• Determining values of plasma renin activity (PRA) or plasma active renin concentration (ARC), plasma aldosterone concentration (PAC), and aldosterone-to-renin ratio (ARR) is essential to diagnose primary aldosteronism (PA), but it takes several days with conventional radioimmunoassays (RIAs). (jsce-ip.com)
  • Bone formation markers in serum and urinary resorption markers were measured at baseline, and after 6 and 12 months. (biomedcentral.com)
  • Furthermore, in 1992 Mourkarzel [ 21 ] reported that a decreased serum Si concentration in total parenterally fed infants was associated with a decreased bone mineral content compared to healthy controls. (biomedcentral.com)
  • In adults with normal liver function, approximately 50% of the total alkaline phosphatase activity arises from the liver and 50% from the bone. (medscape.com)
  • Serum osteocalcin is considered a specific marker of osteoblast function, as its levels correlate with the bone formation rate. (medscape.com)
  • The efficacy of Pex for preventing heterotopic ossifications was evaluated by the presence of flare-ups, measurements of serum bone markers, and changes in the total bone volume calculated by the three-dimensional computed tomography (3D-CT) images. (biomedcentral.com)
  • Serum levels of alkaline phosphatase (ALP) and bone specific ALP (BAP) were significantly and synchronously increased with the occurrence of flare-ups. (biomedcentral.com)
  • Volumetric 3D-CT analysis demonstrated a significant increase in the total bone volume of Case 2 (378 cm 3 ) and Case 3 (833 cm 3 ) during the two-year study period. (biomedcentral.com)
  • Quantification of change in the total bone volume by whole body CT scanning could be a reliable evaluation tool for disease progression in forthcoming clinical trials of FOP. (biomedcentral.com)
  • The major advantages of using osteocalcin as a clinical index of bone turnover are its tissue specificity, its wide availability, and its relatively low within-person variation. (medscape.com)
  • In general, serum levels are elevated in patients with diseases characterized by a high bone turnover rate, and the serum levels reflect the expected changes in bone formation following surgical and therapeutic intervention. (medscape.com)
  • This study examines the effects of 12 weeks of resistance training on serum sex steroid hormone and bone metabolism factors in orchiectomized rats. (ksep-es.org)
  • The investigation revealed that compared to the CON group, the ORX-CON group showed significantly lower levels of testosterone, dihydrotestosterone (DHT), grip strength, bone mineral density (BMD) and breaking force, but much higher levels of osteocalcin and CTx-1. (ksep-es.org)
  • Protein repletion after hip fracture was associated with increased serum levels of insulin-like growth factor-I, attenuation of proximal femur bone loss, and shorter stay in rehabilitation hospitals. (acpjournals.org)
  • A conventional radioimmunoassay (RIA) and two measurement procedures of CLEIA which obtains RIA equivalent values were also compared. (jsce-ip.com)
  • Osteocalcin is a small protein (49 amino acids) synthesized by mature osteoblasts, odontoblasts, and hypertrophic chondrocytes. (medscape.com)
  • Total serum calcium is divisible into protein-bound and ultrafiltrable (diffusible) calcium ( Fig. 6-1 ). (abdominalkey.com)
  • Variations in serum protein alter proportionately the concentration of the protein-bound and total serum calcium. (abdominalkey.com)
  • An increase in serum albumin concentration of 1 g/dL increases protein-bound calcium by 0.8 mg/dL, whereas an increase of 1 g/dL of globulin increases protein-bound calcium by 0.16 mg/dL. (abdominalkey.com)
  • Marked changes in serum sodium concentration also affect the protein binding of calcium. (abdominalkey.com)
  • Thus, it is obvious that changes in total serum calcium concentration cannot be used for the assessment of the effect on bound calcium concentration unless the changes in albumin and globulin concentrations also are determined. (abdominalkey.com)
  • Thus, serum water is forced across the membrane, and the ultrafiltrate is analyzed for calcium concentration and then corrected for total serum solids. (abdominalkey.com)
  • Serum-ionized calcium concentration in normal subjects ranges from 4.0 to 4.9 mg/dL, or 47% of total serum calcium. (abdominalkey.com)
  • Serum levels of ALP and BAP appear to be promising biomarkers for monitoring the development of ectopic ossifications and efficacy of the therapy. (biomedcentral.com)
  • Osteocalcin levels follow a circadian rhythm characterized by a decline during the morning, a low around noon, and a gradual increase to a peak after midnight. (medscape.com)
  • Serum osteocalcin levels reportedly vary significantly during the menstrual cycle, with the highest levels observed during the luteal phase. (medscape.com)
  • Studies consistently report high correlations between serum and salivary cortisol, indicating that salivary cortisol levels reliably estimate serum cortisol levels. (salimetrics.com)
  • The normal range for total serum calcium must be established for each laboratory and varies according to the method used. (abdominalkey.com)
  • Ionized calcium in normal serum, ultrafiltrates and whole blood determined by ion-exchange electrode. (abdominalkey.com)
  • Under normal conditions, ultrafiltrable calcium constitutes 55% to 60% of the total serum calcium. (abdominalkey.com)
  • Determinations are best made on freshly separated serum, because heparin creates complexes with calcium, and the presence of fibrin may interfere with the structural integrity of the porous membrane used in the procedure. (abdominalkey.com)
  • BMD_fn, BMD_ls, BMD_th values using dual energy X-ray absorptiometry, and plasma osteocalcin, serum bone alkaline phosphatase and free soluble tumor necrosis factor (ligand) superfamily, member 11 (sRANKL) concentrations using a solid-phase, two-site chemiluminescent enzyme-labeled immunometric assay, radioimmunoassay or enzyme immunoassay were determined. (nih.gov)
  • Calcium and phosphorus levels in serum and urine samples were determined by the colorimetric method, whereas creatinine and alkaline phosphatase were analyzed by the enzymatic peroxidase antiperoxidase method on a Hitachi 737 autoanalyzer. (medscape.com)
  • In adults with normal liver function, approximately 50% of the total alkaline phosphatase activity arises from the liver and 50% from the bone. (medscape.com)
  • The skeletal maturity indicators included insulin-like growth factors (IGF-1), alkaline phosphatase (ALP), bone-specific alkaline phosphatase (BALP), dehydroepiandrosterone sulfate (DHEAS), vitamin D binding protein (DBP), parathormone-related protein (PTHrP), osteocalcin, metalloproteins, and serotransferrin (TF) along with different metabolites. (rmmj.org.il)
  • Here, we reported that TNTs could upregulate lncRNARMRP, and inhibition of lncRNARMRPin human BMSCs (hBMSCs) grown on TNTs could decrease runt-related transcription factor 2 (RUNX2), alkaline phosphatase, osteopontin, and osteocalcin (OCN) expression. (bvsalud.org)
  • In this study, we compared the sensitivity and specificity of urinary calprotectin with those of serum creatinine in detecting early intrinsic AKI. (jsce-ip.com)
  • Their serum creatinine and urinary calprotectin were measured on the first and third day of admission using Jaffe and Elisa radioimmunoassay methods, respectively. (jsce-ip.com)
  • Besides, urinary calprotectin changes occur much earlier than the rising of serum creatinine. (jsce-ip.com)
  • We aimed to ascertain the validity of the drain fluid creatinine-to-serum creatinine ratio (DCSCR) as an initial indicator of urinary leak in patients undergoing radical cystectomy. (jsce-ip.com)
  • Serum osteocalcin is considered a specific marker of osteoblast function, as its levels correlate with the bone formation rate. (medscape.com)
  • In general, serum levels are elevated in patients with diseases characterized by a high bone turnover rate, and the serum levels reflect the expected changes in bone formation following surgical and therapeutic intervention. (medscape.com)
  • Type I collagen carboxyterminal propeptide (PICP) and type I collagen carboxyterminal cross-linked telopeptide (ICTP) were determined by radioimmunoassay using an Orion Diagnostica analytical kit. (medscape.com)
  • This review aimed to critically appraise the evidence for biomarkers in blood serum, gingival crevicular fluid (GCF), saliva, and urine in comparison with standard radiographic indices for skeletal maturation assessment. (rmmj.org.il)
  • Besides, this study shows that urine calprotectin may be a more sensitive and specific biomarker than serum creatinine in the early phases of intrinsic AKI. (jsce-ip.com)
  • Osteocalcin levels follow a circadian rhythm characterized by a decline during the morning, a low around noon, and a gradual increase to a peak after midnight. (medscape.com)
  • Pubertal growth spurts were correlated with peak serum IGF-1 and BALP in both sexes individually. (rmmj.org.il)
  • To examine the associations of functional GSTM3 gene polymorphisms (Val224Ile and insdelAGG), their haplotypes and, in combination with GSTT1-null and GSTM1-null polymorphisms, with bone mineral density (BMD) measured at femoral neck (_fn), lumbar spine (_ls) and total hip (_th) and biochemical bone turnover markers in 593 Slovenian elderly women and 119 Slovenian elderly men. (nih.gov)
  • Anthropometric variables, PAI-1 and insulin levels, serum lipids and bone turnover markers were measured in 127 postmenopausal women with T2DM. (biomedcentral.com)
  • A total of 117 female patients were divided according to lumbar spine BMD measurements via dual-energy x-ray absorptiometry in three groups: 47 with osteopenia, 21 with osteoporosis and 49 with normal BMD. (biomedcentral.com)
  • MATERIALS AND METHODS: A total of 4577 adults who participated in the National Health and Nutrition Examination Survey (NHANES) during 2009-2014 were included in the study. (bvsalud.org)
  • The major advantages of using osteocalcin as a clinical index of bone turnover are its tissue specificity, its wide availability, and its relatively low within-person variation. (medscape.com)
  • Of the total 81 patients, 67 had the criteria of intrinsic AKI. (jsce-ip.com)
  • Due to the data heterogeneity, a meta-analysis could be performed on seven studies in total on IGF-1 in serum and blood. (rmmj.org.il)