Several neurodegenerative disease susceptibility. Medical search. Frequent questions

Geldanamycin and its derivatives warrant further exploration as cytoprotective agents for the treatment of neurodegenerative diseases involving a-synuclein toxicity, including Parkinson's disease. (scienceblog.com)

Furthermore, they evaluate the pharmacological potential of neuroprotective compounds in the treatment of Parkinson's disease and Alzheimer's disease. (wikipedia.org)
This review will summarize the updated research progress on APOE functions and its role in Alzheimer's disease, Parkinson's disease, cardiovascular diseases, multiple sclerosis, type 2 diabetes mellitus, Type III hyperlipoproteinemia, vascular dementia, and ischemic stroke. (dovepress.com)
3 In this review, we discuss the biological functions of human APOE and its role in Alzheimer's disease (AD), Parkinson's disease (PD), cardiovascular diseases (CVD), multiple sclerosis (MS), type 2 diabetes mellitus (T2DM), vascular dementia (VD), and ischemic (occlusive) stroke (IS). (dovepress.com)
Scientists have averted the onset of neurodegenerative disease in fruit flies by administering medication to flies genetically predisposed to a disorder akin to Parkinson's disease. (scienceblog.com)
The result suggests a new approach to the treatment of human disorders including Parkinson's and Alzheimer's diseases. (scienceblog.com)
Parkinson's disease is the second most common human neurodegenerative disorder, characterized by tremors, postural rigidity and progressive deterioration of dopaminergic neurons in specific areas of the brain. (scienceblog.com)
Like humans, Drosophila melanogaster experiences neuronal loss upon expression of a-synuclein, a protein implicated in the onset of Parkinson's disease in both species. (scienceblog.com)
Medications now prescribed to people with Parkinson's disease, such as levodopa, bromocriptine and deprenyl, relieve symptoms by rescuing neurons compromised by the disease," said Bonini, Penn professor of biology and investigator with the Howard Hughes Medical Institute. (scienceblog.com)
Bonini, Auluck and colleagues showed last year that molecular chaperones can block the progression of neurodegenerative disease in Drosophila, suggesting that diseases like Parkinson's and Alzheimer's may result from reduced chaperone levels and might be averted by pharmacologically boosting chaperone activity. (scienceblog.com)
Blood iron is affected by diet, and abnormally high or low iron levels are linked with age-related conditions such as Parkinson's disease, liver disease, and a reduction in the body's ability to fight infection in older age. (genengnews.com)
Lipoxygenase (LOX) activity has been implicated in neurodegenerative disorders such as Alzheimer's disease, but its effects in Parkinson's disease (PD) pathogenesis are less understood. (sri.com)
While scientific research is still ongoing, studies conducted so far have shown promising results for CBD as a treatment for symptoms associated with neurodegenerative diseases like Alzheimer's disease and Parkinson's. (seniordirectory.com)
An increasing number of studies provide evidence for the existence of a microbiota-gut-brain axis and its potential involvement in the development of sporadic Parkinson's disease and other neurodegenerative conditions. (techscience.com)
The neuropathologic hallmark of Parkinson's disease is the presence of brain intraneuronal aggregates of misfolded alpha-synuclein, known as Lewy bodies. (techscience.com)
In this review, we assess the potential role of putative gut microbiota products in the etiopathogeny of Parkinson's disease, with a special emphasis on functional bacterial amyloid proteins, bacterial biosurfactants, endotoxins and short-chain fatty acids. (techscience.com)
Our research aims to pinpoint how specific classes of transposable elements have contributed to the evolution of human neuronal gene expression networks and understand how these changes may relate to human's increased susceptibility to neurodevelopmental disorders such as Autism and Schizophrenia and human neurodegenerative diseases such as Alzheimer's and Parkinson's disease. (uva.nl)
Yes, age-associated diseases such as cancer and cardiovascular disease are clearly bad, but the most devastating of these involve the nervous system-diseases like Alzheimer's and Parkinson's. (sentientdevelopments.com)
This finding could lead to new treatments for neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease, and Huntington's disease. (thaidietpills.com)
This blog entry reports on recent research which documents the importance of glial pathology as a general underlying factor in essentially all age related neurodegenerative diseases including Alzheimer's Disease, Parkinson's Disease, advanced spinal degeneration, ALS, multiple sclerosis, and several retinal diseases. (anti-agingfirewalls.com)
Embryonic stem cells (ESCs) can grow infinitely and give rise to all types of cells in human body, thus of tremendous therapeutic potentials for a variety of diseases, such as Parkinson's disease, spinal cord injury, and diabetes. (benthamscience.com)
Traumatic injuries are the leading cause of disability, and moreover are associated with elevated risk of developing cognitive impairments and neurodegenerative diseases (ND) such as Alzheimer's Disease (AD) and Parkinson's Disease (PD). (purdue.edu)
Parkinson's disease (PD) is a progressive neurodegenerative disease that comprises a range of motor and nonmotor symptoms. (lu.se)
We conclude that endogenous GDNF does not impact the outcome in the LC-induced proteasome inhibition mouse model of Parkinson's disease. (lu.se)
In vivo conversion of dopamine neurons in mouse models of Parkinson's disease - a future approach for regenerative therapy? (lu.se)
Stem Derived Dopamine Neurons: Will They Replace DBS as the Leading Neurosurgical Treatment for Parkinson's Disease? (lu.se)
GDNF and Parkinson's Disease: Where Next? (lu.se)
Animal Models of Parkinson's Disease: Are They Useful or Not? (lu.se)

Hypoxia (Hx) is a component of multiple disorders, including stroke and sleep-disordered breathing, which often precede or are comorbid with neurodegenerative diseases. (frontiersin.org)
Our studies suggest that a new class of drugs might prevent neurodegenerative disorders by fortifying these neurons even before the onset of disease. (scienceblog.com)
The increased cases of neurodevelopmental disorders in children, together with their increased susceptibility to OP neurotoxicity cannot be explained by genetic factors alone but could be related to gene-environment interactions. (cdc.gov)
Cross-disease analysis may solely comprise different neurodegenerative diseases or include other chronic diseases (e.g. chronic mental or physical disorders). (neurodegenerationresearch.eu)
Common components thought to contribute to the manifestation of these disorders and normal age-related declines in brain performance are increased susceptibility to long-term effects of oxidative stress and inflammatory insults. (sentientdevelopments.com)
There is wide agreement that excessive microglial activation is a key process in nervous system disorders involving release of strong pro-inflammatory cytokines, cytokines which can trigger worsening of multiple disease states. (anti-agingfirewalls.com)
As many of these neurodegenerative disorders are characterized by the presence of pathologic forms of tau and neurofibrillary tangles, studying the effects of tau pathology on the development of epilepsy might prove rewarding. (uantwerpen.be)
Until recently, our understanding of the genetic causes for human diseases were largely limited to the study of extreme phenotypes produced by Mendelian disorders. (bcm.edu)
Recent studies have revealed that the nervous system and the gut interact, bringing one step closer to the mystery of how neurodegenerative disorders occur. (e-jgn.org)
Lysosomal storage diseases describe a heterogeneous group of dozens of rare inherited disorders characterized by the accumulation of undigested or partially digested macromolecules, which ultimately results in cellular dysfunction and clinical abnormalities. (medscape.com)
Lysosomal storage diseases are generally classified by the accumulated substrate and include the sphingolipidoses, oligosaccharidoses, mucolipidoses, mucopolysaccharidoses (MPSs), lipoprotein storage disorders, lysosomal transport defects, neuronal ceroid lipofuscinoses and others. (medscape.com)
Accumulated data indicate that hematopoietic stem cell transplantation may be effective under optimal conditions in preventing the progression of central nervous system symptoms in neuronopathic forms of lysosomal storage diseases (such as Krabbe disease), including some of the mucopolysaccharidoses, oligosaccharidoses, sphingolipidoses, and lipidoses as well as peroxisome disorders such as X-linked adrenoleukodystrophy. (medscape.com)
In general, transplantation yields the best results when performed early in the course of the disease (ie, in an asymptomatic affected sibling of a child with a lysosomal storage disorder), in centers with experience in performing transplantations to treat inherited metabolic disorders, and in patients healthy enough to tolerate the conditioning and transplantation regimen. (medscape.com)
The most common types of dementia are known as neurodegenerative disorders. (medlineplus.gov)

Common variation in nine novel genes are known to increase susceptibility to AD. (neurodegenerationresearch.eu)
We found that GDNF deletion does not increase susceptibility to LC-induced damage. (lu.se)

Dr. Costantino Iadecola's ground-breaking research in neurology, including developing the concept of the 'neurovascular unit' to better understand the causes of stroke and dementia and opening more possible methods of treatment, makes him a true leader at the forefront of his field, significantly impacting how we think about prevention, diagnosis and treatment of neurovascular and neurodegenerative diseases," said Association President Donald M. Lloyd-Jones, M.D., Sc.M., FAHA. (heart.org)
His research demonstrates a relationship between innate immunity and the deleterious effects of hypertension on neurovascular regulation and cognitive function and found that high-salt diets cause dementia through the Alzheimer protein tau, bridging the age-old gap between neurovascular and neurodegenerative diseases. (heart.org)

Further studies on the gut-brain axis are required to predict and prevent neurodegenerative diseases. (e-jgn.org)

Among the research aims of his teamwork, besides the advancement of knowledge, is to identify metabolic targets and genetic alterations that contribute to the malfunctioning of neurotransmission that neurological problems, including neurodegenerative diseases, and even contribute to aging. (wikipedia.org)
Despite being a relatively common disease, the precise molecular mechanisms for the onset of ischemic stroke (IS) are still incompletely understood, with both environmental and genetic factors being implicated in this disease in a complex manner. (hindawi.com)
In addition, a number of different genetic determinants of IS risk have been identified in genome-wide association studies, with single-nucleotide polymorphisms (SNPs) in 9p21, PITX2, HDAC9, ABO, NINJ2, ALDH2, and TSPAN2, all being linked with stroke susceptibility [ 2 ]. (hindawi.com)
These SNPs, however, are still thought to account for less than half of all genetic susceptibility to IS, with a number of yet to be discovered genes also contributing to the development of IS. (hindawi.com)
Gene-environment interaction models have utility in unmasking the impact of specific cellular pathways in toxicity that may not be observed using a solely genetic or toxicant disease model alone. (sri.com)
However, these variants only account for roughly 32% of the genetic aetiology of the disease. (neurodegenerationresearch.eu)
There is clinical, genetic and biochemical evidence that similar molecular pathways are relevant in different neurodegenerative and other chronic diseases. (neurodegenerationresearch.eu)
In this regard, comprehensive studies of the impact of amino acid variation on protein PTMs will be helpful for further understanding of how genetic polymorphisms are involved in regulating biological and pathological processes and providing instructive information for drug development of various related diseases. (deepdyve.com)
Autosomal dominant cerebellar ataxias (ADCA), also known as spinocerebellar ataxias (SCA) are a group of progressive neurodegenerative diseases with remarkable clinical and genetic heterogeneity. (bvsalud.org)
Advances in genomic technologies and statistical methods have converged to allow the discovery of susceptibility loci for complex genetic traits, and the field now confronts the enormous challenge to confirm the responsible genes and define their functions in the biology of health and disease. (bcm.edu)
In the coming years, with the completion of the largest possible genetic meta-analyses along with the advent of whole-genome sequencing, our knowledge of common and rare susceptibility variants will rapidly expand, implicating vast genetic networks including hundreds of loci in neurologic diseases. (bcm.edu)
The clinical manifestation of neurodegenerative disease is the culmination of a multi-tiered pathogenic cascade that evolves over decades-understanding how genetic variants impact this causal chain is essential. (bcm.edu)
Substantial evidence supports a model in which many genetic variants promote the development of neuropathology, subsequently leading to the clinical manifestations of disease. (bcm.edu)
Both genetic and environmental factors are thought to contribute to the pathophysiology of the disease. (molvis.org)
Genetic association studies aimed at defining susceptibility to POAG may provide important insights into the pathogenesis of POAG. (molvis.org)
Neurodegenerative diseases are caused by the interaction of genetic susceptibility and environmental factors. (e-jgn.org)
고령에서 주로 발생하는 신경퇴행질환들은 유전적인 감수성(genetic susceptibility)과 환경적 요인(environmental factor)의 상호작용으로 발생하기 때문에 일부 유전 질환을 제외하고는 대부분 원인을 하나로 특정하기 어렵다. (e-jgn.org)
Our results support proof of principle of genetic differences in the chronic effects of GWI-related exposures and may reveal why the disease has persisted in many of the now aging Gulf War veterans. (cdc.gov)

abstract = "Parkinson{\textquoteright}s disease (PD) is a progressive neurodegenerative disease that comprises a range of motor and nonmotor symptoms. (lu.se)

Our research suggests that toxic tau may spread across different brain regions through direct neuronal connections, much like infectious diseases may spread to different cities through different transportation pathways. (sciencedaily.com)
Others may interfere with neuroinflammatory pathways and susceptibility to neurodegeneration. (techscience.com)
Human biomonitoring samples have been analysed for identifying metabolomics and transcriptomics fingerprints, while they have also been mapped jointly into metabolic pathways, for identifying the perturbated pathways that are mostly associated with neurodegenerative diseases. (aiche.org)
In conclusion, our comprehensive investigation employing both rat and hiPSC models uncovers plausible molecular pathways connecting SCI to neurodegenerative diseases, providing insights into the enduring consequences of these injuries on affected patients. (purdue.edu)
In fact, a number of biochemical pathways such as mammalian target of rapamycin (mTOR), transcription factor EB (TFEB), Bcl2-associated athanogene 1/3 (BAG3/1) and glycogen synthase kinase beta (GSk3β), which are widely explored as potential targets in neurodegenerative proteinopathies, operate at the crossroad between autophagy and UPS. (nih.gov)

Targeting APOE may be a potential approach for diagnosis, risk assessment, prevention, and treatment of various neurodegenerative and cardiovascular diseases in humans. (dovepress.com)

At the conference it was impressively demonstrated that these chronic diseases are based on similar pathological mechanisms. (csn-deutschland.de)
Although the causal relationship between these mutations and disease development is widely accepted, the exact molecular mechanisms underlying disease pathogenesis remain enigmatic. (nih.gov)
Here, we review the current knowledge on the functional impact of specific mutations, possible Pol III-related disease-causing mechanisms, and animal models that may help to better understand the links between Pol III mutations and disease. (nih.gov)
By investigating these complex interactions, researchers strive to unravel the intricate mechanisms underlying the aging process and identify strategies to delay or prevent age-related diseases. (eumag.org)
By studying individuals like Mr. Johnson who exhibit exceptional health outcomes despite their old age, researchers can uncover valuable insights into protective mechanisms against age-related diseases such as Alzheimer's or cardiovascular conditions. (eumag.org)
Therefore, JPND will launch a call for multidisciplinary proposals to perform network analyses across such diseases and to elucidate the underlying mechanisms involved. (neurodegenerationresearch.eu)
That same blog entry also cites publications arguing that, t o a considerable extent, aging-related neurodegenerative diseases appear to depend on the same underlying mechanisms. (anti-agingfirewalls.com)
This concept inspired new research on mechanisms that regulate cerebral perfusion and on how their failure causes brain diseases. (heart.org)
Many aspects regarding the molecular mechanisms of small heat shock proteins, both in health and disease, remain to be unraveled. (uantwerpen.be)
Her research focuses on defining the mechanisms underlying amyloid heart disease. (stanford.edu)

In addition, the Biorepository collaborates with the Temple University ALS Postmortem Core to support and expand ALS research in the areas of biomarkers, genetics, and disease progression. (cdc.gov)
Dr Tamara Jamaspishvili is a research pathologist, translational research scientist focusing on developing, evaluating, validating, and applying tissue-based prognostic and predictive biomarkers and models for improved disease prognostication and management of cancer patients. (upstate.edu)
We used a previously validated multiplexed 10-min, targeted proteomic assay to assess 54 candidate cerebrospinal fluid (CSF) biomarkers in two independent cohorts comprising individuals with neurodegenerative dementias and healthy controls. (lu.se)

Toxic versions of the protein tau are believed to cause death of neurons of the brain in Alzheimer's disease. (sciencedaily.com)
Specifically, the results suggest that therapies that limit uptake of tau into the neurons or transportation or excretion of tau, could limit disease progression," says Oskar Hansson. (sciencedaily.com)
Effects of mutant huntingtin in oxytocin neurons on non-motor features of Huntington's disease. (lu.se)

Improved methods using mass spectrometry to monitor OP-adducted biomarker proteins are needed and will be extremely helpful in early life biomonitoring, while measurement of PON1 status as a biomarker of susceptibility will help identify mothers and children highly sensitive to OPs. (cdc.gov)
«Evaluation of α-synuclein as a novel cerebrospinal fluid biomarker in different forms of prion diseases» has been accepted for publication in Alzheimer's & Dementia . (neurodegenerationresearch.eu)
His discovery of the cerebrovascular effects of the amyloid-beta peptide and tau established that neurovascular dysfunction is an early biomarker for Alzheimer's disease. (heart.org)

Patients with motor neuron disease (MND) are generally free of cognitive impairment, but evidence is growing to support an association between MND and frontal lobe or frontotemporal dementia (FTD). (medscape.com)
For example, we know that patients with Alzheimer's disease tend to have metabolic problems, Mutlu said. (neurosciencenews.com)
In multiple sclerosis patients, lower power was associated with greater levels of neuroinflammatory activity (R=−0.64, p=0.006) but not neurodegenerative disease markers. (biorxiv.org)
Several studies have confirmed that intestinal alpha-synuclein deposition is prominent in patients with Parkinson disease and rapid eye movement sleep behavior disorder, and pathological changes can be transmitted through the vagus nerve. (e-jgn.org)
Age of onset and clinical manifestations may vary widely among patients with a given lysosomal storage disease, and significant phenotypic heterogeneity between family members carrying identical mutations has been reported. (medscape.com)
Enzyme replacement therapy (ERT) appears safe and effective for peripheral manifestations in patients with Gaucher disease types I and III, Fabry disease, mucopolysaccharidosis I (Hurler, Hurler-Scheie, and Scheie syndromes), mucopolysaccharidosis II (Hunter syndrome), mucopolysaccharidosis VI (Maroteaux-Lamy syndrome), Pompe disease, and recently Batten disease (neuronal ceroid lipofuscinoses, CLN2). (medscape.com)
Patients with PID have increased susceptibility to recurrent and persistent infections, but other symptoms are also common. (lu.se)
Enzyme replacement therapy (ERT) appears safe and effective for peripheral manifestations in patients with Gaucher disease types I and III, Fabry disease, mucopolysaccharidosis I (Hurler, Hurler-Scheie, and Scheie syndromes), mucopolysaccharidosis II (Hunter syndrome), mucopolysaccharidosis VI (Maroteaux-Lamy syndrome), and Pompe disease. (medscape.com)
Decreased CSF oxytocin relates to measures of social cognitive impairment in Huntington's disease patients. (lu.se)

The Journal of Alzheimer's Disease is an international multidisciplinary journal to facilitate progress in understanding the etiology, pathogenesis, epidemiology, genetics, behavior, treatment and psychology of Alzheimer's disease. (iospress.com)
However, these genes can not account for the overall inheritance of susceptibility to POAG pathogenesis. (molvis.org)

The aggregation and deposition of amyloid-β (Aβ) in the brain is thought to be an early event in the pathology of Alzheimer's disease (AD). (iospress.com)
To gain more insight into the relation between tau pathology and epileptogenesis, the Tau58/4 tauopathy mouse model was subjected to a seizure susceptibility analysis. (uantwerpen.be)
We reported increased seizure susceptibility in young Tau58/4 mice, which are still in an early pathologic stage, but not in old Tau58/4 mice with full-blown tau pathology. (uantwerpen.be)
A complementary approach directly leverages the underlying disease pathology as an intermediate trait, or endophenotype. (bcm.edu)
Although two percent of the population over age 65 are clinically diagnosed with PD, the defining pathology of disease (alpha-synuclein Lewy bodies) is discovered in 20 percent of brains from population-based autopsy studies. (bcm.edu)
Early white matter pathology in the fornix of the limbic system in Huntington disease. (lu.se)

[ 9 ] This is different from the neurofibrillary tangles of Alzheimer disease, dominant in layer II-III of the entorhinal cortex. (medscape.com)
This may provide a basis for clinical characterization of memory deficits of ALS, which may be distinct from those of Alzheimer disease. (medscape.com)
Identifying and studying genes that contribute to Alzheimer s disease (AD) development will help us to understand the causes of AD, providing the basis for developing new treatments. (neurodegenerationresearch.eu)
Inheritance of the TNF-α (−863) C allele has been associated with an elevated risk of Alzheimer disease. (molvis.org)
The neuronal injuries associated with Alzheimer disease have several similarities with the optic nerve changes often seen with POAG. (molvis.org)
It is unclear whether Alzheimer disease is the starting point for pathological changes in the gut like Parkinson disease. (e-jgn.org)
이로 인해 다양한 신경계 질환들의 유병률이 급격하게 증가하고 있는데, 특히 파킨슨병(Parkinson disease)과 알츠하이머병(Alzheimer disease) 등의 신경퇴행질환의 증가세가 가파르다[ 3 ]. (e-jgn.org)
Alzheimer disease (AD) is the most common form of dementia. (medscape.com)
The reason why Alzheimer disease (AD) is more frequent in individuals with Down syndrome (DS) is not known. (medscape.com)
Introduction: Synaptic dysfunction and degeneration is one of the earliest events in Alzheimer's disease (AD) and the best correlate of cognitive decline. (lu.se)
Alzheimer's disease (AD) is the most common cause of dementia. (lu.se)

Worldwide, frontotemporal lobe dementia with motor neuron disease (FTD/MND) is a sporadic condition with an unknown etiology. (medscape.com)

Our findings thus suggest that exposure to GWI-related agents may converge on similar targets with roles in inflammation, neurotransmitter and lipid metabolism, and detoxification which may have impacts on neurodegenerative-like disease and oxidative stress in Veterans with GWI. (cdc.gov)

Aggression is commonly reported in individuals with Huntington's disease (HD). (researchgate.net)
Comorbidities and clinical outcomes in adult- and juvenile-onset Huntington's disease: a study of linked Swedish National Registries (2002-2019). (lu.se)
Microarray profiling of hypothalamic gene expression changes in Huntington's disease mouse models. (lu.se)
IKKβ signaling mediates metabolic changes in the hypothalamus of a Huntington's disease mouse model. (lu.se)
Hypothalamic expression of huntingtin causes distinct metabolic changes in Huntington's disease mice. (lu.se)

It was reported that K630A mutation in androgen receptor has been shown to cause a loss of acetylation site and has been implicated in Kennedy's disease, an inherited neurodegenerative disorder [8]. (deepdyve.com)

Surprisingly, it was discovered in the last decade that various inherited mutations in genes encoding nine distinct subunits of Pol III cause tissue-specific diseases rather than a general failure of all vital functions. (nih.gov)
Furthermore, other rare diseases are also associated with mutations in genes encoding subunits of Pol III (POLR3H, POLR3GL) and the BRF1 component of the TFIIIB transcription initiation factor. (nih.gov)
In addition to the potential for fundamental biological insights, functional dissection of susceptibility genes will be essential to realize the full promise of human genetics for clinical applications. (bcm.edu)
Most notably, rare pathogenic mutations have been identified in the amyloid precursor protein, microtubule associate protein tau, and alpha-synuclein genes, encoding the primary constituents of the defining disease pathologies (amyloid plaques and Tau neurofibrillary tangles in AD, and Lewy bodies in PD, respectively). (bcm.edu)
DNA methylation map of mouse and human brain identifies target genes in Alzheimer's disease. (nature.com)

The OECD has published a new report summarising the second Lausanne Workshop on «Global Action to Drive Innovation in Alzheimer's disease and other Dementias - Connecting Research, Regulation and Access. (neurodegenerationresearch.eu)
The aim of this workshop was to review the policy and stakeholder actions needed to accelerate biomedical research and health innovation for Alzheimer's disease and other dementias. (neurodegenerationresearch.eu)
To download the full report, entitled « Global Action to Drive Innovation in Alzheimer's Disease and Other Dementias ,» click here . (neurodegenerationresearch.eu)

One of the most critical factors determining our susceptibility to neurological diseases is neuroinflammation, or inflammation affecting our nervous system. (seniordirectory.com)
What troubles me, however, is that many of these advances don't address the single most important aging related problem we face today: neurological diseases. (sentientdevelopments.com)
That we are facing a looming epidemic of neurological diseases shouldn't really come as a surprise to anyone. (sentientdevelopments.com)

There are two proteins that are known to be linked to Alzheimer's disease -- beta-amyloid, which forms what is known as a plaque in the brain, and tau, which forms tangles within brain cells. (sciencedaily.com)
7] analyzed amino acid variations of 15 different PTMs and indicated that about 4.5% of amino acid variations may affect protein function through disruption of PTMs, and the mutation of 238 PTMs sites in human proteins was causative of disease. (deepdyve.com)
More recently, the concept of lysosomal storage disease has been expanded to include deficiencies or defects in proteins necessary for the normal post-translational modification of lysosomal enzymes (which themselves are often glycoproteins), activator proteins, or proteins important for proper intracellular trafficking between the lysosome and other intracellular compartments. (medscape.com)

Greatly concerned, participants noted the increasing prevalence of chronic multisystem illnesses such as multiple chemical sensitivity (MCS), chronic fatigue syndrome (CSF), fibromyalgia (FMS) as well as cardiovascular diseases, metabolic syndrome, neurodegenerative diseases, auto immune diseases, and cancer. (csn-deutschland.de)
Sleep restriction increases the risk of developing cardiovascular diseases by augmenting proinflammatory responses through IL-17 and CRP. (who.int)

In this study, we sought to understand the disease stages and therapeutic hypotheses studied in clinical trials conducted in neurodegenerative diseases to date. (nature.com)
Our goals were to characterize clinical trials across major neurodegenerative disease indications, identifying correlations and temporal trends, particularly with regards to disease stages and molecular targets of drugs. (nature.com)
In contrast, cynomolgus macaques have not shown evidence of clinical disease as of 70 months postinfection. (cdc.gov)
Ongoing clinical trials are currently evaluating whether antibodies developed to bind to tau might stop the disease. (sciencedaily.com)
This has led to active clinical trials evaluating the safety and efficacy of intrathecal enzyme delivery in several lysosomal storage diseases (see www.ClinicalTrials.gov ). (medscape.com)
We are now in an era of unprecedented technology development, where the combination of high throughout technologies, longitudinal sampling and clinical data allow for a deep and comprehensive characterization of human health and disease. (lu.se)

Dr. Iadecola's work also details how microbiota of the gut can influence a patient's susceptibility to ischemic stroke. (heart.org)

Though often linked to disease initiation, not progression, these targets were tested mostly at symptomatic disease stages. (nature.com)
I think these findings have implications for therapies aiming at stopping the spread of tau and thereby halting the disease progression in Alzheimer's," says Oskar Hansson, professor of neurology at Lund University and co-lead investigator of the study. (sciencedaily.com)
Accumulated data indicate that hematopoietic stem cell transplantation may be effective under optimal conditions in preventing the progression of central nervous system symptoms in neuronopathic forms of lysosomal storage diseases, including some of the mucopolysaccharidoses, oligosaccharidoses, sphingolipidoses, and lipidoses. (medscape.com)

The potential for disease modification through early intervention against root molecular causes of disease remains largely unexplored. (nature.com)
The future of medical research relies on the ability of scientists to bridge biomedical and computational expertise to deconvolute such complex layers of molecular data and pave the way for delineating novel therapies for infectious and immune-related diseases. (lu.se)

The neuroinflammatory disease multiple sclerosis is associated with infiltration of peripheral immune cells into the brain via these vessels. (biorxiv.org)
Understanding venous pathophysiology in multiple sclerosis is thus critical for understanding early disease aetiology. (biorxiv.org)

During that same year, he directed the summer school of the International Society of Neurochemistry and the Journal of Neurochemistry under the theme of Cerebral Metabolism in Health and Disease. (wikipedia.org)
We speculate that our findings on iron metabolism might also start to explain why very high levels of iron-rich red meat in the diet has been linked to age-related conditions such as heart disease. (genengnews.com)
In addition, the findings are relevant to the observations that have been made between olfaction, fat metabolism and neurodegenerative diseases. (neurosciencenews.com)

The current research is aimed at assessing the correlation between two functional GAS5 variants (rs145204276 and rs55829688) and susceptibility to IS in a Han Chinese population. (hindawi.com)
Variants in the GAS5 promoter region have been reported to be linked to mutiple diseases. (hindawi.com)
Copy number variants (CNVs) are known to confer risk in several related neuropsychiatric and neurodegenerative conditions. (bmj.com)

This accumulation leads to the death of nerve cells and the symptoms of the disease. (thaidietpills.com)
They found that the mutant enzyme caused the death of nerve cells and the symptoms of the disease. (thaidietpills.com)
In contrast to epilepsy, sleep abnormalities are among the first noticeable symptoms of the disease. (uantwerpen.be)
Treatments may help to maintain mental function longer, manage behavioral symptoms, and slow down the symptoms of disease. (medlineplus.gov)

The monkeys' brains showed spongiform encephalopathy and protease-resistant prion protein (PrPres) diagnostic of prion disease. (cdc.gov)
Prion diseases are a diverse group of neurodegenerative diseases, caused by prion protein misfolding. (bmj.com)

The detrimental consequences of OPs on neurodevelopment can lead to future generations with permanent cognitive problems and susceptibility to develop neurodegenerative diseases. (cdc.gov)

2012). We have also contributed to genome-wide association studies (GWAS) seeking novel susceptibility loci for AD neuropathologic traits, including amyloid neuritic plaques and Tau neurofibrillary tangles. (bcm.edu)

The burden of foodborne and waterborne disease is not uniformly distributed globally: because of the inequitable distribution of the world's resources some countries carry a disproportionately heavy burden of infectious disease, and what is considered a re-emergent pathogen in one location may be endemic in another. (who.int)
They are now the most commonly reported bacterial cause of infectious intestinal diseases in the United Kingdom and most other industrialized countries [4]. (who.int)
The honor, which includes a travel stipend, recognizes early career scientists for research excellence and potential in the fields of microbiology and infectious disease. (stanford.edu)

Some examples include bovine spongiform encephalopathy (BSE) in cattle, scrapie in sheep and goats, Creutzfeldt-Jakob disease (CJD) in humans, and chronic wasting disease (CWD) in cervids. (cdc.gov)

Neurodegenerative disease is increasingly prevalent and remains without disease-modifying therapies. (nature.com)
Epilepsy is more prevalent in certain neurodegenerative diseases. (uantwerpen.be)

Exposome science will help us understand the intricate web of relationships between environmental exposures, lifestyle, genetics and disease, contributing significantly to the determination of causal associations between environmental factors and human health. (aiche.org)

Human aging is characterized by a progressive decline in the body's ability to maintain homeostasis, which is linked with major causes of death, including heart disease, cancer, and dementia. (genengnews.com)
The spread is restricted during normal aging, but in Alzheimer's disease the spread may be facilitated by beta-amyloid, and likely leads to widespread neuronal death and eventually dementia," says lead author Jacob Vogel from McGill University. (sciencedaily.com)
For patient education information, see the Brain and Nervous System Center , as well as Dementia Overview , Dementia Medication Overview , and Dementia in Amyotrophic Lateral Sclerosis (Lou Gehrig's Disease) . (medscape.com)
He was honored again by the Association with a 2019 Distinguished Scientist Award to recognize his research contributions to cardiovascular disease, stroke and dementia. (heart.org)
Alzheimer's disease , which is the most common form of dementia among older people. (medlineplus.gov)
For example, some people have both Alzheimer's disease and vascular dementia. (medlineplus.gov)
There is no cure for most types of dementia, including Alzheimer's disease and Lewy body dementia. (medlineplus.gov)

Centers for Disease Control and Prevention. (cdc.gov)
The Centers for Disease Control and Prevention (CDC) cannot attest to the accuracy of a non-federal website. (cdc.gov)
There is currently no cure or (meaningful) prevention for most of these diseases. (sentientdevelopments.com)

Despite the common co-occurrence of Hx with neural disease, few studies have investigated how pre-exposure to Hx changes the long-term ability of resident CNS macrophages/microglia to respond to a subsequent inflammatory insult, such as pathogen exposure or a sterile inflammatory stimulus. (frontiersin.org)
Mar. 18, 2022 Alzheimer's disease is the most common and best known of the tauopathies, a set of neurodegenerative brain diseases caused by toxic tangles of the protein tau. (sciencedaily.com)
Physical activity can prevent various common diseases such as high blood pressure, low bone density, heart disease, diabetes, obesity, and certain types of cancer. (seniordirectory.com)
The most common prodromal symptom of Parkinson disease is constipation. (e-jgn.org)
However, common pathomechanisms could be applied to both diseases: disrupting the gut and blood-brain barriers, facilitating inflammations, and engaging hormones. (e-jgn.org)
However, increased susceptibility to infections is common to all immunodeficiencies. (lu.se)

Initial autopsy results showed that Knut, the polar bear, suffered from a brain disease. (csn-deutschland.de)
Recent scientific research has shown that pesticides cause different brain diseases. (csn-deutschland.de)
What caused Knut's brain disease will require further investigation. (csn-deutschland.de)
Now the sadness is great, and the cause of Knut's brain disease is still under investigation. (csn-deutschland.de)
We do not know exactly which brain disease Knut, the public's favorite animal in the Berlin Zoo, suffered from, but further studies will hopefully determine the nature and cause of his brain disease. (csn-deutschland.de)
Amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig's disease, is a rapidly progressive, fatal neurological disease that affects nerve cells in the brain and spinal cord, causing nerves in the muscle to die, thereby affecting voluntary muscle movement. (cdc.gov)
Intense research is ongoing to better understand how toxic tau spreads in the brain, in order to develop new therapies that can stop the spread and thereby stop the disease. (sciencedaily.com)
Feb. 6, 2020 The protein tau has long been implicated in Alzheimer's and a host of other debilitating brain diseases. (sciencedaily.com)
The findings suggest that the mutant enzyme causes the disease by leaking out of cells and accumulating in the brain. (thaidietpills.com)
In a new study, researchers have found that a mutated enzyme that is linked to neurodegenerative disease causes "leaky" activity in the brain. (thaidietpills.com)
Alzheimer's disease: early alterations in brain DNA methylation at ANK1, BIN1, RHBDF2 and other loci. (nature.com)
Thus far, ERT has been largely unsuccessful in improving central nervous system manifestations of the lysosomal storage diseases, putatively due to difficulty in penetrating the blood-brain barrier. (medscape.com)
These are diseases in which the cells of the brain stop working or die. (medlineplus.gov)

Rheumatoid arthritis (RA) is an autoimmune and inflammatory disease that occurs when a person's immune system attacks healthy cells in the body. (medicaldaily.com)

If omics-based assays were applied with appropriate study designs, thorough validation of the markers, and careful interpretation of study results then a bioinformatics database could be built of the human response to different chemical exposures and associated chronic diseases. (who.int)

In 2023, I started my own group at Lund University using systems immunology as a data-driven approach to decipher how biological sex impacts human immunity and disease susceptibility. (lu.se)

Imbalance of the oxytocin-vasopressin system contributes to the neuropsychiatric phenotype in the BACHD mouse model of Huntington disease. (lu.se)

However, little is known about how hypoxia affects the ability of microglia, resident CNS macrophages, to respond to subsequent inflammatory challenges that are often present during neurodegenerative processes. (frontiersin.org)
Chronic wasting disease (CWD) is a transmissible spongiform encephalopathy, or prion disease, that affects deer, elk, and moose. (cdc.gov)
The amino acid variation S326C of human OGG1 disrupts Ser-326 phosphorylation site and affects susceptibility to a variety of cancers [9]. (deepdyve.com)

We annotated targets and eligibility criteria for 3238 neurodegenerative disease trials registered at ClinicalTrials.gov from 2000 to 2020. (nature.com)
Mar. 3, 2020 The toxic protein tau is a key biological feature in the brains of people with Alzheimer's disease. (sciencedaily.com)

It is conceivable that such pathologies could confer a susceptibility to further acute inflammation or lead to hypo-perfusion, thus exacerbating neuronal injury. (biorxiv.org)

Increased susceptibility to the long-term effects of OS and inflammatory insults are thought to be contributing factors to the decrements in cognitive and/or motor performance seen in ageing and other neurodegenerative diseases. (cambridge.org)

Previously I have written about the roles of glia and microglia in Alzheimer's disease and in spinal cord injury. (anti-agingfirewalls.com)

We used 2 nonhuman primate species, cynomolgus macaques and squirrel monkeys, as human models for CWD susceptibility. (cdc.gov)
Unravelling it requires to simultaneously identify, characterize and quantify exogenous and endogenous exposures and modifiable risk factors that predispose to and predict disease throughout the human life span. (aiche.org)
Numerous harmful factors that affect the human body from birth to old age cause many disturbances, e.g., in the structure of the genome, inducing cell apoptosis and their degeneration, which leads to the development of many diseases, including cancer. (mdpi.com)
She is studying the role of the human erythrocyte in host susceptibility to malaria. (stanford.edu)

Our findings have implications for understanding the disease, but more importantly for the development of therapies against Alzheimer's, which are directed against either beta-amyloid or tau. (sciencedaily.com)
Liddelow examines the role of astrocytes in central nervous system injury and neurodegenerative disease, with the goal of developing new therapies. (stanford.edu)

Anatomy25

Organisms12

Diseases59

Chemicals and Drugs61

Analytical, Diagnostic and Therapeutic Techniques and Equipment29

Psychiatry and Psychology9

Phenomena and Processes65

Disciplines and Occupations3

Information Science3

Named Groups2

Health Care8

Geographicals2

Including Parkinson's disease1

Parkinson's27

Disorders14

Increase Susceptibility2

Neurovascular and neurodegenerative diseases2

Prevent Neurodegenerative Diseases1

Genetic18

Abstract1

Pathways5

Various neurodegenerative1

Mechanisms10

Biomarkers3

Neurons3

Biomarker3

Patients9

Pathogenesis2

Pathology6

Alzheimer11

Etiology1

Oxidative stress1

Huntington's5

Disorder1

Genes5

Dementias3

Neurological diseases3

Proteins3

Cardiovascular diseases2

Clinical6

Ischemic stroke1

Progression3

Molecular2

Multiple sclerosis2

Metabolism3

Variants3

Symptoms4

Prion protein2

Cognitive problems1

Neuropathologic1

Infectious3

Humans1

Prevalent2

Genetics1

Dementia7

Prevention3

Common6

Brain13

Rheumatoid1

Chronic diseases1

Immunity1

Neuropsychiatric1

Affects3

20202

Confer1

Inflammatory1

Spinal1

Human4

Therapies2