• Homeobox genes encode homeodomain protein products that are transcription factors sharing a characteristic protein fold structure that binds DNA to regulate expression of target genes. (wikipedia.org)
  • The protein encoded by this gene is a DNA binding homeobox transcription factor involved in embryonic stem (ES) cell proliferation, renewal, and pluripotency. (nih.gov)
  • Recent studies have suggested that menin may act as a scaffold protein to coordinate gene transcription, and that menin is an oncogenic cofactor for homeobox (HOX) gene expression in hematopoietic cancer. (elsevierpure.com)
  • The protein encoded by this gene is a homeobox protein that is similar to the Drosophila 'sine oculis' gene product. (antibodies-online.cn)
  • E08L0106-96 Dog LIM/homeobox protein Lhx8(LHX8. (gentaur.pl)
  • A competitive ELISA for quantitative measurement of Canine LIM/homeobox protein Lhx8(LHX8) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. (gentaur.pl)
  • Background: This gene is a member of the Antp homeobox family andencodes a nuclear protein with a homeobox DNA-binding domain. (hatinhibitor.com)
  • A homeobox is a DNA sequence, around 180 base pairs long, that regulates large-scale anatomical features in the early stages of embryonic development. (wikipedia.org)
  • A murine homeobox gene was disrupted at high frequency in embryonic stem cells by its replacement with Escherichia coli lacZ. (pasteur.fr)
  • Next, the importance of embryonic developmental genes such as homeobox and T-box transcription factors are highlighted in conduction system development and function. (medscape.com)
  • We identified and cloned a mouse double homeobox gene (Duxbl), which encodes two homeodomains. (ntnu.edu.tw)
  • Homeobox genes that encode transcription factors play important roles in development and differentiation of both plant and animal systems. (elsevierpure.com)
  • Background: Homeobox-containing genes encode crucial transcription factors involved in animal, plant and fungal development, and changes to homeobox genes have been linked to the evolution of novel body plans and morphologies. (st-andrews.ac.uk)
  • abstract = "Characterisation of a sea urchin (P. lividus) homeobox gene PIHbox 9 is reported. (northwestern.edu)
  • abstract = "The homoeobox gene zerkn{\"u}llt (zen) plays an important role in the differentiation of dorsal tissues during Drosophila development1,2. (princeton.edu)
  • Mutations in a homeobox may change large-scale anatomical features of the full-grown organism. (wikipedia.org)
  • In this review , we summarize the expression pattern, loss- and/or gain-of-function mouse models, and naturally occurring mouse and human mutations of known homeobox genes required for the development of ectodermal appendages. (bvsalud.org)
  • The transcription factor encoded by the homeobox patterning gene DLX4 is overexpressed in a wide range of malignancies. (tmc.edu)
  • MNX1 (motor neuron and pancreas homeobox 1), also known as HLXB9, is a homeodomain-containing transcription factor [ 13 ]. (biomedcentral.com)
  • In the ventral limb bud, the transcription factor engrailed-1 (En-1) is produced. (medscape.com)
  • SHOX is a homeobox-containing gene, highly conserved among species as diverse as fish, chicken and humans. (bath.ac.uk)
  • HLXB9 homeobox gene and caudal regression syndrome. (cdc.gov)
  • Our data suggest that the LIM-homeobox genes, Lhx1 and Lhx9 , regulated by ventral and/or dorsal signals, may play important roles in controlling regionalization of the diencephalon during chick development. (ehu.eus)
  • Here we examined expression patterns of several chick orthologs of LIM-homeobox genes. (ehu.eus)
  • Western blot revealed that knockdown of miR-205 expression in ESCC cells substantially enhanced expression of zinc finger E-box binding homeobox 2, accompanied by reduction of E-cadherin, a regulator of epithelial mesenchymal transition. (biomedcentral.com)
  • Here, we report the discovery of exonic GGC trinucleotide repeat expansions, encoding poly-glycine, in zinc finger homeobox 3 (ZFHX3) in these families. (lu.se)
  • The homeobox domain was first identified in a number of Drosophila homeotic and segmentation proteins, but is now known to be well-conserved in many other animals, including vertebrates. (wikipedia.org)
  • The existence of homeobox genes was first discovered in Drosophila by isolating the gene responsible for a homeotic transformation where legs grow from the head instead of the expected antennae. (wikipedia.org)
  • The existence of additional Drosophila genes containing the antennapedia homeobox sequence was independently reported by Ernst Hafen, Michael Levine, William McGinnis, and Walter Jakob Gehring of the University of Basel in Switzerland and Matthew P. Scott and Amy Weiner of Indiana University in Bloomington in 1984. (wikipedia.org)
  • The homoeobox gene zerknüllt (zen) plays an important role in the differentiation of dorsal tissues during Drosophila development 1,2 . (princeton.edu)
  • En-1 blocks Wnt-7a expression, preventing expression of Lmx-1b there, and establishes the dorsal-ventral axis. (medscape.com)
  • In characterizing ribosome binding to a regulatory element within a Homeobox (Hox) 5' UTR, we identify a modular stem-loop within this element that binds to a single ES, ES9S. (nih.gov)
  • In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. (nih.gov)
  • The HB9 homeobox gene has been cloned from several vertebrates and is implicated in motor neuron differentiation. (ox.ac.uk)
  • LIM homeobox 2 promotes interaction between human iPS-derived hepatic progenitors and iPS-derived hepatic stellate-like cells. (ca.gov)
  • Isolation of homologous genes by Edward de Robertis and William McGinnis revealed that numerous genes from a variety of species contained the homeobox. (wikipedia.org)
  • Mutational analysis of two positional candidate susceptibility genes for bipolar disorder on chromosome 12q23-q24: phenylalanine hydroxylase and human LIM-homeobox LHX5. (wikigenes.org)
  • Also, our chromosome-level assembly allows the inference of ancient gene linkages (synteny) for the homeobox-containing genes, even though a number of the homeobox gene clusters, like the Hox/ParaHox clusters, are undergoing dispersal in molluscs such as this oyster. (st-andrews.ac.uk)
  • The induction cascades of early morphogenesis involve numerous growth factors, homeobox genes, and paired domain genes. (medscape.com)
  • Furthermore, 4 genes from these two sets of significant genes, coiled-coil domain containing-99 (Ccdc99), muscle segment homeobox gene-2 (Msx2), nitric oxide synthase-2 (Nos2), and wingless-type inhibitory factor-1 (Wif1), showed significant mRNA expression perturbations at both time points. (cdc.gov)
  • Our paper reviewed data from many labs on the temporal and spatial patterns of expression of homeobox genes in mouse embryos. (the-scientist.com)
  • Sea urchin (echinoid) embryogenesis is initiated by zygotic expression of pmar1, a paired-class homeobox gene that has been considered to be present only in the lineage of modern urchins (euechinoids). (elsevierpure.com)
  • Consequently, analyses of homeobox gene organization across animal phylogeny provide important insights into the evolution of genome organization and developmental gene control, and their interaction. (st-andrews.ac.uk)
  • EDDY, E. M. Identification and characterization of Rhox13, a novel X-linked mouse homeobox gene. (bvsalud.org)
  • The Mnx homeobox gene class defined by HB9, MNR2 and amphioxus AmphiMnx. (ox.ac.uk)
  • Homeobox genes are an evolutionarily conserved class of transcription factors that are key regulators during developmental processes such as regional specification, patterning, and differentiation. (bvsalud.org)
  • Animal studies have suggested an important role for the homeobox- containing gene MSX1 in limb, oralfacial, and cardiac malformations. (johnshopkins.edu)
  • The data support the hypothesis that homeobox genes play a central role. (the-scientist.com)
  • Role of homeobox genes in the patterning, specification, and differentiation of ectodermal appendages in mammals. (bvsalud.org)
  • These findings demonstrate that chronic exposure of esophageal keratinocytes to acid pH induces transcription of cdx 2, an intestinal specific homeobox gene known to play a critical role in the differentiation and maintenance of intestinal epithelial functions. (silverchair.com)
  • Homeoboxes are found within genes that are involved in the regulation of patterns of anatomical development (morphogenesis) in animals, fungi, plants, and numerous single cell eukaryotes. (wikipedia.org)
  • Next, we generated iPS cell lines overexpressing LIM homeobox 2 (LHX2), which suppresses myofibroblastic changes in HSCs in mice. (ca.gov)
  • In vitro function of MNX1 (Motor neuron and pancreas homeobox 1) in bladder cancer cell was evaluated using MTT assay, colony formation assay, and bromodeoxyuridine incorporation assay. (biomedcentral.com)
  • The "homeo-" prefix in the words "homeobox" and "homeodomain" stems from this mutational phenotype, which is observed when some of these genes are mutated in animals. (wikipedia.org)
  • Subsequent phylogenetic studies detailing the evolutionary relationship between homeobox-containing genes showed that these genes are present in all bilaterian animals. (wikipedia.org)
  • In animals, some homeobox genes are clustered together in the genome, either as remnants from ancestral genomic arrangements, or due to coordinated gene regulation. (st-andrews.ac.uk)
  • They're a type of homeobox genes - which determine animals' body plans. (npr.org)