Serum resistance gene. Medical search. Frequent questions

The bacteria were also tested for their susceptibility to human blood serum. (alipac.us)
Reducing expression of this gene increases susceptibility to ER stress-induced death and results in cell proliferation. (genscript.com)
Here, it was investigated the association of INDEL variants in apoptotic genes-rs10562972 (FAS), rs4197 (FADD), rs3834129 and rs59308963 (CASP8), rs61079693 (CASP9), rs4647655 (CASP3), rs11269260 (BCL-2), and rs17880560 (TP53)-and the influence of genetic ancestry with susceptibility to malaria and parasite density in an admixed population from the Brazilian Amazon. (bvsalud.org)
CONCLUSIONS: In conclusion, variants in apoptosis genes are associated with malaria susceptibility and parasite density, indicating the role of apoptosis-related genetic profiles in immune responses against malaria infection. (bvsalud.org)

Functional analyses reveal that YAP1 positively regulates numerous genes related to cancer stemness and lipid metabolism and interacts with COUP-TFII to form a transcriptional complex. (nih.gov)
In addition, treatment with EnzaR-EVs induces the abilities of cancer stemness, lipid metabolism and enzalutamide resistance in its parental cells. (nih.gov)
Insuf﫿cient adipose lipid storage is asso- ciated with many pathological conditions including hyperlipidemia, insulin resistance, and type 2 diabetes. (deepdyve.com)
Adipocyte Senp2 de﫿ciency resulted in less adipose lipid storage accompanied by an ectopic fat accumulation and insulin resistance under high-fat diet feed- ing. (deepdyve.com)
In adipocyte Senp2-de﫿ciency mice, accumulation of the SUMOylated Setdb1 suppressed the expression of Pparg and Cebpa genes as well as lipid metabolism-related target genes, which would decrease the ability of lipid storage in adipocytes. (deepdyve.com)
This mouse also showed an ectopic lipid in﫿ammation indicates that HFD induced adipocyte death would distribution and insulin resistance. (deepdyve.com)
adqcKO Mechanistically, adipocyte Senp2 de﫿ciency caused the downregula- Senp2 mice exhibit an ectopic lipid accumulation and tion of Pparg and Cebpa as well as their downstream target genes insulin resistance related to lipid storage. (deepdyve.com)
Association of RBP4 gene variants with adverse lipid profile and obesity. (cdc.gov)
Omega-3 fatty acids had no significant effect on serum lipid levels, ApoA-I, glucose, insulin and HbA1c. (who.int)

ABSTRACT In order to define the protein expressional changes related to the process of meglumine antimoniate resistance in anthroponotic cutaneous leishmaniasis (CL), we performed a comparative proteomics analysis on sensitive and resistant strains of Leishmania tropica isolated from Iranian CL patients. (who.int)
On the other hand, mechanisms that impair the circadian clock genes, such as circadian locomotor output cycles kaput ( CLOCK ), brain and muscle Arnt-like protein 1 ( BMAL1 ), and period genes ( PER1 , PER2 , and PER3 ), contribute to defective beta-cell function and development of type 2 diabetes [ 7 - 12 ]. (hindawi.com)
The aim of the present study was to investigate the usefulness of multidrug resistance protein 1 (MDR1) and neuropeptide Y (NPY) levels in predicting the efficacy of levetiracetam (LEV) plus oxcarbazepine (OXC) treatment administered to children with epilepsy and to determine their prognosis. (usp.br)
Chen W, Tan Y, Ge Y, Chen Y, Liu X. The effects of levetiracetam on cerebrospinal fluid and plasma NPY and GAL, and on the components of stress response system, hs-CRP, and S100B protein in serum of patients with refractory epilepsy. (usp.br)
What does this gene/protein do? (cancerindex.org)
gene, that codes for regulatory X-protein[5,6]. (eprf.ca)
HBV genome consists of a gene coding for the HBx protein that has been studied to potentially contribute in inducing hepatocytes malignancy and transformation. (eprf.ca)
We further found that SET domain bifurcated 1 (Setdb1) was a SUMOylated protein and that SUMOylation promoted Setdb1 occupancy on the promoter locus of Pparg and Cebpa genes to suppress their expressions by H3K9me3. (deepdyve.com)
The protein encoded by this gene is localized in the endoplasmic reticulum (ER) and golgi, and is also secreted. (genscript.com)
Furthermore, genomic DNA samples extracted from dried blood spots collected on filter paper from one hundred and forty-four Schistosoma haematobium-infected school-children was tested for P. falciparum parasite positivity by an allele-specific nested-PCR analysis of merozoite surface protein (msp)-1 and -2 genes and a real-time PCR assay. (bvsalud.org)
[ 3 ] In addition, mutations of the gene encoding chromodomain-helicase DNA-binding protein 7 ( CHD7 ) have been found in some patients with Kallmann syndrome or idiopathic hypogonadotropic hypogonadism, some of whom have features of the CHARGE syndrome (characterized by delayed growth and development, congenital cardiac defects, dysmorphic ears, hearing loss, coloboma of the eyes). (medscape.com)
This gene encodes a member of a family of E3 small ubiquitin-related modifier (SUMO) ligases that mediates the attachment of a SUMO protein to proteins involved in nuclear transport, transcription, chromosome segregation and DNA repair. (nih.gov)
Effects of Nephrolithiasis on Serum DNase (Deoxyribonuclease I and II) Activity and E3 SUMO-Protein Ligase NSE2 (NSMCE2) in Malaysian Individuals. (nih.gov)
The HFE protein is thought to play an important role in the process by which duodenal crypt cells sense body iron stores, and the variant gene leads to increased iron absorption from the duodenum. (mhmedical.com)
An uncommon juvenile-onset variant that is characterized by severe iron overload, cardiac dysfunction, hypogonadotropic hypogonadism, and a high mortality rate is usually linked to a variant gene on chromosome 1q designated HJV that produces a protein called hemojuvelin (type 2a) or, rarely, to a variant of the HAMP gene on chromosome 19 that encodes hepcidin (type 2b). (mhmedical.com)
The normal version of the gene makes a protein on the surface of white blood cells that HIV uses as a "door handle" to invade and kill the cell. (newscientist.com)
Donors who are fully resistant have two "faulty" versions of the gene, which produce a misshapen protein that the virus cannot latch onto. (newscientist.com)
Retinol binding protein 4 as a candidate gene for type 2 diabetes and prediabetic intermediate traits. (cdc.gov)
Effects of genetic variation in the human retinol binding protein-4 gene (RBP4) on insulin resistance and fat depot-specific mRNA expression. (cdc.gov)
Effects of variation in retinol binding protein 4 gene and adipose specific expression of gestational diabetes in Beijing, China. (cdc.gov)
[ 3 ] In addition, mutations of the gene encoding chromodomain-helicase DNA-binding protein 7 ( CHD7 ) have been found in some patients with Kallmann syndrome or idiopathic hypogonadotropic hypogonadism. (medscape.com)

To screen for factors influencing serum resistance, an assay was developed based on a colorimetric serum bactericidal assay. (uni-wuerzburg.de)
99.9% of the bacterial cells by serum treatment, the colorimetric assay was used to screen 1000 colonies, of which 35 showed enhanced serum resistance. (uni-wuerzburg.de)
Isolates from 259 episodes of gonorrhoea were tested by a PCR assay for the sac-4 gene. (bmj.com)
A total of 1795 influenza viruses were tested for oseltamivir-resistance using a fluorometric neuraminidase inhibition assay. (who.int)

Neisseria meningitidis employs polysaccharides and outer membrane proteins to cope with human serum complement attack. (uni-wuerzburg.de)
Viral proteins play their tasks through altering gene manifestation. (eprf.ca)
These proteins augment oncogenesis, metastases and resistance to apoptosis and growth inhibition. (eprf.ca)
In addition, immunogold electron microscopy using antisera against EbpA-EbpC proteins as well as patient serum demonstrated that E. faecalis produces pleomorphic surface pili. (jci.org)

When RTH is suspected, the diagnosis should be confirmed by direct sequencing of the TR-β gene to identify mutations. (endocrine-abstracts.org)
Mutations of the KAL1 gene, which encodes a putative neural cell adhesion molecule (anosmin), have been described in several patients with X-linked Kallmann syndrome. (medscape.com)
Loss-of-function mutations of the gene encoding fibroblast growth factor receptor 1 (FGFR1) have been described in patients with autosomal dominant Kallmann syndrome. (medscape.com)
[ 2 , 3 ] Heterozygous loss-of-function mutations of the gene encoding FGFR1 have also been described in individuals with idiopathic hypogonadotropic hypogonadism, normal smell sense, and normal MRI of the olfactory system. (medscape.com)
Mutations of the gene encoding fibroblast growth factor 8 have been found in a small minority of patients with autosomal dominant Kallmann syndrome. (medscape.com)
Naturally occurring mutations in this gene, that abolish the SUMO ligase activity, are associated with primordial dwarfism and extreme insulin resistance. (nih.gov)
Zettner MA, Flor S, Ludewig G, Wagner J, Robertson LW, Lehmann L. Quinoid metabolites of 4-monochlorobiphenyl induce gene mutations in cultured Chinese hamster v79 cells. (who.int)
Mutations of the DAX1 gene, which encodes a nuclear transcription factor, lead to X-linked idiopathic hypogonadotropic hypogonadism associated with adrenal hypoplasia congenita (AHC). (medscape.com)
[ 10 ] Mutations of genes encoding either leptin or the leptin receptor underlie isolated cases of autosomally transmitted idiopathic hypogonadotropic hypogonadism associated with early-onset obesity. (medscape.com)
[ 11 ] Several loss-of-function mutations of the GnRH receptor gene leading to GnRH resistance and autosomally transmitted hypogonadotropic hypogonadism have been described. (medscape.com)
[ 12 ] . In addition, autosomal recessive mutations of the GnRH gene may underlie hypogonadotropic hypogonadism. (medscape.com)
Rarely, hypogonadotropic hypogonadism occurs as a result of isolated follicle-stimulating hormone (FSH) deficiency due to homozygous mutations in the FSH beta subunit gene. (medscape.com)
7. Known HIV-1 resistance mutations that would preclude remaining on current ART or a switch to a study regimen, in the opinion of the site investigator. (who.int)

High serum ferritin levels are seen in hyperferritinemia cataract syndrome associated with pathogenic variants in the FTL (ferritin L-chain) gene. (mhmedical.com)
Effect of RBP4 gene variants on circulating RBP4 concentration and type 2 diabetes in a Chinese population. (cdc.gov)
Association of RBP4 gene variants and serum HDL cholesterol levels in the Newfoundland population. (cdc.gov)
and RBP4 gene variants on metabolic syndrome in HIV-infected patients with anti-retroviral therapy. (cdc.gov)
RBP4 gene variants are associated with insulin resistance in women with previous gestational diabetes. (cdc.gov)

Chen M, Hou C, Huo D, Bao J, Fa H, Shen C. An electrochemical DNA biosensor based on nitrogen-doped graphene/Au nanoparticles for human multidrug resistance gene detection. (usp.br)

Sleep disorder is associated with insulin resistance and impaired glucose tolerance in multiple metabolic pathways in healthy subjects or in subjects with diabetes [ 6 ]. (hindawi.com)
Furthermore, obstructive sleep apnea-hypopnea syndrome (OSAHS) is also associated with insulin resistance, and it is common in subjects with diabetes. (hindawi.com)
Title: Circulating mesencephalic astrocyte-derived neurotrophic factor is increased in newly diagnosed prediabetic and diabetic patients, and is associated with insulin resistance. (genscript.com)

This Special Issue of "Genes" seeks reviews and original papers covering a wide range of topics related to microRNA biology, such as regulation of expression in various disorders (cancer, metabolism, autoimmunity to mention but a few), genetics of microRNAs and their target sites, functional analysis of microRNA function and studies of interactions between microRNAs and target genes. (mdpi.com)
These genes increase oxygen availability by inducing erythropoiesis and angiogenesis, and also reduce its demand via regulation of energy metabolism by reducing oxidative phosphorylation and inducing non-oxygen-demanding glycolysis [ 5 , 6 , 7 ]. (springer.com)

The data suggest that the mucoid phenotype could be associated with extrachromsomal element(s) carrying resistance genes to antibiotics and that these extrachromosomal elements may not harbour resistance determinants to chloramphenicol. (scirp.org)
Furthermore, the extrachromosomal elements bearing the mucoid phenotype and the resistance elements in the mucoid strains do not significantly impact on the fitness of the cognate strain. (scirp.org)
Whether these phenotype and resistances that had no fitness cost to the bacterium could significantly affect the virulence of the bacteria in vivo remains to be investigated. (scirp.org)
The contribution of the mucoid phenotype to pathogenesis has been demonstrated in several models: in general, the mucoid isolates are more resistant to phagocytosis, less sensitive to serum killing and more virulent in animal studies. (scirp.org)
Polymorphisms in modifier genes have been shown to lead to a high iron phenotype. (mhmedical.com)

Therefore, it is important to describe their mechanisms of actions, expression patterns and possible target genes and cellular pathways with which they interact. (mdpi.com)

however, none of these in addition to none of the other serum lipids, differed between bread treatments, within either participant group. (biomedcentral.com)

Over the long term one assumes that 'better solutions' will emerge which do not have so high a fitness drag, perhaps through the evolution of modifier genes which mask the deleterious outcomes of the initial mutant. (discovermagazine.com)

Effect of Chronic Aerobic/Resistive Exercises with Supplementation of Cinnamon on Insulin Resistance in Women with Polycystic Ovary Syndrome in Ahvaz City in 2017. (ac.ir)

It is characterized by high serum concentrations of free T4 (Ft4) and usually free T3 (Ft3) accompanied by normal or slightly high serum TSH concentrations. (endocrine-abstracts.org)
Changes in PCB serum concentrations among capacitor manufacturing workers. (who.int)

Transcript levels of circadian clock genes ( BMAL1 , PER1 , PER2 , and PER3 ) were determined by real-time quantitative polymerase chain reaction. (hindawi.com)
Serum MDR1 and NPY levels exhibited a high predictive value for early epilepsy diagnosis, treatment efficacy assessment, and prognostication in children with epilepsy treated with LEV plus OXC combination. (usp.br)
The clinical onset and progression of most CRPC is accompanied by rising levels of serum prostate specific antigen (PSA), a gene transcriptionally regulated by AR. (ubc.ca)
The formation of GFP-LC3 (light chain 3) punctae and PE (phosphatidylethanolamine)-conjugated LC3 (LC3-II) in serum-starved cells was inhibited by NRBF2 knockdown in the absence and presence of lysosomal inhibitors, and p62 levels were increased. (nih.gov)
On both diets, the Hif-p4h-2 gt/gt mice gained less weight and had less white adipose tissue (WAT) and its inflammation, lower serum cholesterol levels, and lighter livers with less steatosis and lower serum ALT levels than the wild type (WT). (springer.com)
Unusually low levels of triglycerides can be present in disease states, producing syndromes of malabsorption in addition to patients who carry genes for familial hypobetalipoproteinemia . (medscape.com)
Levels greater than 149 mg/dL constitute hypertriglyceridemia , and severity of TG is further classified by serum values falling within classification value ranges. (medscape.com)
Very high levels of triglycerides are defined by serum levels of 500 mg/dL or greater and can be concerning for development of pancreatitis . (medscape.com)
A third gene variant (S65C) may lead to increased serum iron and ferritin levels without clinical significance (type 1c). (mhmedical.com)
This study investigates the effect of stevia on serum omentin and visfatin levels as novel adipocytokines in diabetic induced rats to find potential mechanisms for the anti hyperglycemic effect of stevia. (researchgate.net)
Serum organochlorine levels and breast cancer: a nested case-control study of Norwegian women. (who.int)
This patient presented with hypogonadotropic hypogonadism, despite high levels of immunoreactive serum LH. (medscape.com)
Preceding the 2007/2008 northern hemisphere season, instances of oseltamivir-resistance occurred at low levels in seasonal human influenza viruses. (who.int)

Sickle-cell disease one of the classical illustrations of heterozygote advantage, whereby those who carry one copy of the mutation on the gene have increased fitness vis-a-vis those who carry two normal copies of the gene. (discovermagazine.com)
HFE gene mutation (usually C282Y/C282Y) is found in most cases. (mhmedical.com)
In one patient, isolated bioinactive luteinizing hormone (LH) was present as a result of a homozygous mutation in the LH beta subunit gene, which prevented binding of LH to its receptor. (medscape.com)
A second patient had a different homozygous mutation in the LH beta subunit gene that prevented LH heterodimerization and secretion. (medscape.com)
Sequencing of the neuraminidase gene showed that the resistant viruses contained an H275Y mutation, and S247N was also identified in the neuraminidase gene of one seasonal influenza A(H1N1) virus that exhibited enhanced resistance. (who.int)

To assess this phenomenon, we established tumor myofibroblasts cell line and analyzed the up-regulating genes in myofibroblasts upon exposure with hypoxia and/or serum starvation. (nii.ac.jp)
In particular, the present invention provides methods for enhancing the effectiveness of chemotherapy by inducing differential stress resistance in normal cells and cancer cells via short-term starvation, cell growth inhibitors, or reduced caloric or glucose intake. (justia.com)

We suggest that autoaggregation reduced the surface area accessible to serum complement and protected from killing. (uni-wuerzburg.de)
2 This gene conferred stable (not lost on subculture) complement factor C1q dependent serum resistance in gonococci. (bmj.com)
Sera from most healthy children less than 16 months old lacked NTS-specific antibody, and sera lacking antibody did not kill NTS despite normal complement function. (ox.ac.uk)
All NTS strains tested had long-chain lipopolysaccharide and the rck gene, features that resist direct complement-mediated killing. (ox.ac.uk)
We conclude that Salmonella-specific antibody that overcomes the complement resistance of NTS develops by 2 years of life in Malawian children. (ox.ac.uk)

This study aimed to investigate the possible association between exon 1 polymorphisms of the NOEY2 gene in women with PCOS and diabetes. (ac.ir)

As a result, when tumor vasculature was focused, we found that cancer stem cells existing near myofibroblasts abundantly localizing at perivascular area show drug resistance. (nii.ac.jp)
In this treatment, we identified that CD44 is up-regulated under the hypoxia and this molecule supports stemness of cancer stem cells and induces drug resistance of cancer cells. (nii.ac.jp)
Spheroids exhibit drug resistance and slow proliferation, suggesting involvement in cancer recurrence. (duke.edu)
Since enzalutamide is innovated and approved by US FDA as a new treatment option for mCRPC patients, drug resistance for enzalutamide is a critical issue during clinical usage. (nih.gov)
Over the last decade there has been an extensive amount of research into the development and occurrence of antiviral drug resistance in human influenza viruses. (who.int)
7 Such work not only determines the present efficacy of the drug but also reveals important information on the genesis of anti-viral drug resistance in influenza viruses. (who.int)
Drug resistance val (CI) = 1.4-62) did not outperform corresponding classifiers based on clinical variables. (lu.se)
Possible mechanisms for gram for breast cancer in southern Sweden issued 1991, pre- recurrence after treatment are low initial drug sensitivity or menopausal lymph node positive (N+) breast cancer patients an acquired drug resistance. (lu.se)
Radiotherapy was delivered to ipsilateral axil- cancer patients in the future, it is essential to increase our lary and supraclavicular lymph nodes and the remaining knowledge in mechanisms responsible for drug resistance, breast parenchyma after breast conservation surgery or tho- and to define reliable indicators for response to therapy. (lu.se)

The purpose of this study was to evaluate the sensitivity, specificity, and predictive value of serum procalcitonin (PCT) for osteomyelitis and septic arthritis in children. (lww.com)

Serum biomarkers of fibrosis may be an alternative to liver biopsy for identifying advanced fibrosis. (mhmedical.com)
How Reliable Are Gene Expression-Based and Immunohistochemical Biomarkers Assessed on a Core-Needle Biopsy? (lu.se)

Naoise McGarry, Stephen Smith, Escherichia coli serum resistance : roles for cell number and Haemolysin. (tcd.ie)

Furthermore, mRNA expression of circadian clock genes is dampened in peripheral leucocytes of subjects with poor sleep quality. (hindawi.com)

Scholars@Duke publication: Targeting Dormant Ovarian Cancer Cells In Vitro and in an In Vivo Mouse Model of Platinum Resistance. (duke.edu)
The tumor-suppressor gene ARHI (DIRAS3) suppresses ovarian cancer cell migration through inhibition of the Stat3 and FAK/Rho signaling pathways. (ac.ir)
The tumor suppressor gene ARHI regulates autophagy and tumor dormancy in human ovarian cancer cells. (ac.ir)

Isogenic mutant analysis demonstrated that in ST-41/44 cc strains the L8/L1 immunotype was more serum resistant than the L3 immunotype. (uni-wuerzburg.de)
The researchers discovered that E. coli strains with the MCR-1 gene were at least twice as resistant to human serum compared to those lacking the gene. (alipac.us)
Finally, a human prostate cancer cell line model resistant to growth inhibition by EPI-002 was generated, allowing future studies to investigate mechanisms of resistance against AR inhibition through the NTD. (ubc.ca)
Although several underlying mechanisms causing enzalutamide resistance were previously identified, most of them revealed that drug resistant cells are still highly addicted to androgen and AR functions. (nih.gov)
One received a graft from a resistant donor who had one faulty copy of the CCR5 gene. (newscientist.com)
The importance of surveillance for resistance to oseltamivir has been highlighted by two global events: the emergence of an oseltamivir-resistant seasonal influenza A(H1N1) virus in 2008, and emergence of the influenza A(H1N1)pdm09 virus in 2009. (who.int)
To determine the frequency of oseltamivir-resistance in the context of a medicine reclassification in 2007, the importation of an oseltamivir-resistant seasonal influenza virus in 2008, and the emergence of a pandemic in 2009. (who.int)

NSMCE2, a novel super-enhancer-regulated gene, is linked to poor prognosis and therapy resistance in breast cancer. (nih.gov)

Diagnosis involves measurement of serum calcium with adjustment for serum albumin concentration. (msdmanuals.com)

These processes to severe lipodystrophy and induces insulin resistance in mice (He et al. (deepdyve.com)

At the end of the study significant reductions in fasting blood sugar (FBS), the homeostasis model assessment insulin resistance (HOMA-IR), triglyceride (TG), alkaline phosphatase (ALP), and Omentin level were found in groups 3 and 4 in comparison with group 2. (researchgate.net)

It is generally believed that dawn phenomenon is a result of pancreatic beta-cell dysfunction, which increases endogenous glucose production, persistent insulin resistance, and hepatic glucose output. (hindawi.com)
Disruption of these clock genes affects locomotor activity, feeding behavior, metabolism, and glucose homeostasis [ 14 ]. (hindawi.com)
Serum MANF level was higher in patients with newly diagnosed prediabetes and T2 Diabetes Mellitus than in normal glucose tolerance controls. (genscript.com)
This invention relates to methods of inducing differential stress resistance in a subject with cancer by starving the subject for a short term, administering a cell growth inhibitor to the subject, or reducing the caloric or glucose intake by the subject. (justia.com)

Usually suspected because of a family history or an elevated iron saturation or serum ferritin. (mhmedical.com)

Hypertriglyceridemia is indicative of insulin resistance when present with low high-density lipoprotein (HDL) and elevated low-density lipoprotein (LDL), while elevated triglyceride is a clinical risk factor for coronary artery disease (CAD), especially when low HDL is present. (medscape.com)

Serum and nasal wash antibodies associated with resistance to experimental challenge with influenza A wild-type virus. (wikipedia.org)
Nor can we find antibodies to the virus, as they all seem to have disappeared from our patients' serum," he said. (newscientist.com)

In the study, E. coli strains carrying a resistance gene called MCR-1 were exposed to AMPs known to play significant roles in innate immunity across chickens, pigs and humans. (alipac.us)
The Multiple Antibiotic Resistance (MAR) index shows the themucoid strains with a high MAR index range of 0.7 - 1.0 with a median MAR index of 0.8, while the non-mucoid strains had a MAR index of 0.2 - 0.8 with a median MAR index of 0.35. (scirp.org)

In addition, our research efforts are focused on ways of combatting resistance mechanisms to existing drugs. (gene.com)

Despite these efforts, however, the new study suggests that antibiotic resistance continues to rise, posing a major threat to human health and global food security. (alipac.us)
As the world grapples with the challenge of antibiotic resistance, it is clear that urgent action is needed to address this growing problem. (alipac.us)
Umar, U. , Anagor, S. , Aliyu, A. and Suleiman, A. (2016) Hypermucoviscosity in Clinical Isolates of Klebsiella pneumoniae Correlates with High Multiple Antibiotic Resistance (MAR) Index. (scirp.org)

For example, vascular function was unchanged following a nanosilver exposure despite lung injury, increased inflammatory cell influx, and induction of inflammatory genes. (cdc.gov)

Mechanistically, EPB41L4A-AS2, acting at least in part as a tumor suppressor, upregulated tumor suppressor gene expression. (cancerindex.org)
NOEY2 (ARHI), an imprinted putative tumor suppressor gene in ovarian and breast carcinomas. (ac.ir)
Biochemistry and biology of ARHI (DIRAS3), an imprinted tumor suppressor gene whose expression is lost in ovarian and breast cancers. (ac.ir)

Some of the genes involved in the pathogenesis of Kallmann syndrome and idiopathic hypogonadotropic hypogonadism have been identified. (medscape.com)

and 3) Generation of a prostate cancer cell line model with resistance to EPI-002. (ubc.ca)
To generate a prostate cancer cell line model that developed resistance to EPI-002, LNCaP human prostate cancer cells were cultured under chronic EPI-002 exposure. (ubc.ca)
The diterpenoids blocked androgen-dependent AR transcriptional activity with a structure-activity relationship, reduced androgen-regulated gene expression, and inhibited the proliferation of androgen-sensitive prostate cancer cells. (ubc.ca)
Introduction: Psoriasis is not only a skin disease, is a chronic inflammatory disease associated with serious comorbidities: psoriatic arthritis, metabolic syndrome (obesity, dyslipidemia and insulin resistance), Crohn s disease, depression, ocular problems, cardio-vascular diseases (myocardial infarction), cancer.Methods: 1236 patients (male 54.13% and female 45.87%) with psoriasis were seen in an Outpatient Clinic over a period of 8 years (2004. (endocrine-abstracts.org)
Taken together, these results suggest that YAP1 might be a crucial factor involved in the development of enzalutamide resistance and can be an alternative therapeutic target in prostate cancer. (nih.gov)
The present invention provides a novel approach to cancer therapy by providing a method to differentially enhance the resistance of normal cells to chemotherapeutic agents, thereby, improving the effectiveness of chemotherapeutic agents in killing cancerous cells. (justia.com)
More specifically, in one aspect, the invention features methods of inducing differential stress resistance in a subject with cancer. (justia.com)
In another aspect, the invention features methods of contacting a cancer cell with a chemotherapy agent and methods of increasing resistance of a non-cancer cell to a chemotherapy agent. (justia.com)
Our data have provided evidence for a comparable prediction of clinical outcome in CMF-treated breast cancer patients using conventional clinical variables and gene expression based markers. (lu.se)
or known personal history of breast cancer (BRCA) gene. (who.int)

Since the first microRNA was identified in 1993 by Victor Ambros and colleagues (the lin-4 heterochronic gene in C. Elegans ), more than 24,000 microRNAs have now been identified. (mdpi.com)

A single amino acid in the PB2 gene of influenza A virus is a determinant of host range. (wikipedia.org)

The following MANF gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). (genscript.com)
A primer pair was designed and synthesized for the exon 1 sequence of the NOEY2 gene. (ac.ir)

We mapped k13 as the central mediator of ART resistance in vitro and identified secondary markers. (bvsalud.org)

Hemochromatosis is an autosomal recessive disease caused in most cases by a pathogenic variant in the HFE gene on chromosome 6. (mhmedical.com)

This is potentially much more dangerous than resistance to antibiotics," warned study lead author Craig MacLean, a professor of Evolution and Microbiology at Oxford. (alipac.us)

To discover novel AR inhibitors, candidate compounds identified from high throughput screening were characterized by fluorescent ligand binding assays, AR-driven reporter assays, qPCR gene expression analyses, and proliferation assays. (ubc.ca)

Conversely, an incidental nanoparticle exposure to resistance spot welding particles induced marked vascular dysfunction with no alterations in general lung toxicity or inflammation. (cdc.gov)
Serum from mice exposed to multi-walled carbon nanotubes (MWCNT) attenuated vascular dilation, decreased nitric oxide production, and induced cellular inflammation. (cdc.gov)

Production of infectious human respiratory syncytial virus from cloned cDNA confirms an essential role for the transcription elongation factor from the 5' proximal open reading frame of the M2 mRNA in gene expression and provides a capability for vaccine development. (wikipedia.org)
We tried several gene selection strategies, and built classifiers using the resulting cDNA microarray gene lists. (lu.se)

Search the gene expression profiles from curated DataSets in the Gene Expression Omnibus (GEO) repository. (cancerindex.org)

By implementing a P. falciparum genetic cross using humanized mice, we report the identification of key determinants of resistance to artemisinin (ART) and piperaquine (PPQ) in the dominant Asian KEL1/PLA1 lineage. (bvsalud.org)

It is considered the hepatic manifestation of metabolic syndrome, strongly linked to obesity and insulin resistance (IR), which further predisposes for diabetes and cardiovascular diseases [ 2 ]. (springer.com)

Disruption of lipopolysaccharide biosynthesis enabled killing of NTS by serum lacking Salmonella-specific antibody. (ox.ac.uk)

MacLean noted that the danger lies in the potential evolution of bacterial resistance to AMP-based drugs. (alipac.us)
Increasing multidrug resistance in Enterococcus faecalis, a nosocomial opportunist and common cause of bacterial endocarditis, emphasizes the need for alternative therapeutic approaches such as immunotherapy or immunoprophylaxis. (jci.org)

Applying bulk segregant analysis, quantitative trait loci mapping using 34 recombinant haplotypes, and gene editing, our data reveal an epistatic interaction between mutant PfCRT and multicopy plasmepsins 2/3 in mediating high-grade PPQ resistance. (bvsalud.org)

On average, the gene increased resistance to human and animal AMPs by 62 percent. (alipac.us)
A549-ASCoV2 NLRP1 cells and their control cell line overexpress the genes encoding the SARS-CoV-2 human receptors, ACE2 and TMPRSS2 [1], and are thus highly permissive to SARS-CoV-2 infection. (invivogen.com)

The aims of this study were to determine the frequency of the sac-4 gene in a larger sample of isolates of different serovars and to assess the prevalence of sac-4 in gonococcal isolates from patients with and without coexisting chlamydial infection. (bmj.com)
1 Recently a gene, sac-4, was found in a high proportion of gonococcal isolates from patients with coexisting chlamydial infection and it was postulated that sac-4 increased the risk of development of mixed gonococcal and chlamydial infection. (bmj.com)
Finally, YAP1, COUP-TFII, and miR-21 are detected in the extracellular vesicles (EVs) isolated from EnzaR cells and sera of patients. (nih.gov)
However, the genes involved remain unidentified in over 50% of patients. (medscape.com)
Two further patients, known as the " Boston patients ", received bone marrow from normal donors, but each patient naturally had single copies of a faulty version of CCR5 , giving them partial resistance to the virus. (newscientist.com)
Neither of the Sydney patients had any natural resistance. (newscientist.com)

The increase in frequency of the mutant gene though is balanced by the fact that mutant homozygotes have decreased fitness. (discovermagazine.com)

After gene amplification by polymerase chain reaction (PCR) and evaluation of band quality, Sanger sequencing was performed on PCR products. (ac.ir)

This indicates aberrant AR transcriptional activity is involved in driving CRPC and conferring therapy-resistance. (ubc.ca)

Anatomy10

Organisms53

Diseases10

Chemicals and Drugs84

Analytical, Diagnostic and Therapeutic Techniques and Equipment23

Phenomena and Processes82

Anthropology, Education, Sociology and Social Phenomena1

Technology, Industry, Agriculture8

Information Science4

Health Care1

Susceptibility4

Lipid9

Protein21

Assay4

Proteins4

Mutations13

Variants5

Multidrug resistance gene1

Associated with insulin resistance3

Regulation2

Phenotype5

Target genes1

Lipids1

Modifier genes1

Insulin resistance in women1

Concentrations2

Levels13

Mutation5

Starvation2

Complement5

Polymorphisms1

Drug resistance9

Predictive value1

Biomarkers2

Escherichia1

MRNA expression1

Ovarian cancer3

Resistant7

Poor prognosis1

Concentration1

Induces1

HOMA-IR1

Glucose4

Ferritin1

Triglyceride1

Antibodies2

Strains2

Mechanisms1

Antibiotic resistance3

Induction1

Tumor3

Hypogonadotropic hypogonadism1

Cancer10

Elegans1

Influenza A vir1

Sequence2

Markers1

Chromosome1

Antibiotics1

Reporter1

Inflammation2

CDNA2

DataSets1

Determinants1

Obesity1

Disruption1

Bacterial2

Recombinant1

Human2

Patients6

Mutant1

Amplification1

Transcriptional activity1