AnatomyDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesDisciplines and OccupationsInformation ScienceHealth CareGeographicals
Glasgow Outcome ScaleGlasgow Coma ScaleBrain InjuriesDiffuse Axonal InjurySubarachnoid HemorrhageIntracranial AneurysmCerebral Hemorrhage, TraumaticPregnatrienesAneurysm, RupturedTreatment OutcomeCraniocerebral TraumaVasospasm, IntracranialCraniotomyNeurosurgical ProceduresBrain Injury, ChronicIntracranial PressureHead Injuries, ClosedNeuroendoscopyTrauma Severity IndicesInjury Severity ScoreEmbolization, TherapeuticOutcome Assessment (Health Care)Cerebral HemorrhageProspective StudiesRecovery of FunctionRetrospective StudiesPrognosisSeverity of Illness IndexDisability EvaluationCerebral AngiographyHematomaMeningitis, BacterialPredictive Value of TestsTomography, X-Ray ComputedFollow-Up StudiesTime FactorsScotlandComaDecompressive CraniectomyBrain IschemiaCohort StudiesBiological MarkersCerebral VentriclesBrainStroke
TraumaticMortalityNeurologic outcomesFavorable outcomesVegetativeObservational StudyAcuteSecondaryUnfavorableClinical outcomePrimaryAssess neurologicalDisability Rating ScaleHealth outcomesRecovery outcomesAssessmentReducing cerebral perfusioWorsePrognosisPediatricInjuriesCerebralComaGood outcomeScoreMethodsResuscitationIntraventricularDecompressive craniectomyConclusionsModerate to severeIncidenceNeurological outcomeBrain injurySurvivorsPoorOccurrence and outcomeImpairment1981StudyProspectivelySignificantlyRESULTSPneumoniaIllness
Traumatic20
  • citation needed] The Glasgow Outcome Scale Extended (GOSE) is an expanded version of the scale which helps to evaluate global disability and recovery after traumatic brain injuries. (wikipedia.org)
  • Goal-oriented management of traumatic brain injury (TBI) can save the lives and/or improve the long-term outcome of millions of affected patients worldwide. (nih.gov)
  • A strong association exists between hyperglycemia and outcome in pediatric traumatic brain injury (TBI). (frontiersin.org)
  • Hyperglycemia occurs frequently in the pediatric traumatic brain injury (TBI) population and the occurrence of elevated blood glucose values has been linked to increased mortality and worse neurological outcomes ( 3 - 6 ). (frontiersin.org)
  • The aim of this study was to compare acute outcome between men and women after sustaining a traumatic brain injury (TBI). (hindawi.com)
  • Previous reports of mortality and morbidity in pediatric severe traumatic brain injury (TBI) vary considerably, with few population-based studies. (lu.se)
  • Objective To evaluate the clinical outcomes and prognostic factors in surgically treated patients with severe brain injury (Glasgow Coma Scale [GCS] score ≤8) diagnosed with traumatic epidural hematoma (EDH). (koreamed.org)
  • The use of neuromuscular blocking agents to facilitate prehospital intubation does not impair outcome after traumatic brain injury. (bmj.com)
  • In patients with severe traumatic brain injury, does early prophylactic hypothermia improve long-term neurologic outcomes? (emdocs.net)
  • Outcome predictors of Glasgow Outcome Scale score in patients with severe traumatic brain injury. (bvsalud.org)
  • The company reported today the enrollment of the first patient in the second cohort of its global Phase IIb clinical trial to investigate the safety and tolerability of Oxycyte in patients with severe, non-penetrating traumatic brain injury. (seekingalpha.com)
  • Functional status of the patients will be measured by the Glasgow Outcome Scale - Extended (GOS-E), a validated tool that aids in assessing progress in patients with traumatic brain injury. (seekingalpha.com)
  • The clinical outcome was divided into the favorable group (patients who were in conservative treatment with a stable Glasgow Coma Scale [GCS] score and discharged following treatment) and the unfavorable group (patients who had a drop in GCS motor score of one or more, or expired or underwent surgical intervention) within 72 h following traumatic brain injury. (surgicalneurologyint.com)
  • Epileptic seizures/post-traumatic epilepsy (ES/PTE) are frequent in persons with brain injuries, particularly for patients with more severe injuries including ones that result in disorders of consciousness (DoC). (sciencegate.app)
  • Of the 3.5 million Americans who sustain a TBI every year, approximately 27,000 experience prolonged traumatic coma, the most severe form of TBI. (umich.edu)
  • 11. LeBlanc J, de Guise E, Gosselin N, Feyz M. Comparison of functional outcome following acute care in young, middle‑aged and elderly patients with traumatic brain injury. (ac.ir)
  • Outcome and surgical management for geriatric traumatic brain injury: Analysis of 888 cases registered in the Japan neurotrauma data bank. (ac.ir)
  • Hyperosmolar solutions are widely used to treat raised intracranial pressure following severe traumatic brain injury. (ox.ac.uk)
  • The Sugar or Salt Trial is a UK randomised, allocation concealed open label multicentre pragmatic trial designed to determine the clinical and cost-effectiveness of hypertonic saline compared with mannitol in the management of patients with severe traumatic brain injury. (ox.ac.uk)
  • This study recruited 606 patients with severe traumatic brain injury within 24 hours. (medscape.com)
Mortality19
  • 0.01), in-hospital mortality (9% vs. 24%, p = 0.035) and 6‑month mortality (13% vs. 28%, p = 0.031), as well as of unfavorable outcome (34% vs. 57%, p = 0.015) and observed vs. expected ratio for mortality (0.42 vs. 0.84) in the WNH (citicoline receivers) group. (nih.gov)
  • The primary outcome of interest was patient global outcome, as assessed by any of: mortality, modified Rankin Score, Glasgow Outcome Score, or any other functional or neuropsychiatric outcome. (springer.com)
  • Nine studies demonstrated prognostic value of the FOUR score in predicting mortality and functional outcomes. (springer.com)
  • Thirty-two studies demonstrated equivalency or superiority of the FOUR score compared to Glasgow Coma Score in prediction of mortality and functional outcomes. (springer.com)
  • These have revealed that IA thrombolysis results in significantly higher recanalization rates, 6 , 7 , 10 and that recanalization is independently associated with reduced mortality and better functional outcome. (ajnr.org)
  • Outcome measures included the length of stay (LOS), the Extended Glasgow Outcome Scale (GOSE), the functional independence measure instrument (FIM), discharge destination, and mortality rate. (hindawi.com)
  • In a prospective cohort of patients with moderate and severe TBI followed for a period of 3.5 years, mortality was 1.28 times higher in females than males, with the greatest difference being in deaths after discharge which was 2.14 times higher. (hindawi.com)
  • Hospital mortality was 39.6% for females and 32.5% for males and the rates of unfavorable outcome were 58.7% for females and 53.4% for males [ 8 ]. (hindawi.com)
  • In their work, females had a significantly higher mortality and poorer outcome compared with males but this difference was no longer significant when covariables (presence of multiple injuries, postresuscitation pupil abnormalities, and Glasgow Coma Score) were controlled for. (hindawi.com)
  • Mortality rates from 3-33 % and varying morbidity have been reported, most commonly using the Extended Glasgow Outcome Scale (eGOS). (lu.se)
  • EHS is the most severe form of heat-related illness, characterized by core body temperature of 104° F (40° C) or greater and significant neurological dysfunction, and carries high rates of morbidity and mortality. (mhaus.org)
  • This study aimed to assess the hospital incidence and mortality of HSE, and to evaluate the characteristics, management, the potential value of decompressive craniectomy and the outcome of patients with HSE admitted to intensive care units (ICUs). (biomedcentral.com)
  • Few data are available for the most severe cases of HSE, those admitted to intensive care units (ICUs), particularly as concerns their epidemiology, initial management, acute-phase mortality, and long-term outcome. (biomedcentral.com)
  • Patient stratification using the prehospital Glasgow Coma Score (GCS) was also used and outcomes included mortality, with good outcome taken as survival to discharge with a GCS of 14/15. (bmj.com)
  • Mortality from severe head injury (TBI g) in pediatric patients increases in direct proportion to the severity of the initial injury. (una.py)
  • Outcomes measured included in-hospital and post-discharge mortality. (mak.ac.ug)
  • Significant predictors of in-hospital mortality included admission Glasgow Coma Scale and Karnofsky Performance Scale (KPS), tachypnea, leukocytosis and thrombocytopenia. (mak.ac.ug)
  • Conceptually, CP has the highest chance of showing efficacy if used for early treatment of patients at the highest risk for severe disease and mortality. (umich.edu)
  • [ 7 , 9 ] Patients with severe head injury have a 30-50% mortality rate, and those who survive are often left with severe neurological deficits that may include a persistent vegetative state. (medscape.com)
Neurologic outcomes1
Favorable outcomes1
  • Complete recovery and partial disability were considered as favorable outcomes, whereas severe disability, vegetative state, and death were defined as unfavorable outcomes. (ac.ir)
Vegetative2
  • Outcome was good in 60%, moderate in 25%, unfavorable in 15%, with none in a vegetative status. (lu.se)
  • The primary endpoint was the outcome on the Glasgow Outcome Scale (GOS) between 1 and 4, which represents a vegetative state and severe disability. (medscape.com)
Observational Study2
  • This prospective observational study was done on moderate to severe head injury patients. (surgicalneurologyint.com)
  • We conducted a prospective observational study reporting the management and outcomes of severely septic patients in two Ugandan hospitals. (mak.ac.ug)
Acute9
  • The Glasgow Coma Scale (GCS) is the mainstay for rapid neurologic assessment in acute head injury. (medscape.com)
  • Low GCS score did not correlate with poor neurologic outcome in patients with acute basilar artery thrombosis managed with IA therapy. (ajnr.org)
  • A study comparing serum metabolite levels in adults with acute TBI with those of patients with acute orthopedic trauma but no acute or previous brain trauma showed that expression patterns of 43 metabolites significantly differed between TBI cases and controls, and that the differences were most pronounced among patients with severe TBI, said Jussi Posti, MD, PhD, a neurosurgeon at Turku University Hospital in Finland. (medscape.com)
  • The notion that high intracranial pressure (ICP) might be associated with a poor acute-phase outcome of severe cases of encephalitis arose from the historical series of Barnett et al. (biomedcentral.com)
  • COVID-19 is a respiratory illness caused by the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). (umich.edu)
  • In combination, these factors exacerbate poor health outcomes in populations disproportionately affected by social conditions beyond their control, including infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus that causes COVID-19. (cdc.gov)
  • This is the first edition of this document for novel coronavirus, an adaption of WHO Clinical management of severe acute respiratory infection when MERS-CoV infection is suspected publication (2019). (who.int)
  • This document is intended for clinicians taking care of hospitalised adult and paediatric patients with severe acute respiratory infection (SARI) when 2019-nCoV infection is suspected. (who.int)
  • a history of travel to or residence in the city of Wuhan, Hubei Province, China in the 14 days prior to symptom onset, or · patient is a health care worker who has been working in an environment where severe acute respiratory infections of unknown etiology are being cared for. (who.int)
Secondary5
  • Secondary brain injury persists for weeks and may contribute to a further loss of potentially viable cerebral tissue, ultimately worsening neurological outcome ( 1 ). (frontiersin.org)
  • Study outcomes measures were healing time and secondary outcome measures were complications of surgery RESULTS: One hundred and thirty-three patients (median age 44 and M:F ratio 2.8:1) with 206 fistulae were accrued. (scielo.org.za)
  • Is optic nerve sheath diameter a promising screening tool to predict neurological outcomes and the need for secondary decompressive craniectomy in moderate to severe head injury patients? (surgicalneurologyint.com)
  • Other secondary outcomes include functional, cognitive and behavioral assessments at 6 months, safety, survival to discharge, shortened time to follow commands, and reduction of total brain hypoxia exposure. (umich.edu)
  • The primary outcome was mechanical ventilation-free days and secondary outcomes were in -hospital outcomes. (wright.edu)
Unfavorable4
  • Knowledge regarding the diagnostic accuracy of ONSD for predicting unfavorable outcomes within 72 hours (h) of moderate and severe head injury is limited. (surgicalneurologyint.com)
  • Unfavorable outcomes were observed only in 20.4% of the patients. (ac.ir)
  • Moreover, intraventricular hemorrhage was significantly associated with the highest prevalence of unfavorable outcome followed by intracranial hemorrhage. (ac.ir)
  • Moderate and severe head injuries in patients had unfavorable clinical outcome. (ac.ir)
Clinical outcome2
  • clinical outcome was measured by 90-day mRS. (ajnr.org)
  • Adverse medical events were recorded and clinical outcome was assessed by the Glasgow outcome scale throughout a 6-month follow-up period. (erowid.org)
Primary2
  • The Glasgow Outcome Scale-Extended (GOS-E) measured at 6 months post injury will be the primary outcome. (umich.edu)
  • The primary outcome for the study will be the Extended Glasgow Outcome Scale assessed at six months after randomisation. (ox.ac.uk)
Assess neurological2
  • Traditionally, the Glasgow Coma Scale (GCS) has been widely adopted to document and formally assess neurological status. (springer.com)
  • ONSD is an efficient screening tool to assess neurological outcomes in severe head injury patients. (surgicalneurologyint.com)
Disability Rating Scale1
Health outcomes1
  • PTSD symptoms often compound with pre-existing issues further deteriorating health outcomes for these patients. (preprints.org)
Recovery outcomes5
  • Here, our aim was to determine if glial fibrillary acidic protein (GFAP) and neurofilament light (NfL) measured 1-year postinjury in EVs could distinguish patients from controls, and whether these biomarkers relate to TBI severity or recovery outcomes. (quanterix.com)
  • These findings suggest that blood-derived EV concentrations of GFAP and NfL drawn even 1 year after injury are higher in TBI patients compared to controls, and are related to injury severity and poor recovery outcomes, suggesting that TBIs alter the activity of these biomarkers, likely contributing to individual variability in recovery. (quanterix.com)
  • It is unknown why patients with similar extent of injury, similar care, and similar demographic factors have different recovery outcomes. (pitt.edu)
  • This project aims to detect CpGs whose methylation levels associate with TBI patients' recovery outcomes in human subjects. (pitt.edu)
  • Result: No significant associations between CpG methylation and recovery outcomes were observed at the genome-wide threshold for statistical significance (2.4 x 10-7). (pitt.edu)
Assessment9
  • The Glasgow Outcome Score applies to patients with brain damage allowing the objective assessment of their recovery in five categories. (wikipedia.org)
  • Its theoretical benefit over preexisting scores is its evaluation of brainstem reflexes and respiratory pattern which may allow better assessment of patients with severe neurologic impairment. (springer.com)
  • Clinical assessment of neurological status is a vital element in decision making, outcome prediction, and information sharing among medical professionals. (springer.com)
  • The use of a validated and well-known instrument to evaluate neurological functioning, such as the Glasgow Coma Scale, provides a reliable assessment of CNS impairment and its progression over time. (mhaus.org)
  • This audit aimed to report the assessment and management of these fistulae to benchmark the outcomes from these approaches at a South African tertiary colorectal unit METHODS: Retrospective analysis of prospectively collected data of patients with anorectal fistulae over a 13-year period at a tertiary referral centre. (scielo.org.za)
  • The Clinical Trial of COVID-19 Convalescent Plasma in Outpatients (C3PO) is a multi-center randomized, single blind, two arm, placebo controlled phase III trial with blinded outcome assessment to establish the safety and efficacy of a single dose of convalescent plasma (CP) for preventing the progression from mild to severe COVID-19 illness. (umich.edu)
  • Between April 2014 and May 2016, 500 TBI and 100 control subjects were enrolled and 376 TBI and 78 control subjects completed outcome assessment. (johnshopkins.edu)
  • Severe head injury in the elderly: risk factor assessment and outcome analysis in a series of 100 consecutive patients at a Level 1 trauma centre. (ac.ir)
  • All clinical assessment of post operative wound was made using Southampton Wound Assessment Scale, where erythema is a grade 1C, all subjects healed primarily. (ejournals.ca)
Reducing cerebral perfusio1
  • The Lund concept is a treatment algorithm for severe TBI aiming at controlling intracranial pressure (ICP) by reducing cerebral perfusion pressure (CPP). (lu.se)
Worse2
  • worse clinical outcomes: and concomitant testing for mycobacterial, fungal, or other viral infections. (cdc.gov)
  • [ 10 ] Penetrating intracranial injuries have worse outcomes than closed head injuries. (medscape.com)
Prognosis2
Pediatric3
  • A retrospective analysis was performed on pediatric severe TBI patients admitted to Addenbrookes Hospital Paediatric Intensive Care Unit (PICU) between January 2001 and December 2013. (frontiersin.org)
  • Increases in systemic glucose are associated with impaired cerebrovasular autoregulation after severe pediatric TBI. (frontiersin.org)
  • All cases of severe pediatric TBI (age <18 years) in the southern region of Sweden during 19 years were identified. (lu.se)
Injuries11
  • The Glasgow Outcome Score (GOS) is a scale of patients with brain injuries, such as cerebral traumas that groups victims by the objective degree of recovery. (wikipedia.org)
  • Patients sustaining a head injury from an assault or from being struck with a falling object have a markedly greater likelihood of poorer vocational outcomes than patients sustaining the more common acceleration/deceleration injuries, presumably because the former injury types entail greater axonal damage. (medscape.com)
  • The presence of prior head injuries, particularly prior concussive episodes in sports, can indicate the potential for more severe long-term outcomes. (medscape.com)
  • Patients with less severe injuries may have no gross structural damage. (msdmanuals.com)
  • The intubation rates were 17% for the mild head injuries, 58% for moderate head injuries, and 95% for severe cases. (bmj.com)
  • This neurotrauma center treats approximately 200 severe brain injuries annually. (seekingalpha.com)
  • What's more, the lifetime costs arising from these severe, permanent injuries can be exorbitant. (preszlerlaw.com)
  • According to the SABs, catastrophically impaired accident survivors - including injured drivers, passengers, cyclists, pedestrians, and motorcyclists - should be entitled to higher amounts of accident benefits than people with less severe injuries. (preszlerlaw.com)
  • This is because of the ongoing, expensive costs associated with severe, permanent injuries. (preszlerlaw.com)
  • The rise in public awareness regarding brain injuries and their outcomes now prompts many in Ocean County to panic upon receiving news that someone they love has suffered one. (sfhlaw.com)
  • Yet not all brain injuries produce devastating outcomes. (sfhlaw.com)
Cerebral1
  • Seizures were less common in patients with more severe anoxic injury, particularly in those with injury to the lateral temporal white matter.Discussion:Anoxic brain injury was most prevalent in posterior cerebral regions, and this regional pattern of injury was a better predictor of disorders of consciousness than whole-brain injury measures. (sciencegate.app)
Coma8
  • Controlling for age, admission Glasgow Coma Scale score, penetrating as compared to blunt injury, and presence of multiple trauma, females were 1.75 times more likely to die of their brain injury than males. (hindawi.com)
  • The study was primarily designed to assess the change in the level of neurological impairment in subjects suffering from the symptoms of EHS, from baseline to 90 minutes post-randomization, using the Glasgow Coma Scale ("GCS"), a validated and widely used tool among clinicians. (mhaus.org)
  • Sixty-seven patients, aged 16-65 yrs, Glasgow Coma Scale score of 4-8, injured within 6 hrs of treatment. (erowid.org)
  • Statistical analysis of these differences by a logistic model using dose, entry Glasgow coma scale score, and computed tomograph as covariates yielded p values for the effect of treatment of .03 and .14 at 3 and 6 months, respectively. (erowid.org)
  • One hundred and seventeen patients with a Glasgow Coma Scale score ≤ 8 were included in the study. (biomedcentral.com)
  • The mean Glasgow Coma Scale of patients equaled 13.42 ± 3.29. (ac.ir)
  • Glasgow Coma Scale ≤ 12). (wright.edu)
  • This test is known as the Glasgow Coma Scale. (sfhlaw.com)
Good outcome4
  • ARDS due to scrub typhus appeared to be mild with good outcome. (rcpe.ac.uk)
  • Patients intubated with the use of NMBAs were significantly more likely to survive and have a good outcome, when adjusted for confounding variables. (bmj.com)
  • 3 patients recorded as having absent SEP who went on to have a good outcome. (thebottomline.org.uk)
  • Patients undergoing prolonged CPR can survive with good outcome. (hindawi.com)
Score4
  • Our goal was to perform a scoping systematic review on the available literature for FOUR score and outcome prediction in critically ill patients. (springer.com)
  • The FOUR score has been shown to be a useful outcome predictor in many patients with depressed level of consciousness. (springer.com)
  • The investigators also created a statistical model to see whether serum metabolites could predict patient outcomes, determined by a Glasgow Outcomes Scale (extended) score of 4 (upper severe disability) vs greater than 4. (medscape.com)
  • A trauma registry was used to identify patients who had a head Abbreviated Injury Scale score of 3 or more, and the records were matched with prehospital databases. (bmj.com)
Methods2
  • Methods From January 2018 to June 2021, 1,122 patients with severe TBI were. (koreamed.org)
  • Methods: We obtained DNA methylation profiles of cerebrospinal fluid samples collected at three different time points, first or second day, third or fourth day, and fifth or sixth day post-TBI from 120 severe TBI patients. (pitt.edu)
Resuscitation2
  • And to be more explicit, some advocate for Do Not Attempt Resuscitation since outcomes are by no means guaranteed for a survival after the initial resuscitation. (pallimed.org)
  • In this paper we describe a case of prolonged resuscitation with successful outcome. (hindawi.com)
Intraventricular1
  • In several institutions, intraventricular catheter (IVC) placement and decompressive craniectomy (DC) have been included in the treatment protocols of the patients with severe head injury besides the conventional therapies including normoventilation, normothermia, sedation-analgesia and osmotic diuresis. (biomedcentral.com)
Decompressive craniectomy1
Conclusions2
  • CONCLUSIONS: Dexanabinol was safe and well tolerated in severe head injury. (erowid.org)
  • CONCLUSIONS: Severe patients with CNSI can be efficiently and effectively treated in an ICU specialized in infectious diseases when compared to mixed medical/surgical and neurological ICUs from the public health system. (cdc.gov)
Moderate to severe2
  • In the monocentric cohort, 87 % of the patients were still alive after one year but half of them had moderate to severe disability. (biomedcentral.com)
  • The objective of this study was to measure ONSD measurements at 24-h intervals in moderate to severe head injury patients and to find its association with clinical outcomes in the target population. (surgicalneurologyint.com)
Incidence2
  • A total of 135 cases of severe TBI <18 years of age were recorded (incidence 2.0/100000) and 86 patients were admitted to the tertiary NICU. (lu.se)
  • Compared to trauma/healthy controls, the HIBRID group had a higher incidence of moderate/severe depressive symptoms and a similar incidence of moderate/severe PCS. (johnshopkins.edu)
Neurological outcome2
  • The objective was to determine the survival rate, the neurological outcome, and the characteristics of the survivors. (hindawi.com)
  • Our goal was to determine the success rate and neurological outcome of these patients and to define the characteristics of patients who might benefit from such heroic measures. (hindawi.com)
Brain injury1
  • Preclinical and clinical investigations (discussed below) strongly indicate that HBO2 is physiologically active in reducing brain injury and improving outcomes in severe TBI. (umich.edu)
Survivors1
  • Tremors and dystonia recede with time, but these still can affect as many as 12% of survivors of severe head injury 2 years after the initial trauma. (medscape.com)
Poor11
  • Abnormal postresuscitation pupillary reactivity correlates with a poor 1-year outcome. (medscape.com)
  • We hypothesize that low GCS does not correlate with poor outcome and that it should not preclude IA therapy. (ajnr.org)
  • Furthermore, females were 1.57 times more likely to experience poor outcomes than males [ 5 ]. (hindawi.com)
  • 15 were associated with poor outcome, supporting current guidelines. (lu.se)
  • In patients treated with therapeutic hypothermia following cardiac arrest, can clinical examination, neuronspecific enolase (NSE), and median nerve somatosensory-evoked potentials (SEPs) predict poor outcome? (thebottomline.org.uk)
  • As the authors state this can lead to a self-fulfilling prophecy as treatment is withdrawn on the basis of this test, and the withdrawal of treatment itself can lead to a poor outcome. (thebottomline.org.uk)
  • In patients treated with therapeutic hypothermia following cardiac arrest the use of clinical examination at 72 hours, neuronspecific enolase and somatosensory-evoked potentials can help predict a poor outcome. (thebottomline.org.uk)
  • Background and Objectives:Disorders of consciousness, EEG background suppression and epileptic seizures are associated with poor outcome after cardiac arrest. (sciencegate.app)
  • Clinical studies demonstrate that brain tissue hypoxia is common, that there is a strong relationship between low PbtO2 and poor outcome, and that timely interventions can reverse brain tissue hypoxia. (umich.edu)
  • After 6 months, the percentage of patients with a poor outcome was 44% in the active treatment group and 45% in the placebo group. (medscape.com)
  • This trial had to be terminated prematurely when it turned out that there was a 50% higher risk for a poor outcome in patients receiving hypothermia. (medscape.com)
Occurrence and outcome1
  • 8 In our region there exists a lacunae in knowledge on the frequency of occurrence and outcome. (rcpe.ac.uk)
Impairment1
  • However, a shortcoming of the GCS is its inaccuracy in certain patient populations, including those with severe neurological impairment. (springer.com)
19811
Study6
  • In this study we prospectively studied the aetiology of ARDS and its short-term outcome. (rcpe.ac.uk)
  • Informed consent before enrolling in to the study was obtained from all study participants or from the next of kin if the patient was unable to give consent because of severe illness. (rcpe.ac.uk)
  • The least severe and most common type of TBI is termed a concussion, which is technically defined as a brief loss of consciousness after a head injury without any physical evidence of damage on an imaging study such as a CT or MRI scan. (encyclopedia.com)
  • Here, we have performed a prospective nationwide genetic association study using the Human Exome BeadChip and identified gene variants in encoding dynactin 4 ( DCTN4 ), retinoic acid early transcript 1E ( RAET1E ), and V-akt murine thymoma viral oncogene homolog 3 ( AKT3 ) to be associated with unfavourable outcome in patients with pneumococcal meningitis. (biomedcentral.com)
  • Here, we report our genome wide association study on the host side, analysing the associations between human genome variants and functional outcome in patients with pneumococcal meningitis using the Human Exome BeadChip. (biomedcentral.com)
  • This study aimed to identify the outcomes of head trauma due to road traffic accidents (RTAs) in elderly patients. (ac.ir)
Prospectively2
  • The duration of mechanical ventilation, the ICU stay, surgical procedures, computerised tomography results, and Glasgow Outcome Scores were prospectively recorded. (biomedcentral.com)
  • Such studies should be performed prospectively, using a clear definition of cases with microbiological confirmation, and validated outcome scales [ 18 ]. (biomedcentral.com)
Significantly1
  • Both initial and worst GCS postresuscitation scores have correlated significantly with 1-year outcomes following severe head injury. (medscape.com)
RESULTS3
  • which results in severe brain dysfunction. (msdmanuals.com)
  • Methodology/Results: Three-hundred eighty-two patients fulfilled enrollment criteria for a severe sepsis syndrome. (mak.ac.ug)
  • Thus, our results show that AKT3 influences outcome of pneumococcal meningitis. (biomedcentral.com)
Pneumonia1
  • the latter includes severe pneumonia, ARDS, sepsis and septic shock. (who.int)
Illness2
  • The majority (80%) of cases are categorized as mild, while approximately 15-20% of cases are categorized as severe, with about 5% of all cases progressing into critical illness, characterized by hypoxemic respiratory failure, shock, and end-organ failure. (umich.edu)
  • The overarching goal of this trial is to confirm or refute the role of passive immunization as a safe and efficacious therapy in preventing the progression from mild to severe/critical COVID-19 illness and to understand the immunologic kinetics of anti-SARS-CoV-2 antibodies after passive immunization. (umich.edu)