• Sesquiterpene lactones, polyacetylenes, achilleine and flavonoids such as apigenin. (gaiaherbs.com)
  • Yarrow is strongly pungent and aromatic and contains sesquiterpene lactones, azulene, coumarins and flavonoids. (vitacart.com)
  • Studies with its main characteristic constituents sesquiterpene lactones, helenalin, and dihydrohelenalin are included. (escop.com)
  • Some plants containing these compounds include: Artichoke Boneset Eupatorium perfoliatum Burdock Calea ternifolia Chamomile Chrysanthemum Cocklebur Feverfew Gaillardia Ginkgo biloba Laurus nobilis Lettuce (Lactuca) Marsh elder Mugwort Parthenium Poverty weed Pyrethrum Ragweed Sagebrush Sneezeweed Spinach Star anise Sunflower Ironweed Wormwood Yellow star thistle bitter leaf Quorum sensing inhibitors Sesquiterpene lactones have been found to possess the ability to inhibit quorum sensing in bacteria. (wikipedia.org)
  • Three sesquiterpene lactone compounds, 2 α ,5 α -dihydroxy-11 α H-eudesma-4(15)-en-12,8 β -olide ( 1 ), telekin ( 2 ), oxoeudesm-11(13)-eno-12,8 α -lactone ( 3 ) were obtained. (researchsquare.com)
  • In conclusion, three sesquiterpene lactone compounds inhibited the proliferation of HepG-2 cells via suppressing the JAK2/STAT3 signaling pathway. (researchsquare.com)
  • Artichoke is a relevant source of health-promoting compounds such as polyphenols and sesquiterpene lactones. (unicatt.it)
  • However, the relatively high bioavailability values recorded for flavonols, phenolic acids, and sesquiterpene lactones (from 71.6% up to 82.4%) demonstrated that these compounds are able to be transported through the Caco-2 monolayer. (unicatt.it)
  • Our research program in natural products chemistry involved the study of organic compounds from higher plants with a primary focus on the isolation, structure determination, chemistry, biomimetic and biosynthetic studies of terpenoids, in particular, sesquiterpene lactones. (lsu.edu)
  • Wormwood contains bitter substances (including sesquiterpene lactones such as absinthin), an essential oil which contains thujone and other compounds. (standardprocess.com)
  • Cross-reactions between IBOA and the three components of SLM (alantolactone, costunolide, and dehydrocostus lactone) seem unlikely, because of their different spatial structures. (lu.se)
  • The precursor to most sesquiterpene lactones is costunolide. (academicjournals.org)
  • By 2013 other Sesquiterpene lactones, such as costunolide, were being studied alongside parthenolide. (canceractive.com)
  • Alantolactone, a sesquiterpene lactone, inhibits breast cancer growth by antiangiogenic activity via blocking VEGFR2 signaling. (harvard.edu)
  • The anti-inflammatory sesquiterpene lactone helenalin found in Arnica inhibits the transcription factor NF-kappaB by directly targeting p65. (greenmedinfo.com)
  • Chromatography indicated that these were the same anti-inflammatory agents - sesquiterpene lactones - thathave previously been found in arnica. (nutraingredients.com)
  • Results Arnica montana at the 2c dilution (final concentration of sesquiterpene lactones in cell culture = 10 −8 mol/L) significantly stimulated the expression of three genes which code for regulatory proteins of the extracellular matrix, namely FN1 (fibronectin 1, % increase of 21.8 ± standard error of the mean 4.6), low-density lipoprotein-receptor-related protein 1 (% increase of 33.4 ± 6.1) and heparan sulphate proteoglycan 2 (% increase of 21.6 ± 9.1). (thieme-connect.com)
  • Pulchelloid A, a sesquiterpene lactone from the Canadian prairie plant Gaillardia aristata inhibits mitosis in human cells. (nih.gov)
  • The sesquiterpene lactone helenalin is a potent anti-inflammatory drug whose molecular mechanism of action remains unclear despite numerous investigations. (greenmedinfo.com)
  • We have previously shown that helenalin and other sesquiterpene lactones selectively inhibit activation of the transcription factor NF-kappaB, a central mediator of the human immune response. (greenmedinfo.com)
  • Determining sesquiterpene lactones in Belgian endive roots (Cichorium intybus L. var. (ilvo.be)
  • is a source of sesquiterpene lactone arglabin, which has antitumor, radiosensitizing and immunomodulatory activity. (academicjournals.org)
  • Carpesium abrotanoides L. is rich in sesquiterpene lactones, the experiments of anti-tumor activity in vitro showed that total sesquiterpene lactone extracts exhibited the most cytotoxicity activities against HepG-2 cells (IC 50 = 4.2 μg/mL). (researchsquare.com)
  • In vitro antiplasmodial and cytotoxic activities of sesquiterpene lactones from Vernonia fimbrillifera Less. (univ-reunion.fr)
  • After 20 h of in vitro large intestine fermentation, a decrease in polyphenols and sesquiterpene lactones content was observed. (unicatt.it)
  • Alternatively a macrocyclic lactone can be used to treat for scab and will also be part of the strategy to remove resistant worms. (yourdictionary.com)
  • Carpesium abrotanoides L., is rich in sesquiterpene lactones with significant cytotoxicity effects on the HepG-2 cell line. (researchsquare.com)
  • For structure-biological activity correlation studies (antineoplastic activity, cytotoxicity, and phosphofructokinase deactivation), acetate, isobutyrate, hexanoate, and palmitate ester derivatives were prepared of four melampolide-type sesquiterpene lactones from Melampodium: melampodin B (86), melcanthin B (99), melampodin A (100), and cinerenin (101). (lsu.edu)
  • In this investigation, the cytotoxicity of 23 α-methylene-γ-lactones towards normal breast epithelial MCF-10A cells as well as breast cancer JIMT-1 cells is compared. (lu.se)
  • Sesquiterpene lactones (STLs) are a large group of terpenoids most commonly found in plants of the Asteraceae family, e.g., in chicory plants, displaying a wide range of interesting biological activities. (mdpi.com)
  • Overall, a large abundance of phenolic acids and sesquiterpene lactones was detected, being 13.77 and 11.99 mgg1, respectively. (unicatt.it)
  • Twenty-two melampolide-type sesquiterpene lactones and their ester derivatives were tested for inhibition of the enzyme phosphofructokinase (PFK) and the apparent K(,i) values were determined. (lsu.edu)
  • a new antifungal melampolide - sesquiterpene lactone named sonchifolin, as well as three known melampolides, polymatin B, uvedalin and enhydrin. (stuartxchange.org)
  • It was then found that on reducing the lactone of the acid obtained from d-mannonic acid, ordinary glucose resulted. (yourdictionary.com)
  • On reducing the lactone prepared from the inactive acid an inactive galactose is obtained from which l-galactose may be separated by fermentation. (yourdictionary.com)
  • Feverfew, or wild chamomile, or Bachelor's button, ( tanacetum parthenium ), is a truly powerful herb because of several bioactive ingredients called sesquiterpene lactones including one in particular, Parthenolide, found in the largest concentration in the flowers and the fruit. (canceractive.com)
  • The Chemistry and Biological Activity of Sesquiterpene Lactones of Heliantheae (Compositae). (lsu.edu)
  • In this study, the antiprotozoal activity of the sesquiterpene lactone psilostachyin C was investigated. (conicet.gov.ar)
  • Fig 1A ) is a sesquiterpene lactone isolated from Centipeda minima that has been studied in hematological and solid forms of cancer and has been revealed to exhibit activity without significant toxicity ( 2 - 4 ). (spandidos-publications.com)
  • Although the reactivity of the α-methylene-γ-lactone moiety is important for these effects, the Michael addition is reversible and it can be assumed that also other parts of the molecules will moderate any given biological activity. (lu.se)
  • 6‑O‑angeloylplenolin (6‑OAP) is a sesquiterpene lactone agent that has been previously demonstrated to inhibit the growth of multiple myeloma (MM) cells through mitotic arrest with accumulated cyclin B1. (spandidos-publications.com)
  • It has previously been reported that sesquiterpene lactones exert their effect by inhibiting degradation of IkappaB, the inhibitory subunit of NF-kappaB. (greenmedinfo.com)
  • This graph shows the total number of publications written about "Sesquiterpenes, Eudesmane" by people in Harvard Catalyst Profiles by year, and whether "Sesquiterpenes, Eudesmane" was a major or minor topic of these publication. (harvard.edu)
  • Sesquiterpene lactones containing a 3-methylenedihydrofuran-2(3H)-one (or α-methylene-γ-lactone) moiety, for example damsin (1), are Michael acceptors that affect biological processes such as cell proliferation, death/apoptosis, and cell migration, by interfering with cell signalling pathways. (lu.se)
  • These studies indicated that chrysanthemums contain two types of allergens, those which are soluble in hexane and include sesquiterpene lactones, and those which are soluble in water and include proteins. (cdc.gov)
  • This sesquiterpene lactone is the first anti-inflammatory agent shown to exert its effect by directly modifying NF-kappaB. (greenmedinfo.com)
  • Using specific primers, mRNA fragments of genes encoding sesquiterpene lactones biosynthesis enzymes were amplified and their nucleotide sequences were determined. (academicjournals.org)
  • ß-Eudesmol, an Oxygenized Sesquiterpene, Reduces the Increase in Saliva 3-Methoxy-4-Hydroxyphenylglycol After the "Trier Social Stress Test" in Healthy Humans: A Randomized, Double-Blind, Placebo-Controlled Cross-Over Study. (harvard.edu)
  • Ook de Engelse naam Sneezewort, sneezeweed geeft hezelfde neusprikkeld effect aan en de Franse naam, Achillée sternutatoire verwijst naar zijn gebruik als snuifmiddel, als sternutatorium, zoals dat deftig in de apothekersboeken vermeld werd. (google.com)
  • Wilde bertram wordt nu niet meer gebruikt, maar zijn prikkelend en verdovend effect is in de praktijk genoeg bewezen, deze werking doet mij sterk denken aan het effect van Rode zonnehoed bij tandontstekingen. (google.com)
  • De sterk uitgebreide ondergrondse uitlopers en wortelstokken kunnen goed tegen de schurende werking van water. (google.com)
  • Sedanolic acid readily decomposes into water and its lactone sedanolid, C 12 H 18 0 2, the odorous constituent of celery oil. (yourdictionary.com)
  • Therefore, the present work is focus on isolating target sesquiterpenes rapidly via the strategy of high-pressure liquid chromatography coupled with electrospray ionization-quadrupole time-of-flight mass spectrometry (HPLC-ESI-Q-TOF-MS/MS) combined with high-speed counter-current chromatography (HSCCC). (researchsquare.com)