should consider RYGB over sleeve gastrectomy and medical therapy," he summarized. (medscape.com)
  • Bariatric surgery is recommended for patients with severe obesity and type 2 diabetes, but it is unclear which type of surgery is optimal or if diabetes severity impacts cost effectiveness, Lauren and colleagues write. (medscape.com)
  • The researchers constructed a model to simulate nationally representative cohorts of US adults with severe obesity and type 2 diabetes, using 1999-2018 cycles of National Health and Nutrition Examination Survey (NHANES) data. (medscape.com)
  • Rates of adherence to available recommendations for dose adjustments in patients with severe obesity are generally low. (biomedcentral.com)
  • The aim of the study was to analyse the impact of an antimicrobial stewardship programme based on a computerised clinical decision support system for optimal dosing and antimicrobial use in inpatients with severe obesity. (biomedcentral.com)
  • Data were collected from all hospitalised adults receiving antimicrobials which required dose adjustment for severe obesity and were stratified by body mass index. (biomedcentral.com)
  • The percentage of children and adolescents with severe obesity has nearly quadrupled over the last five decades, from 1% in the early 1970s to 6.1% in 2017-18. (cdc.gov)
  • Data from NCHS's National Health and Nutrition Examination Survey (NHANES) show that 4.5 million children and adolescents have severe obesity. (cdc.gov)
  • Prior to today's release, the growth charts did not extend high enough to plot very high BMIs for the increasing number of children with severe obesity. (cdc.gov)
  • While patients with severe [type 2 diabetes] experience less weight loss and diabetes remission after RYGB" than patients with mild or moderate type 2 diabetes, Hur added, "RYGB was still cost-effective. (medscape.com)
  • While 90% of patients with mild type 2 diabetes have diabetes remission after bariatric surgery, only 2% to 12% of patients with severe type 2 diabetes have diabetes remission after bariatric surgery. (medscape.com)
  • The researchers used the Individualized Metabolic Surgery (IMS) score developed by Aminian et al (2017) to classify an individual as having mild, moderate, or severe type 2 diabetes. (medscape.com)
  • Status asthmaticus can vary from a mild form to a severe form with bronchospasm, airway inflammation, and mucus plugging that can cause difficulty breathing, carbon dioxide retention, hypoxemia, and respiratory failure. (medscape.com)
  • Differential trend of mild and severe preeclampsia among nulliparous women: a population-based study of South Korea. (qxmd.com)
  • We explored the annual risks of mild and severe preeclampsia (PE) among nulliparous women. (qxmd.com)
  • Mild PE increased from 0.9% in 2010 to 1.4% in 2019 (P for trend=0.006), while severe PE decreased from 0.4% in 2010 to 0.3% in 2019 (P=0.049). (qxmd.com)
  • The incidence of all types of PE (mild and severe) showed no linear change (P=0.514). (qxmd.com)
  • Asthma is an inflammatory lung disease that can lead to mild to severe symptoms. (medscape.com)
  • GlaxoSmithKline (GSK) and Theravance, Inc. (NASDAQ: THRX) today announced positive results from three, separate phase 2b studies assessing efficacy and safety of GSK's inhaled corticosteroid (ICS) fluticasone furoate (FF or GW685698) across a range of eight doses (25 - 800 mcg) in over 1,800 patients with mild, moderate and severe asthma. (gsk.com)
  • Methods - Retrospective population-based descriptive study of Ontario adults undergoing bariatric surgery between January 1, 2009 and December 31, 2015. (ices.on.ca)
  • Methods: The pharmacokinetics and safety of nemonoxacin was evaluated in a single-dose, open-label, nonrandomized, parallel-group study after single oral dose of 0.5 g nemonoxacin capsule in 10 patients with severe renal impairment and 10 healthy controls. (authorea.com)
  • Methods In this double-blind, placebo-controlled study, patients with moderate-to-severe SLE were randomised to atacicept 75 mg or atacicept 150 mg administered subcutaneously, or placebo twice-weekly for 4 weeks, then weekly for 48 weeks. (bmj.com)
  • Methods: We assigned 295 community-dwelling patients who had been treated with donepezil for at least 3 months and who had moderate or severe Alzheimer's disease (a score of 5 to 13 on the Standardized Mini-Mental State Examination [SMMSE, on which scores range from 0 to 30, with higher scores indicating better cognitive function]) to continue donepezil, discontinue donepezil, discontinue donepezil and start memantine, or continue donepezil and start memantine. (ox.ac.uk)
  • Conclusions - The risk of severe nutritional complications after bariatric surgery is low but similar to that of other major bariatric surgery complications. (ices.on.ca)
  • Conclusions A high BMI in late adolescent men was associated with an increased risk of future severe liver disease, including HCC. (bmj.com)
  • Conclusions Consistent with a chronic overlapping pain condition, patients with DE disease with more severe NOP symptoms report more frequent and severe non-ocular functional comorbid pain disorders. (bmj.com)
  • Conclusions Introduction of a comprehensive management protocol to address early recognition and management of severe sepsis in the ED is associated with sustained improvements in processes of care. (bmj.com)
  • Conclusions: In patients with moderate or severe Alzheimer's disease, continued treatment with donepezil was associated with cognitive benefits that exceeded the minimum clinically important difference and with significant functional benefits over the course of 12 months. (ox.ac.uk)
  • Conclusions Lower dose opioids are not associated with increased admissions or deaths in patients with COPD and might be safe for symptom reduction in severe respiratory disease. (bmj.com)
  • Conclusions and Relevance: Among patients with emphysema and severe hyperinflation treated for 12 months, the use of endobronchial coils compared with usual care resulted in an improvement in median exercise tolerance that was modest and of uncertain clinical importance, with a higher likelihood of major complications. (sutterhealth.org)
  • We conducted a trial to test the electronic Illness Management and Recovery (e-IMR) intervention to provide conclusions on the potential efficacy of eHealth for people with severe mental illness (SMI). (jmir.org)
  • In another post-hoc analysis, people with two or more prescriptions for ICS in the 150 days before study start were at a slightly higher risk of severe COVID-19 compared with all other individuals (ie, no or one ICS prescription): HR 1·13 (1·03-1·23) for hospitalisation, 1·63 (1·18-2·24) for ICU admission, and 1·15 (1·01-1·31) for death. (ox.ac.uk)
  • Which children are at higher risk of severe COVID-19? (fox59.com)
  • The investigation showed that the top 10 percent of the most stressed river basins support about 19 percent of the world's population, 19 percent of thermal electricity generation, and one-third of irrigated agricultural production. (earth.com)
  • At least half of the world's population still lacks access to essential health services and out-of-pocket expenses on health drive almost 100 million people into poverty each year. (bvsalud.org)
  • Worldwide, about half a billion people (almost 8% of the world's population) have hearing loss ( 1). (msdmanuals.com)
  • We evaluated preeclampsia /HELLP ( hemolysis , elevated liver enzymes and low platelets ) syndrome and composite severe maternal morbidity (SMM) among pregnant people who gave birth during the COVID-19 pandemic and compared these data with those of people who gave birth before the pandemic in Ontario , Canada . (bvsalud.org)
  • Main outcome measures Severe neonatal morbidity was defined as intraventricular haemorrhage grades III and IV, cystic periventricular leukomalacia, surgical necrotizing enterocolitis and retinopathy of prematurity grades ≥3. (bmj.com)
  • All cases of severe pediatric TBI (age <18 years) in the southern region of Sweden during 19 years were identified. (lu.se)
  • A total of 135 cases of severe TBI <18 years of age were recorded (incidence 2.0/100000) and 86 patients were admitted to the tertiary NICU. (lu.se)
  • Results During a follow-up of more than 34 million person-years, 5281 cases of severe liver disease including 251 cases of HCC were identified. (bmj.com)
  • There are 750 000 cases of severe sepsis annually in North America. (bmj.com)
  • During the first roprevalence of IgG against severe acute respiratory syn- drome coronavirus 2 in Chennai, India. (cdc.gov)
  • Coronavirus disease 2019 (COVID-19) caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has led to an ongoing global pandemic. (biomedcentral.com)
  • Remdesivir, a viral RNA polymerase inhibitor, has constituted a key component of therapeutic regimens against the pandemic caused by severe acute respiratory syndrome coronavirus‑2 (SARS‑CoV‑2). (spandidos-publications.com)
  • Originally approved for administration in hospitalized patients, remdesivir leads to improved outcomes in patients with moderate to severe coronavirus disease 2019 (COVID‑19). (spandidos-publications.com)
  • Current management approaches for patients infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are based on the clinical course, the patient's risk factors and the availability of the agents ( 2 ). (spandidos-publications.com)
  • Aims: To optimize the dosing regimen in patients with severe renal impairment based on population pharmacokinetic/pharmacodynamic (PPK/PD) analysis. (authorea.com)
  • Results: The data best fitted to a two-compartment model, from which the PPK parameters were estimated, including clearance (8.55 L/h), central compartment volume (80.8 L), and peripheral compartment volume (50.6 L). The accumulative urinary excretion was 23.4±6.5% in severe renal impairment patients and 66.1±16.8% in healthy controls. (authorea.com)
  • loading dose 0.5 g on Day 1 followed by 0.25 g q24h) were insufficient to cover the pathogens even if MIC ≤ 0.5 mg/L. Conclusion: An extended dosing interval (0.5 g q48h) may be appropriate for optimal efficacy of nemonoxacin in case of severe renal impairment. (authorea.com)
  • eHealth is also used for persons with severe mental illness (SMI). (jmir.org)
  • The effectiveness of assertive community treatment for homeless populations with severe mental illness: A meta-analysis. (bvsalud.org)
  • The aim of this study was to assess whether chronic lung disease or use of inhaled corticosteroids (ICS) affects the risk of contracting severe COVID-19. (ox.ac.uk)
  • People with COPD and interstitial lung disease appear to have a modestly increased risk of severe disease, but their risk of death from COVID-19 at the height of the epidemic was mostly far lower than the ordinary risk of death from any cause. (ox.ac.uk)
  • High amounts in the air can cause severe lung damage. (cdc.gov)
  • 5 Patients with severe COPD are more breathless than patients with advanced lung cancer and are breathless for longer periods of time. (bmj.com)
  • Importance: Preliminary clinical trials have demonstrated that endobronchial coils compress emphysematous lung tissue and may improve lung function, exercise tolerance, and symptoms in patients with emphysema and severe lung hyperinflation. (sutterhealth.org)
  • Objectives - Describe incidence and factors associated with severe nutritional complications after adult bariatric surgery. (ices.on.ca)
  • To study the epilepsy syndromes among the severe epilepsies of infancy and assess their incidence, etiologies, and outcomes. (cureepilepsy.org)
  • Symptoms associated with severe chronic neutropenia include recurring fevers, mouth sores (ulcers), inflammation of the tissues that surround and support the teeth (periodontitis) and inflammation of the sinuses (sinusitis), throat (pharyngitis) and/or ear (otitis). (rarediseases.org)
  • Symptoms and physical findings associated with severe chronic neutropenia vary greatly depending on how low the level of neutrophils in the blood falls. (rarediseases.org)
  • Objective A high body mass index (BMI) is associated with an increased risk for severe liver disease. (bmj.com)
  • Development of T2DM during follow-up was associated with a further increased risk of severe liver disease, independent of baseline BMI. (bmj.com)
  • People with advanced HIV who contract mpox are at risk of severe illness and death. (cdc.gov)
  • Interpretation: The risk of severe COVID-19 in people with asthma is relatively small. (ox.ac.uk)
  • Use of inhaled steroids might be associated with a modestly increased risk of severe COVID-19. (ox.ac.uk)
  • DENVER ( KDVR ) - A new study published in the Journal of the American Medical Association (JAMA) is providing insight into which children have a higher risk of developing severe complications from COVID-19. (fox59.com)
  • How can we predict beforehand which of these kids are going to go on to develop severe disease and be at higher risk for deterioration," said Martin, who's tackling that and more with the study. (fox59.com)
  • Every community has at-risk citizens who need extra assistance during severe weather events. (securitymagazine.com)
  • Nonetheless, any storm that manages to develop and become sustained in the aforementioned kinematic/thermodynamic environment may become briefly supercellular, supporting an isolated severe hail/wind risk. (noaa.gov)
  • Data shows that the country has sufficient food reserve, but food imbalance due to disproportionate production and distribution posed a threat to food security in Nepal with 7.8 percent population at risk of a severe food crisis. (arthasarokar.com)
  • After proving to be effective in hospitalized patients, its use gained approval in early‑stage disease for symptomatic outpatients who are at a high risk of progression to severe disease. (spandidos-publications.com)
  • Background: Previous studies suggested that the prevalence of chronic respiratory disease in patients hospitalised with COVID-19 was lower than its prevalence in the general population. (ox.ac.uk)
  • 1 In the USA, it is estimated that DED has a prevalence of 15% in the general population, with prevalence estimates ranging from 5% to 30% in patients aged ≥50 worldwide. (bmj.com)
  • Therefore, more-detailed mapping of variants across TNF/LTA genes and their flanking regions in the Gambian and allied populations may need to be undertaken to find any causal polymorphisms. (edu.au)
  • Severe fever with thrombocytopenia syndrome (SFTS) is a tick-borne infection. (wikipedia.org)
  • Population-based preconception expanded carrier screening for severe recessive disorders: Does a GP-provided test offer with couple results meet criteria for responsible implementation? (rug.nl)
  • The primary outcome was a severe nutritional complication (hospital admission with malnutrition or nutrient deficiency). (ices.on.ca)
  • Although patients who have severe sepsis generally require admission to an intensive care unit (ICU), they frequently present to the emergency department (ED), where prompt diagnosis and treatment can significantly improve outcome. (bmj.com)
  • The notion that high intracranial pressure (ICP) might be associated with a poor acute-phase outcome of severe cases of encephalitis arose from the historical series of Barnett et al. (biomedcentral.com)
  • A secondary outcome included severe bronchopulmonary dysplasia (BPD), data available in 14 regions. (bmj.com)
  • All infants with EIEE or EIMFS had severe-profound delay or were deceased, but only 19 of 64 (30%) infants with WS, "WS-like," or "unifocal epilepsy" had severe-profound delay, and only two of 64 (3%) were deceased. (cureepilepsy.org)
  • Results - Of Ontario adults, 18,783 (81.8% female, mean age 45.1 ± 10.6 yr) underwent bariatric surgery during the study period (88.8% Roux-en-Y gastric bypass, 10.8% sleeve gastrectomy). (ices.on.ca)
  • The Lund concept is a treatment algorithm for severe TBI aiming at controlling intracranial pressure (ICP) by reducing cerebral perfusion pressure (CPP). (lu.se)
  • Admission to ICU was rare, but the HR for people with asthma was 1·08 (0·93-1·25) and severe asthma was 1·30 (1·08-1·58). (ox.ac.uk)
  • The term " severe asthma " refers to asthma that remains uncontrolled despite this treatment, including asthma in patients who stopped treatments or therapies owing to a lack of response. (medscape.com)
  • Severe asthma is a heterogeneous condition that consists of such phenotypes as eosinophilic asthma . (medscape.com)
  • How much do you know about severe asthma? (medscape.com)
  • Patient populations with varying severities of asthma were randomised in three separate double-blind, double-dummy, placebo-controlled studies. (gsk.com)
  • These findings indicate most of based serosurvey in July 2020, to estimate the serop- the population of Chennai is still susceptible to this virus. (cdc.gov)
  • In a post-hoc analysis, relative risks of severe COVID-19 in people with respiratory disease were similar before and after shielding was introduced on March 23, 2020. (ox.ac.uk)
  • Georgetown and Leander were revealed as the fastest-growing cities in the country with populations greater than 50,000, both increasing their populations by more than 10% between 2020 and 2021. (kxan.com)
  • The city's population increased from 2,258 in 2020 to 4,565 in 2021, a 102.2% increase. (kxan.com)
  • For consistency, KXAN has used July 1 population estimates for 2010 and 2020 in the map above, rather than census numbers, which show population totals as of April 1. (kxan.com)
  • Three quarters of severe epilepsies of infancy could be assigned an epilepsy syndrome or "variant syndrome" at presentation. (cureepilepsy.org)
  • The congenital forms of severe chronic neutropenia are often the most severe of all types of SCN and can be detected by doing a blood count in infancy or during early childhood. (rarediseases.org)
  • Type 2 usually begins in infancy with severe neurologic involvement. (medlineplus.gov)
  • Objective To evaluate the safety of benzodiazepines and opioids in patients with very severe chronic obstructive pulmonary disease (COPD). (bmj.com)
  • Risks might be higher in frail patients, especially if they have not previously been treated with either or both drugs, and in people with severe COPD and hypercapnia. (bmj.com)
  • With Cox regression, we examined the risks of COVID-19-related hospitalisation, admission to ICU, and death in relation to respiratory disease and use of ICS, adjusting for demographic and socioeconomic status and comorbidities associated with severe COVID-19. (ox.ac.uk)
  • In an effort to implement evidence-based recommendations for the management of severe sepsis, we developed a sepsis protocol as a collaborative quality improvement initiative between the ED and ICU at our hospital. (bmj.com)
  • Findings from this study will enhance knowledge of mpox pathogenesis in severely immunocompromised people, which can inform treatment and prevention of severe illness and deaths associated with mpox in people with advanced HIV. (cdc.gov)
  • This study investigates the effectiveness of a comprehensive management protocol for recognition and initial treatment of severe sepsis that spans from the emergency department (ED) to the intensive care unit. (bmj.com)
  • Recent years have seen a revolution in the diagnosis and treatment of sepsis, with the development of operational definitions for severe sepsis and septic shock 3 and application of best evidence to define standards of care for this complex disease. (bmj.com)
  • The objectives of this study were to elicit self-reported health status, quantify osteoporosis-related burden, and understand preferences for treatment attributes among postmenopausal women with severe osteoporosis in Greece. (dovepress.com)
  • TNF-α may therefore pose a promising target for the treatment of severe cases of COVID-19 exhibiting hyperinflammation. (biomedcentral.com)
  • It is not known whether treatment benefits continue after the progression to moderate-to-severe disease. (ox.ac.uk)
  • Cristina Cusin, MD, staff psychiatrist at the Depression Clinical and Research Program (DCRP) and co-director of the Ketamine Clinic for Depression, is passionate about helping patients with the most severe and treatment-resistant forms of depression. (massgeneral.org)
  • The Food and Drug Administration (FDA) granted remdesivir as the first drug licensed for the treatment of severe COVID-19( 3 ). (spandidos-publications.com)
  • Severe sepsis is a complex syndrome comprising a range of clinical conditions caused by the body's systemic response to an infection resulting in single or multiple organ dysfunction or failure. (bmj.com)
  • 9 Benzodiazepines are also used to treat anxiety and opioids to treat pain, conditions that are highly prevalent in patients with severe COPD. (bmj.com)
  • Factors associated with severe nutritional complication included younger age, major co-morbidities, low socioeconomic status, surgical or perioperative complication, imperfect follow-up attendance, greater weight loss during the first year, and drop in albumin at 6 months. (ices.on.ca)
  • Neighboring Caddo Mills grew at the third-fastest pace statewide, with a 2021 population of 2,321, up 53.7% from the prior year. (kxan.com)
  • The new data shows populations for each city as of July 1, 2021. (kxan.com)
  • Severe chronic neutropenia (SCN) is a rare blood disorder characterized by abnormally low levels of certain white blood cells (neutrophils) in the bloodstream (neutropenia) not explained by medication use, infections or another underlying health condition like blood cancers or systemic autoimmune diseases associated with neutropenia. (rarediseases.org)
  • Severe cases are characterised by a systemic inflammatory reaction driven by the release of pro-inflammatory cytokines such as IL-6 and tumour-necrosis-factor alpha (TNF-α). (biomedcentral.com)
  • The Hill ) - More than 20 million people face a threat of severe thunderstorms, and some areas are bracing for tornadoes ahead of what could be the busiest holiday travel week ever. (myfox8.com)
  • Isolated strong to severe thunderstorms are possible across the southern Plains Wednesday afternoon and evening. (noaa.gov)
  • Latest guidance consensus suggests that adequate buoyancy may develop across the warm sector over portions of the southern Plains to support isolated strong to potentially severe thunderstorms Wednesday afternoon and evening. (noaa.gov)
  • Given early day convection and expected height rises with the approaching upper ridge, overall confidence in an organized round of severe thunderstorms is low. (noaa.gov)
  • It is not out of the question that a couple of stronger thunderstorms could produce some hail/wind approaching severe limits. (noaa.gov)
  • Severe postoperative nutritional complications are believed to be rare, but few studies have described them. (ices.on.ca)
  • The term idiopathic neutropenia is used when severe chronic neutropenia occurs for unknown reasons. (rarediseases.org)
  • As earlier noted, the three main subdivisions of severe chronic neutropenia are congenital, autoimmune and idiopathic. (rarediseases.org)
  • Individuals with congenital forms of severe chronic neutropenia are especially susceptible to various bacterial infections that affect the skin, digestive (gastrointestinal) tract and respiratory system, with the source of bacteria usually from the patient's own skin and gut flora. (rarediseases.org)
  • According to the study, Asia faces an even greater dilemma due to their high stress indices combined with the total human and livestock population, reservoir capacity, electricity generation, and production of irrigated crops. (earth.com)
  • Our study revealed that osteoporosis placed a considerable burden on QoL for postmenopausal women with severe osteoporosis in Greece. (dovepress.com)
  • This study aimed to describe patient-reported health status and quality of life in postmenopausal women with severe osteoporosis in Greece, and to understand patient preferences for osteoporosis therapies. (dovepress.com)
  • 0.05) in="" each of="" the="" three study populations and="" at all doses, with the="" exception of="" the="" very lowest dose tested. (gsk.com)
  • About 1/800 to 1/1000 neonates are born with severe to profound hearing loss. (msdmanuals.com)
  • During childhood, another 2 to 3/1000 children acquire moderate to severe hearing loss. (msdmanuals.com)
  • Data regarding new events of severe liver disease and T2DM during follow-up were obtained by record-linkage of population-based registers. (bmj.com)
  • An association with severe liver disease was found for overweight (HR 1.49, 95% CI 1.35 to 1.64) and for obese men (HR 2.17, 95% CI 1.82 to 2.59). (bmj.com)
  • Postmenopausal women with self-reported severe osteoporosis, defined as having suffered at least one osteoporotic fracture and reporting a T-score of ≤− 2.5, were asked to evaluate their health status, osteoporosis management, and disease-related physical, emotional, and financial burden. (dovepress.com)
  • Postmenopausal women with self-reported severe osteoporosis evaluated their health status, osteoporosis management, and disease-related physical, emotional, and financial burden. (dovepress.com)
  • Gaucher disease is rare in the general population. (medlineplus.gov)
  • Combining data from genome-wide association studies (GWAS) conducted at different locations, using genotype imputation and fixed-effects meta-analysis, has been a powerful approach for dissecting complex disease genetics in populations of European ancestry. (ox.ac.uk)
  • Thus far, despite intense global research, no causal therapy has been established for this severe condition. (biomedcentral.com)
  • We included sive picture of community spread of severe acute all eligible persons in the household who consented. (cdc.gov)
  • The U.S. is once again in the midst of a severe weather stretch that will threaten communities across the country. (securitymagazine.com)
  • In light of the challenges underway and the weeks ahead, it's a good time for public safety, emergency management, and law enforcement officials to revisit severe weather plans. (securitymagazine.com)
  • The challenge, of course, is implementing severe weather solutions that work well for all people in any type of situation. (securitymagazine.com)
  • Once a severe weather event begins, public safety teams need to inform people about what's happening. (securitymagazine.com)
  • Probability of severe weather within 25 miles of a point. (noaa.gov)
  • The total population of GCC is 7.1 selected 51 wards by using probability proportion to million and 31% of the population resides in slums. (cdc.gov)
  • Hatched Area: 10% or greater probability of significant severe within 25 miles of a point. (noaa.gov)