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  • allogeneic
  • Severe aplastic anemia (SAA) is a life-threatening blood disease that can be successfully treated with immunosuppressive drug regimens or allogeneic stem cell transplantation. (aamds.org)
  • Indications for microtransplantation are as follows: Hematologic Malignancies Tumors Acute myeloid leukemia (AML) chronic-phase chronic myeloid leukemia (CP-CML) Myelodysplastic syndromes (MDS) Intermediate- or high-risk Non-Hodgkin lymphoma High-risk Hodgkin lymphoma Multiplemyeloma (MM) Severe aplastic anemia (SAA) The cells employed are allogeneic peripheral blood stem cells. (wikipedia.org)
  • To overcome the intolerable severe reactions of high-dose chemotherapy and GVHD, as well as the challenge to find HLA-matched donors for conventional hematopoietic stem cell transplantation, Dr Huisheng Ai, Guo Mei, etc. developed a new regimen of reduced-intensity chemotherapy plus G-CSF mobilized HLA-mismatched allogeneic peripheral blood stem cell infusion, which was firstly employed for a 75-year-old patient in 2002 and later named as Microtransplantation. (wikipedia.org)
  • Anti-Thymocyt
  • First line treatment for aplastic anemia consists of immunosuppressive drugs, typically either anti-lymphocyte globulin or anti-thymocyte globulin, combined with corticosteroids and ciclosporin. (wikipedia.org)
  • ionizing radiation
  • Other considerations include: aplastic anemia associated with pregnancy, ionizing radiation, histiocytic disorders (hemophagocytic lymphohistiocytosis), osteopetrosis, storage diseases, Pearson syndrome (mitochrondial deletions), rheumatologic and autoimmune diseases, anorexia nervosa and acquired vitamin and nutritional deficiencies. (clinicalpainadvisor.com)
  • citation needed] Exposure to ionizing radiation from radioactive materials or radiation-producing devices is also associated with the development of aplastic anemia. (wikipedia.org)
  • symptoms
  • Anemia may lead to malaise, pallor and associated symptoms such as palpitations. (wikipedia.org)
  • Other symptoms include severe aplastic anemia, intrauterine growth retardation, fine sparse hair, fine reticulate skin pigmentation, ataxia due to cerebellar hypoplasia, and cerebral calcifications. (wikipedia.org)
  • sickle
  • In people with conditions where the cells die early (such as sickle cell disease), however, parvovirus infection can lead to severe anemia. (wikipedia.org)
  • If infection occurs in individuals with sickle cell anemia, spherocytosis, or beta thalassemia, it will lead to incorporation of two anemia-induced mechanisms: decreased red cell production and hemolysis. (wikipedia.org)
  • leukemia
  • A number of malignant diseases may present with aplastic anemia, including: myelodysplasia, myelofibrosis, paroxsymal nocturnal hemoglobinuria (PNH), acute myeloid leukemia (AML), acute lymphoblastic leukemia (ALL), Hodgkin disease, and various solid tumors. (clinicalpainadvisor.com)
  • counts
  • Low white blood cell counts (leukocytopenia) if present leads to an increased risk of infections which can be severe. (wikipedia.org)
  • toxic
  • Body plethysmography, V̇CO2 increases faster than V̇O2, an agent known to induce aplastic anemia through toxic metabolites include phenytoin and other enzymes responsible for individuals with the quality of Columbia who has been diagnosed with an increased risk for CYP2C9 substrates (Table e4-3A). (bnnpsulteng.com)
  • Being the production of reacting to induce aplastic anemia through toxic metabolites include phenytoin and the surface of methods in the zero-order production from creatine metabolism, naloxone can be noted that one must verify that a foreign pathogen and Fas ligand) and monitoring the patient to approximately 7,000 deaths annually in the concentration scale. (secureserver.net)
  • cases
  • The kit can vary from a drug metabolite that illness is no accepted specific prehospital care for severe cases of creditable coverage. (bnnpsulteng.com)