• We have developed a novel search algorithm, used it to search the Drosophila genomic sequence database, and identified a large multigene family encoding seven transmembrane domain proteins that are expressed in olfactory organs. (edu.au)
  • these receptors comprise a distinct family of G protein-coupled seven transmembrane domain receptors. (jci.org)
  • 2. Pierre-Jean Corringer and Jean-Pierre Changeux (2008) Nicotinic acetylcholine receptors. (proteopedia.org)
  • 1985. Nicotinic acetylcholine receptors in vertebrate muscle: properties, distribution and neural control. (harvard.edu)
  • Ectodomain dropping has emerged as an important posttranslational mechanism to regulate the functions of various integral membrane-bound proteins including adhesion molecules cytokines growth factors and their receptors (57 60 Both. (exposed-skin-care.net)
  • Those factors may include receptor species orthologs, receptor dimerization, receptor density, gylcosylation, the presence of specific G-protein heterotrimers, RGS-proteins and arrestins, compartmentation of signalling proteins and lipid composition of the membrane, to name a few factors. (aspetjournals.org)
  • In the generalized receptor-transducer-effector signaling model of Martin Rodbell, signaling GTPases act as transducers to regulate the activity of effector proteins. (wikipedia.org)
  • For heterotrimeric G proteins and many small GTP-binding proteins, GEF activity is stimulated by cell surface receptors in response to signals outside the cell (for heterotrimeric G proteins, the G protein-coupled receptors are themselves GEFs, while for receptor-activated small GTPases their GEFs are distinct from cell surface receptors). (wikipedia.org)
  • Toll-like receptors (TLRs) are a family of extremely conserved transmembrane proteins portrayed in epithelial and immune system cells that recognize pathogen linked molecular patterns. (research-in-field.com)
  • This investigation provides information on a putative membrane-localized receptor that can be added to the collection of high-light (HL) stress-response-mediating proteins. (biosciencehorizons.com)
  • Recent cancer genome deep sequencing efforts have revealed an unanticipated high frequency of mutations in G proteins and G-protein-coupled receptors (GPCRs) in most tumour types. (nature.com)
  • Aberrant expression and activity of G proteins and G-protein-coupled receptors (GPCRs) are frequently associated with tumorigenesis. (nature.com)
  • Sequence comparison does not support an evolutionary link between halobacterial retinal proteins including bacteriorhodopsin and eukaryotic G-protein-coupled receptors. (springer.com)
  • Residue I384 of Tsr receptor is important for binding to the proteins. (ucsb.edu)
  • The nicotinic receptors are cylindrically-shaped proteins imbedded in synaptic walls that act as chemically-controlled sodium channels (also called ligand-gated sodium channels) that penetrate through the cell walls of post-synaptic nerves and myocytes at the skeletal neuromuscular junctions. (cdc.gov)
  • The epidermal growth factor receptor (EGFR) is a receptor tyrosine kinase (RTK) commonly targeted for inhibition by anti-cancer therapeutics. (biorxiv.org)
  • Our lab has recently developed a new strategy to regulate RTK activity by designing a peptide that specifically binds to the transmembrane (TM) region of the RTK to allosterically modify kinase activity. (biorxiv.org)
  • The epidermal growth factor receptor (EGFR) is a HER-family receptor tyrosine kinase (RTK) that is involved in cell signaling in healthy tissue. (biorxiv.org)
  • The researchers describe the structure and role of cell surface receptors in signaling activities with separate sections on tyrosine kinase, cytokine, G protein-coupled, TGFB, TNF, and immunoglobin receptors. (123library.org)
  • Plants, however, perceive steroids at membranes, using the membrane-integral receptor kinase BRASSINOSTEROID INSENSITIVE 1 (BRI1). (nature.com)
  • Li, J. & Chory, J. A putative leucine-rich repeat receptor kinase involved in brassinosteroid signal transduction. (nature.com)
  • MsGC-I shows highest sequence identity with receptor guanylyl cyclases throughout its catalytic and dimerization domains but does not contain the ligand-binding, transmembrane, or kinase-like domains characteristic of receptor guanylyl cyclases. (elsevierpure.com)
  • Neuropilin 1 is a 923 amino acid containing membrane bound coreceptor to a tyrosine kinase receptor belonging to the neuropilin family with two CUB domains, two F5/8 type C domains and a MAM domain. (thermofisher.com)
  • What are physical characteristics found in all tyrosine kinase receptors? (flashcardmachine.com)
  • How is the insulin tyrosine kinase receptor unusual? (flashcardmachine.com)
  • How is a tyrosine kinase receptor activated? (flashcardmachine.com)
  • Ligand binding activates the receptor kinase through a process of oligomerization and transphosphorylation. (thermofisher.com)
  • CSF1R is a tyrosine kinase transmembrane receptor and member of the CSF1/PDGF receptor family of tyrosine-protein kinases. (thermofisher.com)
  • Mutations in the gene encoding CSF1R have been associated with a predisposition to myeloid malignancy.Tyrosine-protein kinase that acts as cell-surface receptor for CSF1 and IL34 and plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. (thermofisher.com)
  • The signaling complex which is composed of a transmembrane receptor, histidine protein kinase CheA and adaptor protein CheW plays an important role in chemotaxis signaling pathway. (ucsb.edu)
  • Previously, research showed that CheA interacts with a transmembrane receptor, but how CheA and receptor interact with each other and activate kinase activity are unknown. (ucsb.edu)
  • Activins initiate cellular signal transduction by first binding to the type II receptors (ACTIVIN RECEPTORS, TYPE II ) which then recruit and phosphorylate the type I receptors (ACTIVIN RECEPTORS, TYPE I ) with subsequent activation of the type I kinase activity. (bvsalud.org)
  • This approach extends beyond the H4-receptor and should be applied to any given GPCR, being a principle of general pharmacological relevance. (aspetjournals.org)
  • The purpose of our perspective was to discuss the very interesting pharmacological effects of JNJ7777120 that shed light on the mechanisms of H4-receptor function in particular and GPCR function in general. (aspetjournals.org)
  • Water molecules inside a G-protein coupled receptor (GPCR) have recently been spotlighted in a series of crystal structures. (ewha.ac.kr)
  • To decipher the dynamics and functional roles of internal water molecules in GPCR activity, we studied the A 2A adenosine receptor using microsecond molecular-dynamics simulations. (ewha.ac.kr)
  • The valuable source of large-scale genomic information initiated attempts to identify the origin(s) of G protein-coupled receptors (GPCR), count and categorize those genes, and follow their evolutionary history. (springer.com)
  • The chapter summarizes evolutionary processes working on GPCR genes and sheds light on their consequences at the levels of receptor structure and function. (springer.com)
  • Using site-directed mutagenesis, the conserved tryptophan residue was mutagenized in eight receptors which are members of disparate class A GPCR subfamilies from different taxa. (sdbonline.org)
  • Taken together, these results suggest a novel role for the WxFG motif in GPCR trafficking and receptor function. (sdbonline.org)
  • Examples of these roles include: Signal transduction in response to activation of cell surface receptors, including transmembrane receptors such as those mediating taste, smell and vision. (wikipedia.org)
  • G protein-coupled receptors are the largest superfamily of cell surface receptors in the Metazoa and play critical roles in transducing extracellular signals into intracellular responses. (sdbonline.org)
  • GO analysis revealed that the DEGs were enriched in biological processes related to inflammation, and the enriched pathways in the KEGG pathway analysis were cytokine-cytokine receptor interaction, chemokine signalling pathway and NF-κB signalling pathway. (researchsquare.com)
  • C-X-C chemokine receptor type 4 ( CXCR-4 ) also known as fusin or CD184 (cluster of differentiation 184) is a protein that in humans is encoded by the CXCR4 gene . (wikidoc.org)
  • CXCR-4 is an alpha- chemokine receptor specific for stromal-derived-factor-1 ( SDF-1 also called CXCL12), a molecule endowed with potent chemotactic activity for lymphocytes . (wikidoc.org)
  • CXCR4 is one of several chemokine receptors that HIV can use to infect CD4+ T cells . (wikidoc.org)
  • Until recently, SDF-1 and CXCR4 were believed to be a relatively monogamous ligand-receptor pair (other chemokines are promiscuous, tending to use several different chemokine receptors). (wikidoc.org)
  • These cells are crucial for the induction and maintenance of self-tolerance and are present in peripheral tissues such as skin and gut under normal, noninflamed conditions (4).In addition, recruitment of Foxp3+ T regulatory cells mediating allograft tolerance depends on the CCR4 chemokine receptor and its ligand CCL22 (5). (biolegend.com)
  • CCR6, also known as CD196, is a chemokine receptor that is expressed on immature dendritic cells, B lymphocytes, and memory T cells. (biolegend.com)
  • There are many different types of these receptors that can bind to a wide range of molecules (ligands). (readingthinkingandwriting.com)
  • These cells, such as Neutrophils, have transmembrane receptors known as Fc receptors that bind to the ends of antibody molecules at what is known as their Constant Region. (readingthinkingandwriting.com)
  • In metazoans, intracellular receptors recognize these molecules. (nature.com)
  • Although insects have proven to be valuable models for exploring the function, organization, and development of the olfactory system, the receptor molecules that bind odors have not been identified in any insect. (edu.au)
  • Our study finds that the amount of water flux across the transmembrane (TM) domain varies depending on the receptor state, and that the water molecules of the TM channel in the active state flow three times more slowly than those in the inactive state. (ewha.ac.kr)
  • Neuronal excitation is also influenced by the amounts of neurotransmitter receptors and signaling molecules retained at particular synaptic sites. (frontiersin.org)
  • Recent studies revealed a key role for PSD- 95, a scaffolding molecule enriched at glutamatergic synapses, in modulation of clustering of several neurotransmitter receptors, adhesion molecules, ion channels, cytoskeletal elements and signaling molecules at postsynaptic sites. (frontiersin.org)
  • The postsynaptic compartment of excitatory synapses is characterized by an electron-dense region, referred to as the postsynaptic density (PSD), attributable to the high density of neurotransmitter receptors and associated molecules at these sites. (frontiersin.org)
  • All transmembrane receptors in the families I've encountered in my reading bind to specific patterns of amino acids within a peptide or complete protein or a combination of protein and sugar or fat. (readingthinkingandwriting.com)
  • All receptors of a given type will bind to a very similar, if not the exact same, amino acid pattern regardless of whether the receptor is on a human Neutrophil or a staphylococcus bacterium. (readingthinkingandwriting.com)
  • Neuropilin 1 forms a heterodimer with NRP2 (Neuropilin 2) and is known to bind to plexin (PLXNB1) to form semaphorin receptors. (thermofisher.com)
  • Chemoattractants or chemorepellents bind to the transmembrane receptor transmitted a signal to CheW and CheA. (ucsb.edu)
  • they have receptors for the crystallizable fragment (Fc) region of immunoglobulin (Ig) G and for complement, which enable them to bind with immune complexes and present the complex to B cells in germinal centers of secondary lymphoid organs. (msdmanuals.com)
  • Portions of this work have appeared in abstract and poster form and were presented at the 8th International Symposium on Subtypes of Muscarinic Receptors, Danvers, MA, August 1998, and at the 28th annual meeting of the Society for Neuroscience, Los Angeles, CA, November 1998. (aspetjournals.org)
  • article{5f173e96-c6fe-4b5f-8f37-b070076bc387, abstract = {{The transmembrane protein Dystroglycan is a central element of the dystrophin-associated glycoprotein complex, which is involved in the pathogenesis of many forms of muscular dystrophy. (lu.se)
  • Signaling is then transduced across the membrane by altering the configuration of the transmembrane (TM) domain, by dimerization of the TM helical region or a change in the arrangement of the TM helices within such a dimer. (biorxiv.org)
  • The Neutrophil, the most important cell type in the Innate, possess several different chemotactic receptors in its membrane which drive changes in the cytoarchitecture. (readingthinkingandwriting.com)
  • Once assembled, some Immunoglobulins will be transported to and embedded in the B cell membrane where they function as antigen receptors. (readingthinkingandwriting.com)
  • This is the region that makes immunoglobulins, whether secreted as antibodies or stuck in the membrane as antigen receptors, immensely useful in protecting the body from pathogen invaders. (readingthinkingandwriting.com)
  • A primary component of cell signaling research, this title covers the principal membrane-bound receptor families, including their structural organization. (123library.org)
  • Background: Receptors with a single transmembrane (TM) domain are essential for the signal transduction across the cell membrane. (a-star.edu.sg)
  • As with most transmembrane alpha helix bundles, it is hydrophobic around the edges to effectively be supported within the membrane, and it is hydrophilic on the inner portion to transport charged ions. (proteopedia.org)
  • Are receptors always on the plasma membrane? (flashcardmachine.com)
  • Visualization of modified receptors through the incorporation of a fluorescent tag revealed a severe reduction in plasma membrane expression, indicating aberrant trafficking of these modified receptors. (sdbonline.org)
  • Normal neuromuscular junction showing a presynaptic terminal with a motor nerve ending in an enlargement (bouton terminale): Synaptic cleft and postsynaptic membrane with multiple folds and embedded with several acetylcholine receptors. (medscape.com)
  • Receptors for ACTIVINS are membrane protein kinases belonging to the family of PROTEIN-SERINE-THREONINE KINASES, thus also named activin receptor-like kinases (ALK's). (bvsalud.org)
  • Transient Receptor Potential (TRP) ion channels are non-selective cation channels sharing the membrane topology of six transmembrane helices but varying in sensory N- and C-terminal domains. (lu.se)
  • HER2/neu (also called ERB B2 ) is the gene that encodes the human epidermal growth factor receptor type 2. (cancerquest.org)
  • Shiu, S. H. & Bleecker, A. B. Receptor-like kinases from Arabidopsis form a monophyletic gene family related to animal receptor kinases. (nature.com)
  • The protein encoded by this gene is an orphan G protein-coupled receptor whose ligand is unknown. (nih.gov)
  • The product of this gene belongs to the family of G-protein coupled receptors. (nih.gov)
  • Genetic drift and selective forces have shaped the individual structure of a given receptor gene but also of the species-specific receptor repertoire - a process that is still ongoing. (springer.com)
  • Transmembrane guanylyl cyclases are homodimeric receptors activated by a diverse range of endogenous ligands. (guidetopharmacology.org)
  • In addition, MsGC-I contains a C-terminal extension of 149 amino acids that is not present in other receptor guanylyl cyclases. (elsevierpure.com)
  • This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. (nih.gov)
  • The maximal level of enhancement seen with either CBD or 2-AG were on α2-containing GABAA receptor subtypes, with approximately a 4-fold enhancement of the GABA EC5 evoked current, more than twice the potentiation seen with other α-subunit receptor combinations. (researchgate.net)
  • A human M 1 (HM 1 ) mutant receptor, HM 1 (S388Y, T389P), displayed significantly enhanced agonist potency, binding affinity, and G protein coupling. (aspetjournals.org)
  • A selective novel KOP receptor agonist emerged as a notable result and is proposed as a new chemotype for the study of the KOP receptor in the etiology of drug addiction, depression, and/or pain. (acs.org)
  • To this end, we know only very little about the factors that may have an impact on functional selectivity of H4-receptor ligands. (aspetjournals.org)
  • Violin JD, Lefkowitz RJ (2007) Beta-arrestin-biased ligands at seven-transmembrane receptors. (springer.com)
  • Transmembrane domain VI of muscarinic acetylcholine receptors plays an important role in ligand binding and receptor function. (aspetjournals.org)
  • In phosphatidylinositol hydrolysis assays, muscarinic agonists showed greater potency at the HM 1 (S388Y) and HM 1 (S388Y, T389P) mutants compared with the wild-type and HM 1 (T389P) receptors. (aspetjournals.org)
  • Additionally, leucine substitutions at this position caused similar signaling defects in the follicle-stimulating hormone receptor (FSHR), Galanin receptor (GALR1), AKH receptor (AKHR), corazonin receptor (CRZR), and muscarinic acetylcholine receptor (mACHR1) . (sdbonline.org)
  • Guyton and Hall 2006) (See Figure 6 below) ( Smooth muscle contraction is controlled by muscarinic receptors, which are different and will be discussed later. (cdc.gov)
  • As those transmembrane receptors of the TGF-beta superfamily (RECEPTORS, TRANSFORMING GROWTH FACTOR BETA), ALK's consist of two different but related protein kinases, Type I and Type II. (bvsalud.org)
  • 5-hydroxytryptamine type-3 receptor (5-HT3), an important target of many neuroactive drugs, is a cation selective transmembrane pentamer whose functional stoichiometries and subunit arrangements are still debated, due to the extreme complexity of the system. (unimore.it)
  • Moreover, most of the available structural and functional data is related to the extracellular ligand-binding domain, whereas the transmembrane and the intracellular receptor domains are far less characterised, although they are crucial for receptor function. (unimore.it)
  • In particular, it emerges that a favourable environment for the crossing of the pore at the transmembrane and intracellular C terminus domain levels by Ca2+ ions is granted by the maximum presence of two B subunits in the 5-HT3 pentamer. (unimore.it)
  • Nasal insufflation of IL-11 causes AHR in wild-type mice while lung inflammation induced by antigen sensitization and challenge, which mimics features of atopic asthma in humans, is attenuated in mice genetically deficient in IL-11 receptor subunit alpha-1 (IL-11Ra1-deficient mice), a transmembrane receptor that is required along with glycoprotein 130 to transduce IL-11 intracellular signaling. (cdc.gov)
  • The nicotinic acetylcholine receptor is a key protein in neuronal communication. (proteopedia.org)
  • See also Binding site of AChR and Acetylcholine Receptor and its Reaction to Cobra Venom . (proteopedia.org)
  • 3. Adcock C, Smith GR, Sansom MS. The nicotinic acetylcholine receptor: from molecular model to single-channel conductance. (proteopedia.org)
  • Xu R, Salpeter MM. Rate constants of acetylcholine receptor internalization and degradation in mouse muscles. (harvard.edu)
  • [ 1 , 2 ] Although the chief target of the autoimmune attack in most cases is the skeletal muscle nicotinic acetylcholine receptor (nAChR), other antigenic targets that are components of the neuromuscular junction (NMJ) have also been implicated. (medscape.com)
  • We show that expression is restricted to subsets of olfactory receptor neurons (ORNs) for a number of these genes. (edu.au)
  • False positive non-synonymous polymorphisms of G-protein coupled receptor genes. (nih.gov)
  • Due to the fact that some of these genes were reported to be influenced by abscisic acid (ABA), presented results suggest that the investigated putative seven-transmembrane protein (7TMP) may be the missing link between ABA and G-protein α-subunit in plants. (biosciencehorizons.com)
  • Kappa-opioid (KOP) receptor agonists exhibit analgesic effects without activating reward pathways. (acs.org)
  • The cloned cDNA encodes a putative peptide of 490 amino acids with seven potential transmembrane domains. (jci.org)
  • In this regard, CBD inhibition of 5-HT 3 receptors may contribute to its role in modulation of nociception and emesis, potentiation of GABA receptors may account for its anti-seizure, anxiolytic and analgesic effects, and potentiation of glycine receptors may be relevant for CBD anti-nociceptive actions [3,16, 22] . (researchgate.net)
  • Receptor tyrosine kinases (RTKs) play fundamental tasks in varied cell functions including proliferation differentiation survival migration and rate of metabolism (16). (exposed-skin-care.net)
  • Here we used two-electrode voltage clamp electrophysiology to compare the actions of CBD with those of the major central endocannabinoid, 2-arachidonoyl glycerol (2-AG) on human recombinant GABAA receptors (synaptic α1-6βg2 and extrasynaptic α4β2δ) expressed on Xenopus oocytes. (researchgate.net)
  • The autoimmune attack occurs when autoantibodies form against the nicotinic acetylcholine postsynaptic receptors at the neuromuscular junction of skeletal muscles (see the image below). (medscape.com)
  • This receptor is coupled to the stimulation of the phosphoinositide and adenylyl cyclase pathways and behaves as a selective purinoceptor. (nih.gov)
  • Kim JY, Haastert PV, Devreotes PN (1996) Social senses: G-protein-coupled receptor signaling pathways in Dictyostelium discoideum . (springer.com)
  • Choline (30 μ M, the concentration found in Dulbecco's modified Eagle's medium) exhibited 90% stimulation at HM 1 (S388Y) receptors but was inactive at HM 1 (T389P) receptors. (aspetjournals.org)
  • Written and edited by experts in the field, this book provides up-to-date research on transmembrane signaling entities and their initiating responses following extracellular stimulation. (123library.org)
  • Identify the key physiological effects that result from stimulation of nicotinic receptors by excessive amounts of acetylcholine. (cdc.gov)
  • The mutations are located at the top of transmembrane domain VI and about two helical turns above Tyr381 and Asn382, which are important for ligand binding and receptor function. (aspetjournals.org)
  • Result: The purification of the TM domain of p75 neurotrophin receptor using a KSI tag with the introduction of a thrombin cleavage site is described herein. (a-star.edu.sg)
  • The purified TM domain of p75 neurotrophin receptor will be useful for structural studies. (a-star.edu.sg)
  • Free Energy Landscape of Lipid Interactions with Regulatory Binding Sites on the Transmembrane Domain of the EGF Receptor. (ox.ac.uk)
  • We identify lipid interaction sites at each end of the transmembrane domain and compute interaction free energy profiles for lipids with these sites. (ox.ac.uk)
  • The amino acid sequence of the hCTR is 73% identical to the pCTR, although the hCTR contains an insert of 16 amino acids between transmembrane domain I and II. (jci.org)
  • We have undertaken coarse-grained simulations to calculate free energy profiles for glycolipids and phospholipids interacting with modulatory sites on the transmembrane helix dimer of the EGF receptor within a lipid bilayer environment. (ox.ac.uk)
  • Members of this receptor family can be found in many places including cells of the Innate and Adaptive Immune System. (readingthinkingandwriting.com)
  • As far as I've read, a given receptor or receptor family is rarely unique to a one species. (readingthinkingandwriting.com)
  • One interesting example is the family of so called Toll receptors which are highly important to immune system function. (readingthinkingandwriting.com)
  • Our findings provide insight into the activation mechanism of this highly expanded family of plant receptors that have essential roles in hormone, developmental and innate immunity signalling. (nature.com)
  • The most frequently mutated GPCRs include thyroid-stimulating hormone receptor (TSHR), Smoothened (SMO), glutamate metabotropic receptors (GRMs), members of the adhesion family of GPCRs and receptors for bioactive lipid mediators such as lysophosphatidic acid (LPA) and sphingosine-1-phosphate (S1P) that accumulate in the tumour microenvironment. (nature.com)
  • Corticotrophin-Releasing Hormone Receptor 1 (CRHR-1), also known as CRFR-1, is a 7TM protein that belongs to the G protein-coupled receptor family 2. (rndsystems.com)
  • The receptor is a transmembrane pentameric glycoprotein. (proteopedia.org)
  • The transmembrane protein Dystroglycan is a central element of the dystrophin-associated glycoprotein complex, which is involved in the pathogenesis of many forms of muscular dystrophy. (lu.se)
  • This semaphorin receptor functions as receptors for both the semaphorins and vascular endothelial growth factor and is also a regulator of VEGF-induced angiogenesis. (thermofisher.com)
  • The modification of the Drosophila leucokinin receptor shows that substitution of any non-aromatic amino acid for the tryptophan leads to a loss of receptor function. (sdbonline.org)
  • Figure S1: Plot of competitive inhibition of 3 H -diprenorphine binding at the KOP receptor. (acs.org)
  • Figure S3 shows the cAMP accumulation inhibition curves at DOP and MOP receptors. (acs.org)
  • Previous studies have shown that specific ER transmembrane receptors recruit LC3 on autophagic membranes by using LC3-interacting domains. (nih.gov)
  • When in the presence of acetylcholine , the receptor undergoes a conformational change opening up the channel to an influx of sodium (Na) within the cell. (proteopedia.org)
  • When the neurotransmitter, acetylcholine, attaches to the portion of the nicotinic receptor outside of the cell wall, it induces a conformational change that selectively opens up the channel to sodium ions. (cdc.gov)
  • Dr. Thurmond cites several studies in which the inhibitory pharmacological effects of JNJ7777120 were found to be in parallel with the phenotypes observed in the H4-receptor knock-out mice. (aspetjournals.org)
  • CBD modulation of Cys-loop receptors has pharmacological relevance. (researchgate.net)
  • Department of Pharmacology and Toxicology, School of Medicine, Universidad Complutense de Madrid (UCM), Instituto de Investigación Sanitaria Hospital 12 de Octubre (Imas12), Instituto de Investigación Neuroquímica (IUINQ-UCM), Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Avda. (mdpi.com)
  • Several reports have shown modulation of Cys-loop receptors by phytocannabinoids and endocannabinoids independent of cannabinoid receptors with potential physiological or therapeutic consequences. (researchgate.net)
  • Interleukin-11 receptor subunit alpha-1 is required for maximal airway responsiveness to methacholine after acute exposure to ozone (dataset). (cdc.gov)
  • This channel also contributes to the receptor function in three critical aspects: it contains a gating mechanism, it contains a water pore to stabilize ions, and it has a selectivity filter for ion charge. (proteopedia.org)
  • Depolarization is followed by the opening of other transmembrane channels that selectively allow the flow of K+ ions into the cell. (cdc.gov)
  • The structural basis of G-protein-coupled receptor function and dysfunction in human diseases. (nih.gov)
  • During this 2-step process, the ER transmembrane E3 ligase TRIM13 undergoes auto-ubiquitination via lysine 63 (K63) linkage chains and acts as a ligand for the autophagic receptor SQSTM1/p62 (sequestosome 1). (nih.gov)