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  • mitogen-activa
  • Increased transcription in response to growth factors or stress is most commonly mediated by transcription factors of the Elk-1 / SAP-1 / SAP-2 family, which are activated by MAP-Kinase family (mitogen activated protein kinase). (atlasgeneticsoncology.org)
  • phorbol
  • The role of the CaR was established by expression of a dominant-negative CaR that eliminated calcium-induced 5-HT secretion but not secretion in response to KCl or phorbol esters. (jneurosci.org)
  • protein
  • The shear stress inductions of the promoters of monocyte chemotactic protein-1 (MCP-1) and c- fos , driven by TPA-responsive element (TRE) and serum-responsive element (SRE), respectively, were attenuated by v-src(K295R). (ahajournals.org)
  • mice
  • Mice carrying an equivalent G-CSF receptor mutation were neutropenic, although bone marrow cells from these mice were hyperproliferative in response to G-CSF ( 23 , 24 ). (jimmunol.org)
  • Systemic immunisation of mice by intramuscular injection of plasmid DNA expressing HBV envelope proteins and HBV surface antigen (HBsAg) induces rapid, strong and sustained humoral and cell-mediated immune responses. (bmj.com)
  • These Tg mice secrete large amounts of HBsAg into the serum without antibody production and without apparent liver pathology. (bmj.com)
  • chronic
  • The immunogenicity of selected HBV envelope or capsid based vaccine formulations for the induction or the broadening of T and B cell responses, deficient in HBV chronic carriers, are currently under study in animal models and in clinical trials. (bmj.com)
  • By inducing immune responses closely related to those involved in clearing virus from the host, DNA vaccines may represent an alternative therapeutic approach for chronic HBV infection. (bmj.com)
  • expression
  • Using stably transfected rat-1 fibroblasts, we confirmed that PE induced c -fos mRNA expression in a time- and dose-dependent manner, and also increased [Ca 2+ ] i (measured with Fura-2 AM). These responses were blocked by the α 1 -adrenergic receptor antagonist doxazosin. (aspetjournals.org)
  • stress
  • 20 Despite many investigations on MAPKs in response to shear stress, the upstream molecules involved in the mechanotransduction to activate MAPKs are still unclear. (ahajournals.org)
  • specific
  • DNA based or genetic vaccination is an efficient new technique to stimulate specific immune responses after in vivo delivery of bacterial plasmids encoding antigens. (bmj.com)
  • critical
  • Polymorphonuclear cells (PMNs), including neutrophilic, eosinophilic, and basophilic granulocytes, execute highly effective responses against microorganisms, which are of critical importance for tissue homeostasis and wound healing ( 1 ). (frontiersin.org)