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  • steady-state
  • We directly measured the amplitude, kinetic properties, and pharmacology of Kv current in primary murine lymphocytes as well as the contribution of each current component to the steady-state membrane potential. (rupress.org)
  • The model response is validated with existing literature reporting entrainment in steady state visually evoked potentials (SSVEP)-brain oscillations corresponding to periodic visual stimuli recorded via electroencephalography (EEG). (frontiersin.org)
  • pore
  • Direct plasma membrane stretch triggered cation current activity that was blocked by tranilast and specific TRPV2 pore-blocking antibodies and mimicked by the TRPV2 activator, Δ9-tetrahydrocannabinol. (arvojournals.org)
  • chloride
  • Canine cardiac Purkinje fibers exposed to sodium-free solutions containing 16 mM CaCl2, 20 mM tetraethylammonium chloride, 108 mM tetramethylammonium chloride, and 2.7 mM KCl may be quiescent at a resting potential of either -50 mV or -90 mV. (semanticscholar.org)
  • mechanism
  • Our results reveal a mechanism with potential physiological importance, by which glutamatergic synapses induce an endocannabinoid-mediated inhibition of the GABAergic inputs onto Purkinje cells. (jneurosci.org)
  • Targeting platelet-derived growth factor receptors (PDGFR) is a potential mechanism to improve the efficacy of first-line therapy. (bioportfolio.com)
  • A mechanism that accounts for these changes may involve K 2P 6.1 setting the resting membrane potential of VSMCs. (ahajournals.org)
  • cells
  • LFPy consists of a set of easy-to-use classes for defining cells, synapses and recording electrodes as Python objects, implementing this biophysical modeling scheme. (frontiersin.org)
  • Helps maintain the cells resting potential. (brainscape.com)
  • Hi, I've been very confused on how to initialize of cells' resting potential at the beginning of the simulation. (yale.edu)
  • The resting membrane potential of JG cells was −32 mV and activation of BK Ca with cAMP hyperpolarized cells on average 16 mV, and inhibition with TEA depolarized cells by 17 mV. (ahajournals.org)
  • electrical
  • Despite their potential importance in neuronal function, direct experimental evidence on electrical signaling in dendritic spines is lacking as their small size makes them inaccessible to standard electrophysiological techniques. (jneurosci.org)
  • Using an electrode within the micropipette, researchers can "clamp" or control the electrical properties of the membrane, which is important for analysis of channel activity. (jove.com)
  • plasma
  • We report that K 2P 6.1 -deficient mice have depolarized plasma membranes of VSMCs, increased vascular contractility, and hypertension. (ahajournals.org)
  • current
  • The ability to store charge and determines how quickly the membrane potential can respond to a change in current. (brainscape.com)
  • The membrane potential of these fibers can be switched from -50 mV to -90 mV by a hyperpolarizing current pulse and from -90 mV to -50 mV by a depolarizing current pulse. (semanticscholar.org)
  • Lack of cholesterol-induced inhibition of BK current may reflect the contribution of a variety of factors, including changes in channel expression and/or cell membrane sorting to the overall cholesterol effect on macroscopic current, as well as inappropriate access of cholesterol from a bath-perfusing solution to the vicinity of the BK channel. (rupress.org)
  • consistent
  • Analyses of speech and musical databases are consistent with the idea that the chromatic scale (the set of tones used by humans to create music), consonance and dissonance, worldwide preferences for a few dozen scales from the billions that are possible, and the emotions elicited by music in different cultures all stem from the relative similarity of musical tonalities and the characteristics of voiced (tonal) speech. (coursera.org)
  • input
  • this is because simulations on SpiNNaker work in real time for time-steps dt ⩾ 1 ms. The model output shows entrainment with both sets of input and contains harmonic components of the fundamental frequency. (frontiersin.org)
  • study
  • In this prospective observational study, we wanted to shed light on the kinetic of plasmatic RAGE and cytokeratin 18 isoforms after severe trauma, thereby also addressing the association of these markers with inflammation and their potential use as biomarkers. (jove.com)