• Because multiple other factors can contribute to AKI development in the complex clinical setting of LuTx, we next investigated the role of exogenous CFH administration in a mouse model of mild bilateral renal ischemia reperfusion injury (IRI). (stanford.edu)
  • Sprague-Dawley (SD) rats were subjected to bilateral renal artery clamping for 45 min followed by perfusion restoration for establishing a simulated renal IRI model. (frontiersin.org)
  • A total of 24 Adult males of Swiss albino mice were randomized to four groups: I/R group (n = 6), mice underwent 30 minute bilateral renal ischemia and 48 hr reperfusion. (biomedcentral.com)
  • B) The localization of miR-181d-5p in the mouse kidney after IRI (45 min of bilateral renal ischemia followed by 24 h of reperfusion) was assessed by hybridization. (opioid-receptors.com)
  • Cells were harvested at different time points after the bilateral renal pedicle was clamped for 45 min (= 4 or 5 5 per group). (opioid-receptors.com)
  • C57BL/6 mice had been injected with AAVs and, 3 weeks afterwards, were put through 45 min of bilateral renal ischemia accompanied by 24 h of reperfusion. (opioid-receptors.com)
  • Rats, subjected to bilateral renal ischemia (45 min) followed by reperfusion (6 h), were administered EUK-134 (0.3 and 3 mg/kg, i.v.) prior to and during reperfusion, after which biochemical and histological indicators of renal dysfunction and injury were measured. (scienceopen.com)
  • hybridization assay outcomes uncovered that miR-181d-5p staining was distributed generally in renal tubular epithelial cells (RTECs) in the renal cortex (Amount 1B). (opioid-receptors.com)
  • The tubular epithelial cells of the S3 segment of the proximal tubule in the outer stripe of the medulla, at the corticomedullary junction, are most susceptible to ischemic injury as these cells live in a relatively hypoxic environment. (medscape.com)
  • In conclusion, the intricate relations between endothelial and epithelial cells, based in part on the relations between endothelial and inducible nitric oxide synthases, are perturbed in renal ischemia primarily as a result of endothelial dysfunction precipitating epithelial injury. (scienceopen.com)
  • In this study, we induced iPSCs differentiation into RPCs using a nephrogenic cocktail of factors combined with the renal epithelial cell growth medium. (biomedcentral.com)
  • We showed that the differentiation efficiency of iPSCs to RPCs increased when cultured with renal epithelial cell growth medium after stimulation with a nephrogenic cocktail of factors. (biomedcentral.com)
  • The necrosis degree and range of renal tubular epithelial cells and inflammatory cell infiltration degree were reduced in the IRI+ MDSC group. (cma-cmc.com.cn)
  • In vitro experiments showed that OA alleviated HR-induced mitochondrial homeostasis imbalance in renal tubular epithelial cells. (figshare.com)
  • The therapeutic effect of MSCs came from paracrine effect to inhibit testicular apoptosis, reduce intra-testicular oxidative stress, and maintain serum testosterone level. (biomedcentral.com)
  • One of the primary causes of ARF is ischemia/reperfusion (I/R). Inflammatory process and oxidative stress are thought to be the major mechanisms causing I/R. MK-886 is a potent inhibitor of leukotrienes biosynthesis which may have anti-inflammatory and antioxidant effects through inhibition of polymorphonuclear leukocytes (PMNs) infiltration into renal tissues. (biomedcentral.com)
  • Dey A, Cederbaum AI: Alcohol and oxidative liver injury. (edu.pl)
  • Thus, inhibition of oxidative stress and myocardial apoptosis is beneficial in the treatment of myocardial I/R injury. (spandidos-publications.com)
  • Oxidative and nitrosative stress plays important roles in the pathogenesis of renal ischemia/reperfusion (I/R) injury. (scienceopen.com)
  • Here we investigate the effect of EUK-134, a synthetic superoxide dismutase and catalase mimetic, (i) on renal dysfunction and injury caused by I/R in vivo and (ii) on proximal tubular cell (PTC) injury and death caused by oxidative and nitrosative stress. (scienceopen.com)
  • We propose that EUK-134 reduces renal I/R injury not only via reduction of oxidative stress, but also by reducing nitrosative stress caused by renal I/R. (scienceopen.com)
  • The findings emphasize the role of concomitant oxidative and nitrosative stress and the role of peroxynitrite in the ensuing renal dysfunction. (scienceopen.com)
  • The ischemic injury underlying these illnesses is complex, involving intricate interplays among many biological functions including energy metabolism, vascular regulation, hemodynamics, oxidative stress, inflammation, platelet activation, and tissue repair that take place in a context- and time-dependent manner. (cdc.gov)
  • Testicular torsion is an urological emergency that may lead to infertility due to ischemic injury. (biomedcentral.com)
  • Scavenging peroxynitrite using seleno-organic compounds like ebselen provides renoprotection against ischemic injury. (scienceopen.com)
  • hence, NGAL is considered to be a novel urinary biomarker for ischemic injury. (medscape.com)
  • At 24 h post-operatively, we assessed the serum levels of creatinine and urea nitrogen, expression levels of peroxisome proliferator-activated receptor gamma (PPAR-γ) and NF-κB-related (p-IKK-β and IκB-α) proteins, and mRNA expression levels of the inflammatory cytokines, including TNF-α and MCP-1, in the renal tissue of various study groups. (frontiersin.org)
  • The histopathological evaluation of renal tissue was also conducted. (frontiersin.org)
  • In rat renal tissue, pioglitazone treatment decreased the serum levels of post-renal IRI creatinine and urea nitrogen, as well as necrosis. (frontiersin.org)
  • Pioglitazone also decreased the mRNA expression of TNF-α and MCP-1 in the renal tissue. (frontiersin.org)
  • The microvascular and parenchymal organ damage induced upon ischemia tissue reperfusion is mainly attributed to the reactive oxygen-free radicals, and it has been demonstrated in many organs. (frontiersin.org)
  • The production of antioxidant enzymes that scavenge free radicals in ischemic tissue is then impaired, thereby exacerbating the damage caused by these free radicals in the post ischemic reperfusion tissue. (frontiersin.org)
  • One of the primary causes of ARF is I/R which is a drop in blood flow leading to inadequate supply of oxygen and nutrients to renal tissue which can be caused by, amongst others, surgery, organ transplantation and shock [ 1 ]. (biomedcentral.com)
  • This technique reduced TBARS levels in blood and intestinal tissue and promoted the maintenance of antioxidant defense in mesenteric acute injury. (scielo.org)
  • The extension phase is characterized by ongoing hypoxia leading to sustained tissue ischemia, which triggers an inflammatory response. (medscape.com)
  • Correia Miranda LE, Capellini VK, Reis GS, Celotto AC, Carlotti Jr CG, PRB: Effects of partial liver ischemia followed by global liver reperfusion on the remote tissue expression of nitric oxide synthase: lungs and kidneys evora. (edu.pl)
  • Restoration of blood supply, termed reperfusion, has been used to treat ischemic myocardium and prevent further tissue damage. (spandidos-publications.com)
  • Twenty-four hours after perfusion, blood and kidney tissue samples of mice were collected, and the pathological changes of kidney tissue were observed by hematoxylin-eosin (HE) staining, and the contents of blood urea nitrogen (BUN) and serum creatinine (Cr) were detected. (cma-cmc.com.cn)
  • Physical trauma includes fractures, respiratory compromise, injuries to soft tissue and internal organs, internal and external blood loss with shock, burns, and sensory impairment, especially of hearing and sight. (msdmanuals.com)
  • The supersonic blast wave in primary blast injury compresses gas-filled spaces, which then rapidly reexpand, causing shearing and tearing forces that can damage tissue and perforate organs. (msdmanuals.com)
  • Traumatic Brain Injury (TBI) Traumatic brain injury (TBI) is physical injury to brain tissue that temporarily or permanently impairs brain function. (msdmanuals.com)
  • but reperfusion may introduce additional harm to the tissue through a process known as ischemia/reperfusion injury. (cdc.gov)
  • These observations raise the prospect for therapeutic modulation of SGK-1 to reduce the burden of such diseases as myocardial infarction and acute kidney injury . (bvsalud.org)
  • The essential role of the mitochondrial permeability transition pore in cell death coupled with the pro- survival function of SGK-1 raise the prospect that its therapeutic modulation could beneficially impact conditions associated with ischemia-reperfusion injury . (bvsalud.org)
  • Thus, evaluation of existing information should help identify gaps in our current knowledge and also determine whether and how its therapeutic modulation could impact the outcome of ischemia-reperfusion injury . (bvsalud.org)
  • Moreover, the transitivity of exRNA information between cells suggests their functional and probably therapeutic roles in renal diseases. (biomedcentral.com)
  • Since many situations resulting from traumatic accidents or pathologies are due to cell damage caused by ischemia-reperfusion syndrome, it is relevant to study new therapeutic alternatives that will contribute to reducing these lesions. (scielo.org)
  • Next, we examined the renal function-related markers and renal histology to assess the therapeutic effect of the injected cells. (biomedcentral.com)
  • Although pharmacological therapy, modern dialysis techniques, and intermittent or continuous renal replacement therapies exist, the therapeutic approaches for AKI remain very limited. (biomedcentral.com)
  • Methods: The therapeutic effect of OA was evaluated by using ischemia-reperfusion (IR) and cisplatin mediated-AKI mice and HK-2 cells under hypoxia-reoxygenation (HR) conditions. (figshare.com)
  • Here we review the current literature on scutellarin to provide a comprehensive understanding of the pharmacological activity, mechanism of action, toxicity, and therapeutic potential of scutellarin for the treatment of ischemia, diabetic complications, and other chronic diseases. (cdc.gov)
  • Liver ischemia/reperfusion (IR) often affects distant organs, such as small intestine, kidney, and lung. (rjme.ro)
  • Exogenous administration of CFH after reperfusion caused overt AKI with creatinine increase, tubular injury, and enhanced markers of renal inflammation compared with vehicle-treated animals. (stanford.edu)
  • In this study, we investigated the role of the NF-κB signaling pathway and inflammation in the amelioration of renal IRI using pioglitazone. (frontiersin.org)
  • Recent clinical studies have reported that using statins during the perioperative period can limit inflammation and oxidation, reduce cardiac muscle injury, and improve the patient's prognosis [ 2 - 4 ], but the dosage, duration, effects, and mechanisms associated with these outcomes are not clear. (hindawi.com)
  • The underlying mechanisms behind myocardial I/R injury are associated with a number of factors, including substantial free radical production, intracellular calcium overload, increased inflammation, myocardial necrosis and apoptosis ( 6 ). (spandidos-publications.com)
  • Kaul K., Hodgkinson A., Tarr J.M. Is inflammation a common retinal-renal-nerve pathogenic link in diabetes? (jscientia.org)
  • Sevoflurane represses the release of inflammatory factors, lowers ROS level and apoptosis of renal cells and improves renal function through activation of RISK signaling pathway in kidney tissues of rats with renal IRI. (ajol.info)
  • We designed this study to identify changes in HMGB1 expression in rat kidney tissues after ischemia reperfusion injury and effects of EP on the expression of HMGB1. (elsevierpure.com)
  • However, reperfusion following a period of prolonged ischemia can often cause myocardial ischemia-reperfusion (I/R) injury, leading to damage of cardiac tissues ( 5 ). (spandidos-publications.com)
  • The transplantation of iPSC-derived RPCs decreased the levels of biomarkers indicative of renal injury and attenuated the necrosis and apoptosis of renal tissues, but resulted in the up-regulation of renal tubules formation, cell proliferation, and the expression of pro-renal factors. (biomedcentral.com)
  • In the present work, a hypoxia/reoxygenation (H/R) model in NRK-52E cells and ischemia-reperfusion model in rats were used. (mdpi.com)
  • Of whether miR-181d-5p was overexpressed or suppressed Irrespective, its appearance exhibited a downward development after either I/R or H/R (Statistics 1E,F). Open up in another window Amount 1 Manifestation and localization of miR-181d-5p during renal IRI and hypoxia = 4 per group). (opioid-receptors.com)
  • The results demonstrated that SA inhibited apoptosis signaling in H9c2 cardiomyocytes via downregulation of p38 mitogen-activated protein kinase (p38MAPK) and c-Jun N-terminal kinase (JNK) signaling pathways following hypoxia/reoxygenation (H/R) injury. (spandidos-publications.com)
  • Photomicrograph of a kidney biopsy specimen shows renal medulla, which is composed mainly of renal tubules. (medscape.com)
  • This overview provides information on the pathophysiology of the inducible nitric oxide synthase/nitric oxide (iNOS/NO) system in the injury to cultured renal tubular epithelia, freshly isolated proximal tubules, and the whole organ after hypoxic or ischemic insult. (scienceopen.com)
  • Our results revealed that iPSC-derived RPCs can protect AKI rat from renal function impairment and severe tubular injury by up-regulating the renal tubules formation, promoting cell proliferation, reducing apoptosis, and regulating the microenvironment in the injured kidney. (biomedcentral.com)
  • MATERIALS AND METHODS: We randomly divided 34 Macaca cynomolgus monkeys into groups 1 and 2, which received a renal autograft after 2 hours of cold ischemia, and groups 3 and 4, which received the autograft after 24 hours of cold ischemia. (unica.it)
  • The objective of this study was to determine whether homing of endothelial progenitor cells (EPCs) induced by ischemic preconditioning (IPC) contributed to the protection of renal acute ischemia-reperfusion injury (IRI) in male rats. (annalsoftransplantation.com)
  • Cell-based therapy with mesenchymal stem cells or renal progenitor cells (RPCs) resident in the kidney has appeared to be an effective strategy for the treatment of AKI. (biomedcentral.com)
  • To investigate the effect and mechanism of simvastatin on myocardial injury in cardiac valve surgery with CPB. (hindawi.com)
  • Perioperative statin therapy reduced myocardial injury by regulating myocardial autophagy and activating the phosphorylation of AMPK. (hindawi.com)
  • However, the role of SA in myocardial I/R injury is unclear. (spandidos-publications.com)
  • The present study aimed to clarify the cardioprotective effect of SA in myocardial I/R injury in vitro and explore the potential molecular mechanisms. (spandidos-publications.com)
  • However, the role of SA in myocardial I/R injury remains to be elucidated. (spandidos-publications.com)
  • In addition, SGK-1 regulates major physiological effects, such as renal solute transport, and contributes to the pathogenesis of non-neoplastic conditions involving major organs including the heart and the kidney . (bvsalud.org)
  • This review will provide insights into the roles of exRNA in pathogenesis, diagnosis and therapy of renal diseases. (biomedcentral.com)
  • Nitric oxide production (by iNOS) may play several roles in renal pathophysiology, including induction of tubular damage. (biomedcentral.com)
  • Thanks to the evolving techniques, exRNAs, particularly those detected from urine have gained great interest in renal diseases. (biomedcentral.com)
  • The recovery phase, in which tubular function recovers, is characterized by an increase in urine volume (if oliguria was present during the maintenance phase) and by a gradual decrease in BUN and serum Cr to their preinjury levels. (medscape.com)
  • This study aims to explore the role of standardized Boswellia serrata (containing 35 % boswellic acid) in attenuating kidney and liver damage in a model of rats with renal insult. (boswellia.org)
  • To investigate the effect of sevoflurane on renal ischemia-reperfusion injury (IRI) in rats and its regulatory effect on reperfusion injury salvage kinase (RISK) signaling pathway. (ajol.info)
  • To investigate the effect and mechanism of myeloid-derived suppressor cells (MDSCs) on renal ischemia-reperfusion injury (IRI) in mice. (cma-cmc.com.cn)
  • Renal injury was determined using hematoxylin and eosin (HE) staining. (ajol.info)
  • We further examined renal pathological injury by hematoxylin and eosin (HE) staining. (opioid-receptors.com)
  • Renal tubular cells (RTC) were co-cultured with CD11c+ bone-marrow derived dendritic cells (BMDC) from IL1R1 CD11cKO and IL1R1 CD11cWT mice. (asn-online.org)
  • On the basis of recent data that T cells are important mediators of isolated renal IRI, WBIRI was evaluated in T cell-deficient nu/nu mice. (johnshopkins.edu)
  • T cell-deficient mice had a significantly reduced rise in SCr and decreased tubular injury compared with wild-type mice. (johnshopkins.edu)
  • T cell-deficient mice had a decrease in ICAM-1 expression after WBIRI, but no decrease in renal MPO. (johnshopkins.edu)
  • This study describes a new, clinically relevant, model of ARF after WBIRI in mice and identifies the T cell as an important mediator of renal injury following WBIRI. (johnshopkins.edu)
  • Sham group (n = 6), mice underwent same anesthetic and surgical procedures except for ischemia induction. (biomedcentral.com)
  • After the end of reperfusion phase mice were sacrificed, blood samples were collected directly from the heart for determination of serum TNF-a, IL-6, urea and Creatinine. (biomedcentral.com)
  • MiR-181d-5p Improves Kidney Function in Mice With Renal IRI and Ameliorates H/R-Induced Damage in H/R-Exposed HK-2 Cells Control adeno-associated disease (AAV-control), AAV-miR-181d-5p or AAV-shRNA was perfused into the bilateral kidney parenchyma of mice before treatment with ischemia for 45 min and reperfusion for 24 h. (opioid-receptors.com)
  • Number 2B showed that kidneys from sham group mice exhibited normal histology, but those from IRI and AAV-control group mice exhibited severe kidney injury with tubular damage. (opioid-receptors.com)
  • These results suggested that miR-181d-5p may play a protecting part against renal IRI in mice. (opioid-receptors.com)
  • Open in another window Amount 2 MiR-181d-5p improved kidney function in mice with renal IRI and in RTECs. (opioid-receptors.com)
  • A) Serum creatinine and BUN amounts were evaluated in mice with or without miR-181d-5p infusion after IRI (= 6 per group). (opioid-receptors.com)
  • B) Pathological rating of renal tubular damage in mice. (opioid-receptors.com)
  • Results: OA ameliorated tubular damage and dramatically decreased serum creatinine (Scr) and urea nitrogen (BUN), and the expressions of renal injury markers (Kim-1, Ngal) in AKI mice induced by both IR injury and cisplatin, as well as attenuating AKI-to-CKD transition. (figshare.com)
  • Renal ischemia-reperfusion injury (IRI) impaired renal and liver function significantly, but Boswellia attenuated this impairment in a dose-dependent fashion. (boswellia.org)
  • Furthermore, the level of kidney injury molecule-1 (KIM-1) in renal cortical cells was determined by qRT-PCR and was found to be significantly decreased after miR-181d-5p overexpression (Number 2C). (opioid-receptors.com)
  • EUK-134 produced a significant reduction in renal dysfunction and injury caused by I/R. Specifically, serum creatinine levels, an indicator of renal dysfunction, were reduced from 227 ± 11 (n = 12, I/R only) to 146 ± 9 µ M (n = 12, I/R +3 mg/kg EUK-134). (scienceopen.com)
  • These sequelae of renal ischemia are a result of endothelial dysfunction, which is most probably responsible for the 'no-reflow' phenomenon and further aggravation of tubular ischemia during the early reperfusion period. (scienceopen.com)
  • Thus, pioglitazone ameliorates renal IRI by inhibiting the NF-κB signaling pathway and inflammatory response in rats. (frontiersin.org)
  • Therefore, in this study, we aimed to investigate the molecular mechanisms underlying pioglitazone hydrochloride-mediated amelioration of renal IRI with respect to the nuclear factor-kappaB (NF-κB) signaling pathway and inflammatory response using a rat model. (frontiersin.org)
  • Cardiopulmonary bypass (CPB) causes systemic inflammatory response and ischemia-reperfusion (IR) injury. (hindawi.com)
  • However, CPB inevitably causes systemic inflammatory response and ischemia-reperfusion (IR) injury, which can negatively affect postoperative cardiac function and a patient's long-term prognosis [ 1 ]. (hindawi.com)
  • IR injury and inflammatory response can substantially activate cell autophagy [ 6 ], and autophagy has been demonstrated to play an important role in the pathologic process of cardiac muscle injury [ 7 ]. (hindawi.com)
  • [ 27 ] Dexmedetomidine pretreatment attenuated the I/R injury by reducing inflammatory response mediated by toll-like receptor4 expression. (medscape.com)
  • Sprague-Dawley rats, exposed to renal injury via ischemia-reperfusion model, were administered a daily regimen of 1000 or 2000 mg/kg Boswellia for seven days then rats were sacrificed on day eight. (boswellia.org)
  • It is considered as a major cause of acute renal failure and the main factor in early recovery of renal graft function and long-term survival post renal transplantation. (frontiersin.org)
  • Renal enzymes, creatinine and urea levels were measured biochemically in serum. (rjme.ro)
  • 7. Serum activities of mitochondrial, plasma membrane, microsomal, lysosomal and cytosol marker enzymes tended to increase post-ligation, particularly at 8 days. (portlandpress.com)
  • In support of these findings, in vitro co-culture studies showed that RTC co-cultured with IL1R1 CD11cKO BMDC (in the presence of IL1β or LPS) exhibited higher mRNA levels of the kidney injury marker neutrophil gelatinase-associated lipocalin (NGAL) than those co-cultured with IL1R1 CD11cWT BMDC. (asn-online.org)
  • The history, physical examination, and laboratory and imaging findings, especially renal ultrasonogram and urinalysis, are particularly helpful in identifying the cause of ATN (see Presentation and Workup ). (medscape.com)
  • Further, it is unknown whether its major active component, Oroxylin A (OA), can alleviate kidney injury. (figshare.com)
  • Renal IRI models were created in model and sevoflurane groups, while sham group had no ligation. (ajol.info)
  • In this study, we investigated the plasma levels of CFH and haptoglobin, a CFH-binding serum protein, in prospectively enrolled LuTx patients (n = 20) with and without AKI. (stanford.edu)
  • LuTx patients with postoperative AKI had higher CFH plasma levels at the end of surgery compared with no-AKI patients, and CFH correlated with serum creatinine at 48 h. (stanford.edu)
  • Renal myeloperoxidase (MPO) levels increased at 24 h after WBIRI. (johnshopkins.edu)
  • A marked increase in TLR9, NF-κB, IL-6, IL-1β, TNF-α, and MDA besides decreased GSH levels were observed in the kidney and liver after renal IRI. (boswellia.org)
  • In the EP injection group, serum creatinine and TNF-α levels were lower than the ischemic control group. (elsevierpure.com)
  • We hypothesized that elevated levels of circulating inflammatory mediators are associated with IRI and/or acute kidney injury (AKI) after liver transplantation (LT). (atcmeetingabstracts.com)
  • The effects of EUK-134 on serum levels of NO in rats subjected to renal I/R or on NO production by PTCs incubated with interferon-γ (IFN-γ, 100 IU/ml) and bacterial lipopolysaccharide (LPS, 10 µg/ml) in combination for 24 h were also measured. (scienceopen.com)
  • However, EUK-134 also reduced nitrosative stress caused by I/R in vivo (reduction of iNOS expression and nitrotyrosine formation), which was reflected by a significant reduction in serum NO levels in rats subjected to renal I/R. Specifically, serum NO levels were reduced from 57 ± 12 (n = 12, I/R only) to 23 ± 3 m M (n = 12, I/R +3 mg/kg EUK-134). (scienceopen.com)
  • [ 24 ] Small increases in postoperative serum creatinine levels after cardiac surgery have been reported to be associated with increased morbidity and mortality even if the renal function has returned to normal at discharge. (medscape.com)
  • it acts as an anti-inflammatory cytokine and in vascular protection, besides important cardiac protection in the presence of ischemia-reperfusion syndrome. (scielo.org)
  • To estimate the group size, a pilot study was conducted for measuring the serum cardiac troponin T (cTnT) at 6 h after surgery in 10 patients who received statin and placebo treatment (ratio 1 : 1). (hindawi.com)
  • Following a brief description of the structure and function of SGK family of proteins , the present review is primarily focused on our current understanding of the role of SGK-1 in pathologies related to ischemia-reperfusion injury involving several organs (e.g., heart , kidney ). (bvsalud.org)
  • PURPOSE: We established a primate model to investigate the effects of the antileukocyte function associated antigen 1 (CD 11a) mAb odulimomab (Imtix-Sangstad, Lyon, France) for preventing renal ischemia-reperfusion injury. (unica.it)
  • CONCLUSIONS: This study provides evidence for the validity of this ischemia-reperfusion injury model in primates. (unica.it)
  • In conclusion, CFH is a possible factor contributing to postoperative AKI after LuTx and promotes AKI in an experimental model of mild transient renal ischemia. (stanford.edu)
  • We evaluated a new murine model of ARF after whole body ischemia reperfusion injury (WBIRI). (johnshopkins.edu)
  • We then established the rat ischemia-reperfusion injury (IR) model and transplanted the iPSC-derived RPCs into the injured rats in combination with the hydrogel. (biomedcentral.com)
  • RESULTS: A decrease in renal function was shown after 2 hours of cold ischemia with tubular necrosis and mild cell infiltration, while after 24 hours of cold ischemia there was severe renal failure with tubular and glomerular necrosis, and leukocyte infiltration. (unica.it)
  • Acute kidney injury (AKI) is a severe disease with high morbidity and mortality. (biomedcentral.com)
  • However, surgical detorsion-induced reperfusion injury may occur, and germ cells cannot be regenerated by the surgery [ 1 ]. (biomedcentral.com)
  • We previously explored that local injection of mesenchymal stem cells (MSCs) 30 min before surgical detorsion was applicable to prevent testicular torsion-induced I/R injury on germ cell and maintain the spermatogenesis at acute stage. (biomedcentral.com)
  • In response to acute injury, the adult kidney shows some level of regeneration characterized by the proliferation of the surviving cells and the replacement of the necrotic tubular cells with functional tubular epithelium [ 3 ]. (biomedcentral.com)
  • Title: Citrate, not phosphate, can dissolve calcium oxalate monohydrate crystals and detach these crystals from renal tubular cells. (aablocks.com)
  • The family of serum - glucocorticoid -regulated kinase (SGK) consists of three paralogs- SGK-1, SGK-2 and SGK-3 with SGK-1 being the better studied. (bvsalud.org)
  • Groups 1 and 3 monkeys were treated with an antileukocyte function associated antigen 1 mAb before cold ischemia and then for 3 days, while groups 2 and 4 monkeys received an IgG1 isotype control. (unica.it)
  • A significant improvement in renal function and decrease in kidney lactoferrin content was evident in group 1 compared to group 2 at 72 hours, while no significant difference was noted in groups 3 and 4. (unica.it)
  • The protective effects of antileukocyte function associated antigen 1 mAb on renal injury was not as dramatic as in rodent models but a significant improvement in renal function was observed in treated animals after 2 hours of cold ischemia. (unica.it)
  • Acute kidney injury (AKI) is a common clinical syndrome characterized by rapid deterioration of renal function. (biomedcentral.com)
  • Background: The impact of liver allograft ischemia/reperfusion injury (IRI) on native renal function remains to be characterized. (atcmeetingabstracts.com)
  • Renal function at 1-year post-transplant was noted as MDRD eGFR. (atcmeetingabstracts.com)
  • [ 1 ] At present, serum creatinine, which is used to measure the glomerular filtration rate (GFR), is the most commonly used marker of renal function. (medscape.com)
  • In particular, we evaluated renal function, diabetes parameters and coagulation tests. (scirp.org)
  • A series of quality of life parameters improved within the first 6 weeks of treatment and up to 3 months of treatment without impacting renal function, metabolic parameters or coagulation tests. (scirp.org)
  • Guha D, Mukerji SS, Chettimada S, Misra V, Lorenz DR, Morgello S, Gabuzda D. Cerebrospinal fluid extracellular vesicles and neurofilament light protein as biomarkers of central nervous system injury in HIV-infected patients on antiretroviral therapy. (biovendor.com)
  • and, most recently, microRNAs have been rigorously investigated over the past decade as possible biomarkers for early and accurate identification of AKI rather than secondary consequences of injury. (medscape.com)
  • Adapted from de Geus HR, Betjes MG, Bakker J. Biomarkers for the prediction of acute kidney injury: a narrative review on current status and future challenges. (medscape.com)
  • American Journal of Physiology - Renal Physiology , 285 (1 54-1), F87-F94. (johnshopkins.edu)
  • Acute kidney injury (AKI) is a leading cause of organ failure in hospitalized and critically ill patients. (asn-online.org)
  • Acute kidney injury (AKI) is a sudden incident that is linked with a high lethality rate commonly due to distant organ injury. (boswellia.org)