AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPsychiatry and PsychologyPhenomena and ProcessesDisciplines and OccupationsInformation ScienceHealth Care
Erectile DysfunctionVentricular Dysfunction, LeftVentricular DysfunctionSexual Dysfunction, PhysiologicalSexual Dysfunctions, PsychologicalEndothelium, VascularVentricular Dysfunction, RightDisease Models, AnimalOxidative StressPrimary Graft DysfunctionPenile ErectionVasodilationDiastoleAutonomic Nervous System DiseasesMitochondriaTime FactorsMyocardiumHeart FailureMyocardial ContractionEchocardiographyMultiple Organ FailureCardiomyopathiesVasodilator AgentsImpotence, VasculogenicMitochondrial DiseasesMice, Inbred C57BLNitric OxideCognition DisordersSystoleBiological MarkersVentricular Function, LeftPenisStroke VolumeReactive Oxygen SpeciesHeartRats, Sprague-DawleyHeart Failure, DiastolicNitric Oxide Synthase Type IIIKidney DiseasesHemodynamicsTreatment OutcomeSeverity of Illness IndexRisk FactorsBlood PressureProspective StudiesVascular DiseasesMice, KnockoutVentricular RemodelingAcetylcholineEchocardiography, DopplerCase-Control StudiesAgingMice, TransgenicAnalysis of VarianceBrainRats, WistarMyocytes, CardiacCells, CulturedSulfonesSphincter of Oddi DysfunctionNeuropsychological TestsHeart DiseasesEndothelial CellsMicrocirculationFollow-Up StudiesHypertensionChronic DiseaseKidneyDose-Response Relationship, DrugSignal TransductionBrachial ArteryNatriuretic Peptide, BrainMagnetic Resonance ImagingDiabetes Mellitus, ExperimentalSepsisSuperoxidesPhosphodiesterase 5 InhibitorsNitroprussideApoptosisCoronary CirculationInflammationRetrospective StudiesHeart VentriclesHeart RateRenal InsufficiencyPredictive Value of TestsMembrane Potential, MitochondrialNitric Oxide SynthaseFibrosisAntioxidantsDiabetes Mellitus, Type 2CreatinineThyroid DiseasesCardiomyopathy, DilatedMyocardial IschemiaPurinesPosterior Tibial Tendon DysfunctionElectrocardiographyHypertrophy, Left VentricularMyocardial Infarction
Erectile dysfunctionHepatic DysfunctionLeft ventricular dysfunctionSexual dysfunctionTemporomandibular joint dysfuNeuronal dysfunctionMultiorgan dysfunctionOrganSepsisSyndromeMyocardialEndothelialBladder dysfunctionRespiratory dysfunctionCutaneous Adverse ReactionsAbdominal PainPatientsInfectionDiabetesRenalAbnormalComplicationsMildPotentiallyContinuumRashStenosisSymptoms are severeCommonCause severeEncephalopathyStagesExploreSecondarySurgery
Erectile dysfunction28
Hepatic Dysfunction4
  • History of cholestatic jaundice/hepatic dysfunction associated with amoxicillin and clavulanate potassium. (nih.gov)
  • Hepatic dysfunction and cholestatic jaundice: Discontinue if signs/symptoms of hepatitis occur. (nih.gov)
  • Loss of insulin signaling in hepatocytes leads to severe insulin resistance and progressive hepatic dysfunction. (nature.com)
  • Renal or hepatic dysfunction. (renalandurologynews.com)
Left ventricular dysfunction2
  • Background: In rheumatic severe mitral regurgitation, earlier detection of left ventricular dysfunction is very necessary in order to refer the patients for surgery at appropriate time. (edu.pk)
  • This study tried to find a correlation between conventional parameters of left ventricular dysfunction with systolic strain rate. (edu.pk)
Sexual dysfunction3
  • If the conditions are not treated promptly, they could progressively become worse by causing sexual dysfunction and urinary tract infections. (gousseurology.com)
  • Overview of Sexual Function and Dysfunction in Men In men, sexual dysfunction refers to difficulties engaging in sexual intercourse. (msdmanuals.com)
  • Sexual dysfunction encompasses a variety of disorders that affect Sex drive (libido) The ability to achieve. (msdmanuals.com)
Temporomandibular joint dysfu3
  • Temporomandibular joint dysfunction (TMD, TMJD) is an umbrella term covering pain and dysfunction of the muscles of mastication (the muscles that move the jaw) and the temporomandibular joints (the joints which connect the mandible to the skull). (wikipedia.org)
  • In this article, the term temporomandibular disorder is taken to mean any disorder that affects the temporomandibular joint, and temporomandibular joint dysfunction (here also abbreviated to TMD) is taken to mean symptomatic (e.g. pain, limitation of movement, clicking) dysfunction of the temporomandibular joint. (wikipedia.org)
  • Sometimes, "temporomandibular joint dysfunction" is described as the most common form of temporomandibular disorder, whereas many other sources use the term temporomandibular disorder synonymously, or instead of the term temporomandibular joint dysfunction. (wikipedia.org)
Neuronal dysfunction5
  • Severe spinal cord injury in humans leads to a progressive neuronal dysfunction in the chronic stage of the injury. (nih.gov)
  • Here, we hypothesize that undirected compensatory plasticity within neural systems caudal to a severe spinal cord injury contributes to the development of neuronal dysfunction in the chronic stage of the injury. (nih.gov)
  • In the chronic stage of the injury, rats exhibited significant neuronal dysfunction, which was characterized by co-activation of antagonistic muscles, exhaustion of locomotor muscle activity, and deterioration of electrochemically-enabled gait patterns. (nih.gov)
  • As observed in humans, neuronal dysfunction was associated with the emergence of abnormal, long-latency reflex responses in leg muscles. (nih.gov)
  • Syndromic analysis uncovered significant correlations between the development of neuronal dysfunction, emergence of abnormal reflexes, and anatomical remodelling of lumbosacral circuitries. (nih.gov)
Multiorgan dysfunction1
Organ11
  • Alteration in organ function can vary widely from a mild degree of organ dysfunction to completely irreversible organ failure. (medscape.com)
  • The degree of organ dysfunction has a major clinical impact. (medscape.com)
  • MODS is defined as a clinical syndrome characterized by the development of progressive and potentially reversible physiologic dysfunction in 2 or more organs or organ systems that is induced by a variety of acute insults, including sepsis. (medscape.com)
  • The clinical process usually begins with infection, which potentially leads to sepsis and organ dysfunction. (medscape.com)
  • [ 4 ] The task force concluded that sepsis should be defined as life-threatening organ dysfunction caused by a dysregulated host response to infection. (medscape.com)
  • Organ dysfunction scores, based on physiological parameters, have been created to describe organ failure. (springer.com)
  • In a general pediatric intensive care unit (PICU) population, the PEdiatric Logistic Organ Dysfunction-2 score (PELOD-2) score had both a good discrimination and calibration, allowing to describe the clinical outcome of critically ill children throughout their stay. (springer.com)
  • MODS scores can be used to assess the presence and severity of organ dysfunction on admission and throughout the stay [ 9 ]. (springer.com)
  • However, some authors have voiced their concern regarding using organ dysfunction scores in specific subpopulations [ 9 ]. (springer.com)
  • The second stage is identified when there is noticeable organ dysfunction. (selfgrowth.com)
  • Organ dysfunction can include any system of the body. (selfgrowth.com)
Sepsis5
  • Sepsis is a clinical syndrome that complicates severe infection and is characterized by systemic inflammation and widespread tissue injury. (medscape.com)
  • Sepsis is divided into three stages: sepsis, severe sepsis and septic shock. (selfgrowth.com)
  • It is identified when there is severe hypotension, sepsis and despite resuscitation of fluid. (selfgrowth.com)
  • The septic shock has severe symptoms that include pale extremities due to perfusion abnormality, postural (standing) hypotension, palpitations, restlessness, presence of oliguria or anuria and other symptoms similar to severe sepsis or second stage of sepsis. (selfgrowth.com)
  • Myocardial dysfunction is a common complication in patients with severe sepsis, and early recognition and aggressive supportive therapy are mandatory as mortality in patients with septic shock is still high. (hindawi.com)
Syndrome5
  • Liver impairment is another emerging concern with COVID-19, as it was with the similar novel coronavirus, severe acute respiratory syndrome (SARS). (medscape.com)
  • For example, in the United Kingdom, the term pain dysfunction syndrome is in common use. (wikipedia.org)
  • What signs should parents look for if they suspect their children might have severe sensory dysfunction or Asperger's Syndrome? (childrensdisabilities.info)
  • The widespread prevalence of the new coronavirus disease (COVID-19) and associated virus severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has led to some reported cases of IFP. (medscape.com)
  • An 8-year-old boy with Morquio syndrome and severe kyphoscoliosis. (medscape.com)
Myocardial4
  • Myocardial steatosis and left ventricular contractile dysfunction in patients with severe aortic stenosis. (ox.ac.uk)
  • METHODS AND RESULTS: Thirty-nine patients with severe AS (symptomatic=25, asymptomatic=14) with normal LV ejection fraction and no significant coronary artery disease and 20 age- and sex-matched healthy controls underwent cardiac 1H-magnetic resonance spectroscopy and imaging for the determination of steatosis (myocardial triglyceride content) and cardiac function, including circumferential strain (measured by magnetic resonance tagging). (ox.ac.uk)
  • CONCLUSIONS: Pronounced myocardial steatosis is present in severe AS, regardless of symptoms, and is independently associated with the degree of LV strain impairment. (ox.ac.uk)
  • Our findings suggest a novel pathophysiological mechanism in AS, myocardial steatosis, which may be amenable to treatment, thus potentially delaying onset of LV dysfunction. (ox.ac.uk)
Endothelial3
  • 70%. Severe cases exhibit abnormal coagulation, endothelial barrier disruption, and dysfunctional platelet aggregation but the underlying mechanisms remain poorly understood. (cdc.gov)
  • The impaired homeostasis and platelet dysfunction implicate alterations in the protein C pathway, which might contribute to the loss of endothelial barrier function in fatal infections. (cdc.gov)
  • This review will examine and summarise existing data on how immune and inflammatory processes interplay with the pathogenesis of COVID-19, with a particular focus on the impacts that diabetes, endothelial dysfunction and the expression dynamics of ACE2 have on the disease severity. (uhi.ac.uk)
Bladder dysfunction4
  • Severe bladder dysfunction can develop in someone with neurogenic bladder issues or urethral trauma. (gousseurology.com)
  • Severe bladder dysfunction requires the urinary tract to undergo repair in order for these issues to be resolved. (gousseurology.com)
  • Severe bladder dysfunction is called "severe" for a reason. (gousseurology.com)
  • Treatment of sphincter disturbances to prevent urinary tract infection secondary to bladder dysfunction. (nih.gov)
Respiratory dysfunction1
  • These findings may shed new light on neuromuscular respiratory dysfunction as a contributor to prolonged functional impairments after hospitalization for post-COVID-19. (elsevierpure.com)
Cutaneous Adverse Reactions1
  • Severe Cutaneous Adverse Reactions (SCAR): Monitor closely. (nih.gov)
Abdominal Pain1
  • The back-up of juices causes episodes of severe abdominal pain. (iffgd.org)
Patients11
  • Consequently, patients often are not admitted for LF treatment until symptoms are severe and they have failed other therapies. (cdc.gov)
  • Clinicians should be aware of the potential for severe complications of novel influenza A (H1N1) virus infection, particularly in extremely obese patients. (cdc.gov)
  • The surgical intensive care unit (SICU) at the University of Michigan Health System (UMHS) specializes in the evaluation of adult patients with severe ARDS for advanced mechanical ventilation and possible extracorporeal membrane oxygenation (ECMO). (cdc.gov)
  • All 10 patients were referred to the SICU because of severe hypoxemia, ARDS, and an inability to achieve adequate oxygenation with conventional ventilation modalities. (cdc.gov)
  • Five patients received intravenous corticosteroids during their SICU hospitalization: four for treatment of severe vasopressor-dependent refractory septic shock, and one for continuation of therapy for chronic pulmonary disease. (cdc.gov)
  • Chest radiograph findings in all 10 patients were abnormal, with bilateral infiltrates consistent with severe multilobar pneumonia or ARDS. (cdc.gov)
  • Why Is COVID-19 More Severe in Patients With Diabetes? (uhi.ac.uk)
  • Patients with diabetes have chronic, low-level systemic inflammation, which results in global cellular dysfunction underlying the wide variety of symptoms associated with the disease, including an increased risk of respiratory infection. (uhi.ac.uk)
  • Dive into the research topics of 'Why Is COVID-19 More Severe in Patients With Diabetes? (uhi.ac.uk)
  • One hundred and ninety-two patients of severe rheumatic MR and fifty-eight healthy controls were included. (edu.pk)
  • Nevirapine should not be used in patients with severe hepatic impairment (Child-Pugh C, see section 4.3). (who.int)
Infection4
  • Many survivors from severe coronavirus disease 2019 (COVID-19) suffer from persistent dyspnea and fatigue long after resolution of the active infection. (elsevierpure.com)
  • Until now, it was unclear to what extent Natural killer cells contribute to the development of severe COVID-19 infection. (limes-institut-bonn.de)
  • Since severe COVID-19 infection is usually accompanied by tissue remodeling in the lung (pulmonary fibrosis) and NK cells are known for their antifibrotic properties, this aspect was also investigated. (limes-institut-bonn.de)
  • Three weeks after infection, molecular patterns resembling those observed in other immune cells in the context of fibrosis formation were evident in NK cells in severe courses. (limes-institut-bonn.de)
Diabetes5
  • Individuals at high risk for severe COVID-19 are typically of older age and/or present with comorbid conditions such as diabetes, cardiovascular disease, and hypertension . (medscape.com)
  • Meta-analyses have indicated that individuals with type 1 or type 2 diabetes are at increased risk of suffering a severe form of COVID-19 and have a higher mortality rate than the non-diabetic population. (uhi.ac.uk)
  • Diabetes and Parkinson's disease are two examples of chronic conditions that can lead to autonomic dysfunction. (healthline.com)
  • Injury to nerves from conditions like diabetes and Parkinson's disease can cause episodes of orthostatic hypotension due to autonomic dysfunction. (healthline.com)
  • Often several factors contribute to ED. For example, a man with a slight decrease in erectile function caused by diabetes or peripheral vascular disease can develop severe ED after starting a new drug or if stress increases. (msdmanuals.com)
Renal1
  • Classically, chronic cadmium exposure is associated with progressive renal tubular dysfunction. (cdc.gov)
Abnormal1
  • This dysfunction is characterized by premature exhaustion of muscle activity during assisted locomotion, which is associated with the emergence of abnormal reflex responses. (nih.gov)
Complications2
  • Sphincterotomy also carries a small risk of other severe complications such as bleeding and perforation, and the possibility of delayed narrowing of a duct (stenosis) due to scarring. (iffgd.org)
  • Influenza vaccination is the primary method for preventing influenza and its severe complications. (cdc.gov)
Mild2
  • Autonomic dysfunction can range from mild to life-threatening. (healthline.com)
  • You can experience any or all of these symptoms depending on the cause, and the effects may be mild to severe. (healthline.com)
Potentially1
  • Severe poisoning is potentially fatal if treatment is inadequate or delayed. (cdc.gov)
Continuum1
  • While the above checklist provides a starting point, we conceptualize sensory integration and its dysfunction is on a continuum Sensory processing is complex because it is not an all or nothing thing. (childrensdisabilities.info)
Rash1
  • Nevirapine must not be given if it has previously caused severe rash, rash accompanied by constitutional symptoms, hypersensitivity reactions, or clinical hepatitis. (who.int)
Stenosis1
  • BACKGROUND: Aortic stenosis (AS) leads to left ventricular (LV) hypertrophy and dysfunction. (ox.ac.uk)
Symptoms are severe1
  • When symptoms are severe, standard treatment is to perform an endoscopic procedure called ERCP (endoscopic retrograde cholangiopancreatography) . (iffgd.org)
Common5
  • Common peroneal nerve dysfunction is due to damage to the peroneal nerve leading to loss of movement or sensation in the foot and leg. (medlineplus.gov)
  • This condition is also called common fibular nerve dysfunction. (medlineplus.gov)
  • Common peroneal nerve dysfunction is a type of peripheral neuropathy (nerve damage outside the brain or spinal cord). (medlineplus.gov)
  • Bleeding at mucous membranes and edema generally are seen in the most severe cases ( 3 , 4 ), but bleeding diathesis reportedly was common during a recent outbreak in Nigeria ( 4 ). (cdc.gov)
  • Kidney abnormalities were more common and more severe in the cadmium workers than in the hospital workers. (cdc.gov)
Cause severe1
  • Retinal ischemia/reperfusion (I/R) injury can cause severe vision impairment. (mdpi.com)
Encephalopathy1
  • Arg82*) in COX16 with hypertrophic cardiomyopathy, encephalopathy and severe fatal lactic acidosis, and isolated complex IV deficiency. (amsterdamumc.org)
Stages1
  • Dysfunctions associated with sleep, sleep stages, or partial arousals (parasomnias). (cancer.gov)
Explore1
  • If your pain is severe, a pain specialist can help you explore all options for pain relief. (medlineplus.gov)
Secondary1
  • Most individuals with severe relapsing-remitting MS may go on to develop secondary progressive MS if they are untreated. (nih.gov)
Surgery1
  • However, a few weeks after the most recent surgery, he experienced sudden severe back pain. (hdc.org.nz)